A M Little

Summary

Affiliation: Royal Free and University College Medical School
Country: UK

Publications

  1. ncbi request reprint Polymorphism and evolution of HLA class I and II genes and molecules
    A M Little
    Anthony Nolan Research Institute, The Royal Free Hospital, London, UK
    Rev Immunogenet 1:105-23. 1999
  2. ncbi request reprint Identification of HLA-B*0722
    A M Little
    The Anthony Nolan Research Institute and Histocompatibility Laboratories, London, United Kingdom
    Tissue Antigens 57:167-8. 2001
  3. ncbi request reprint HLA class I diversity in Kolla Amerindians
    A M Little
    Anthony Nolan Research Institute, The Royal Free Hospital, London, United Kingdom
    Hum Immunol 62:170-9. 2001
  4. ncbi request reprint Cloning and sequencing full-length HLA-B and -C genes
    S T Cox
    Anthony Nolan Research Institute, The Royal Free Hospital, Hampstead, London, UK
    Tissue Antigens 61:20-48. 2003
  5. ncbi request reprint A new allele, HLA-B*1555, identified in an African patient awaiting bone marrow transplantation
    M A Hoddinott
    Anthony Nolan Research Institute and Histocompatiblity Laboratories, The Royal Free Hospital, Hampstead, London, United Kingdom
    Tissue Antigens 55:463-6. 2000
  6. ncbi request reprint Sequence of two new HLA-Cw alleles: HLA-Cw*0313 and HLA-Cw*1208
    S T Cox
    The Anthony Nolan Research Institute and Histocompatibility Laboratories, London, United Kingdom
    Tissue Antigens 59:49-51. 2002
  7. ncbi request reprint Identification of HLA-A*2306
    S T Cox
    Anthony Nolan Research Institute and Histocompatibility Laboratories, The Royal Free Hospital, London, United Kingdom
    Tissue Antigens 57:73-5. 2001
  8. ncbi request reprint Further diversity at HLA-A and -B loci identified in Afro-Caribbean potential bone marrow donors
    S T Cox
    The Anthony Nolan Research Institute and Histocompatibility Laboratories, London, United Kingdom
    Tissue Antigens 57:70-2. 2001
  9. ncbi request reprint Sequence of a novel HLA-A*0301 intronic variant (A*03010103)
    N P Mayor
    The Anthony Nolan Research Institute, The Royal Free Hospital, Hampstead, London, UK
    Tissue Antigens 65:107-9. 2005
  10. ncbi request reprint Identification of HLA-B*1566
    S T Cox
    The Anthony Nolan Research Institute and Histocompatibility Laboratories, London, United Kingdom
    Tissue Antigens 59:424-5. 2002

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Polymorphism and evolution of HLA class I and II genes and molecules
    A M Little
    Anthony Nolan Research Institute, The Royal Free Hospital, London, UK
    Rev Immunogenet 1:105-23. 1999
    ..In turn, these analyses have provided insight into the mechanisms and selective forces driving change in the HLA complex...
  2. ncbi request reprint Identification of HLA-B*0722
    A M Little
    The Anthony Nolan Research Institute and Histocompatibility Laboratories, London, United Kingdom
    Tissue Antigens 57:167-8. 2001
    ..This polymorphism encodes an amino acid difference from aspartic acid in B*07021 to asparagine in B*0722. The functional significance of this polymorphism on peptide binding and/or T-cell recognition is unknown...
  3. ncbi request reprint HLA class I diversity in Kolla Amerindians
    A M Little
    Anthony Nolan Research Institute, The Royal Free Hospital, London, United Kingdom
    Hum Immunol 62:170-9. 2001
    ..The polymorphism identified within the Kolla HLA-A, -B, and -C alleles supports the hypothesis that HLA evolution is subject to positive selection for diversity within the peptide binding site...
  4. ncbi request reprint Cloning and sequencing full-length HLA-B and -C genes
    S T Cox
    Anthony Nolan Research Institute, The Royal Free Hospital, Hampstead, London, UK
    Tissue Antigens 61:20-48. 2003
    ..To date we have sequenced full-length genomic sequences from representatives of all the major HLA-B and -C allele groups...
  5. ncbi request reprint A new allele, HLA-B*1555, identified in an African patient awaiting bone marrow transplantation
    M A Hoddinott
    Anthony Nolan Research Institute and Histocompatiblity Laboratories, The Royal Free Hospital, Hampstead, London, United Kingdom
    Tissue Antigens 55:463-6. 2000
    ..B*1555 differs from B*1531 in exon 3 by a single nucleotide substitution. This substitution results in a change in the amino acid residue at position 97, which is located within the beta-pleated sheet region of the HLA molecule...
  6. ncbi request reprint Sequence of two new HLA-Cw alleles: HLA-Cw*0313 and HLA-Cw*1208
    S T Cox
    The Anthony Nolan Research Institute and Histocompatibility Laboratories, London, United Kingdom
    Tissue Antigens 59:49-51. 2002
    ..The functional significance of these polymorphisms on peptide-binding and/or T-cell recognition is unknown...
  7. ncbi request reprint Identification of HLA-A*2306
    S T Cox
    Anthony Nolan Research Institute and Histocompatibility Laboratories, The Royal Free Hospital, London, United Kingdom
    Tissue Antigens 57:73-5. 2001
    ..A*2306 is most similar to A*2301 with 1 nucleotide difference at position 331 in exon 2 which was previously a conserved position. This mutation results in an amino acid substitution of glutamine for glutamate at residue 87...
  8. ncbi request reprint Further diversity at HLA-A and -B loci identified in Afro-Caribbean potential bone marrow donors
    S T Cox
    The Anthony Nolan Research Institute and Histocompatibility Laboratories, London, United Kingdom
    Tissue Antigens 57:70-2. 2001
    ..The examples presented here highlight the potential for identification of further polymorphisms within the HLA system as more individuals from the much-needed ethnic minorities are recruited onto bone marrow donor registers...
  9. ncbi request reprint Sequence of a novel HLA-A*0301 intronic variant (A*03010103)
    N P Mayor
    The Anthony Nolan Research Institute, The Royal Free Hospital, Hampstead, London, UK
    Tissue Antigens 65:107-9. 2005
    ..The difference in RSCA mobility between A*03010101 and A*03010103 demonstrates the sensitivity of RSCA to detect single nucleotide polymorphisms...
  10. ncbi request reprint Identification of HLA-B*1566
    S T Cox
    The Anthony Nolan Research Institute and Histocompatibility Laboratories, London, United Kingdom
    Tissue Antigens 59:424-5. 2002
    ..This mutation may have arisen through interallelic recombination as it has been seen in other B*15 alleles and is also present in most B*14, B*27, B*38, B*39 alleles and in B*7301...
  11. doi request reprint Diverging effects of HLA-DPB1 matching status on outcome following unrelated donor transplantation depending on disease stage and the degree of matching for other HLA alleles
    B E Shaw
    Research Department, Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK
    Leukemia 24:58-65. 2010
    ..Conversely, our results suggest that in patients receiving an HLA-mismatched graft, the outcome is significantly better if they are also mismatched for DPB1. We recommend validation of these results in independent datasets...
  12. doi request reprint Two novel MICA alleles, MICA*054 and MICA*056
    S T Cox
    The Anthony Nolan Research Institute and Trust, The Royal Free Hospital, London, UK
    Tissue Antigens 73:85-7. 2009
    ..MICA*056 has a nucleotide substitution at position 758 of G to C resulting in the substitution of tryptophan for serine at codon 230, also in the alpha-3 domain...
  13. ncbi request reprint Factors influencing the outcome of bone marrow transplants using unrelated donors
    J A Madrigal
    Anthony Nolan Research Institute, Royal Free Hospital, London, UK
    Immunol Rev 157:153-66. 1997
    ..We will also mention other relevant factors, drawing on our experience of laboratory studies performed at The Anthony Nolan Research Institute and clinical studies at the Hammersmith Hospital in London...
  14. ncbi request reprint HLA-A*6817, identified in the Kolla Amerindians of North-West Argentina possesses a novel nucleotide substitution
    D Ramon
    Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom
    Tissue Antigens 55:453-4. 2000
    ..This substitution of adenosine 419 A*68012 for thymidine in A*6817 results in a novel amino acid change (aspartate to valine) at residue 116...
  15. ncbi request reprint Sequence of HLA-A*0209 confirmed
    S T Cox
    Anthony Nolan Research Institute, The Royal Free Hospital, Hampstead, London, UK
    Immunogenetics 51:489-90. 2000
  16. ncbi request reprint HLA-B*4413 identified in a UK Caucasoid potential bone marrow donor
    S T Cox
    Anthony Nolan Research Institute, The Royal Free Hospital, London, UK
    Tissue Antigens 55:185-7. 2000
    ..B*4413 is identical to B*44031 except for a unique nucleotide substitution resulting in an amino acid difference at residue 61 in the alpha1 helix...
  17. ncbi request reprint Sequence of HLA-A*6808
    S T Cox
    Anthony Nolan Research Institute, The Royal Free Hospital, Hampstead, London, UK
    Tissue Antigens 53:597-600. 1999
    ..The two nucleotide substitutions found in A*6808 effect an amino acid difference in the encoded protein at residue 156 within the peptide binding site which may evoke alloreactive immune response after HLA-A68 mismatched transplants...
  18. pmc Association of NKG2A with treatment for chronic hepatitis C virus infection
    R J Harrison
    Department of Hepatology, Division of Medicine, Imperial College, London, UK
    Clin Exp Immunol 161:306-14. 2010
    ..6 +/- 5.7, P < 0.02). Our data show that NKG2A expression is dysregulated in chronic HCV infection and that NKG2A-positive NK cells are associated with a beneficial response to pegylated interferon and ribavirin therapy...