Affiliation: Royal Brompton Hospital
- A comparison of gemifloxacin and clarithromycin in acute exacerbations of chronic bronchitis and long-term clinical outcomesRobert Wilson
Royal Brompton Hospital, London, England
Clin Ther 24:639-52. 2002..Gemifloxacin is an enhanced-affinity quinolone with potent activity against lower respiratory tract pathogens...
- Oral gemifloxacin once daily for 5 days compared with sequential therapy with i.v. ceftriaxone/oral cefuroxime (maximum of 10 days) in the treatment of hospitalized patients with acute exacerbations of chronic bronchitisR Wilson
Royal Brompton Hospital, London, U K
Respir Med 97:242-9. 2003..A 5-day course of oral gemifloxacin was shown by this study to be at least equivalent to sequential i.v. ceftriaxone/cefuroxime axetil (for up to 10 days) in patients with AECB who require hospital treatment...
- Short-term and long-term outcomes of moxifloxacin compared to standard antibiotic treatment in acute exacerbations of chronic bronchitisRobert Wilson
Royal Brompton Hospital, London, UK
Chest 125:953-64. 2004..To compare the effectiveness of oral moxifloxacin with standard antibiotic therapy in acute exacerbation of chronic bronchitis (AECB)...
- Moxifloxacin versus amoxicillin/clavulanic acid in outpatient acute exacerbations of COPD: MAESTRAL resultsRobert Wilson
Host Defence Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
Eur Respir J 40:17-27. 2012..The MAESTRAL study showed that moxifloxacin was as effective as amoxicillin/clavulanic acid in the treatment of outpatients with AECOPD. Both therapies were well tolerated...
- Newer fluoroquinolones in the treatment of acute exacerbations of COPDAmit Patel
Royal Brompton Hospital, London, UK
Int J Chron Obstruct Pulmon Dis 1:243-50. 2006..Recent antibiotic trials have compared fluoroquinolones with "standard" antibiotics and found, in the main, longer exacerbation-free intervals and better bacterial eradication rates in those treated with fluoroquinolones...
- A novel study design for antibiotic trials in acute exacerbations of COPD: MAESTRAL methodologyRobert Wilson
Host Defence Unit, Royal Brompton Hospital, London, England, UK
Int J Chron Obstruct Pulmon Dis 6:373-83. 2011..Patients are stratified according to oral corticosteroid use to control their effect across antibiotic treatment arms. Secondary endpoints include quality of life, symptom assessments and health care resource use...
- Respiratory infection in noncystic fibrosis bronchiectasisZaid Zoumot
Host Defence Unit, Royal Brompton Hospital, London, UK
Curr Opin Infect Dis 23:165-70. 2010..We highlight some of the main developments in the investigation and management of bronchiectasis, a condition causing susceptibility to airway infections and in more severe cases chronic bronchial suppuration...
- Pulmonary hypertension in patients with bronchiectasis: prognostic significance of CT signsAnand Devaraj
Department of Radiology, Royal Brompton Hospital, Sydney St, London, SW3 6NP, UK
AJR Am J Roentgenol 196:1300-4. 2011..The purpose of this study was to evaluate the association between pulmonary hypertension estimated with CT and outcome among patients with bronchiectasis...
- Ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis: a phase II randomised studyRobert Wilson
Royal Brompton Hospital, London
Eur Respir J 41:1107-15. 2013..Ciprofloxacin DPI 32.5 mg twice daily for 28 days was well tolerated and achieved significant reductions in total bacterial load compared with placebo in subjects with non-cystic fibrosis bronchiectasis...
- Pharmacotherapy for bronchiectasisMichael R Loebinger
Royal Brompton Hospital, Host Defence Unit, Fulham Road, London, SW3 6NP, UK
Expert Opin Pharmacother 8:3183-93. 2007..This article discusses the management of bronchiectasis with particular reference to the pathophysiological processes involved in the condition. It then looks at the available evidence supporting such a management plan...
- In vitro models of infection I--human respiratory tissue organ cultureAndrew M Middleton
Department of Microbiology, Royal Brompton Hospital, Host Defense Unit, Imperial College School of Science, Technology and Medicine, National Heart and Lung Institute, London, United Kingdom
Methods Mol Med 71:277-95. 2003
- MOSAIC acronymRobert Wilson
Chest 126:1708. 2004
- Short course of antibiotic treatment in acute exacerbations of COPDRobert Wilson
Thorax 63:390-2. 2008
- Endothelial dysfunction in patients with recent myocardial infarction and hyperhomocysteinaemia: effects of vitamin supplementationStanley Chia
Department of Cardiology, National Heart Centre, 17 Hospital Avenue, Singapore 168752, Republic of Singapore
Clin Sci (Lond) 108:65-72. 2005..This endothelial vasomotor dysfunction is unaltered by vitamin supplementation...
- Bacteria and airway inflammation in chronic obstructive pulmonary disease: more evidenceRobert Wilson
Am J Respir Crit Care Med 172:147-8. 2005
- Multiple simultaneous complications of acute otitis media in a child diagnosed with chronic granulomatous disease: a case reportRobert Wilson
Department of Surgery, Division of Otolaryngology, University of Kentucky College of Medicine, 800 Rose St, Lexington, KY 40536 0298, USA
Ear Nose Throat J 87:271-2, 279. 2008..The presented case should encourage physicians to investigate the possibility of an underlying immunodeficiency when treating patients with multiple simultaneous complications of acute otitis media...