J Shepherd

Summary

Affiliation: Royal Infirmary
Country: UK

Publications

  1. ncbi Does statin monotherapy address the multiple lipid abnormalities in type 2 diabetes?
    James Shepherd
    Department of Biochemistry, Royal Infirmary, Glasgow G4 OSF, Scotland, UK
    Atheroscler Suppl 6:15-9. 2005
  2. ncbi Monotherapy vs combination therapy for dyslipidemia in the elderly
    James Shepherd
    University Department of Pathological Biochemistry, Royal Infirmary, Glasgow, Scotland, UK
    Am J Geriatr Cardiol 17:108-13. 2008
  3. ncbi Diabetes in tomorrow's world: dark clouds do have silver linings
    James Shepherd
    Institute of Biochemistry, Glasgow Royal Infirmary, Glasgow, UK
    Diabetes Obes Metab 4:351-5. 2002
  4. ncbi Intensive lipid lowering with atorvastatin in patients with coronary artery disease, diabetes, and chronic kidney disease
    James Shepherd
    University of Glasgow, United Kingdom
    Mayo Clin Proc 83:870-9. 2008
  5. ncbi Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial
    James Shepherd
    University Department of Pathological Biochemistry, University of Glasgow, Royal Infirmary, Scotland, Glasgow, UK
    Lancet 360:1623-30. 2002
  6. ncbi Effect of intensive lipid lowering with atorvastatin on renal function in patients with coronary heart disease: the Treating to New Targets (TNT) study
    James Shepherd
    Department of Vascular Biochemistry, University of Glasgow, G31 2ER, UK
    Clin J Am Soc Nephrol 2:1131-9. 2007
  7. ncbi Guidelines for lowering lipids to reduce coronary artery disease risk: a comparison of rosuvastatin with atorvastatin, pravastatin, and simvastatin for achieving lipid-lowering goals
    James Shepherd
    Department of Pathological Biochemistry, Royal Infirmary, University of Glasgow, Scotland, United Kingdom
    Am J Cardiol 91:11C-17C; discussion 17C-19C. 2003
  8. ncbi Preventing the next event in the elderly: the PROSPER perspective
    James Shepherd
    Department of Pathological Biochemistry, University Department of Pathological Biochemistry, Royal Infirmary, Glasgow, G4 0SF, Scotland, UK
    Atheroscler Suppl 4:17-22. 2003
  9. ncbi Safety of rosuvastatin
    James Shepherd
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
    Am J Cardiol 94:882-8. 2004
  10. ncbi Lipids in health and disease
    J Shepherd
    Institute of Biochemistry, Royal Infirmary, Glasgow G4 0SF, Scotland, UK
    Biochem Soc Trans 32:1051-6. 2004

Collaborators

Detail Information

Publications78

  1. ncbi Does statin monotherapy address the multiple lipid abnormalities in type 2 diabetes?
    James Shepherd
    Department of Biochemistry, Royal Infirmary, Glasgow G4 OSF, Scotland, UK
    Atheroscler Suppl 6:15-9. 2005
    ..In order to achieve improved outcomes in diabetes patients, it will be important to address other abnormalities in their lipid profiles, including elevated triglycerides and low HDL-C...
  2. ncbi Monotherapy vs combination therapy for dyslipidemia in the elderly
    James Shepherd
    University Department of Pathological Biochemistry, Royal Infirmary, Glasgow, Scotland, UK
    Am J Geriatr Cardiol 17:108-13. 2008
    ....
  3. ncbi Diabetes in tomorrow's world: dark clouds do have silver linings
    James Shepherd
    Institute of Biochemistry, Glasgow Royal Infirmary, Glasgow, UK
    Diabetes Obes Metab 4:351-5. 2002
  4. ncbi Intensive lipid lowering with atorvastatin in patients with coronary artery disease, diabetes, and chronic kidney disease
    James Shepherd
    University of Glasgow, United Kingdom
    Mayo Clin Proc 83:870-9. 2008
    ....
  5. ncbi Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial
    James Shepherd
    University Department of Pathological Biochemistry, University of Glasgow, Royal Infirmary, Scotland, Glasgow, UK
    Lancet 360:1623-30. 2002
    ..Our aim was to test the benefits of pravastatin treatment in an elderly cohort of men and women with, or at high risk of developing, cardiovascular disease and stroke...
  6. ncbi Effect of intensive lipid lowering with atorvastatin on renal function in patients with coronary heart disease: the Treating to New Targets (TNT) study
    James Shepherd
    Department of Vascular Biochemistry, University of Glasgow, G31 2ER, UK
    Clin J Am Soc Nephrol 2:1131-9. 2007
    ..This subanalysis of the Treating to New Targets study investigated how intensive lipid lowering with 80 mg of atorvastatin affects renal function when compared with 10 mg in patients with coronary heart disease...
  7. ncbi Guidelines for lowering lipids to reduce coronary artery disease risk: a comparison of rosuvastatin with atorvastatin, pravastatin, and simvastatin for achieving lipid-lowering goals
    James Shepherd
    Department of Pathological Biochemistry, Royal Infirmary, University of Glasgow, Scotland, United Kingdom
    Am J Cardiol 91:11C-17C; discussion 17C-19C. 2003
    ..001). A total of 71% of patients treated with rosuvastatin 10 mg who had triglyceride levels > or =200 mg/dL met both their LDL cholesterol and their non-high-density lipoprotein cholesterol goals...
  8. ncbi Preventing the next event in the elderly: the PROSPER perspective
    James Shepherd
    Department of Pathological Biochemistry, University Department of Pathological Biochemistry, Royal Infirmary, Glasgow, G4 0SF, Scotland, UK
    Atheroscler Suppl 4:17-22. 2003
    ..Therefore, PROSPER extends to elderly individuals the treatment strategy currently used in middle-aged people...
  9. ncbi Safety of rosuvastatin
    James Shepherd
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
    Am J Cardiol 94:882-8. 2004
    ..Rosuvastatin was well tolerated by a broad range of patients who had dyslipidemia, and its safety profile was similar to those of the comparator statins investigated in this extensive clinical program...
  10. ncbi Lipids in health and disease
    J Shepherd
    Institute of Biochemistry, Royal Infirmary, Glasgow G4 0SF, Scotland, UK
    Biochem Soc Trans 32:1051-6. 2004
    ....
  11. ncbi Safety of rosuvastatin: update on 16,876 rosuvastatin-treated patients in a multinational clinical trial program
    James Shepherd
    Department of Pathological Biochemistry, University of Glasgow, Glasgow, UK
    Cardiology 107:433-43. 2007
    ....
  12. ncbi Effect of lowering LDL cholesterol substantially below currently recommended levels in patients with coronary heart disease and diabetes: the Treating to New Targets (TNT) study
    James Shepherd
    Department of Vascular Biochemistry, Royal Infirmary, Glasgow G4 OSF, U K
    Diabetes Care 29:1220-6. 2006
    ..The objective of our study was to investigate whether similar benefits of high-dose intensive atorvastatin therapy can be achieved in patients with CHD and diabetes...
  13. doi Intensive lipid lowering with atorvastatin in patients with coronary heart disease and chronic kidney disease: the TNT (Treating to New Targets) study
    James Shepherd
    University of Glasgow, Glasgow, United Kingdom
    J Am Coll Cardiol 51:1448-54. 2008
    ..This subanalysis of the TNT (Treating to New Targets) study investigates the effects of intensive lipid lowering with atorvastatin in patients with coronary heart disease (CHD) with and without pre-existing chronic kidney disease (CKD)...
  14. ncbi Issues surrounding age: vascular disease in the elderly
    J Shepherd
    Institute of Biochemistry, Royal Infirmary, Glasgow, Scotland, UK
    Curr Opin Lipidol 12:601-9. 2001
    ....
  15. ncbi The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER). PROSPER Study Group. PROspective Study of Pravastatin in the Elderly at Risk
    J Shepherd
    University of Glasgow, Scotland
    Am J Cardiol 84:1192-7. 1999
    ..Finally, an assessment will be made of the effects of treatment on cognitive function, disability, hospitalization or institutionalization, vascular mortality, and all-cause mortality...
  16. ncbi Effects of colestipol alone and in combination with simvastatin on apolipoprotein B metabolism
    A Gaw
    Institute of Biochemistry, Glasgow Royal Infirmary, UK
    Arterioscler Thromb Vasc Biol 16:236-49. 1996
    ..Compared with baseline, combined therapy generated falls in both IDL (35%, P = .01) and LDL (37%, P < .04) apoB pools due to enhanced clearance of IDL (214%, P < .03) and reduced total input of LDL (39%, P < .003)...
  17. ncbi Cholesterol lowering with statins: how WOSCOPS confounded the skeptics
    J Shepherd
    Department of Biochemistry, Macewen Building, Glasgow Royal Infirmary, North Glasgow University Hospital Division, 8 Alexandra Parade, Glasgow G31 2 ER, Scotland, UK
    Atheroscler Suppl 8:9-12. 2007
    ..WOSCOPS revealed for the first time that statin was effective for primary prevention. The benefits appeared early and persisted even after treatment ended. Statins also changed our perceptions with surprising ancillary effects...
  18. ncbi Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS)
    A M Wallace
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, University of Glasgow, Glasgow, Scotland
    Circulation 104:3052-6. 2001
    ..18; 95% CI, 1.00 to 1.39; P=0.05) at the expense of C-reactive protein. CONCLUSIONS: We show, for the first time, in a large prospective study that leptin is a novel, independent risk factor for coronary heart disease...
  19. doi Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly
    N Sattar
    Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, University Place, Glasgow G12 8TA, UK
    Diabetologia 52:235-9. 2009
    ....
  20. ncbi Serial metabolic measurements and conversion to type 2 diabetes in the west of Scotland coronary prevention study: specific elevations in alanine aminotransferase and triglycerides suggest hepatic fat accumulation as a potential contributing factor
    Naveed Sattar
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
    Diabetes 56:984-91. 2007
    ....
  21. ncbi Blood rheology, cardiovascular risk factors, and cardiovascular disease: the West of Scotland Coronary Prevention Study
    G Lowe
    Department of Medicine, University of Glasgow, UK
    Thromb Haemost 84:553-8. 2000
    ..Further studies are required to test this hypothesis...
  22. ncbi Who should receive a statin these days? Lessons from recent clinical trials
    J Shepherd
    Institute of Biochemistry, Royal Infirmary, Glasgow, UK
    J Intern Med 260:305-19. 2006
    ..Progression to hepatitis or liver failure does not occur. This constellation of benefits with little side effect penalty has resulted in the comparison of statins with antibiotics in the global battle against cardiovascular disease...
  23. ncbi Lipid and lipoprotein concentrations in pregnancies complicated by intrauterine growth restriction
    N Sattar
    Department of Pathological Biochemistry, Royal Infirmary University NHS Trust, Glasgow, United Kingdom
    J Clin Endocrinol Metab 84:128-30. 1999
    ....
  24. ncbi Lipoprotein metabolism in hepatic lipase deficiency: studies on the turnover of apolipoprotein B and on the effect of hepatic lipase on high density lipoprotein
    T Demant
    University Department of Biochemistry, Royal Infirmary, Glasgow, UK
    J Lipid Res 29:1603-11. 1988
    ..The pathways of direct plasma catabolism of these species were not affected by the enzyme defect. In vitro studies were performed by adding purified hepatic lipase to the patient's plasma.(ABSTRACT TRUNCATED AT 250 WORDS)..
  25. ncbi Dyslipidaemia in diabetic patients: time for a rethink
    J Shepherd
    Department of Vascular Biochemistry, Glasgow Royal Infirmary, Glasgow, Scotland
    Diabetes Obes Metab 9:609-16. 2007
    ..Together, these data support the proposed strategy of aggressive multidrug treatment of diabetic dyslipidaemia to improve patient outcome...
  26. pmc Statins for primary prevention: strategic options to save lives and money
    James Shepherd
    Institute of Biochemistry, Royal Infirmary, Glasgow G4 0SF, Scotland, UK
    J R Soc Med 97:66-71. 2004
  27. pmc Reduced glomerular filtration rate and its association with clinical outcome in older patients at risk of vascular events: secondary analysis
    Ian Ford
    Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland
    PLoS Med 6:e16. 2009
    ..We aimed to determine the predictive value of the GFR for mortality and morbidity using data from the 5,804 participants randomized in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)...
  28. ncbi Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention study
    Naveed Sattar
    Division of Cardiovascular and Medical Sciences, Universityof Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Diabetes 53:2855-60. 2004
    ..The simplicity of ALT measurement and its availability in routine clinical practice suggest that this enzyme activity could be included in future diabetes prediction algorithms...
  29. ncbi Long-term follow-up of the West of Scotland Coronary Prevention Study
    Ian Ford
    Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom
    N Engl J Med 357:1477-86. 2007
    ..9 to 5.5% (P<0.001) in the treatment group. Extended follow-up data were obtained for approximately 10 years after completion of the trial...
  30. ncbi Lipid-modifying effects of rosuvastatin in postmenopausal women with hypercholesterolemia who are receiving hormone replacement therapy
    James Shepherd
    Glasgow Royal Infirmary, Glasgow, Scotland, UK
    Curr Med Res Opin 20:1571-8. 2004
    ..To evaluate the efficacy and safety of rosuvastatin in postmenopausal women with hypercholesterolemia who are receiving hormone replacement therapy (HRT) in a randomized, double-blind, placebo-controlled trial...
  31. ncbi Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study
    Naveed Sattar
    University Department of Pathological Biochemistry, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    Circulation 108:414-9. 2003
    ..Information on the prospective association of this definition for coronary heart disease (CHD) and type 2 diabetes is currently limited...
  32. ncbi Factors affecting low-density lipoprotein and high-density lipoprotein cholesterol response to pravastatin in the West Of Scotland Coronary Prevention Study (WOSCOPS)
    Leanne Streja
    Robertson Centre for Biostatistics, Glasgow University, Glasgow, Scotland, UK
    Am J Cardiol 90:731-6. 2002
    ..The absolute increment in HDL cholesterol is relatively constant across a range of baseline values, hence the percent change is largely a function of the starting value...
  33. ncbi Resource management in prevention of coronary heart disease: optimising prescription of lipid-lowering drugs
    James Shepherd
    Institute of Biochemistry, Royal Infirmary, Glasgow G4 0SF, UK
    Lancet 359:2271-3. 2002
  34. ncbi A prospective study of pravastatin in the elderly at risk: new hope for older persons
    James Shepherd
    Institute of Biochemistry, Royal Infirmary, University of Glasgow, Glasgow, Scotland
    Am J Geriatr Cardiol 13:17-24. 2004
    ..These results demonstrate the benefits of pravastatin in primary and, particularly, secondary prevention in elderly populations and further support the benefits of statin therapy in high-risk elderly persons...
  35. ncbi International comparison of awareness and attitudes towards coronary risk factor reduction: the HELP study. Heart European Leaders Panel
    J Shepherd
    Institute of Biochemistry, Royal Infirmary, Glasgow, UK
    Atherosclerosis 137:S117-23. 1998
    ..They also have access to sources of heart health information which are perceived as highly credible. Nonetheless, such information has a very limited impact on their practice of health-related behaviours...
  36. ncbi From best evidence to best practice - what are the obstacles?
    J Shepherd
    Department of Pathological Biochemistry, Royal Infirmary, Glasgow, UK
    Atherosclerosis 147:S45-51. 1999
    ..Healthcare professionals, therefore, have an obligation to ensure patients receive the maximum benefit from medical advances by working together to overcome the barriers...
  37. doi Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies
    Naveed Sattar
    Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Lancet 371:1927-35. 2008
    ..We investigated to what extent metabolic syndrome and its individual components were related to risk for these two diseases in elderly populations...
  38. pmc Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population
    Paul Welsh
    Faculty of Medicine, University of Glasgow, Scotland, UK
    Diabetes Care 32:308-10. 2009
    ..To clarify the association of circulating levels of leptin with risk for cardiovascular disease (CVD) events and new-onset diabetes in men and women...
  39. ncbi Plasma lipoproteins and apolipoproteins as predictors of cardiovascular risk and treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER)
    Chris J Packard
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
    Circulation 112:3058-65. 2005
    ..We assessed the role of plasma lipoproteins as predictors of risk and of treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER)...
  40. ncbi C-reactive protein and prediction of coronary heart disease and global vascular events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)
    Naveed Sattar
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland, UK
    Circulation 115:981-9. 2007
    ..The role of C-reactive protein (CRP) in predicting vascular events and response to statin therapy remains uncertain. Additional large prospective studies are required...
  41. doi Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials
    Naveed Sattar
    British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Lancet 375:735-42. 2010
    ..We aimed to establish by a meta-analysis of published and unpublished data whether any relation exists between statin use and development of diabetes...
  42. ncbi Statin therapy in the elderly: does it make good clinical and economic sense?
    Moira M B Mungall
    Clinical Trials Unit, Glasgow Royal Infirmary, Glasgow, UK
    Drugs Aging 20:263-75. 2003
    ....
  43. ncbi The anatomy of a clinical trial. The West of Scotland Coronary Prevention Study
    J Shepherd
    Institute of Biochemistry, Royal Infirmary, Glasgow, UK
    Med Princ Pract 11:17-30. 2002
    ..The time was therefore ripe to determine whether statins could help prevent that first and all important myocardial infarction...
  44. ncbi Economics of lipid lowering in primary prevention: lessons from the West of Scotland Coronary Prevention Study
    J Shepherd
    Institute of Biochemistry, Department of Pathological Biochemistry, Royal Infirmary, Glasgow, Scotland, United Kingdom
    Am J Cardiol 87:19B-22B. 2001
    ....
  45. ncbi Lipid-lowering--translating evidence into benefits
    James Shepherd
    Department of Pathological Biochemistry, University of Glasgow Royal Infirmary, Glasgow, Scotland, UK
    Atheroscler Suppl 2:1-3. 2002
  46. ncbi Nicotinic acid in the management of dyslipidaemia associated with diabetes and metabolic syndrome: a position paper developed by a European Consensus Panel
    James Shepherd
    Department of Vascular Biochemistry, Glasgow Royal Infirmary, Glasgow, UK
    Curr Med Res Opin 21:665-82. 2005
    ..Prolonged-release nicotinic acid with improved tolerability compared with previous formulations may have obvious advantages for use in this setting...
  47. doi Lipoprotein-associated phospholipase A(2), inflammatory biomarkers, and risk of cardiovascular disease in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)
    Muriel J Caslake
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G11 6NT, UK
    Atherosclerosis 210:28-34. 2010
    ..We evaluated the association of Lp-PLA(2) with vascular events in the elderly where the importance of LDL is diminished as a risk factor for coronary disease...
  48. pmc Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events?
    Naveed Sattar
    Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, Scotland, UK
    PLoS Med 6:e1000099. 2009
    ..We tested whether interleukin (IL)-6, C-reactive protein (CRP), and fibrinogen more strongly associate with fatal compared to nonfatal myocardial infarction (MI) and stroke...
  49. ncbi Association between apolipoprotein E4 and cognitive decline in elderly adults
    Chris J Packard
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
    J Am Geriatr Soc 55:1777-85. 2007
    ..To determine the influence of apolipoprotein E on cognitive decline in a cohort of elderly men and women...
  50. pmc Regional and supraregional biochemistry services in Scotland: a survey of hospital laboratory users
    M J Murphy
    Institute of Biochemistry, Glasgow Royal Infirmary
    J Clin Pathol 47:395-8. 1994
    ..To ascertain the views of Scottish hospital laboratory users on aspects of regional and supraregional biochemical services offered by the Institute of Biochemistry at Glasgow Royal Infirmary...
  51. ncbi Influence of atorvastatin and simvastatin on apolipoprotein B metabolism in moderate combined hyperlipidemic subjects with low VLDL and LDL fractional clearance rates
    Lorne F Forster
    Department of Pathological Biochemistry, Glasgow Royal Infirmary University NHS Trust, 4th Floor, Queen Elizabeth Building 10 Alexandra Parade, Glasgow, G31 2ER, Scotland, UK
    Atherosclerosis 164:129-45. 2002
    ..This leads to a substantial, and approximately equivalent, percentage reduction in plasma triglyceride and LDL cholesterol...
  52. pmc Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Clin Endocrinol Metab 95:93-9. 2010
    ..Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven...
  53. ncbi Special report: Highlights of the 75th European Atherosclerosis Society congress
    James Shepherd
    Department of Pathological Biochemistry, University of Glasgow, Royal Infirmary, Glasgow, Scotland
    Atherosclerosis 181:S1-S7. 2005
  54. ncbi Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER
    Eliana Polisecki
    Cardiovascular Research and Lipid Metabolism Laboratories, Friedman School of Nutrition Science and Policy, Tufts University School of Medicine and the Jean Mayer USDA Human Nutrition Research Center at Tufts University, Boston, MA USA
    Atherosclerosis 200:109-14. 2008
    ..Our data indicate that genetic variation at the LDLR locus can affect baseline lipids, response to pravastatin, and CVD risk in subjects placed on statin treatment...
  55. ncbi Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population
    Eliana Polisecki
    Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    Atherosclerosis 200:95-101. 2008
    ..Our data support the concept that the rare allele of the R46L SNP at the PCSK9 locus significantly lowers LDL C, but does not greatly reduce CHD risk in an elderly population with a high prevalence of cardiovascular disease...
  56. doi Intensive lipid-lowering with atorvastatin for secondary prevention in patients after coronary artery bypass surgery
    Sanjiv J Shah
    Division of Cardiology, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
    J Am Coll Cardiol 51:1938-43. 2008
    ....
  57. ncbi Lipids and CVD management: towards a global consensus
    Christie Ballantyne
    Arteriosclerosis and Lipoprotein Section, Baylor College of Medicine, Houston, TX, USA
    Eur Heart J 26:2224-31. 2005
    ..It also highlights areas where the guidelines differ and discusses points to consider when selecting the most appropriate recommendation...
  58. pmc The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease
    Jill Belch
    Institute of Cardiovascular Research, University of Dundee, Ninewells Hospital, Dundee DD1 9SY
    BMJ 337:a1840. 2008
    ..To determine whether aspirin and antioxidant therapy, combined or alone, are more effective than placebo in reducing the development of cardiovascular events in patients with diabetes mellitus and asymptomatic peripheral arterial disease...
  59. ncbi Coronary heart disease in patients with low LDL-cholesterol: benefit of pravastatin in diabetics and enhanced role for HDL-cholesterol and triglycerides as risk factors
    Frank M Sacks
    Nutrition Department, Harvard School of Public Health F M S, Boston, Mass 02115, USA
    Circulation 105:1424-8. 2002
    ..We conducted exploratory analyses of participant characteristics, lipid risk factors, and risk reduction in this group...
  60. doi Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials
    Olga A Iakoubova
    Celera, Inc, Alameda, California 94502, USA
    J Am Coll Cardiol 51:435-43. 2008
    ....
  61. ncbi Effect of pravastatin on rate of kidney function loss in people with or at risk for coronary disease
    Marcello Tonelli
    Division of Nephrology and Division of Critical Care Medicine, University of Alberta, and Institute of Health Economics, Edmonton, Alberta, Canada
    Circulation 112:171-8. 2005
    ..We performed this analysis to determine whether pravastatin reduced the rate of kidney function loss over approximately 5 years in people with or at high risk for coronary disease...
  62. ncbi Intensive lipid lowering with atorvastatin in patients with stable coronary disease
    John C LaRosa
    State University of New York Health Science Center, Brooklyn, NY 11203, USA
    N Engl J Med 352:1425-35. 2005
    ..We prospectively assessed the efficacy and safety of lowering LDL cholesterol levels below 100 mg per deciliter (2.6 mmol per liter) in patients with stable coronary heart disease (CHD)...
  63. ncbi Guidelines for lowering lipids to reduce coronary artery disease risk: a comparison of rosuvastatin with atorvastatin, pravastatin, and simvastatin for achieving lipid-lowering goals. 2003
    James Shepherd
    Atheroscler Suppl 5:115-23. 2004
  64. ncbi Reduction of low-density lipoprotein cholesterol in patients with coronary heart disease and metabolic syndrome: analysis of the Treating to New Targets study
    Prakash Deedwania
    Veterans Affairs Central California Healthcare System and University of California San Francisco School of Medicine, San Francisco, CA, USA
    Lancet 368:919-28. 2006
    ....
  65. ncbi Asp92Asn polymorphism in the myeloid IgA Fc receptor is associated with myocardial infarction in two disparate populations: CARE and WOSCOPS
    Olga A Iakoubova
    Celera Inc, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Arterioscler Thromb Vasc Biol 26:2763-8. 2006
    ..Because the myeloid IgA Fc receptor encoded by FCAR mediates inflammation, we hypothesized that the FCAR Asp92Asn polymorphism is associated with risk of MI and that this risk would be modified by pravastatin...
  66. ncbi Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study
    Scott W Brouilette
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Lancet 369:107-14. 2007
    ..Inter-individual differences in biological ageing could affect susceptibility to coronary heart disease. Our aim was to determine whether mean leucocyte telomere length is a predictor of the development of coronary heart disease...
  67. ncbi Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. 1995
    James Shepherd
    Atheroscler Suppl 5:91-7. 2004
  68. ncbi [Hypercholesterolemia, the future of drug associations]
    James Shepherd
    Presse Med 33:1141-2. 2004
  69. doi Association between ADAMTS1 matrix metalloproteinase gene variation, coronary heart disease, and benefit of statin therapy
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 28:562-7. 2008
    ..The purpose of this study was to investigate the association between the Ala227Pro polymorphism in the ADAMTS1 metalloproteinase gene and coronary heart disease and benefit from statin therapy in 2 independent cohorts...
  70. ncbi Effect of pravastatin on the development of diabetes and adiponectin production
    Toshiyuki Takagi
    Department of Medicine and Pathophysiology, Graduate School of Frontier Bioscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Atherosclerosis 196:114-21. 2008
    ..47+/-0.33 microg/ml, p=0.0003). Taken together, our findings suggest that pravastatin may have beneficial effects on adipose tissue, which may partly explain the reduction of the development of diabetes by pravastatin treatment...
  71. ncbi Effect of pravastatin on cardiovascular events in people with chronic kidney disease
    Marcello Tonelli
    Division of Nephrology, University of Alberta, 7 129 Clinical Science Building, 8440 112 St, Edmonton, Alberta T6G 2G3, Canada
    Circulation 110:1557-63. 2004
    ..The objective of this analysis was to determine whether pravastatin reduced the incidence of cardiovascular events in people with or at high risk for coronary disease and with concomitant moderate CKD...
  72. ncbi Raising high-density lipoprotein cholesterol with reduction of cardiovascular risk: the role of nicotinic acid--a position paper developed by the European Consensus Panel on HDL-C
    M John Chapman
    Institut National de la Sante et de la Recherche Medicale INSERM, Hopital de la Pitie, Paris, France
    Curr Med Res Opin 20:1253-68. 2004
    ..03 mmol/L) in patients with CHD or with a high level of risk for CHD, including patients at high global risk with type 2 diabetes or the metabolic syndrome...
  73. ncbi Combined lipid lowering drug therapy for the effective treatment of hypercholesterolaemia
    James Shepherd
    Eur Heart J 24:685-9. 2003
  74. ncbi Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein
    Paul M Ridker
    JUPITER Coordinating Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 100:1659-64. 2007
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    ....