A H Schapira

Summary

Affiliation: Royal Free and University College Medical School
Country: UK

Publications

  1. ncbi Mitochondrial disorders
    A H Schapira
    University Department of Clinical Neurosciences, Royal Free and University College School of Medicine, and Institute of Neurology, University College London, UK
    Curr Opin Neurol 13:527-32. 2000
  2. ncbi Mitochondrial dysfunction in neurodegenerative disorders
    A H Schapira
    University Department of Clinical Neurosciences, Royal Free Hospital School of Medicine and University Department of Clinical Neurology, Institute of Neurology, Rowland Hill Street, London NW3 2PF, UK
    Biochim Biophys Acta 1366:225-33. 1998
  3. ncbi Human complex I defects in neurodegenerative diseases
    A H Schapira
    University Department of Clinical Neurosciences, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF, UK
    Biochim Biophys Acta 1364:261-70. 1998
  4. ncbi Platelet mitochondrial function in Leber's hereditary optic neuropathy
    P R Smith
    Department of Neurosciences, Royal Free Hospital School of Medicine, London, UK
    J Neurol Sci 122:80-3. 1994
  5. ncbi Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia
    A H Schapira
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF
    Biochim Biophys Acta 1410:159-70. 1999
  6. ncbi The influence of nuclear background on the biochemical expression of 3460 Leber's hereditary optic neuropathy
    H R Cock
    University Department of Clinical Neurosciences, Royal Free Hospital School of Medicine, London, UK
    Ann Neurol 44:187-93. 1998
  7. ncbi Mitochondrial disorders
    A H Schapira
    Royal Free Hospital School of Medicine, London, UK
    Curr Opin Neurol 10:43-7. 1997
  8. ncbi Functional consequences of the 3460-bp mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy
    H R Cock
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
    J Neurol Sci 165:10-7. 1999
  9. ncbi Antibodies to human optic nerve in Leber's hereditary optic neuropathy
    P R Smith
    Department of Clinical Neurosciences, Royal Free Hospital School of Medicine, London, UK
    J Neurol Sci 130:134-8. 1995
  10. ncbi HLA class II genotypes in Leber's hereditary optic neuropathy
    G G Govan
    University Department of Clinical Neurology, Institute of Neurology, London, UK
    J Neurol Sci 126:193-6. 1994

Collaborators

Detail Information

Publications21

  1. ncbi Mitochondrial disorders
    A H Schapira
    University Department of Clinical Neurosciences, Royal Free and University College School of Medicine, and Institute of Neurology, University College London, UK
    Curr Opin Neurol 13:527-32. 2000
    ..Drugs, toxins and deficiency of nuclear encoded proteins that are targeted at mitochondria are now recognized as important causes of secondary mitochondrial respiratory chain deficiency...
  2. ncbi Mitochondrial dysfunction in neurodegenerative disorders
    A H Schapira
    University Department of Clinical Neurosciences, Royal Free Hospital School of Medicine and University Department of Clinical Neurology, Institute of Neurology, Rowland Hill Street, London NW3 2PF, UK
    Biochim Biophys Acta 1366:225-33. 1998
    ..In any event, mitochondria present an important target for future strategies for 'neuroprotection' to prevent or retard neurodegeneration...
  3. ncbi Human complex I defects in neurodegenerative diseases
    A H Schapira
    University Department of Clinical Neurosciences, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF, UK
    Biochim Biophys Acta 1364:261-70. 1998
    ..The actions of specific toxins, e.g., MPTP continue to play an important role in our understanding of pathogenesis of neurodegeneration, particularly in PD...
  4. ncbi Platelet mitochondrial function in Leber's hereditary optic neuropathy
    P R Smith
    Department of Neurosciences, Royal Free Hospital School of Medicine, London, UK
    J Neurol Sci 122:80-3. 1994
    ..002) in those with this mutation who smoked. This reflects an increase in mitochondrial mass with the 11,778 mutation. This effect was not observed with the 3460 mutation even though the complex deficiency was much more severe...
  5. ncbi Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia
    A H Schapira
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF
    Biochim Biophys Acta 1410:159-70. 1999
    ..Clarifying the role of mitochondria in pathogenesis may provide opportunities for the development of treatments designed to reverse or prevent neurodegeneration...
  6. ncbi The influence of nuclear background on the biochemical expression of 3460 Leber's hereditary optic neuropathy
    H R Cock
    University Department of Clinical Neurosciences, Royal Free Hospital School of Medicine, London, UK
    Ann Neurol 44:187-93. 1998
    ..These results suggest that the nuclear environment can influence the expression of the biochemical defect in LHON patients with the A3460G mutation...
  7. ncbi Mitochondrial disorders
    A H Schapira
    Royal Free Hospital School of Medicine, London, UK
    Curr Opin Neurol 10:43-7. 1997
    ..A potential role for inborn mitochondrial defects in these disorders has not yet been defined but is currently attracting interest...
  8. ncbi Functional consequences of the 3460-bp mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy
    H R Cock
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
    J Neurol Sci 165:10-7. 1999
    ..These findings have important implications for our understanding of complex I dysfunction in the pathogenesis of 3460 Leber's hereditary optic neuropathy...
  9. ncbi Antibodies to human optic nerve in Leber's hereditary optic neuropathy
    P R Smith
    Department of Clinical Neurosciences, Royal Free Hospital School of Medicine, London, UK
    J Neurol Sci 130:134-8. 1995
    ..A significant proportion of LHON patients had circulating antibodies to tubulin protein. This finding supports the theory that autoimmunity may play some role in the pathogenesis of LHON...
  10. ncbi HLA class II genotypes in Leber's hereditary optic neuropathy
    G G Govan
    University Department of Clinical Neurology, Institute of Neurology, London, UK
    J Neurol Sci 126:193-6. 1994
    ..Furthermore, affected relative pairs did not share HLA genotypes more than discordant pairs. We conclude that the HLA-DR locus is not a major genetic determinant for the development of blindness in LHON...
  11. ncbi Molecular mechanisms in mitochondrial DNA depletion syndrome
    J W Taanman
    Department of Clinical Neurosciences, Royal Free Hospital School of Medicine, London, UK
    Hum Mol Genet 6:935-42. 1997
    ..Transfer of patient mitochondria with residual mtDNA levels to control cells devoid of mtDNA (rho0 cells) led to restoration of mtDNA levels and, hence, suggests a nuclear involvement in the depletion...
  12. ncbi Clinical, biochemical and molecular genetic features of Leber's hereditary optic neuropathy
    R M Chalmers
    University Department of Clinical Neurosciences, Royal Free Hospital and University College Medical School of University College London, London NW3 2PF, UK
    Biochim Biophys Acta 1410:147-58. 1999
    ..However, the clinical and experimental data reviewed suggest differences in the phenotype associated with each of the three mutations which may reflect variation in the disease mechanisms resulting in this common end-point...
  13. ncbi HLA class I genotypes in Leber's hereditary optic neuropathy
    R M Chalmers
    University Department of Clinical Neurology, Institute of Neurology, London, UK
    J Neurol Sci 135:173-5. 1996
    ..There was no association between LHON and any genotype. We conclude that the classical class I MHC loci are not major determinants of the development of blindness in LHON...
  14. ncbi Nitric oxide enhances MPP(+) inhibition of complex I
    M W Cleeter
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
    FEBS Lett 504:50-2. 2001
    ..Thus, NO(*-) may 'prime' the respiratory chain to the effects of MPP(+). These data provide evidence for an interaction between NO(*-) and MPP(+) at the level of the respiratory chain...
  15. ncbi Metabolic enzyme expression in dopaminergic neurons in Parkinson's disease: an in situ hybridization study
    A E Kingsbury
    Parkinson's Disease Society Brain Research Centre and Institute of Neurology, University College London, UK
    Ann Neurol 50:142-9. 2001
    ..mitochondrial complex I activity is significantly reduced in IPD, intrinsically low expression of glycolytic enzymes, together with disease-related reduction in complex I activity, may be a contributory factor predisposing nigral neurons..
  16. ncbi Immunological phenotyping of fibroblast cultures from patients with a mitochondrial respiratory chain deficit
    S L Williams
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, UK
    Lab Invest 81:1069-77. 2001
    ....
  17. pmc Sensitivity of respiratory chain activities to lipid peroxidation: effect of vitamin E deficiency
    R Rafique
    University Department of Clinical Neuroscience, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Biochem J 357:887-92. 2001
    ..This suggests other antioxidants, such as ubiquinol and GSH, may be more important in protecting liver mitochondria and MRC from lipid peroxidation...
  18. pmc Neuromyelitis optica (Devic's syndrome): no association with the primary mitochondrial DNA mutations found in Leber hereditary optic neuropathy
    H Cock
    Department of Clinical Neurosciences, Royal Free Hospital School of Medicine, London, UK
    J Neurol Neurosurg Psychiatry 62:85-7. 1997
    ..It is concluded that the primary mtDNA mutations currently associated with LHON are not responsible for the prominence of optic nerve disease in Devic's neuromyelitis optica...
  19. doi Perspectives on recent advances in the understanding and treatment of Parkinson's disease
    A H Schapira
    Department of Clinical Neurosciences, Institute of Neurology, University College London, London, UK
    Eur J Neurol 16:1090-9. 2009
    ..The value of existing and novel continuous drug delivery systems in PD is seen as providing simplified regimens, maintenance of motor control, reduction in motor complications and improved patient adherence to drug use...
  20. ncbi Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse
    S J Tabrizi
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
    Ann Neurol 47:80-6. 2000
    ....
  21. ncbi Causes of neuronal death in Parkinson's disease
    A H Schapira
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, London, NW3 2PF
    Adv Neurol 86:155-62. 2001
    ..Future research directed toward developing neuroprotective strategies may reduce oxidative stress and stabilize or improve mitochondrial function...