L Chiecchio

Summary

Affiliation: Salisbury District Hospital
Country: UK

Publications

  1. ncbi request reprint Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma
    L Chiecchio
    Leukaemia Research Fund UK Myeloma Forum Cytogenetics Group, Human Genetics Division, University of Southampton, Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, Wilts, UK
    Leukemia 20:1610-7. 2006
  2. doi request reprint Frequent upregulation of MYC in plasma cell leukemia
    Laura Chiecchio
    Leukaemia Research Fund UK Myeloma Forum Cytogenetics Group, Human Genetics Division, University of Southampton, Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, Wilts, UK
    Genes Chromosomes Cancer 48:624-36. 2009
  3. pmc Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: sequential analysis of a single case
    Laura Chiecchio
    Leukaemia Research Fund UK Myeloma Forum Cytogenetics Group, Human Genetics Division, University of Southampton, Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, Wilts, UK
    Haematologica 94:1024-8. 2009
  4. pmc Timing of acquisition of deletion 13 in plasma cell dyscrasias is dependent on genetic context
    Laura Chiecchio
    Leukaemia Research Fund UK Myeloma Forum Cytogenetics Group, Human Genetics Division, University of Southampton, Wessex Regional Genetics Laboratory, Salisbury District Hospital, Wilts, UK
    Haematologica 94:1708-13. 2009
  5. ncbi request reprint Age has a profound effect on the incidence and significance of chromosome abnormalities in myeloma
    F M Ross
    Wessex Regional Genetics Laboratory, LRF UK Myeloma Forum Cytogenetics Group, Salisbury District Hospital, Salisbury, UK
    Leukemia 19:1634-42. 2005

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma
    L Chiecchio
    Leukaemia Research Fund UK Myeloma Forum Cytogenetics Group, Human Genetics Division, University of Southampton, Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, Wilts, UK
    Leukemia 20:1610-7. 2006
    ..We conclude that Delta13 detected by metaphase analysis is a critical prognostic factor in myeloma. Absence of Delta13, even in those patients yielding only normal or no metaphases, is associated with a relatively good prognosis...
  2. doi request reprint Frequent upregulation of MYC in plasma cell leukemia
    Laura Chiecchio
    Leukaemia Research Fund UK Myeloma Forum Cytogenetics Group, Human Genetics Division, University of Southampton, Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, Wilts, UK
    Genes Chromosomes Cancer 48:624-36. 2009
    ..We conclude that MYC dysregulation by complex mechanisms is one of the major molecular events in the oncogenesis of PCL...
  3. pmc Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: sequential analysis of a single case
    Laura Chiecchio
    Leukaemia Research Fund UK Myeloma Forum Cytogenetics Group, Human Genetics Division, University of Southampton, Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, Wilts, UK
    Haematologica 94:1024-8. 2009
    ..This case report provides a unique insight into the mechanisms of disease progression from smouldering multiple myeloma to multiple myeloma...
  4. pmc Timing of acquisition of deletion 13 in plasma cell dyscrasias is dependent on genetic context
    Laura Chiecchio
    Leukaemia Research Fund UK Myeloma Forum Cytogenetics Group, Human Genetics Division, University of Southampton, Wessex Regional Genetics Laboratory, Salisbury District Hospital, Wilts, UK
    Haematologica 94:1708-13. 2009
    ..We investigated these aspects in a large series of patients...
  5. ncbi request reprint Age has a profound effect on the incidence and significance of chromosome abnormalities in myeloma
    F M Ross
    Wessex Regional Genetics Laboratory, LRF UK Myeloma Forum Cytogenetics Group, Salisbury District Hospital, Salisbury, UK
    Leukemia 19:1634-42. 2005
    ..044) and p53 deletion (P < 0.001) were also significant poor prognostic indicators. Multivariate analysis showed delta13 and t(14;16) to be independent prognostic variables when considered with age and clinical parameters...