Peter Lees

Summary

Affiliation: Royal Veterinary College
Country: UK

Publications

  1. doi request reprint Pharmacokinetics and bioequivalence in the pig of two ivermectin feed formulations
    P Lees
    Royal Veterinary College, Hatfield, Herts, UK
    J Vet Pharmacol Ther 36:350-7. 2013
  2. doi request reprint Veterinary pharmacology: history, current status and future prospects
    P Lees
    The Royal Veterinary College, Hawkshead Campus, Hatfield, Herts, UK
    J Vet Pharmacol Ther 36:105-15. 2013
  3. doi request reprint The role of pharmacokinetics in veterinary drug residues
    Peter Lees
    The Royal Veterinary College, Hatfield, Herts, UK
    Drug Test Anal 4:34-9. 2012
  4. doi request reprint Pharmacokinetics and pharmacodynamics of stereoisomeric drugs with particular reference to bioequivalence determination
    P Lees
    Royal Veterinary College, Hatfield, UK
    J Vet Pharmacol Ther 35:17-29. 2012
  5. ncbi request reprint Rational dosing of antimicrobial drugs: animals versus humans
    Peter Lees
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, Hatfield, Herts AL9 7TA, UK
    Int J Antimicrob Agents 19:269-84. 2002
  6. ncbi request reprint PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology
    P Lees
    Royal Veterinary College, Hawkshead Campus, Hatfield, Hertfordshire AL9 7TA, UK
    J Vet Pharmacol Ther 27:491-502. 2004
  7. ncbi request reprint Pharmacodynamics and pharmacokinetics of nonsteroidal anti-inflammatory drugs in species of veterinary interest
    P Lees
    Royal Veterinary College, Hawkshead Campus, Hatfield, Hertfordshire AL9 7TA, UK
    J Vet Pharmacol Ther 27:479-90. 2004
  8. ncbi request reprint Principles of pharmacodynamics and their applications in veterinary pharmacology
    P Lees
    Department of Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Campus, Hatfield, Hertfordshire AL9 7TA, UK
    J Vet Pharmacol Ther 27:397-414. 2004
  9. ncbi request reprint Pharmacodynamics and enantioselective pharmacokinetics of racemic carprofen in the horse
    P Lees
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Herts, AL9 7TA, United Kingdom
    J Vet Pharmacol Ther 25:433-48. 2002
  10. ncbi request reprint Ketoprofen in the cat: pharmacodynamics and chiral pharmacokinetics
    P Lees
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Herts AL9 7TA, UK
    Vet J 165:21-35. 2003

Collaborators

Detail Information

Publications23

  1. doi request reprint Pharmacokinetics and bioequivalence in the pig of two ivermectin feed formulations
    P Lees
    Royal Veterinary College, Hatfield, Herts, UK
    J Vet Pharmacol Ther 36:350-7. 2013
    ..Analysis of data by the Classic Method yielded confidence intervals of 80.59-114.47 (for AUC0-last ), 90.38-119.68 (for Cmax ) and 84.70-111.96 (for Css ). It was concluded that the two articles were bioequivalent for ivermectin...
  2. doi request reprint Veterinary pharmacology: history, current status and future prospects
    P Lees
    The Royal Veterinary College, Hawkshead Campus, Hatfield, Herts, UK
    J Vet Pharmacol Ther 36:105-15. 2013
    ..We end with words of encouragement for young colleagues intent upon pursuing a career in veterinary pharmacology...
  3. doi request reprint The role of pharmacokinetics in veterinary drug residues
    Peter Lees
    The Royal Veterinary College, Hatfield, Herts, UK
    Drug Test Anal 4:34-9. 2012
    ....
  4. doi request reprint Pharmacokinetics and pharmacodynamics of stereoisomeric drugs with particular reference to bioequivalence determination
    P Lees
    Royal Veterinary College, Hatfield, UK
    J Vet Pharmacol Ther 35:17-29. 2012
    ..This article reviews factors underlying differences in pharmacological properties of enantiomers. The relevance of such differences for studies designed to evaluate the bioequivalence of products containing chiral drugs is also reviewed...
  5. ncbi request reprint Rational dosing of antimicrobial drugs: animals versus humans
    Peter Lees
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, Hatfield, Herts AL9 7TA, UK
    Int J Antimicrob Agents 19:269-84. 2002
    ..Future possible developments in dosage schedule design are considered...
  6. ncbi request reprint PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology
    P Lees
    Royal Veterinary College, Hawkshead Campus, Hatfield, Hertfordshire AL9 7TA, UK
    J Vet Pharmacol Ther 27:491-502. 2004
    ..Using indirect response models and clinically relevant indices, PD data have been determined for flunixin, phenylbutazone and meloxicam in the horse, nimesulide in the dog and meloxicam in the cat...
  7. ncbi request reprint Pharmacodynamics and pharmacokinetics of nonsteroidal anti-inflammatory drugs in species of veterinary interest
    P Lees
    Royal Veterinary College, Hawkshead Campus, Hatfield, Hertfordshire AL9 7TA, UK
    J Vet Pharmacol Ther 27:479-90. 2004
    ..For these drugs there are marked enantiomeric differences in PK and PD properties of individual drugs in a given species, as well as important species differences in both PK and PD properties...
  8. ncbi request reprint Principles of pharmacodynamics and their applications in veterinary pharmacology
    P Lees
    Department of Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Campus, Hatfield, Hertfordshire AL9 7TA, UK
    J Vet Pharmacol Ther 27:397-414. 2004
    ..From these basic theories the operational model and the two-state theory have been developed. For a discussion of more advanced theories see Kenakin (1997)...
  9. ncbi request reprint Pharmacodynamics and enantioselective pharmacokinetics of racemic carprofen in the horse
    P Lees
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Herts, AL9 7TA, United Kingdom
    J Vet Pharmacol Ther 25:433-48. 2002
    ..The good safety margin of carprofen in clinical use might also be explained by weak COX inhibition and by other actions at the molecular level...
  10. ncbi request reprint Ketoprofen in the cat: pharmacodynamics and chiral pharmacokinetics
    P Lees
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Herts AL9 7TA, UK
    Vet J 165:21-35. 2003
    ..Administration of both enantiomers again produced marked and prolonged inhibition of platelet COX-1 and, in the case of R(-)KTP, this was probably attributable to S(+)KTP formed by chiral inversion...
  11. ncbi request reprint Development of in vitro assays for the evaluation of cyclooxygenase inhibitors and predicting selectivity of nonsteroidal anti-inflammatory drugs in cats
    Jerome M Giraudel
    Department of Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
    Am J Vet Res 66:700-9. 2005
    ..To develop and validate in cats suitable in vitro assays for screening and ranking nonsteroidal antiinflammatory drugs (NSAIDs) on the basis of their inhibitory potencies for cyclooxygenase (COX)-1 and COX-2...
  12. doi request reprint Potency and selectivity of carprofen enantiomers for inhibition of bovine cyclooxygenase in whole blood assays
    Claire Brentnall
    The Royal Veterinary College, Hawkshead Lane, Hatfield, Hertfordshire AL9 7TA, United Kingdom
    Res Vet Sci 93:1387-92. 2012
    ..4 mg/kg to calves subcutaneously, S(+)-carprofen concentrations exceeded the in vitro IC80 COX-2 value for 32 h and the IC20 for COX-1 for 33 h. The findings are discussed in relation to efficacy and safety of carprofen in calves...
  13. doi request reprint Pharmacokinetics, pharmacodynamics, metabolism, toxicology and residues of phenylbutazone in humans and horses
    Peter Lees
    Royal Veterinary College, Hawkshead Campus, Hatfield, Hertfordshire AL9 7TA, UK
    Vet J 196:294-303. 2013
    ....
  14. doi request reprint Pharmacodynamics of marbofloxacin for calf pneumonia pathogens
    Joanna Illambas
    The Royal Veterinary College, Hawkshead Campus, Hatfield, Hertfordshire AL9 7TA, United Kingdom
    Res Vet Sci 94:675-81. 2013
    ....
  15. ncbi request reprint Detection of enrofloxacin and its metabolite ciprofloxacin in equine hair
    Mark Dunnett
    Department of Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
    Res Vet Sci 77:143-51. 2004
    ..777 and r2=0.769). Enrofloxacin:ciprofloxacin ratios were 21:1 and 13:1 following intravenous and oral administration, respectively. Longitudinal analyte distributions correlated to treatment-sampling interval...
  16. doi request reprint Development and validation of a timed urinary collection system for use in the cat
    Ludovic Pelligand
    Department of Veterinary Basic Sciences, Royal Veterinary College, Hatfield, Hertfordshire, UK
    Lab Anim 45:196-203. 2011
    ..92 ± 0.37 mL/min/kg) and mean within-cat CV was 12 ± 6.9%. The system was simple in design, readily affordable, allowed normal micturition behaviour and reduced intra-animal variability in 24 h feline urine collection...
  17. pmc Pharmacokinetic/pharmacodynamic modelling of NSAIDs in a model of reversible inflammation in the cat
    Jerome M Giraudel
    UMR 181 de Physiopathologie et Toxicologie Expérimentales INRA ENVT, Ecole Nationale Veterinaire de Toulouse, France
    Br J Pharmacol 146:642-53. 2005
    ..5-15 mg, that is, between 0.1 and 0.3 mg kg(-1)). 6 These findings indicate the potential value of the cat as a laboratory model, and of a PK/PD modelling approach in assisting NSAID development programs in animals and humans...
  18. pmc Pharmacokinetic and pharmacodynamic profiles of danofloxacin administered by two dosing regimens in calves infected with Mannheimia (Pasteurella) haemolytica
    Patxi Sarasola
    Ondax Scientific, 20280 Hondarribia, Gipuzkoa, Spain
    Antimicrob Agents Chemother 46:3013-9. 2002
    ..Thus, danofloxacin exhibited concentration-dependent antimicrobial activity in cattle with respiratory disease caused by M. haemolytica...
  19. ncbi request reprint Veterinary pharmacology: where to in the 21st century?
    Peter Lees
    Vet J 165:95-7. 2003
  20. ncbi request reprint JVPT 25 years on
    Jim Riviere
    J Vet Pharmacol Ther 26:1-2. 2003
  21. ncbi request reprint Spine update: prevention of postoperative infection in patients undergoing spinal surgery
    Erwin M Brown
    Department of Medical Microbiology, Frenchay Hospital, Bristol, UK
    Spine (Phila Pa 1976) 29:938-45. 2004
  22. ncbi request reprint Antimicrobial drug resistance and veterinary therapeutics
    Peter Lees
    Vet Rec 151:454-5. 2002
  23. ncbi request reprint Veterinary advances in PK/PD modelling
    Peter Lees
    J Vet Pharmacol Ther 27:395. 2004