A Mocroft

Summary

Affiliation: Royal Free and University College Medical School
Country: UK

Publications

  1. ncbi request reprint Reasons for modification and discontinuation of antiretrovirals: results from a single treatment centre
    A Mocroft
    Department of Primary Care and Populations Sciences, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, UK
    AIDS 15:185-94. 2001
  2. ncbi request reprint Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group
    A Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, University College London, UK
    Lancet 352:1725-30. 1998
  3. ncbi request reprint Changes in AIDS-defining illnesses in a London Clinic, 1987-1998
    A Mocroft
    Department of Primary Care and Population Sciences, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, University College London, England
    J Acquir Immune Defic Syndr 21:401-7. 1999
  4. ncbi request reprint A comparison of exposure groups in the EuroSIDA study: starting highly active antiretroviral therapy (HAART), response to HAART, and survival
    A Mocroft
    Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, England
    J Acquir Immune Defic Syndr 22:369-78. 1999
  5. ncbi request reprint Virological failure among patients on HAART from across Europe: results from the EuroSIDA study
    A Mocroft
    Royal Free Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Antivir Ther 5:107-12. 2000
  6. ncbi request reprint Are there gender differences in starting protease inhibitors, HAART, and disease progression despite equal access to care?
    A Mocroft
    Royal Free Centre for HIV Medicine, Departments of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    J Acquir Immune Defic Syndr 24:475-82. 2000
  7. ncbi request reprint Time to virological failure of 3 classes of antiretrovirals after initiation of highly active antiretroviral therapy: results from the EuroSIDA study group
    A Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College London Medical Schools, London, United Kingdom
    J Infect Dis 190:1947-56. 2004
  8. ncbi request reprint Reasons for stopping antiretrovirals used in an initial highly active antiretroviral regimen: increased incidence of stopping due to toxicity or patient/physician choice in patients with hepatitis C coinfection
    A Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, NW3 2PF UK
    AIDS Res Hum Retroviruses 21:743-52. 2005
  9. doi request reprint Detection of HIV drug resistance during antiretroviral treatment and clinical progression in a large European cohort study
    Alessandro Cozzi-Lepri
    Research Department of Infection and Population Health, Royal Free and University College Medical School, London, UK
    AIDS 22:2187-98. 2008
  10. doi request reprint Regional differences in the risk of triple class failure in European patients starting combination antiretroviral therapy after 1 January 1999
    A Mocroft
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    HIV Med 9:41-6. 2008

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Reasons for modification and discontinuation of antiretrovirals: results from a single treatment centre
    A Mocroft
    Department of Primary Care and Populations Sciences, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, UK
    AIDS 15:185-94. 2001
    ..To describe the reasons for, and factors associated with, modification and discontinuation of highly active antiretroviral therapy (HAART) regimens at a single clinic...
  2. ncbi request reprint Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group
    A Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, University College London, UK
    Lancet 352:1725-30. 1998
    ..We examined the change in these mortality rates of HIV-1-infected patients across Europe during 1994-98, and assessed the extent to which changes can be explained by the use of new therapeutic regimens...
  3. ncbi request reprint Changes in AIDS-defining illnesses in a London Clinic, 1987-1998
    A Mocroft
    Department of Primary Care and Population Sciences, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, University College London, England
    J Acquir Immune Defic Syndr 21:401-7. 1999
    ....
  4. ncbi request reprint A comparison of exposure groups in the EuroSIDA study: starting highly active antiretroviral therapy (HAART), response to HAART, and survival
    A Mocroft
    Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, England
    J Acquir Immune Defic Syndr 22:369-78. 1999
    ..Given the decreased mortality and incidence of AIDS-defining illnesses among patients with HIV who start HAART, this may lead to a poorer prognosis among intravenous drug users...
  5. ncbi request reprint Virological failure among patients on HAART from across Europe: results from the EuroSIDA study
    A Mocroft
    Royal Free Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Antivir Ther 5:107-12. 2000
    ..To monitor the response to highly active antiretroviral therapy (HAART) over time and the proportions of patients with poor virological control in order to help provide some insight into drug resistance...
  6. ncbi request reprint Are there gender differences in starting protease inhibitors, HAART, and disease progression despite equal access to care?
    A Mocroft
    Royal Free Centre for HIV Medicine, Departments of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    J Acquir Immune Defic Syndr 24:475-82. 2000
    ....
  7. ncbi request reprint Time to virological failure of 3 classes of antiretrovirals after initiation of highly active antiretroviral therapy: results from the EuroSIDA study group
    A Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College London Medical Schools, London, United Kingdom
    J Infect Dis 190:1947-56. 2004
    ....
  8. ncbi request reprint Reasons for stopping antiretrovirals used in an initial highly active antiretroviral regimen: increased incidence of stopping due to toxicity or patient/physician choice in patients with hepatitis C coinfection
    A Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, NW3 2PF UK
    AIDS Res Hum Retroviruses 21:743-52. 2005
    ..Managing adverse events must remain a key intervention in maintaining HAART. There is a need for further studies to describe the relationship between HCV, specific antiretrovirals, and different treatment strategies...
  9. doi request reprint Detection of HIV drug resistance during antiretroviral treatment and clinical progression in a large European cohort study
    Alessandro Cozzi-Lepri
    Research Department of Infection and Population Health, Royal Free and University College Medical School, London, UK
    AIDS 22:2187-98. 2008
    ..To investigate the relationship between detection of HIV drug resistance by 2 years from starting antiretroviral therapy and the subsequent risk of progression to AIDS and death...
  10. doi request reprint Regional differences in the risk of triple class failure in European patients starting combination antiretroviral therapy after 1 January 1999
    A Mocroft
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    HIV Med 9:41-6. 2008
    ..33; 95% CI 0.15-0.74; P=0.0072) or a nonnucleotide reverse transcriptase inhibitor (NNRTI)-based regimen (0.59; 95% CI 0.37-0.94; P=0.026) had a reduced incidence of TCF...
  11. ncbi request reprint Gender differences in virologic response to treatment in an HIV-positive population: a cohort study
    A L Moore
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Hampstead, London, United Kingdom
    J Acquir Immune Defic Syndr 26:159-63. 2001
    ..To establish whether a gender difference in virologic response to highly active antiretroviral treatment (HAART) exists...
  12. ncbi request reprint Normalisation of CD4 counts in patients with HIV-1 infection and maximum virological suppression who are taking combination antiretroviral therapy: an observational cohort study
    A Mocroft
    Royal Free and University College Medical School, London, UK
    Lancet 370:407-13. 2007
    ..We aimed to assess whether the CD4 count for patients with maximum virological suppression (viral load <50 copies per mL) continues to increase with long-term cART to reach levels seen in HIV-negative populations...
  13. doi request reprint Loss to follow-up in an international, multicentre observational study
    A Mocroft
    Royal Free and University College Medical School, London, UK
    HIV Med 9:261-9. 2008
    ..The aim of this work was to assess loss to follow-up (LTFU) in EuroSIDA, an international multicentre observational cohort study...
  14. pmc Temporal changes and regional differences in treatment uptake of hepatitis C therapy in EuroSIDA
    D Grint
    University College London, London, UK
    HIV Med 14:614-23. 2013
    ..All HIV/hepatitis C virus (HCV)-coinfected patients with chronic HCV infection and ≥ F2 fibrosis should be considered for HCV therapy. This study aimed to determine the rate of HCV treatment uptake among coinfected patients in Europe...
  15. doi request reprint Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients
    Amanda Mocroft
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, Division of Population Health, University College London Medical School, Royal Free Campus, London, UK
    AIDS 24:1667-78. 2010
    ..Chronic kidney disease (CKD) in HIV-positive persons might be caused by both HIV and traditional or non-HIV-related factors. Our objective was to investigate long-term exposure to specific antiretroviral drugs and CKD...
  16. doi request reprint Does less frequent routine monitoring of patients on a stable, fully suppressed cART regimen lead to an increased risk of treatment failure?
    Joanne Reekie
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, Royal Free and University College Medical School, London, UK
    AIDS 22:2381-90. 2008
    ..To investigate whether HIV-infected patients on a stable and fully suppressive combination antiretroviral therapy (cART) regimen could safely be monitored less often than the current recommendations of every 3 months...
  17. doi request reprint A comparison of the long-term durability of nevirapine, efavirenz and lopinavir in routine clinical practice in Europe: a EuroSIDA study
    J Reekie
    Research Department of Infection and Population Health, University College London Medical School, Royal Free Campus, London, UK
    HIV Med 12:259-68. 2011
    ..The aim of this analysis was to compare the durability of nevirapine, efavirenz and lopinavir regimens based on these measures...
  18. doi request reprint Stability of hepatitis C virus (HCV) RNA levels among interferon-naïve HIV/HCV-coinfected individuals treated with combination antiretroviral therapy
    D Grint
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, University College London Royal Free Campus, London, UK
    HIV Med 14:370-8. 2013
    ..High HCV RNA levels have been associated with poor treatment response. This study aimed to examine the natural history of HCV RNA in chronically HCV/HIV-coinfected individuals...
  19. ncbi request reprint Decline in the AIDS and death rates in the EuroSIDA study: an observational study
    A Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Lancet 362:22-9. 2003
    ..Since the introduction of highly active antiretroviral therapy (HAART), little is known about whether changes in HIV-1 mortality and morbidity rates have been sustained. We aimed to assess possible changes in these rates across Europe...
  20. ncbi request reprint Reasons for stopping antiretrovirals used in an initial highly active antiretroviral regimen: increased incidence of stopping due to toxicity or patient/physician choice in patients with hepatitis C coinfection
    A Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College London Medical Schools, Roayal Free campus, London, UK
    AIDS Res Hum Retroviruses 21:527-36. 2005
    ..Managing adverse events must remain a key intervention in maintaining HAART. There is a need for further studies to describe the relationship between HCV, specific antiretrovirals, and different treatment strategies...
  21. ncbi request reprint Changes in hospital admissions across Europe: 1995-2003. Results from the EuroSIDA study
    A Mocroft
    Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, UK
    HIV Med 5:437-47. 2004
    ....
  22. doi request reprint Serious fatal and nonfatal non-AIDS-defining illnesses in Europe
    Amanda Mocroft
    Research Department of Infection and Population Health, University College Medical School, London, UK
    J Acquir Immune Defic Syndr 55:262-70. 2010
    ..Little is known about the incidence and risk factors for serious non-AIDS-defining events...
  23. doi request reprint Relationship between current level of immunodeficiency and non-acquired immunodeficiency syndrome-defining malignancies
    Joanne Reekie
    University College London Medical School, London, UK
    Cancer 116:5306-15. 2010
    ..However, conflicting data have been reported on the relationship between immunodeficiency and the development of some non-AIDS-defining malignancies...
  24. ncbi request reprint Response to antiretroviral therapy among patients exposed to three classes of antiretrovirals: results from the EuroSIDA study
    A Mocroft
    Royal Free Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Antivir Ther 7:21-30. 2002
    ..Outcomes in people starting salvage regimens appear to depend on the number of new drugs started but not on the total number of drugs being used...
  25. ncbi request reprint The feasibility of clinical endpoint trials in HIV infection in the highly active antiretroviral treatment (HAART) era
    A Mocroft
    Royal Free Centre for HIV Medicine, Dept Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill St, London NW3 2PF, UK
    Clin Trials 3:119-32. 2006
    ..Cohort studies of patients with HIV can provide key estimates of the likely disease progression, required sample size and follow-up...
  26. doi request reprint A comparison of estimated glomerular filtration rates using Cockcroft-Gault and the Chronic Kidney Disease Epidemiology Collaboration estimating equations in HIV infection
    A Mocroft
    Department of Infection and Population Health, University College London, London, UK
    HIV Med 15:144-52. 2014
    ....
  27. doi request reprint Estimating prevalence of accumulated HIV-1 drug resistance in a cohort of patients on antiretroviral therapy
    Wendy P Bannister
    Research Department of Infection and Population Health, University College London Medical School, London, UK
    J Antimicrob Chemother 66:901-11. 2011
    ....
  28. ncbi request reprint Rate of accumulation of thymidine analogue mutations in patients continuing to receive virologically failing regimens containing zidovudine or stavudine: implications for antiretroviral therapy programs in resource-limited settings
    Alessandro Cozzi-Lepri
    Research Department of Infection and Population Health, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 200:687-97. 2009
    ....
  29. ncbi request reprint Changes in the cause of death among HIV positive subjects across Europe: results from the EuroSIDA study
    A Mocroft
    Royal Free Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    AIDS 16:1663-71. 2002
    ..We investigated these changes, patients who died without an AIDS diagnosis and factors relating to pre-AIDS deaths...
  30. doi request reprint CD4 count and viral load specific rates of AIDS, non-AIDS and deaths according to current antiretroviral use
    A Mocroft
    University College London, London, UK
    J Int AIDS Soc 15:18191. 2012
    ....
  31. ncbi request reprint Changes in lymphocyte subsets in human immunodeficiency virus-positive persons with < 5 CD4 T lymphocytes/mm3
    C A Sabin
    Department of Primary Care and Population Sciences, Royal Free Hospital and School of Medicine, London, United Kingdom
    J Infect Dis 178:1166-9. 1998
    ..Despite almost a complete absence of CD4 T lymphocytes, lymphocyte subset monitoring is useful in identifying decreasing CD8 T lymphocyte levels that predict short-term prognosis...
  32. doi request reprint Transmitted drug resistant HIV-1 and association with virologic and CD4 cell count response to combination antiretroviral therapy in the EuroSIDA Study
    Wendy P Bannister
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    J Acquir Immune Defic Syndr 48:324-33. 2008
    ..To investigate prevalence of transmitted drug-resistant human immunodeficiency virus (TDR) and factors associated with TDR and to compare virological and CD4 count response to combination antiretroviral therapy...
  33. ncbi request reprint Reduced bone mineral density in HIV-positive individuals
    A L Moore
    Centre for HIV Medicine, Royal Free Hospital, London, UK
    AIDS 15:1731-3. 2001
    ..Our results suggest a possible association between PI and reduced BMD, and further complicate the debate regarding when to commence treatment of HIV and with what agents to start...
  34. ncbi request reprint Shorter survival in HIV-positive patients with diarrhoea who excrete adenovirus from the GI tract
    C A Sabin
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, England
    J Med Virol 58:280-5. 1999
    ..Gastrointestinal adenovirus excretion occurs at an advanced stage of HIV disease, and is associated with a poor prognosis. We suggest that adenoviruses may contribute to mortality in this population...
  35. ncbi request reprint Assessing the cost-effectiveness of HAART for adults with HIV in England
    A H Miners
    Royal Free Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    HIV Med 2:52-8. 2001
    ..To assess the cost-effectiveness of highly active antiretroviral therapy (HAART) compared with two nucleoside reverse transcriptase inhibitors (NRTIs) for HIV infected individuals...
  36. doi request reprint Temporal changes and regional differences in treatment uptake of hepatitis C therapy in EuroSIDA
    D Grint
    UCL Royal Free Campus, Research Department of Infection and Population Health, London, UK
    J Int AIDS Soc 15:18118. 2012
    ..HCV treatment was not associated with all-cause or liver-related death in this population...
  37. doi request reprint Impact of antiretroviral therapy (ART), immunosuppression and viraemia on lipid levels: the D:A:D study
    D Kamara
    University College London, Infection and Population Health, London, UK
    J Int AIDS Soc 15:18280. 2012
    ..The higher TC/TG and lower HDL-C levels seen among those with low nadir CD4 count and with a prior AIDS diagnosis suggests severe immunosuppression may be associated with dyslipidaemia over the long-term...