Affiliation: Royal Marsden Hospital
- Predictive genetic testing for BRCA1/2 in a UK clinical cohort: three-year follow-upC Foster
Macmillan Research Unit, School of Nursing and Midwifery, University of Southampton, Southampton, UK
Br J Cancer 96:718-24. 2007....
- Problem-focussed interactive telephone therapy for cancer patients: a phase II feasibility trialM Watson
Psychology Research Group, Sycamore House, Royal Marsden Hospital, UK
Psychooncology 22:1485-91. 2013..The study aimed to evaluate Problem-Focussed Interactive Telephone Therapy, an individual psychological therapy based on cognitive-behavioural therapy adapted for telephone delivery to cancer patients with high psychological needs...
- Coping response and survival in breast cancer patients: a new analysisM Watson
Royal Marsden NHS Foundation Trust, Sutton, UK
Stress Health 28:376-80. 2012..The purpose of this study was to analyse the impact of coping response on survival of breast cancer by using a new method of assessing coping...
- Mental Adjustment to Cancer Scale: psychometric properties in a large cancer cohortM Watson
The Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK
Psychooncology 17:1146-51. 2008..Evidence from these replication studies is reviewed. A re-analysis of the MAC Scale was conducted on a substantial new cohort in order to clarify the factor structure...
- Adolescent's stress responses and psychological functioning when a parent has early breast cancerL Edwards
Royal Marsden Hospital NHS Trust, Sutton and London, UK
Psychooncology 17:1039-47. 2008..To identify factors associated with psychological functioning in adolescent children of early-stage breast cancer patients...
- Factors associated with emotional and behavioural problems among school age children of breast cancer patientsM Watson
Department of Psychological Medicine, The Royal Marsden Hospital NHS Trust, Downs Road, Sutton, Surrey SM2 5PT, UK
Br J Cancer 94:43-50. 2006..Targeted treatments, which focus on maternal depression and family communication may benefit the children and, through improved relationships, enhance the patients' quality of life...
- Influence of psychological response on breast cancer survival: 10-year follow-up of a population-based cohortM Watson
Department of Psychological Medicine, Royal Marsden Hospital NHS Trust, Downs Road, Sutton SM2 5PT, UK
Eur J Cancer 41:1710-4. 2005..Further large studies, with similarly prolonged follow-up, are needed to replicate this effect and clarify its mechanism of action...
- Psychosocial impact of breast/ovarian (BRCA1/2) cancer-predictive genetic testing in a UK multi-centre clinical cohortM Watson
Department of Psychological Medicine, Royal Marsden NHS Foundation Trust, London and Sutton, SM2 5PT, England
Br J Cancer 91:1787-94. 2004..The data show persistent worry in younger female gene carriers and confirm changes in risk management consistent with carrier status. Men were not adversely affected by genetic testing in terms of their general mental health...
- Predictive testing for BRCA1/2: attributes, risk perception and management in a multi-centre clinical cohortC Foster
Psychology Research Group and Cancer Genetics Team, The Institute of Cancer Research, Sutton SM2 5PT, UK
Br J Cancer 86:1209-16. 2002..The findings indicate that younger women may be particularly vulnerable at the time of the offer of a predictive genetic test...
- Disclosure of genetics research results after the death of the patient participant: a qualitative study of the impact on relativesE Ormondroyd
Psychology Research Group, Institute of Cancer Research, Sutton, UK
J Genet Couns 16:527-38. 2007..Implications for informed consent in genetics research programs, and the requirement for genetic counselling when research results are disclosed, are discussed...
- Non-uptake of predictive genetic testing for BRCA1/2 among relatives of known carriers: attributes, cancer worry, and barriers to testing in a multicenter clinical cohortC Foster
Psychology Research Group, The Institute of Cancer Research, Sutton, SM2 5NG, England
Genet Test 8:23-9. 2004..The findings do not indicate that healthy BRCA1/2 test decliners are a more vulnerable group in terms of cancer worry. However, barriers to testing need to be discussed in genetic counseling...
- Communicating genetics research results to families: problems arising when the patient participant is deceasedE Ormondroyd
Psychology Research Group, Institute of Cancer Research, Sutton, UK
Psychooncology 17:804-11. 2008..BRCA2 mutations were found in several men after their death from prostate cancer. Spouses were given the results in a genetic counselling session and asked to inform relatives...
- The feasibility and results of a population-based approach to evaluating prostate-specific antigen screening for prostate cancer in men with a raised familial riskJ Melia
Cancer Screening Evaluation Unit, Institute of Cancer Research, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK
Br J Cancer 94:499-506. 2006..To study further the effects of screening, patients with a raised familial risk should be counselled in clinic about screening of relatives and data routinely recorded so that the effects of screening on high-risk groups can be studied...
- The impact of genetic counselling on risk perception and mental health in women with a family history of breast cancerM Watson
Royal Marsden NHS Trust and Institute of Cancer Research, Sutton, Surrey, UK
Br J Cancer 79:868-74. 1999..Women who continue to over-estimate their risk and worry about breast cancer are likely to go on seeking unnecessary screening if they are not reassured...
- Feasibility of familial PSA screening: psychosocial issues and screening adherenceJ Sweetman
Academic Department of Radiotherapy, Institute of Cancer Research and Royal Marsden NHS Trust, Downs Road, Sutton, Surrey SM2 5PT, UK
Br J Cancer 94:507-12. 2006..05). First-degree relatives entering the linked familial PSA screening programme do not, in general, have high levels of psychological morbidity. However, a small number of men exhibited psychological distress...
- Influence of psychological response on survival in breast cancer: a population-based cohort studyM Watson
Royal Marsden Hospital NHS Trust, Sutton, Surrey, UK
Lancet 354:1331-6. 1999..We have investigated the effect of psychological response on disease outcome in a large cohort of women with early-stage breast cancer...
- Genetic testing for women previously diagnosed with breast/ovarian cancer: examining the impact of BRCA1 and BRCA2 mutation searchingN Hallowell
The Institute of Cancer Research, Royal Marsden Hospital, London, UK
Genet Test 6:79-87. 2002..Some recommendations for clinical practice are discussed...
- Familial breast cancer: a controlled study of risk perception, psychological morbidity and health beliefs in women attending for genetic counsellingS Lloyd
Institute of Cancer Research, Sutton, Surrey, UK
Br J Cancer 74:482-7. 1996..Despite genetic counselling, many cases continued to perceive their risk of breast cancer inaccurately...
- Anticipatory nausea and emesis, and psychological morbidity: assessment of prevalence among out-patients on mild to moderate chemotherapy regimensM Watson
CRC Psychological Medicine Research Group, Royal Marsden Hospital, London, UK
Br J Cancer 66:862-6. 1992....
- A phase I/II study of leucovorin, carboplatin and 5-fluorouracil (LCF) in patients with carcinoma of unknown primary site or advanced oesophagogastric/pancreatic adenocarcinomasA Rigg
GI Unit, Cancer Research Campaign Section of Medicine, The Royal Marsden Hospital, Institute of Cancer Research, Sutton, Surrey, UK
Br J Cancer 75:101-5. 1997..The majority of patients described a symptomatic improvement with LCF chemotherapy. The recommended dose of 5-FU for future studies is 350 mg m-2 combined with leucovorin 20 mg m-2 and carboplatin (AUC5)...
- Development of a disease specific questionnaire to supplement a generic tool for QoL in colorectal cancerJ Davidson-Homewood
Institute of Cancer Research, Sutton, Surrey, UK
Psychooncology 12:675-85. 2003..However, this questionnaire provides a useful alternative tool for use in clinical trials of colorectal cancer treatments alongside a core QoL questionnaire especially when brevity is an important consideration...
- Baseline quality of life predicts survival in patients with advanced colorectal cancerN R Maisey
Department of Medicine, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK
Eur J Cancer 38:1351-7. 2002..0001). Baseline QoL is a strong independent predictor of survival in patients with advanced colorectal cancer. Measurements should be routinely recorded in clinical trials to stratify cohorts and aid in trial comparison...
- Adverse impact of bone marrow transplantation on quality of life in acute myeloid leukaemia patients; analysis of the UK Medical Research Council AML 10 TrialM Watson
Psychological Medicine, Royal Marsden Hospital NHS Trust, Sutton and London and Institute of Cancer Research, Downs Road, Sutton, Surrey SM2 5PT, UK
Eur J Cancer 40:971-8. 2004..These results indicate that a reconsideration of treatment strategies is warranted, and that further, good prospective studies are needed to evaluate more clearly the effects of these treatments in long-term survivors...
- Communication about genetic testing in families of male BRCA1/2 carriers and non-carriers: patterns, priorities and problemsN Hallowell
Public Health Sciences, The Medical School, University of Edinburgh, Edinburgh, UK
Clin Genet 67:492-502. 2005..Some of the problems arising from the adoption of different disclosure patterns are identified and the implications for clinical practice are discussed...
- Men's decision-making about predictive BRCA1/2 testing: the role of familyN Hallowell
Public Health Sciences, The Medical School, University of Edinburgh, United Kingdom
J Genet Couns 14:207-17. 2005..There was evidence that (adult) children were excluded from the decision-making, and some expressed resentment about this. The implications of these findings for the practice of genetic counseling are discussed...
- Does genetic counseling have any impact on management of breast cancer risk?M Watson
Royal Marsden NHS Foundation Trust Hospital, Sutton SM2 5PT, United Kingdom
Genet Test 9:167-74. 2005..Genetic counseling had a positive impact on management of breast cancer risk. Whether this translates into future health gains remains to be established...
- Accommodating risk: responses to BRCA1/2 genetic testing of women who have had cancerN Hallowell
The Medical School, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, UK
Soc Sci Med 59:553-65. 2004..It is observed that women's responses to their genetic risk are influenced by the degree to which they have accommodated their risk status in their biography following their diagnosis and treatment of cancer...
- A randomised controlled trial of a psychoeducational intervention for women at increased risk of breast cancerS Appleton
Cancer Research UK, Edinburgh Oncology Unit, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK
Br J Cancer 90:41-7. 2004....
- Balancing autonomy and responsibility: the ethics of generating and disclosing genetic informationN Hallowell
The Institute of Cancer Research, London, UK
J Med Ethics 29:74-9; discussion 80-3. 2003..The implications of these findings for ethical debates about informed choice in the context of genetic testing are discussed...
- Psychological impact of genetic testing in women from high-risk breast cancer familiesB Meiser
Prince of Wales Clinical School, Faculty of Medicine, University of NSW, Australia
Eur J Cancer 38:2025-31. 2002..Women testing positive may anticipate a sustained increase in breast cancer distress following disclosure, although no other adverse psychological outcomes were observed in this group...