Research Topics
| Margaret JohnsonSummaryAffiliation: Royal Free Hospital Country: UK Publications
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Detail Information
Publications
Definition and epidemiology of late presentation in EuropeMargaret Johnson
HIV Department, Royal Free Hospital, Hampstead, London, UK
Antivir Ther 15:3-8. 2010..Standardizing the definition of late presentation will facilitate understanding, clinical research and, ultimately, effective treatment of late-presenting patients...
The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosisSanjay Lala
Centre for Gastroenterology, Royal Free and University College Medical School and Royal Free Hospital NHS Trust, London, UK
BMC Infect Dis 7:96. 2007..To further define a role for NOD2 in disease pathogenesis, we analysed NOD2 transcriptional responses in pulmonary leucocytes and mononuclear cells harvested from patients with pulmonary tuberculosis (PTB)...
96-week comparison of once-daily atazanavir/ritonavir and twice-daily lopinavir/ritonavir in patients with multiple virologic failuresMargaret Johnson
Royal Free Hospital, London, UK
AIDS 20:711-8. 2006..Results of extended follow-up to 96 weeks are presented...
Raltegravir use in special populationsMargaret Johnson
Royal Free Hospital NHS Trust, University College, London, UK
Eur J Med Res 14:43-6. 2009..Finally, although not licensed for use in pregnancy, raltegravir may need to be considered in some pregnant women with antiretroviral resistance or tolerability issues with current HAART regimens...- Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failuresMargaret Johnson
Royal Free Hospital, London, UK
AIDS 19:685-94. 2005.... - Comparison of gastrointestinal tolerability and patient preference for treatment with the 625 mg and 250 mg nelfinavir tablet formulationsM Johnson
Royal Free Hospital, London, UK
HIV Med 6:107-13. 2005..To compare gastrointestinal (GI) tolerability and patient preference for the new 625 mg formulation of nelfinavir (NFV) and the marketed 250 mg tablets (Viracept) in HIV-1-infected patients... - Are previous treatment interruptions associated with higher viral rebound rates in patients with viral suppression?Loveleen K Bansi
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Hampstead Campus, Rowland Hill Street, London, NW3 2PF, UK
AIDS 22:349-56. 2008..We investigated whether previous treatment interruptions are associated with a raised risk of viral rebound in individuals who have attained virological suppression... - Factors influencing lopinavir and atazanavir plasma concentrationWolfgang Stöhr
MRC Clinical Trials Unit, London, UK
J Antimicrob Chemother 65:129-37. 2010..The aim of this study was to evaluate which demographic factors and concomitant drugs are associated with lopinavir and atazanavir plasma concentration... - Determinants of virological failure after successful viral load suppression in first-line highly active antiretroviral therapyAnna M Geretti
Royal Free and University College Medical School, London, UK
Antivir Ther 13:927-36. 2008.... - Data linkage reduces loss to follow-up in an observational HIV cohort studyTeresa Hill
Research Department of Infection and Population Health, UCL Medical School, London, UK
J Clin Epidemiol 63:1101-9. 2010..To ascertain the degree of loss to follow-up in a cohort and to identify its predictors... - Predictors and kinetics of occult hepatitis B virus infection in HIV-infected personsGaia Nebbia
Department of Virology, Royal Free Hospital and Royal Free and University College Medical School, London, UK
J Med Virol 79:1464-71. 2007..The intermittent nature of HBV-DNA detection poses a diagnostic challenge, but no association is observed with ALT levels... - Biomarkers to monitor safety in people on art and risk of mortalityLoveleen Bansi
UCL Medical School, Royal Free Campus, London, UK
J Acquir Immune Defic Syndr 60:51-8. 2012..Using time-updated laboratory measurements, we use several methods to derive a score that can be used to identify individuals at high risk of mortality... - Adherence to antiretroviral treatment in patients with HIV in the UK: a study of complexityLorraine Sherr
Department of Primary Care and Population Sciences, Royal Free University College Medical School, London, UK
AIDS Care 20:442-8. 2008..42, p=0.01). The softer markers of adherence are not usually measured in follow up and may account for variations in treatment responses. The complexity of adherence needs to be understood and addressed to maximise treatment efficacy... - Outcomes in the first year after initiation of first-line HAART among heterosexual men and women in the UK CHIC StudyTristan J Barber
St Stephen s AIDS Trust Clinical Trials Unit, Chelsea and Westminster NHS Foundation Trust, London, UK
Antivir Ther 16:805-14. 2011..We analysed the influence of gender on use and outcomes of first-line HAART in a UK cohort... - Risk of extensive virological failure to the three original antiretroviral drug classes over long-term follow-up from the start of therapy in patients with HIV infection: an observational cohort studyAndrew N Phillips
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
Lancet 370:1923-8. 2007..We estimated the proportion of patients who had extensive triple-class failure during long-term follow-up and examined characteristics associated with an increased rate of failure... - Gender and mental health aspects of living with HIV disease and its longer-term outcomes for UK heterosexual patientsLorraine Sherr
Department of Infection and Population Health, University College London, London, UK
Women Health 52:214-33. 2012..The groups had generally similar HIV experiences with high psychological distress. Adherence monitoring and gender appropriate psychological support are needed for these groups... - Discordant responses on starting highly active antiretroviral therapy: suboptimal CD4 increases despite early viral suppression in the UK Collaborative HIV Cohort (UK CHIC) StudyR J C Gilson
Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, The Mortimer Market Centre, Camden Primary Care Trust, London, UK
HIV Med 11:152-60. 2010..This study was designed to determine the incidence of a discordant response at two time-points, soon after 6 months and at 12 months, and to determine the relationship with clinical outcomes... - Clinical and behavioural aspects of aging with HIV infectionLorraine Sherr
Department of Thoracic Medicine, Royal Free and University College Medical School, London, UK
Psychol Health Med 14:273-9. 2009..The older group were similar in employment, education and disclosure, but complained less and reported much higher tolerance... - Low-frequency K103N strengthens the impact of transmitted drug resistance on virologic responses to first-line efavirenz or nevirapine-based highly active antiretroviral therapyAnna Maria Geretti
Department of Virology, Royal Free Hampstead NHS Trust, London, UK
J Acquir Immune Defic Syndr 52:569-73. 2009..There are conflicting data on the impact of low-frequency transmitted drug-resistant mutants on responses to first-line highly active antiretroviral therapy (HAART)... - Is 1 alanine transaminase >200 IU enough to define an alanine transaminase flare in HIV-infected populations? A new definition derived from a large cohort studyLoveleen Bansi
Research Department of Infection and Population Health, University College London Medical School, London, UK
J Acquir Immune Defic Syndr 52:391-6. 2009..However, the definition of an ALT flare is arbitrary and the extent to which such increases represent normal fluctuations has not been explored... - Suicidal ideation in UK HIV clinic attendersLorraine Sherr
Royal Free and University College Medical School, London, UK
AIDS 22:1651-8. 2008..Although new treatments have changed prognosis, they also bring new challenges. This study measured suicidal ideation in HIV clinic attenders in the United Kingdom (London/Southeast) and explored associated factors... - Factors influencing efavirenz and nevirapine plasma concentration: effect of ethnicity, weight and co-medicationWolfgang Stöhr
MRC Clinical Trials Unit, London, UK
Antivir Ther 13:675-85. 2008..The aim of this study was to examine factors influencing plasma concentration of efavirenz and nevirapine... - Late diagnosis in the HAART era: proposed common definitions and associations with mortalityCaroline A Sabin
Research Department of Infection and Population Health, UCL Medical School, London, UK
AIDS 24:723-7. 2010.... - What factors are associated with patient self-reported health status among HIV outpatients? A multi-centre UK study of biomedical and psychosocial factorsRichard Harding
King s College London, Department of Palliative Care, Policy and Rehabilitation, Cicely Saunders Institute, London, UK
AIDS Care 24:963-71. 2012..As HIV management focuses on treatment for extended survival and a chronic model of disease, clinical attention to physical and psychological dimensions of patient care are essential to achieve optimal well-being... - HIV-associated central nervous system diseases in the recent combination antiretroviral therapy eraLucy Garvey
Clinical Trials Centre, Winston Churchill Wing, St Mary s Hospital, London, W2 1NY, UK
Eur J Neurol 18:527-34. 2011..Data describing the incidence and survival of HIV-related central nervous system diseases (CNS-D) in recent years are sparse... - Rate of AIDS diseases or death in HIV-infected antiretroviral therapy-naive individuals with high CD4 cell countAndrew N Phillips
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
AIDS 21:1717-21. 2007..To assess the absolute rate of AIDS and death in antiretroviral therapy (ART)-naive patients with a high CD4 cell count. Such information would be helpful in the design of a trial investigating early initiation of ART... - Physical and psychological symptoms and risk of virologic rebound among patients with virologic suppression on antiretroviral therapyFiona C Lampe
Department of Infection and Population Health, University College London Medical School, London, UK
J Acquir Immune Defic Syndr 54:500-5. 2010..We examined the association of self-reported physical and psychological symptoms with subsequent virologic rebound among patients with viral suppression on combination antiretroviral therapy (cART)... - CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UKMark Bower
Research Department of Infection and Population Health, Division of Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
Haematologica 94:875-80. 2009..Earlier highly active anti-retroviral therapy initiation and wider access to HIV testing is advocated to reduce the risk of systemic non-Hodgkin's lymphoma... - Behavioral surveillance study: sexual risk taking behaviour in UK HIV outpatient attendeesRichard Harding
Department of Palliative Care, Policy and Rehabilitation, King s College London, Cicely Saunders Institute, King s Health Partners, UK
AIDS Behav 16:1708-15. 2012..Psychological symptoms should be assessed and managed in the HIV outpatient setting to ensure integrated care that enhances prevention... - Increased duration of viral suppression is associated with lower viral rebound rates in patients with previous treatment failuresAndrew A Benzie
St Mary s Hospital, London, UK
AIDS 21:1423-30. 2007.... - A randomized comparative trial of tenofovir DF or abacavir as replacement for a thymidine analogue in persons with lipoatrophyGraeme J Moyle
Chelsea and Westminster Hospital, London, UK
AIDS 20:2043-50. 2006..Peripheral fat loss, lipoatrophy, appears most associated with prolonged therapy with thymidine nucleoside analogues... - The effect of transmitted HIV-1 drug resistance on pre-therapy viral loadLinda Harrison
HIV and Infections Group, MRC Clinical Trials Unit, London, UK
AIDS 24:1917-22. 2010..Reduced replication capacity of viruses expressing drug resistant mutations implies that patients with transmitted drug resistance (TDR) could have lower HIV RNA viral load than those infected with wild-type virus... - Survival following HIV infection of a cohort followed up from seroconversion in the UKFiona M Ewings
MRC Clinical Trials Unit, London, UK
AIDS 22:89-95. 2008..To estimate changes over calendar time in survival following HIV seroconversion in the era of HAART and to provide updated survival estimates... - Responses to highly active antiretroviral therapy and clinical events in patients with a low CD4 cell count: late presenters vs. late startersL Waters
Department of GU HIV Medicine, Chelsea and Westminster Hospital Foundation Trust, London, UK
HIV Med 12:289-98. 2011..We investigated whether adverse responses to highly active antiretroviral therapy (HAART) associated with late HIV presentation are secondary to low CD4 cell count per se or other confounding factors... - Serious fatal and nonfatal non-AIDS-defining illnesses in EuropeAmanda Mocroft
Research Department of Infection and Population Health, University College Medical School, London, UK
J Acquir Immune Defic Syndr 55:262-70. 2010..Little is known about the incidence and risk factors for serious non-AIDS-defining events... - The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapyC A Sabin
Department of Primary Care and Population Science, Royal Free and UC Medical School, London, UK
HIV Med 10:35-43. 2009.... - Responses to switching to maraviroc-based antiretroviral therapy in treated patients with suppressed plasma HIV-1-RNA loadPaola Vitiello
UCL Medical School, London, UK
Intervirology 55:172-8. 2012..The aim of this study was to evaluate patients on suppressive ART switching to an MVC-containing regimen (MVC-CR), and test the hypothesis that the switch may have an impact on T cell activation... - Saquinavir/low-dose ritonavir: its use in HIV infectionMargaret Johnson
Infection and Immunity Services, Royal Free Hospital, Pons Street, London NW3 2QG, UK
AIDS Rev 5:44-51. 2003..In addition, data suggest that "double-boosting" strategies, including the combination of saquinavir with lopinavir/ritonavir, provide valuable treatment options in the salvage setting... - Long-term trends in adherence to antiretroviral therapy from start of HAARTValentina Cambiano
HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, London, UK
AIDS 24:1153-62. 2010..We aimed to investigate long-term trends in highly active antiretroviral therapy (HAART) adherence to identify the main predictors and to evaluate whether participants experience periods of low adherence (<or=60%)... - An open-label, randomized comparative pilot study of a single-class quadruple therapy regimen versus a 2-class triple therapy regimen for individuals initiating antiretroviral therapyGraeme Moyle
Chelsea and Westminster Hospital, London, UK
Antivir Ther 11:73-8. 2006..To examine the antiviral potency and tolerability profile of a single-class four drug (quadruple) nucleoside reverse transcriptase inhibitor (NRTI) regimen compared with a 2-class standard-of-care regimen... - Clinical epidemiology of HIV-associated end-stage renal failure in the UKLoveleen Bansi
University College London Medical School, London, UK
AIDS 23:2517-21. 2009..To describe the clinical epidemiology of HIV-associated end-stage renal failure (HIV/ESRF) from 1998 to 2007 in the United Kingdom... - Successive switching of antiretroviral therapy is associated with high psychological and physical burdenLorraine Sherr
Royal Free and University College Medical School, London, UK
Int J STD AIDS 18:700-4. 2007..A holistic approach is needed to understand the psychological effects of such switches if lifelong treatment is to be maintained and those on antiretroviral treatment are to attain good quality of life and minimize symptom burden... - Detection of low-frequency K103N mutants after unstructured discontinuation of efavirenz in the presence of the CYP2B6 516 TT polymorphismAna Garcia-Diaz
Royal Free Hospital and Royal Free and University College Medical School, London, UK
J Antimicrob Chemother 62:1188-90. 2008.... - Pneumocystis pneumonia revisited: delayed diagnosis in an HIV infected individual with high blood and low lung CD4 T cell countsBen Killingley
The Royal Free Centre for HIV Medicine, Royal Free Hospital, London, United Kingdom
J Infect 53:e159-60. 2006..On each occasion the possibility of PCP was discounted as he had a well-preserved blood CD4 count. Subsequent examination of his pulmonary T-lymphocyte subsets revealed marked CD4 lymphopenia... - The changing pattern of bronchoscopy in an HIV-infected populationSimon Taggart
Royal Free Hospital HIV Centre, Hampstead, London, UK
Chest 122:878-85. 2002..This study was performed to identify any changes to our pattern of use of bronchoscopy over the last decade, and how this might relate to the introduction of more effective ARTs to our center in 1996... - CD4 cell count changes in individuals with counts above 500 cells/mm and viral loads below 50 copies/ml on antiretroviral therapyAndrew N Phillips
Royal Free Centre for HIV Medicine, London, UK
AIDS 16:1073-5. 2002 - Impaired antigen-specific CD4(+) T lymphocyte responses in cavitary tuberculosisSimon Barry
Department of Respiratory Medicine, Royal Free Hospital, Pond Street, London, UK
Tuberculosis (Edinb) 89:48-53. 2009..It remains unclear whether neutrophilia is a cause, or a result of cavitation in pulmonary tuberculosis... - Reconstitution of herpes simplex virus-specific T cell immunity in HIV-infected patients receiving highly active antiretroviral therapyMeghna Ramaswamy
Department of Virology, Royal Free Hospital and Royal Free and University College Medical School, North Middlesex University Hospital, London, UK
J Infect Dis 195:410-5. 2007..6/month (95% confidence interval, 1.2-9.9 [P=.01]) and 21.3/100 CD4 cells/mm(3) gained (95% confidence interval, 13.8-28.7 [P<.0001]). Responses were correlated with LTNP status and CD4 cell count... - Acetyl-l-carnitine: a pathogenesis based treatment for HIV-associated antiretroviral toxic neuropathyAndrew M Hart
Blond McIndoe Centre, Royal Free and University College Medical School, London, UK
AIDS 18:1549-60. 2004..HIV RNA load, CD4 and CD8 cell counts did not alter significantly throughout the study. CONCLUSIONS: ALCAR treatment improves symptoms, causes peripheral nerve regeneration and is proposed as a pathogenesis-based treatment for DSP... - Gender differences in virologic response to treatment in an HIV-positive population: a cohort studyA L Moore
Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Hampstead, London, United Kingdom
J Acquir Immune Defic Syndr 26:159-63. 2001..To establish whether a gender difference in virologic response to highly active antiretroviral treatment (HAART) exists... - Patterns and predictors of the use of different antiretroviral drug regimens at treatment initiation in the UKP J Easterbrook
Department of HIV GU Medicine, Kings College London School of Medicine at Guy s, London, UK
HIV Med 9:47-56. 2008..We describe the patterns of antiretroviral drug use at treatment initiation from 1996 to 2005 in a large UK multicentre cohort... - Use of a prescription-based measure of antiretroviral therapy adherence to predict viral rebound in HIV-infected individuals with viral suppressionV Cambiano
HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, London, UK
HIV Med 11:216-24. 2010..The aim of the study was to assess whether a simple, routinely available measure of antiretroviral therapy (ART) adherence predicts viral rebound at the next HIV viral load (VL) measurement in virally suppressed patients... - Rash in an HIV-positive patientC Herzmann
The Royal Free Centre for HIV Medicine, London, UK
HIV Med 6:379. 2005 - Practical strategies in case managementMargaret Johnson
Department of Thoracic Medicine, Royal Free Hospital, London, UK
Int J STD AIDS 16:35-9; discussion 39-43. 2005 - Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per microL in Europe and North America: a pooled cohort observational studyRebecca K Lodwick
HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, London, UK
Lancet 376:340-5. 2010..We aimed to examine this by analysis of pooled data from industrialised countries... - Use of a stochastic model to develop understanding of the impact of different patterns of antiretroviral drug use on resistance developmentA N Phillips
Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, University College London, London, UK
AIDS 15:2211-20. 2001..CONCLUSIONS: This model helps to develop understanding of key principles concerning development of resistance under different patterns of treatment use... - British HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapy (2006)B Gazzard
Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK
HIV Med 7:487-503. 2006 - Human immunodeficiency virus (HIV) antibody avidity testing to identify recent infection in newly diagnosed HIV type 1 (HIV-1)-seropositive persons infected with diverse HIV-1 subtypesA Chawla
Department of Virology, Royal Free Hospital, Royal Free and University College Medical School, London, UK
J Clin Microbiol 45:415-20. 2007..Results are affected by advanced disease and should therefore be interpreted in the context of other clinical parameters... - Multiple myeloma and human immunodeficiency virus-1 (HIV-1) infectionT T Yee
Department of Haematology, Royal Free and University College Medical School, University College, London, United Kingdom
Am J Hematol 66:123-5. 2001.... - Assessing the cost-effectiveness of HAART for adults with HIV in EnglandA H Miners
Royal Free Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
HIV Med 2:52-8. 2001..To assess the cost-effectiveness of highly active antiretroviral therapy (HAART) compared with two nucleoside reverse transcriptase inhibitors (NRTIs) for HIV infected individuals... - Long term recovery of IgG and IgM production during HIV infection in a patient with common variable immunodeficiency (CVID)S Jolles
The National Institute for Medical Research, Division of Cellular Immunology, The Ridgeway, Mill Hill, London, NW7 1AA, UK
J Clin Pathol 54:713-5. 2001..This paper describes the immunological consequences of human immunodeficiency virus (HIV) infection in a patient with familial CVID subsequently treated with highly active antiretroviral therapy (HAART)... - British HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapyA Pozniak
Chelsea and Westminster Hospital, London, UK
HIV Med 4:1-41. 2003 - Cervical screening in HIV-positive women: characteristics of those who default and attitudes towards screeningS Shah
Department of Thoracic Medicine, Royal Free Centre for HIV Medicine, London, UK
HIV Med 7:46-52. 2006..Cervical screening experience varies by ethnicity and language... - The prevalence of hepatitis C virus (HCV) infection in HIV-positive individuals in the UK - trends in HCV testing and the impact of HCV on HIV treatment outcomesJ Turner
Centre for Sexual Health and HIV Research, UCL Medical School and The Mortimer Market Centre, Camden Primary Care Trust, London, UK
J Viral Hepat 17:569-77. 2010..HCV infection had no impact on HIV virological outcomes or immunological response to HIV treatment. The long-term impact on morbidity and mortality remain to be determined... - Tuberculosis complicating treatment of hepatitis C in an HIV-infected haemophilia A patientB Killingley
Royal Free Centre for HIV Medicine, Royal Free Hospital, London, UK
Haemophilia 12:545-7. 2006..The association of pegIFN and ribavirin therapy with tuberculosis (TB) has not been described previously... - Multicenter study of human immunodeficiency virus-related germ cell tumorsT Powles
Chelsea and Westminster Hospital, London, United Kingdom
J Clin Oncol 21:1922-7. 2003..After a median follow-up of 4.6 years, 9% of the patients died from GCT. Most of the mortality relates to HIV infection... - National review of first treatment change after starting highly active antiretroviral therapy in antiretroviral-naïve patientsE Hart
North Manchester General Hospital, Manchester, UK
HIV Med 8:186-91. 2007..Reference was made to the British HIV Association (BHIVA) guidelines on HIV management... - Once-daily atazanavir/ritonavir versus twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 48 week efficacy and safety results of the CASTLE studyJean Michel Molina
Department of Infectious Diseases, Saint Louis Hospital, AP HP, Paris University of Paris Diderot, Paris 7, France
Lancet 372:646-55. 2008..We compared these two combinations directly in treatment-naive patients... - Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophreniaA Marutle
Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research (NEUROTEC, Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, S-141 86, Stockholm, Sweden
J Chem Neuroanat 22:115-26. 2001.... - Mechanisms involved in stimulation of human immunodeficiency virus type 1 replication by aminooxypentane RANTESA J Marozsan
Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Virol 75:8624-38. 2001..MAPK/ERK1 and -2 appear to phosphorylate the HIV-1 preintegration complex, a step necessary for nuclear translocation and successful integration... - Genotypic and epidemiologic characteristics of hepatitis C virus infections among recent injection drug user and nonuser populationsL Krekulova
Program in Infectious Diseases, School of Public Health, University of California, Berkeley 94720, USA
Clin Infect Dis 33:1435-8. 2001.... - Effects of repeated anaesthesia on central cholinergic function in the rat cerebral cortexC D Hanning
Leicester General Hospital, Department of Anaesthesia, Leicester, UK
Eur J Anaesthesiol 20:93-7. 2003..General anaesthesia may contribute to postoperative cognitive decline in the elderly. The aim was to determine the effects of repeated pentobarbital anaesthesia throughout life on central cholinergic function in the rat... - Outcome of patients with HIV-related germ cell tumours: a case-control studyT Powles
Department of Oncology, Chelsea and Westminster Hospital, Fulham Road, London SW10 9NH, UK
Br J Cancer 90:1526-30. 2004..78). The overall survival has not improved since the introduction of highly active antiretroviral therapy (log rank P=0.4). Thus, HIV-related GCT is not more aggressive than GCT in the general population... - Adenovirus viraemia and dissemination unresponsive to antiviral therapy in advanced HIV-1 infectionG Nebbia
AIDS 19:1339-40. 2005 - Survey of HIV and hepatitis B or C co-infection management in the UK 2004S de Silva
Mortimer Market Centre, Capper Street, London WC1E 5AU, UK
Int J STD AIDS 17:799-801. 2006..In conclusion, we identified several areas of concern in the diagnosis and management of HIV/hepatitis co-infection in several UK HIV treatment centres... - Aspirin and extended-release dipyridamole versus clopidogrel for recurrent strokeRalph L Sacco
Miller School of Medicine, University of Miami, Miami, USA
N Engl J Med 359:1238-51. 2008..Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel... - Effects of intensive glucose lowering in type 2 diabetesHertzel C Gerstein
N Engl J Med 358:2545-59. 2008..These findings identify a previously unrecognized harm of intensive glucose lowering in high-risk patients with type 2 diabetes. (ClinicalTrials.gov number, NCT00000620.)..