A G Nicholson

Summary

Affiliation: Royal Brompton Hospital
Country: UK

Publications

  1. pmc Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trial
    Jurgen Behr
    Medizinische Klinik I, Klinikum Grosshadern der Ludwig Maximilians Universit├Ąt, Munchen, Germany
    Respir Res 10:101. 2009
  2. pmc Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts
    Elisabetta A Renzoni
    Interstitial Lung Disease Unit, Royal Brompton Hospital, Imperial College of Science, Technology and Medicine, Emmanuel Kaye Building, 1B Manresa Road, SW3 6LR, London, UK
    Respir Res 5:24. 2004
  3. ncbi request reprint Malignant myxoid endobronchial tumour: a report of two cases with a unique histological pattern
    A G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Histopathology 35:313-8. 1999
  4. ncbi request reprint Classification of idiopathic interstitial pneumonias: making sense of the alphabet soup
    A G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Histopathology 41:381-91. 2002
  5. ncbi request reprint Histopathological approach to patterns of interstitial pneumonia in patient with connective tissue disorders
    Andrew G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Sarcoidosis Vasc Diffuse Lung Dis 19:10-7. 2002
  6. ncbi request reprint Unusual sclerosing haemangiomas and sclerosing haemangioma-like lesions, and the value of TTF-1 in making the diagnosis
    A G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Histopathology 41:404-13. 2002
  7. ncbi request reprint An assessment of the expanded classification of congenital cystic adenomatoid malformations and their relationship to malignant transformation
    Fergus Macsweeney
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Am J Surg Pathol 27:1139-46. 2003
  8. ncbi request reprint Successful treatment of endogenous lipoid pneumonia due to Niemann-Pick Type B disease with whole-lung lavage
    Andrew G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 165:128-31. 2002
  9. pmc Inter-observer variation between pathologists in diffuse parenchymal lung disease
    A G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Thorax 59:500-5. 2004
  10. ncbi request reprint The prognostic significance of the histologic pattern of interstitial pneumonia in patients presenting with the clinical entity of cryptogenic fibrosing alveolitis
    A G Nicholson
    Department of Histopathology, Interstitial Lung Disease Unit, Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 162:2213-7. 2000

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. pmc Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trial
    Jurgen Behr
    Medizinische Klinik I, Klinikum Grosshadern der Ludwig Maximilians Universit├Ąt, Munchen, Germany
    Respir Res 10:101. 2009
    ..To better understand the clinical implications of these findings we performed additional, explorative analyses of the IFGENIA data set...
  2. pmc Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts
    Elisabetta A Renzoni
    Interstitial Lung Disease Unit, Royal Brompton Hospital, Imperial College of Science, Technology and Medicine, Emmanuel Kaye Building, 1B Manresa Road, SW3 6LR, London, UK
    Respir Res 5:24. 2004
    ..Even though the effects of TGFbeta on the gene expression of several proteins have been investigated in several lung fibroblast cell lines, the global pattern of response to this cytokine in adult lung fibroblasts is still unknown...
  3. ncbi request reprint Malignant myxoid endobronchial tumour: a report of two cases with a unique histological pattern
    A G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Histopathology 35:313-8. 1999
    ..To present two cases of malignant endobronchial myxoid tumours with a highly distinctive sarcomatoid pattern not previously described at this site, and discuss their histogenesis in relation to previously documented endobronchial neoplasms...
  4. ncbi request reprint Classification of idiopathic interstitial pneumonias: making sense of the alphabet soup
    A G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Histopathology 41:381-91. 2002
    ....
  5. ncbi request reprint Histopathological approach to patterns of interstitial pneumonia in patient with connective tissue disorders
    Andrew G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Sarcoidosis Vasc Diffuse Lung Dis 19:10-7. 2002
    ..Finally, the recently published prognostic data relating to these histological patterns in idiopathic disease should not be extrapolated to patients with connective tissue disorders...
  6. ncbi request reprint Unusual sclerosing haemangiomas and sclerosing haemangioma-like lesions, and the value of TTF-1 in making the diagnosis
    A G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Histopathology 41:404-13. 2002
    ..This study presents and discusses the histogenesis of four cases where difficulties in diagnosis were encountered, and reports the value of the antibody TTF-1 in making the diagnosis...
  7. ncbi request reprint An assessment of the expanded classification of congenital cystic adenomatoid malformations and their relationship to malignant transformation
    Fergus Macsweeney
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Am J Surg Pathol 27:1139-46. 2003
    ..However, stromal cellularity in a type 4 CCAM should raise the possibility of blastomatous transformation...
  8. ncbi request reprint Successful treatment of endogenous lipoid pneumonia due to Niemann-Pick Type B disease with whole-lung lavage
    Andrew G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 165:128-31. 2002
    ..3 kPa from 8.4 kPa. Whole-lung lavage may be a potentially useful modality of treatment for patients with pulmonary involvement by Niemann-Pick Type B disease...
  9. pmc Inter-observer variation between pathologists in diffuse parenchymal lung disease
    A G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Thorax 59:500-5. 2004
    ..There have been few inter-observer studies of diffuse parenchymal lung disease (DPLD), but the recent ATS/ERS consensus classification provides a basis for such a study...
  10. ncbi request reprint The prognostic significance of the histologic pattern of interstitial pneumonia in patients presenting with the clinical entity of cryptogenic fibrosing alveolitis
    A G Nicholson
    Department of Histopathology, Interstitial Lung Disease Unit, Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 162:2213-7. 2000
    ..However, in patients with clinically typical CFA, a histologic diagnosis of fibrotic NSIP needs to be interpreted with caution and does not necessarily denote a good outcome...
  11. ncbi request reprint The relationship between individual histologic features and disease progression in idiopathic pulmonary fibrosis
    Andrew G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 166:173-7. 2002
    ..These data suggest a reproducible method on biopsy for predicting rate of disease progression in patients with idiopathic pulmonary fibrosis...
  12. ncbi request reprint Cystic fibrohistiocytic tumours presenting in the lung: primary or metastatic disease?
    M Osborn
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Histopathology 43:556-62. 2003
    ..This study presents four cases and reviews the literature concerning this pattern of disease and its aetiology...
  13. ncbi request reprint Investigation of young children with severe recurrent wheeze: any clinical benefit?
    S Saglani
    Dept of Respiratory Paediatrics, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Eur Respir J 27:29-35. 2006
    ..This hypothesis-generating work should form the basis of future interventional studies...
  14. pmc Corticosteroid responsiveness and clinical characteristics in childhood difficult asthma
    C J Bossley
    Dept of Respiratory Paediatrics, Royal Brompton Hospital, London SW3 6NP, UK
    Eur Respir J 34:1052-9. 2009
    ..93, 95% CI 0.90-0.97). Only 11% of DA children exhibited complete corticosteroid responsiveness. The rarity of complete corticosteroid responsiveness suggests alternative therapies are needed for children with DA...
  15. ncbi request reprint Marginal decline in forced vital capacity is associated with a poor outcome in idiopathic pulmonary fibrosis
    C J Zappala
    Royal Brompton Hospital and National Heart and Lung Institute, London, UK
    Eur Respir J 35:830-6. 2010
    ..Marginal change in FVC in IPF denotes a poor outcome. These findings are applicable to clinical practice and to the selection of patients with more progressive disease for therapeutic studies...
  16. ncbi request reprint Use of intravenous cyclophosphamide in known or suspected, advanced non-specific interstitial pneumonia
    T J Corte
    Royal Brompton Hospital, London, United Kingdom
    Sarcoidosis Vasc Diffuse Lung Dis 26:132-8. 2009
    ..This study reviews the tolerability and efficacy of i.v. cyclophosphamide in known or suspected non-specific interstitial pneumonia (NSIP) following the introduction of an i.v. cyclophosphamide protocol...
  17. ncbi request reprint Elevated nocturnal desaturation index predicts mortality in interstitial lung disease
    T J Corte
    Royal Brompton Hospital and National Heart and Lung Institute, London, UK
    Sarcoidosis Vasc Diffuse Lung Dis 29:41-50. 2012
    ..Nocturnal desaturation may contribute to long-term pulmonary vascular stress in interstitial lung disease (ILD). We study the prevalence, severity and prognostic utility of nocturnal desaturation across ILD...
  18. ncbi request reprint Desquamative interstitial pneumonia, respiratory bronchiolitis and their relationship to smoking
    P J Craig
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Histopathology 45:275-82. 2004
    ..The aim of this study was to compare histological parameters in cases of DIP and RB and then to review in detail clinical, imaging and histological data for DIP in relation to a history of smoking...
  19. ncbi request reprint CT and histopathological correlation of congenital cystic pulmonary lesions: a common pathogenesis?
    N Griffin
    Royal Brompton and Harefield NHS Trust, London, UK
    Clin Radiol 63:995-1005. 2008
    ..To determine whether similarities exist in both the imaging and histopathological features of congenital cystic lung lesions and whether a more appropriate classification would be to adopt the theory of "malinosculation"...
  20. ncbi request reprint BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia
    S Veeraraghavan
    Interstitial Lung Disease Unit, Dept of Occupational and Environmental Medicine, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College of Science Technology and Medicine, London, UK
    Eur Respir J 22:239-44. 2003
    ....
  21. ncbi request reprint Pulmonary fibrosis and lung cancer: risk and benefit analysis of pulmonary resection
    P Kumar
    Department of Thoracic Surgery, Royal Brompton Hospital, London, United Kingdom
    J Thorac Cardiovasc Surg 125:1321-7. 2003
    ..Pulmonary fibrosis is associated with an increased risk of lung cancer and outcome of surgical resection in this setting is unknown...
  22. ncbi request reprint Variations in histological patterns of interstitial pneumonia between connective tissue disorders and their relationship to prognosis
    D Tansey
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Histopathology 44:585-96. 2004
    ..Mortality is similar to that seen in idiopathic NSIP and, coupled with pulmonary presentation occurring prior to the systemic manifestation of disease, this may have a bearing on the origin of some cases of putative idiopathic NSIP...
  23. ncbi request reprint Pulmonary involvement by Niemann-Pick disease. A report of six cases
    A G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Histopathology 48:596-603. 2006
    ..The purpose of this study is to document the histological features seen in pulmonary involvement by types B and C Niemann-Pick disease and to correlate them with clinical and imaging data...
  24. ncbi request reprint Interstitial lung disease--the new synergy between radiology and pathology
    M Quigley
    Department of Radiology, Royal Brompton Hospital, London, UK
    Histopathology 49:334-42. 2006
    ..This latter process is now accepted as providing the highest levels of diagnostic accuracy in patients with DPLD and lung biopsy is primarily reserved for cases with atypical clinical or radiological presentations...
  25. ncbi request reprint Inhibition of adherence of Mycobacterium avium complex and Mycobacterium tuberculosis to fibronectin on the respiratory mucosa
    A M Middleton
    Royal Brompton Hospital, London SW3 6NP, UK
    Respir Med 98:1203-6. 2004
    ..01) and not at later timepoints. We conclude that M. avium complex and M. tuberculosis infection of the mucosa proceeds by different mechanisms, since M. tuberculosis infection is independent of fibronectin adherence...
  26. ncbi request reprint Congenital cystic adenomatoid malformation presenting as in-flight systemic air embolisation
    E Belcher
    Department of Thoracic Surgery, Royal Brompton Hospital, London, UK
    Eur Respir J 30:801-4. 2007
    ..The patient later underwent elective excision of the pulmonary malformation. Since the overall mortality of in-flight cerebral air embolisation is high, patients with such asymptomatic cysts should be considered for elective surgery...
  27. pmc HRCT diagnosis of diffuse parenchymal lung disease: inter-observer variation
    Z A Aziz
    Department of Radiology, Royal Brompton Hospital, London, UK
    Thorax 59:506-11. 2004
    ....
  28. ncbi request reprint Lesson of the month: Necrotizing sarcoid granulomatosis with skin involvement
    C C Shirodaria
    Host Defence Unit, Department of Histopathology, Royal Brompton Hospital, London, UK
    Histopathology 43:91-3. 2003
  29. doi request reprint Leukotriene B4 release by human lung macrophages via receptor- not voltage-operated Ca2+ channels
    T K Finney-Hayward
    Department of Airways Disease, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK
    Eur Respir J 33:1105-12. 2009
    ..These data suggest that platelet-activating factor-stimulated leukotriene B(4) release from human lung macrophages is mediated, in part, by Ca(2+) influx through receptor- but not voltage-operated Ca(2+) channels...
  30. pmc Extracellular thioredoxin levels are increased in patients with acute lung injury
    M E Callister
    Unit of Critical Care, National Heart and Lung Institute Division, Imperial College Faculty of Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Thorax 61:521-7. 2006
    ..We therefore investigated whether thioredoxin is raised extracellulary in patients with ALI and whether the extent of any increase is dependent upon the nature of the precipitating insult...
  31. ncbi request reprint Immunohistochemical markers in the differentiation of thymic and pulmonary neoplasms
    S Pomplun
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Histopathology 40:152-8. 2002
    ..We have assessed a panel of antibodies that may help to distinguish between neoplasms from these two sites...
  32. ncbi request reprint Inflammatory endobronchial polyps in childhood: clinical spectrum and possible link to mechanical ventilation
    D McShane
    Department of Paediatric Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, UK
    Pediatr Pulmonol 34:79-84. 2002
    ..The small caliber of the main airways in neonates may also be a contributory factor in presentation...
  33. ncbi request reprint Thoracic metastasectomy in thyroid malignancies
    A D Protopapas
    Department of Thoracic Surgery, Royal Brompton Hospital, London, England
    Ann Thorac Surg 72:1906-8. 2001
    ..Further follow-up and more observations will be required for evaluating these preliminary findings...
  34. ncbi request reprint Epithelial-myoepithelial carcinomas of the bronchus
    L G Fulford
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Am J Surg Pathol 25:1508-14. 2001
    ..Nevertheless, the term epithelial-myoepithelial carcinoma is preferred because of their malignant potential. A high mitotic rate, tumoral necrosis, and nuclear pleomorphism appear to be adverse prognostic factors...
  35. ncbi request reprint Lung fibrosis: new classifications and therapy
    S Veeraraghavan
    Department of Interstitial Lung Disease, Royal Brompton Hospital, London, United Kingdom
    Curr Opin Rheumatol 13:500-4. 2001
    ..Strong circumstantial evidence of a therapeutic benefit justifies the continued use of cyclophosphamide in progressive lung fibrosis in systemic sclerosis...
  36. pmc Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages
    S J Smith
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Br J Pharmacol 149:393-404. 2006
    ..p38 MAPK may regulate cytokine production, therefore, the effect of two p38 MAPK inhibitors, SB239063 and SD-282, on the release of TNF-alpha, GM-CSF and IL-8 from human macrophages was investigated...
  37. ncbi request reprint Reproducibility of the WHO/IASLC grading system for pre-invasive squamous lesions of the bronchus: a study of inter-observer and intra-observer variation
    A G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Histopathology 38:202-8. 2001
    ..The WHO/IASLC system is therefore recommended for future use in both clinical and research fields...
  38. doi request reprint Transformation to "high grade" neuroendocrine carcinoma as an acquired drug resistance mechanism in EGFR-mutant lung adenocarcinoma
    S Popat
    Royal Marsden Hospital NHS Foundation Trust, London, and Surrey, UK
    Lung Cancer 80:1-4. 2013
    ..This case highlights acquired EGFR-TKI resistance through transformation to the high-grade neuroendocrine carcinoma spectrum and that that such transformation may not be evident at time of progression on TKI therapy...
  39. ncbi request reprint Adenocarcinoma arising in a retained esophageal remnant
    O Genc
    Department of Thoracic Surgery, Royal Brompton Hospital, London, United Kingdom
    Ann Thorac Surg 72:2117-9. 2001
    ..We present such a case in which there was also malignant transformation in the cyst wall, manifested by invasive adenocarcinoma and widespread high-grade glandular dysplasia...
  40. ncbi request reprint The value of 'mesothelium-associated' antibodies in distinguishing between metastatic renal cell carcinomas and mesotheliomas
    M Osborn
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Histopathology 41:301-7. 2002
    ....
  41. pmc The safety and quality of endobronchial biopsy in children under five years old
    S Saglani
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London SW3, UK
    Thorax 58:1053-7. 2003
    ..The safety of endobronchial biopsy and the quality of biopsies obtained were reviewed in infants and preschool children...
  42. doi request reprint Capillary apposition and density in the diagnosis of alveolar capillary dysplasia
    L Melly
    Department of Histopathology, Royal Free Hospital, London, UK
    Histopathology 53:450-7. 2008
    ..The aim was to characterise further the histological features of patients suspected of having ACD and to correlate histopathological features with outcome...
  43. doi request reprint Pulmonary veno-occlusive disease presenting with recurrent pulmonary oedema and the use of nitric oxide to predict response to sildenafil
    B C Creagh-Brown
    Adult Intensive Care Unit corrected Royal Brompton Hospital, London, UK
    Thorax 63:933-4. 2008
    ..Concern over the risk of precipitating pulmonary oedema led us to use inhaled nitric oxide to predict the safety and efficacy of sildenafil...
  44. ncbi request reprint Variable tissue expression of transferrin receptors: relevance to acute respiratory distress syndrome
    R L Upton
    Dept of Critical Care, Royal Brompton Hospital, Imperial College Faculty of Medicine, London, UK
    Eur Respir J 22:335-41. 2003
    ..These findings have implications for the pathogenesis of acute respiratory distress syndrome, especially in relation to the role of iron as a mediator of oxidative stress...
  45. ncbi request reprint Concurrent cysts of the mediastinum, pleura and neck
    W I Awad
    Department of Thoracic Surgery, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Eur J Cardiothorac Surg 20:861-3. 2001
    ..We know of no other report of concurrent multicystic lesions in the chest and neck and hypothesize that these cysts may have a common embryonic origin...
  46. ncbi request reprint Interaction between mycobacteria and mucus on a human respiratory tissue organ culture model with an air interface
    A M Middleton
    Royal Brompton Hospital, London, UK
    Exp Lung Res 30:17-29. 2004
    ....
  47. ncbi request reprint Rupture of pulmonary aneurysms in association with long-standing Waterston shunts
    D A Hull
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Cardiol Young 11:123-7. 2001
    ..Rupture should, therefore, be recognized as a late complication of this procedure, and be considered in the long-term follow-up of such patients, especially when the shunted lung is hypertensive...
  48. ncbi request reprint Computed tomography findings in fibrosing mediastinitis
    A Devaraj
    Department of Radiology, Royal Brompton Hospital, London, UK
    Clin Radiol 62:781-6. 2007
    ..To describe the CT features of fibrosing mediastinitis...
  49. doi request reprint Progressive dyspnoea, pleural effusions and lytic bone lesions
    A G Nicholson
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Thorax 63:492, 554. 2008
  50. ncbi request reprint Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung
    D A Groneberg
    Thoracic Medicine, National Heart and Lung Institute, Imperial College of Science Technology and Medicine, London, UK
    Respir Med 96:81-6. 2002
    ..MUC5AC and MUC5B are expressed in the same histological pattern in CF compared to normal tissues with an increase of MUC5AC-positive cells due to goblet cell hyper- and metaplasia...
  51. ncbi request reprint Expression of renal cell carcinoma-associated markers erythropoietin, CD10, and renal cell carcinoma marker in diffuse malignant mesothelioma and metastatic renal cell carcinoma
    Kelly J Butnor
    Department of Pathology, University of Vermont Fletcher Allen Health Care, Burlington, VT 05401, USA
    Arch Pathol Lab Med 130:823-7. 2006
    ..Standard panels of immunohistochemical markers are of limited benefit...
  52. ncbi request reprint Prognosis of fibrotic interstitial pneumonia: idiopathic versus collagen vascular disease-related subtypes
    Joo Hun Park
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Asan Medical Center, University of Ulsan, 388 1, Poongnap dong, Songpa Gu, Seoul, South Korea
    Am J Respir Crit Care Med 175:705-11. 2007
    ....
  53. ncbi request reprint Airway eosinophilia in children with severe asthma: predictive values of noninvasive tests
    Christiane Lex
    Department of Pediatric Respiratory Medicine, Imperial College of Science, Technology, and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 174:1286-91. 2006
    ....
  54. pmc Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease
    Susan J Davies
    Department of Histopathology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Thorax 62:248-52. 2007
    ..A review was undertaken of 19 patients diagnosed with diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) between 1992 and 2006...
  55. ncbi request reprint Pulmonary capillaritis and its relationship to development of emphysema in hypocomplementaemic urticarial vasculitis syndrome
    David P J Hunt
    Interstitial Lung Disease Unit, Royal Brompton and Harefield NHS Trust, Emmanuel Kaye Building, Manresa Rd, London, UK
    Sarcoidosis Vasc Diffuse Lung Dis 23:70-2. 2006
    ..We suggest that there is a role for ongoing immunosuppressive therapy in these patients...
  56. pmc Challenges in pulmonary fibrosis . 4: smoking-induced diffuse interstitial lung diseases
    Athol U Wells
    Interstitial Lung Disease Unit, Royal Brompton Hospital, Emmanuel Kaye Building, Manresa Road, London SW3 6LR, UK
    Thorax 62:904-10. 2007
    ..Possible relationships between smoking and other diffuse lung diseases are explored briefly...
  57. ncbi request reprint Idiopathic nonspecific interstitial pneumonia: report of an American Thoracic Society project
    William D Travis
    Attending Thoracic Pathologist, Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Am J Respir Crit Care Med 177:1338-47. 2008
    ..Concern was expressed that NSIP was a "wastebasket" category, difficult to distinguish from other idiopathic interstitial pneumonias...
  58. ncbi request reprint Bronchioloalveolar carcinoma in congenital cystic adenomatoid malformation of lung
    Douglas West
    Department of Cardiothoracic Surgery, The Royal Hospital for Sick Children, Dalnair Street, Glasgow, UK
    Ann Thorac Surg 83:687-9. 2007
    ..This case demonstrates the indolent nature of malignancies seen in association with type 1 CCAMs and also that complete excision, probably by lobectomy, is the treatment of choice to avoid recurrence...
  59. ncbi request reprint Bronchioloalveolar carcinoma and lung adenocarcinoma: the clinical importance and research relevance of the 2004 World Health Organization pathologic criteria
    William D Travis
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Thorac Oncol 1:S13-9. 2006
    ..Advances in the pathology and computed tomography (CT) of lung adenocarcinoma and bronchioloalveolar carcinoma (BAC) have demonstrated important new prognostic features that have led to changes in classification and diagnostic criteria...
  60. doi request reprint Nonspecific interstitial pneumonia and idiopathic pulmonary fibrosis: changes in pattern and distribution of disease over time
    C Isabela S Silva
    Department of Radiology, Vancouver General Hospital, University of British Columbia, 3350 950 W 10th Ave, Vancouver, BC, Canada V5Z 4E3
    Radiology 247:251-9. 2008
    ....
  61. ncbi request reprint Thyroid transcription factor 1 immunohistochemistry as an intraoperative diagnostic tool at frozen section for distinction between primary and secondary lung tumors
    David N Butcher
    Department of Histopathology, Royal Brompton Hospital, London SW3 6NP, United Kingdom
    Arch Pathol Lab Med 131:582-7. 2007
    ..Intraoperative distinction between primary and metastatic carcinomas in the lung at frozen section remains problematic...
  62. pmc Airway remodelling in children with cystic fibrosis
    Tom N Hilliard
    Department of Gene Therapy, National Heart and Lung Institute, Imperial College, London, UK
    Thorax 62:1074-80. 2007
    ..A study was undertaken to determine changes in airway remodelling in children with CF compared with appropriate disease and healthy controls...
  63. ncbi request reprint Idiopathic pulmonary fibrosis: outcome in relation to smoking status
    Katerina M Antoniou
    Interstitial Lung Disease Unit, c o Emmanuel Kaye Building, Manresa Road, London SW3 6LR, UK
    Am J Respir Crit Care Med 177:190-4. 2008
    ..However, better survival has been reported for current smokers with IPF, although this might reflect less severe disease at presentation (a "healthy smoker effect")...
  64. ncbi request reprint Prognostic implications of histologic patterns in multiple surgical lung biopsies from patients with idiopathic interstitial pneumonias
    Hannah Monaghan
    Department of Pathology, Edinburgh University Medical School, Edinburgh, Scotland, UK
    Chest 125:522-6. 2004
    ....
  65. ncbi request reprint High-dose acetylcysteine in idiopathic pulmonary fibrosis
    Maurits Demedts
    University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium
    N Engl J Med 353:2229-42. 2005
    ..Idiopathic pulmonary fibrosis is a chronic progressive disorder with a poor prognosis...
  66. ncbi request reprint The impact of stage and cell type on the prognosis of pulmonary neuroendocrine tumors
    Eric Lim
    Department of Thoracic Surgery, Royal Brompton Hospital, London, United Kingdom
    J Thorac Cardiovasc Surg 130:969-72. 2005
    ..To clarify this relationship, we studied patients treated at our institution over a 23-year period...
  67. ncbi request reprint TTF-1 expression is specific for lung primary in typical and atypical carcinoids: TTF-1-positive carcinoids are predominantly in peripheral location
    Emma Z Du
    Department of Pathology, University of California San Diego Medical Center, San Diego, CA 92103 8720, USA
    Hum Pathol 35:825-31. 2004
    ..Prevalent TTF-1 positivity in TLs and peripheral carcinoids suggest that they may be histogenetically distinct from the central carcinoids, which are typically composed of TTF-1-negative, more rounded cells...
  68. ncbi request reprint Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome
    Demosthenes Bouros
    Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 165:1581-6. 2002
    ..005). We conclude that NSIP is the histopathologic pattern in most patients with FASSc. However, outcome is linked more strongly to disease severity at presentation and serial DL(CO) trends than to histopathologic findings...
  69. ncbi request reprint Lung heme oxygenase-1 is elevated in acute respiratory distress syndrome
    Sharon Mumby
    Unit of Critical Care, Imperial College Faculty of Medicine, Royal Brompton Hospital, Sydney Street, London, UK
    Crit Care Med 32:1130-5. 2004
    ..Control of such processes by heme oxygenase has implications for the onset, progression, and resolution of ARDS...
  70. ncbi request reprint Intraoperative pleural lavage cytology is an independent prognostic indicator for staging non-small cell lung cancer
    Eric Lim
    Department of Thoracic Surgery, Royal Brompton Hospital, London, UK
    J Thorac Cardiovasc Surg 127:1113-8. 2004
    ..To ascertain the frequency and quantify the effect of this finding on survival, we performed a prospective study of intraoperative pleural lavage cytology...
  71. ncbi request reprint The importance of complete screening for amyloid fibril type and systemic disease in patients with amyloidosis in the respiratory tract
    Pallav L Shah
    Department of Medicine, Royal Brompton Hospital, London, UK
    Sarcoidosis Vasc Diffuse Lung Dis 19:134-42. 2002
    ..Furthermore, CT scanning is now a frequent investigation for the diagnosis of thoracic disease. We wished to determine the value of these investigations on the management of such patients with amyloidosis...
  72. ncbi request reprint Asbestosis and idiopathic pulmonary fibrosis: comparison of thin-section CT features
    Susan J Copley
    Department of Radiology, Hammersmith Hospital, London, England
    Radiology 229:731-6. 2003
    ....
  73. ncbi request reprint Fibrotic idiopathic interstitial pneumonia: the prognostic value of longitudinal functional trends
    Panagiota I Latsi
    Interstitial Lung Disease Unit, Emmanuel Kaye Building, Manresa Road, Chelsea, London SW6 LR6, UK
    Am J Respir Crit Care Med 168:531-7. 2003
    ..Their histologic distinction provides no additional prognostic information when pulmonary function trends are clear cut or when functional impairment is severe...
  74. ncbi request reprint Terminal diffuse alveolar damage in relation to interstitial pneumonias. An autopsy study
    Alexandra J Rice
    Department of Histopathology, Royal Brompton Hospital, London, England
    Am J Clin Pathol 119:709-14. 2003
    ..Acute exacerbations of IPF/CFA may be a more common terminal event than previously thought...
  75. ncbi request reprint Idiopathic pulmonary fibrosis: a composite physiologic index derived from disease extent observed by computed tomography
    Athol U Wells
    Department of Radiology, Royal Brompton Hospital, Interstitial Lung Disease Unit, Emmanuel Kaye Building, Manresa Road, Chelsea, London SW6 LR6, UK
    Am J Respir Crit Care Med 167:962-9. 2003
    ..002; PO2, p = 0.002). In conclusion, a new CPI, derived against CT and validated using split sample testing, is a more accurate prognostic determinant in usual interstitial pneumonia than an individual pulmonary function test...
  76. ncbi request reprint Large cell neuroendocrine carcinoma and large cell carcinomas with neuroendocrine morphology of the lung: prognosis after complete resection and systematic nodal dissection
    Joseph Zacharias
    Department of Thoracic Surgery and Histopathology, Royal Brompton Hospital, London, United Kingdom
    Ann Thorac Surg 75:348-52. 2003
    ..We retrospectively reviewed a cohort of patients at our institution who had this type of tumor to determine factors that might influence survival...
  77. ncbi request reprint Interstitial vascularity in fibrosing alveolitis
    Elisabetta A Renzoni
    Department of Pathology, Interstitial Lung Disease Unit, Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 167:438-43. 2003
    ..006). In conclusion, there is net vascular ablation and redistribution of blood vessels in areas of interstitial thickening in both CFA and FASSc, which may contribute to gas exchange impairment...
  78. ncbi request reprint Cystic lung lesions in the pediatric and adult population: surgical experience at the Brompton Hospital
    Konstantinos Papagiannopoulos
    Department of Thoracic Surgery, Royal Brompton Hospital, London, United Kingdom
    Ann Thorac Surg 73:1594-8. 2002
    ..Cystic lung lesions are found in the adult and pediatric populations. We present our 19-year experience with such lesions from a single institution...
  79. ncbi request reprint Mediastinal hemangioma: successful treatment by alpha-2a interferon and postchemotherapy resection
    Pankaj Kumar
    Departments of Thoracic Surgery and Histopathology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, United Kingdom
    J Thorac Cardiovasc Surg 124:404-6. 2002
  80. ncbi request reprint CT features of lung disease in patients with systemic sclerosis: comparison with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia
    Sujal R Desai
    Department of Radiology, King s College Hospital, Denmark Hill, London SE5 9RS, England
    Radiology 232:560-7. 2004
    ....
  81. pmc Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis
    Brigham C Willis
    Department of Anesthesiology Critical Care Medicine, Childrens Hospital Los Angeles, California, USA
    Am J Pathol 166:1321-32. 2005
    ..These results suggest that AECs undergo EMT when chronically exposed to TGF-beta1, raising the possibility that epithelial cells may serve as a novel source of myofibroblasts in IPF...
  82. ncbi request reprint Is a two-week trial of oral prednisolone predictive of target lung function in pediatric asthma?
    Christiane Lex
    Department of Respiratory Paediatrics, Imperial College of Science, Technology and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, London, UK
    Pediatr Pulmonol 39:521-7. 2005
    ..5-39.9) vs. 1.4 (0.0-4.8) cells/mm2, P = 0.018). In conclusion, a 2-week course of prednisolone is not necessarily predictive of "target" lung function. Definitions such as PAL should be regularly reviewed on individual basis...
  83. pmc LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription
    Tyson V Sharp
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 101:16531-6. 2004
    ..Our data indicate that LIMD1 is a tumor-suppressor gene, the protein product of which functionally interacts with pRB and the loss of which promotes lung carcinogenesis...
  84. ncbi request reprint Pulmonary manifestations of primary Sjogren's syndrome: a clinical, radiologic, and pathologic study
    Isao Ito
    Department of Respiratory Medicine, Kyoto University Hospital, 54 Shogoin Kawaharacho, Sakyo, Kyoto, Japan
    Am J Respir Crit Care Med 171:632-8. 2005
    ..Clinicopathologic pulmonary manifestations associated with primary Sjogren's syndrome have yet to be reviewed in a large series since the recognition of nonspecific interstitial pneumonia (NSIP) as a distinct histologic pattern...
  85. ncbi request reprint Factor XII auto-antibodies present in a patient with a B-cell lymphoma
    Simon J Davidson
    Department of Haematology, Royal Brompton Hospital, London, UK
    Blood Coagul Fibrinolysis 16:365-7. 2005
    ..Factor XII was 9 U/dl and results were unaffected by increasing dilution, suggesting specific antibodies to factor XII. The factor XII antigen was 40 U/dl. The patient had immunoglobulin M auto-antibodies to factor XII...
  86. ncbi request reprint Gene expression signature for angiogenic and nonangiogenic non-small-cell lung cancer
    Jiangting Hu
    Cancer Research UK Tumour Pathology Group, Nuffield Department of Clinical Laboratory Science, University of Oxford, John Radcliffe Hospital, Headington OX3 9DU, Oxford, UK
    Oncogene 24:1212-9. 2005
    ..We raise the hypothesis that in nonangiogenic tumours, hypoxia leads to a higher activation of the mitochondrial respiratory chain, which allows tumour growth without triggering angiogenesis...
  87. ncbi request reprint Feasibility of the detection of the sentinel lymph node in peripheral non-small cell lung cancer with radio isotopic and blue dye techniques
    Olivier Tiffet
    FRCS, Department of Thoracic Surgery, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK
    Chest 127:443-8. 2005
    ....
  88. ncbi request reprint Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma
    William D Travis
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 23:3279-87. 2005
    ..To review recent advances in pathology and computed tomography (CT) of lung adenocarcinoma and bronchioloalveolar carcinoma (BAC)...
  89. ncbi request reprint Nuclear overexpression of the E2F3 transcription factor in human lung cancer
    Colin S Cooper
    Section of Molecular Carcinogenesis, Male Urological Cancer Research Centre, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK
    Lung Cancer 54:155-62. 2006
    ....
  90. pmc Surveillance for the detection of early lung cancer in patients with bronchial dysplasia
    Philip Jeremy George
    Centre for Respiratory Research, Department of Medicine, University College London, London UK
    Thorax 62:43-50. 2007
    ..Previous studies have treated severe dysplasia and carcinoma in situ (CIS) on the assumption that most will progress to invasive carcinoma...
  91. ncbi request reprint Pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis: a clinicopathologic study of 35 cases
    Sylvie Lantuejoul
    Department of Histopathology, Royal Brompton and Harefield Hospitals, London, UK
    Am J Surg Pathol 30:850-7. 2006
    ..The cause of the venous obliteration was not identified but the occasional identification of phlebitis suggests this plays a role in venous damage in some cases...
  92. ncbi request reprint Somatic mutations of the protein kinase gene family in human lung cancer
    Helen Davies
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, United Kingdom
    Cancer Res 65:7591-5. 2005
    ..The results suggest that several mutated protein kinases may be contributing to lung cancer development, but that mutations in each one are infrequent...
  93. ncbi request reprint Nature of airway inflammation and remodeling in chronic cough
    Akio Niimi
    Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, UK
    J Allergy Clin Immunol 116:565-70. 2005
    ..Chronic cough may be a result of asthma and non-asthma causes, but it is unclear whether there are specific inflammatory or remodeling changes...
  94. ncbi request reprint High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury
    Michael R Wilson
    Dept of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    J Appl Physiol (1985) 95:1385-93. 2003
    ..The apparently transient nature of TNF-alpha upregulation may help explain previous controversy regarding the involvement of cytokines in ventilator-induced lung injury...
  95. ncbi request reprint A clinicopathologic study of 12 neuroendocrine tumors arising in the thymus
    Olivier Tiffet
    Department of Thoracic Surgery, Royal Brompton Hospital, London, UK
    Chest 124:141-6. 2003
    ..To determine whether the new classification system for thymic carcinoid tumors/neuroendocrine carcinomas provides prognostic data, and to study the presentation, diagnosis, treatment, and prognostic factors of these rare tumors...
  96. ncbi request reprint Epithelioid hemangioendothelioma and other vascular mediastinal tumors: a role for alpha-2a interferon?
    Pankaj Kumar
    Ann Thorac Surg 76:653; author reply 653. 2003
  97. ncbi request reprint The role of transbronchial fine needle aspiration in an integrated care pathway for the assessment of patients with suspected lung cancer
    Pallav L Shah
    Department of Respiratory Medicine, Royal Brompton Hospital, London, England, UK
    J Thorac Oncol 1:324-7. 2006
    ..TBNA improves the diagnostic yield and staging of patients with lung cancer. Moreover, it is a simple, low-cost, and safe test, which should be incorporated into the diagnostic pathway of patients with suspected lung cancer...
  98. ncbi request reprint Different mitogen-activated protein kinase-dependent cytokine responses in cells of the monocyte lineage
    Susan J Tudhope
    Airway Disease Section, Guy Scadding Building, National Heart and Lung Institute, Imperial College London, Dovehouse St, London SW3 6LY, UK
    J Pharmacol Exp Ther 324:306-12. 2008
    ..The pattern of GM-CSF, IL-6, and IL-8 release was comparable with that of TNF-alpha. These data suggest a differential involvement for each of these MAPK pathways in macrophage cytokine production compared with monocytes...
  99. ncbi request reprint Atypical goblet cell hyperplasia in congenital cystic adenomatoid malformation as a possible preneoplasia for pulmonary adenocarcinoma in childhood: A genetic analysis
    Elvira Stacher
    Institute of Pathology, University of Graz, Graz, Austria
    Hum Pathol 35:565-70. 2004
    ..This likely reflects an association with goblet cell differentiation, but it also drives proliferation in AGCH...
  100. pmc Quantitative analysis of mycobacterial and propionibacterial DNA in lymph nodes of Japanese and European patients with sarcoidosis
    Yoshinobu Eishi
    Department of Human Pathology, School of Medicine, Tokyo Medical and Dental University, Japan
    J Clin Microbiol 40:198-204. 2002
    ..Propionibacterium spp. are more likely than Mycobacteria spp. to be involved in the etiology of sarcoidosis, not only in Japanese but also in European patients with sarcoidosis...
  101. pmc Acute exacerbations of idiopathic pulmonary fibrosis
    Harold R Collard
    Department of Medicine, San Francisco General Hospital, University of California, USA
    Am J Respir Crit Care Med 176:636-43. 2007
    ..The potential pathobiological roles of infection, disordered cell biology, coagulation, and genetics are discussed, and future research directions are proposed...