Research Topics
| Peter LeesSummaryAffiliation: Royal Veterinary College Country: UK Publications
| Collaborators
|
Detail Information
Publications
The role of pharmacokinetics in veterinary drug residuesPeter Lees
The Royal Veterinary College, Hatfield, Herts, UK
Drug Test Anal 4:34-9. 2012....- Pharmacokinetics and pharmacodynamics of stereoisomeric drugs with particular reference to bioequivalence determinationP Lees
Royal Veterinary College, Hatfield, UK
J Vet Pharmacol Ther 35:17-29. 2012..This article reviews factors underlying differences in pharmacological properties of enantiomers. The relevance of such differences for studies designed to evaluate the bioequivalence of products containing chiral drugs is also reviewed... 
PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacologyP Lees
Royal Veterinary College, Hawkshead Campus, Hatfield, Hertfordshire AL9 7TA, UK
J Vet Pharmacol Ther 27:491-502. 2004..Using indirect response models and clinically relevant indices, PD data have been determined for flunixin, phenylbutazone and meloxicam in the horse, nimesulide in the dog and meloxicam in the cat...- Pharmacodynamics and pharmacokinetics of nonsteroidal anti-inflammatory drugs in species of veterinary interestP Lees
Royal Veterinary College, Hawkshead Campus, Hatfield, Hertfordshire AL9 7TA, UK
J Vet Pharmacol Ther 27:479-90. 2004..For these drugs there are marked enantiomeric differences in PK and PD properties of individual drugs in a given species, as well as important species differences in both PK and PD properties... - Principles of pharmacodynamics and their applications in veterinary pharmacologyP Lees
Department of Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Campus, Hatfield, Hertfordshire AL9 7TA, UK
J Vet Pharmacol Ther 27:397-414. 2004..From these basic theories the operational model and the two-state theory have been developed. For a discussion of more advanced theories see Kenakin (1997)... - Rational dosing of antimicrobial drugs: animals versus humansPeter Lees
Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, Hatfield, Herts AL9 7TA, UK
Int J Antimicrob Agents 19:269-84. 2002..Future possible developments in dosage schedule design are considered... - Ketoprofen in the cat: pharmacodynamics and chiral pharmacokineticsP Lees
Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Herts AL9 7TA, UK
Vet J 165:21-35. 2003..Administration of both enantiomers again produced marked and prolonged inhibition of platelet COX-1 and, in the case of R(-)KTP, this was probably attributable to S(+)KTP formed by chiral inversion... - Pharmacodynamics and enantioselective pharmacokinetics of racemic carprofen in the horseP Lees
Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Herts, AL9 7TA, United Kingdom
J Vet Pharmacol Ther 25:433-48. 2002..The good safety margin of carprofen in clinical use might also be explained by weak COX inhibition and by other actions at the molecular level... - Development of in vitro assays for the evaluation of cyclooxygenase inhibitors and predicting selectivity of nonsteroidal anti-inflammatory drugs in catsJerome M Giraudel
Department of Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
Am J Vet Res 66:700-9. 2005..To develop and validate in cats suitable in vitro assays for screening and ranking nonsteroidal antiinflammatory drugs (NSAIDs) on the basis of their inhibitory potencies for cyclooxygenase (COX)-1 and COX-2... - Detection of enrofloxacin and its metabolite ciprofloxacin in equine hairMark Dunnett
Department of Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
Res Vet Sci 77:143-51. 2004..777 and r2=0.769). Enrofloxacin:ciprofloxacin ratios were 21:1 and 13:1 following intravenous and oral administration, respectively. Longitudinal analyte distributions correlated to treatment-sampling interval... - Development and validation of a timed urinary collection system for use in the catLudovic Pelligand
Department of Veterinary Basic Sciences, Royal Veterinary College, Hatfield, Hertfordshire, UK
Lab Anim 45:196-203. 2011..92 ± 0.37 mL/min/kg) and mean within-cat CV was 12 ± 6.9%. The system was simple in design, readily affordable, allowed normal micturition behaviour and reduced intra-animal variability in 24 h feline urine collection... 
Pharmacokinetic and pharmacodynamic profiles of danofloxacin administered by two dosing regimens in calves infected with Mannheimia (Pasteurella) haemolyticaPatxi Sarasola
Ondax Scientific, 20280 Hondarribia, Gipuzkoa, Spain
Antimicrob Agents Chemother 46:3013-9. 2002..Thus, danofloxacin exhibited concentration-dependent antimicrobial activity in cattle with respiratory disease caused by M. haemolytica...- Pharmacokinetic/pharmacodynamic modelling of NSAIDs in a model of reversible inflammation in the catJerome M Giraudel
, , France
Br J Pharmacol 146:642-53. 2005..5-15 mg, that is, between 0.1 and 0.3 mg kg(-1)). 6 These findings indicate the potential value of the cat as a laboratory model, and of a PK/PD modelling approach in assisting NSAID development programs in animals and humans... - Spine update: prevention of postoperative infection in patients undergoing spinal surgeryErwin M Brown
Department of Medical Microbiology, Frenchay Hospital, Bristol, UK
Spine 29:938-45. 2004 - Antimicrobial drug resistance and veterinary therapeuticsPeter Lees
Vet Rec 151:454-5. 2002 - Veterinary pharmacology: where to in the 21st century?Peter Lees
Vet J 165:95-7. 2003 - JVPT 25 years onJim Riviere
J Vet Pharmacol Ther 26:1-2. 2003 - Veterinary advances in PK/PD modellingPeter Lees
J Vet Pharmacol Ther 27:395. 2004