Margaret Johnson

Summary

Affiliation: Royal Free Hospital
Country: UK

Publications

  1. doi Definition and epidemiology of late presentation in Europe
    Margaret Johnson
    HIV Department, Royal Free Hospital, Hampstead, London, UK
    Antivir Ther 15:3-8. 2010
  2. pmc The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis
    Sanjay Lala
    Centre for Gastroenterology, Royal Free and University College Medical School and Royal Free Hospital NHS Trust, London, UK
    BMC Infect Dis 7:96. 2007
  3. ncbi Comparison of gastrointestinal tolerability and patient preference for treatment with the 625 mg and 250 mg nelfinavir tablet formulations
    M Johnson
    Royal Free Hospital, London, UK
    HIV Med 6:107-13. 2005
  4. ncbi 96-week comparison of once-daily atazanavir/ritonavir and twice-daily lopinavir/ritonavir in patients with multiple virologic failures
    Margaret Johnson
    Royal Free Hospital, London, UK
    AIDS 20:711-8. 2006
  5. ncbi Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures
    Margaret Johnson
    Royal Free Hospital, London, UK
    AIDS 19:685-94. 2005
  6. pmc Raltegravir use in special populations
    Margaret Johnson
    Royal Free Hospital NHS Trust, University College, London, UK
    Eur J Med Res 14:43-6. 2009
  7. doi Are previous treatment interruptions associated with higher viral rebound rates in patients with viral suppression?
    Loveleen K Bansi
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Hampstead Campus, Rowland Hill Street, London, NW3 2PF, UK
    AIDS 22:349-56. 2008
  8. pmc Factors influencing lopinavir and atazanavir plasma concentration
    Wolfgang Stöhr
    MRC Clinical Trials Unit, London, UK
    J Antimicrob Chemother 65:129-37. 2010
  9. ncbi Determinants of virological failure after successful viral load suppression in first-line highly active antiretroviral therapy
    Anna M Geretti
    Royal Free and University College Medical School, London, UK
    Antivir Ther 13:927-36. 2008
  10. doi Data linkage reduces loss to follow-up in an observational HIV cohort study
    Teresa Hill
    Research Department of Infection and Population Health, UCL Medical School, London, UK
    J Clin Epidemiol 63:1101-9. 2010

Collaborators

Detail Information

Publications90

  1. doi Definition and epidemiology of late presentation in Europe
    Margaret Johnson
    HIV Department, Royal Free Hospital, Hampstead, London, UK
    Antivir Ther 15:3-8. 2010
    ..Standardizing the definition of late presentation will facilitate understanding, clinical research and, ultimately, effective treatment of late-presenting patients...
  2. pmc The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis
    Sanjay Lala
    Centre for Gastroenterology, Royal Free and University College Medical School and Royal Free Hospital NHS Trust, London, UK
    BMC Infect Dis 7:96. 2007
    ..To further define a role for NOD2 in disease pathogenesis, we analysed NOD2 transcriptional responses in pulmonary leucocytes and mononuclear cells harvested from patients with pulmonary tuberculosis (PTB)...
  3. ncbi Comparison of gastrointestinal tolerability and patient preference for treatment with the 625 mg and 250 mg nelfinavir tablet formulations
    M Johnson
    Royal Free Hospital, London, UK
    HIV Med 6:107-13. 2005
    ..To compare gastrointestinal (GI) tolerability and patient preference for the new 625 mg formulation of nelfinavir (NFV) and the marketed 250 mg tablets (Viracept) in HIV-1-infected patients...
  4. ncbi 96-week comparison of once-daily atazanavir/ritonavir and twice-daily lopinavir/ritonavir in patients with multiple virologic failures
    Margaret Johnson
    Royal Free Hospital, London, UK
    AIDS 20:711-8. 2006
    ..Results of extended follow-up to 96 weeks are presented...
  5. ncbi Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures
    Margaret Johnson
    Royal Free Hospital, London, UK
    AIDS 19:685-94. 2005
    ....
  6. pmc Raltegravir use in special populations
    Margaret Johnson
    Royal Free Hospital NHS Trust, University College, London, UK
    Eur J Med Res 14:43-6. 2009
    ..Finally, although not licensed for use in pregnancy, raltegravir may need to be considered in some pregnant women with antiretroviral resistance or tolerability issues with current HAART regimens...
  7. doi Are previous treatment interruptions associated with higher viral rebound rates in patients with viral suppression?
    Loveleen K Bansi
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Hampstead Campus, Rowland Hill Street, London, NW3 2PF, UK
    AIDS 22:349-56. 2008
    ..We investigated whether previous treatment interruptions are associated with a raised risk of viral rebound in individuals who have attained virological suppression...
  8. pmc Factors influencing lopinavir and atazanavir plasma concentration
    Wolfgang Stöhr
    MRC Clinical Trials Unit, London, UK
    J Antimicrob Chemother 65:129-37. 2010
    ..The aim of this study was to evaluate which demographic factors and concomitant drugs are associated with lopinavir and atazanavir plasma concentration...
  9. ncbi Determinants of virological failure after successful viral load suppression in first-line highly active antiretroviral therapy
    Anna M Geretti
    Royal Free and University College Medical School, London, UK
    Antivir Ther 13:927-36. 2008
    ....
  10. doi Data linkage reduces loss to follow-up in an observational HIV cohort study
    Teresa Hill
    Research Department of Infection and Population Health, UCL Medical School, London, UK
    J Clin Epidemiol 63:1101-9. 2010
    ..To ascertain the degree of loss to follow-up in a cohort and to identify its predictors...
  11. ncbi Predictors and kinetics of occult hepatitis B virus infection in HIV-infected persons
    Gaia Nebbia
    Department of Virology, Royal Free Hospital and Royal Free and University College Medical School, London, UK
    J Med Virol 79:1464-71. 2007
    ..The intermittent nature of HBV-DNA detection poses a diagnostic challenge, but no association is observed with ALT levels...
  12. doi Biomarkers to monitor safety in people on art and risk of mortality
    Loveleen Bansi
    UCL Medical School, Royal Free Campus, London, UK
    J Acquir Immune Defic Syndr 60:51-8. 2012
    ..Using time-updated laboratory measurements, we use several methods to derive a score that can be used to identify individuals at high risk of mortality...
  13. ncbi Risk of extensive virological failure to the three original antiretroviral drug classes over long-term follow-up from the start of therapy in patients with HIV infection: an observational cohort study
    Andrew N Phillips
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Lancet 370:1923-8. 2007
    ..We estimated the proportion of patients who had extensive triple-class failure during long-term follow-up and examined characteristics associated with an increased rate of failure...
  14. doi Adherence to antiretroviral treatment in patients with HIV in the UK: a study of complexity
    Lorraine Sherr
    Department of Primary Care and Population Sciences, Royal Free University College Medical School, London, UK
    AIDS Care 20:442-8. 2008
    ..42, p=0.01). The softer markers of adherence are not usually measured in follow up and may account for variations in treatment responses. The complexity of adherence needs to be understood and addressed to maximise treatment efficacy...
  15. doi Outcomes in the first year after initiation of first-line HAART among heterosexual men and women in the UK CHIC Study
    Tristan J Barber
    St Stephen s AIDS Trust Clinical Trials Unit, Chelsea and Westminster NHS Foundation Trust, London, UK
    Antivir Ther 16:805-14. 2011
    ..We analysed the influence of gender on use and outcomes of first-line HAART in a UK cohort...
  16. doi Gender and mental health aspects of living with HIV disease and its longer-term outcomes for UK heterosexual patients
    Lorraine Sherr
    Department of Infection and Population Health, University College London, London, UK
    Women Health 52:214-33. 2012
    ..The groups had generally similar HIV experiences with high psychological distress. Adherence monitoring and gender appropriate psychological support are needed for these groups...
  17. doi Discordant responses on starting highly active antiretroviral therapy: suboptimal CD4 increases despite early viral suppression in the UK Collaborative HIV Cohort (UK CHIC) Study
    R J C Gilson
    Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, The Mortimer Market Centre, Camden Primary Care Trust, London, UK
    HIV Med 11:152-60. 2010
    ..This study was designed to determine the incidence of a discordant response at two time-points, soon after 6 months and at 12 months, and to determine the relationship with clinical outcomes...
  18. doi Clinical and behavioural aspects of aging with HIV infection
    Lorraine Sherr
    Department of Thoracic Medicine, Royal Free and University College Medical School, London, UK
    Psychol Health Med 14:273-9. 2009
    ..The older group were similar in employment, education and disclosure, but complained less and reported much higher tolerance...
  19. doi Low-frequency K103N strengthens the impact of transmitted drug resistance on virologic responses to first-line efavirenz or nevirapine-based highly active antiretroviral therapy
    Anna Maria Geretti
    Department of Virology, Royal Free Hampstead NHS Trust, London, UK
    J Acquir Immune Defic Syndr 52:569-73. 2009
    ..There are conflicting data on the impact of low-frequency transmitted drug-resistant mutants on responses to first-line highly active antiretroviral therapy (HAART)...
  20. ncbi Factors influencing efavirenz and nevirapine plasma concentration: effect of ethnicity, weight and co-medication
    Wolfgang Stöhr
    MRC Clinical Trials Unit, London, UK
    Antivir Ther 13:675-85. 2008
    ..The aim of this study was to examine factors influencing plasma concentration of efavirenz and nevirapine...
  21. doi Suicidal ideation in UK HIV clinic attenders
    Lorraine Sherr
    Royal Free and University College Medical School, London, UK
    AIDS 22:1651-8. 2008
    ..Although new treatments have changed prognosis, they also bring new challenges. This study measured suicidal ideation in HIV clinic attenders in the United Kingdom (London/Southeast) and explored associated factors...
  22. doi Is 1 alanine transaminase >200 IU enough to define an alanine transaminase flare in HIV-infected populations? A new definition derived from a large cohort study
    Loveleen Bansi
    Research Department of Infection and Population Health, University College London Medical School, London, UK
    J Acquir Immune Defic Syndr 52:391-6. 2009
    ..However, the definition of an ALT flare is arbitrary and the extent to which such increases represent normal fluctuations has not been explored...
  23. doi Late diagnosis in the HAART era: proposed common definitions and associations with mortality
    Caroline A Sabin
    Research Department of Infection and Population Health, UCL Medical School, London, UK
    AIDS 24:723-7. 2010
    ....
  24. doi What factors are associated with patient self-reported health status among HIV outpatients? A multi-centre UK study of biomedical and psychosocial factors
    Richard Harding
    King s College London, Department of Palliative Care, Policy and Rehabilitation, Cicely Saunders Institute, London, UK
    AIDS Care 24:963-71. 2012
    ..As HIV management focuses on treatment for extended survival and a chronic model of disease, clinical attention to physical and psychological dimensions of patient care are essential to achieve optimal well-being...
  25. doi HIV-associated central nervous system diseases in the recent combination antiretroviral therapy era
    Lucy Garvey
    Clinical Trials Centre, Winston Churchill Wing, St Mary s Hospital, London, W2 1NY, UK
    Eur J Neurol 18:527-34. 2011
    ..Data describing the incidence and survival of HIV-related central nervous system diseases (CNS-D) in recent years are sparse...
  26. doi Physical and psychological symptoms and risk of virologic rebound among patients with virologic suppression on antiretroviral therapy
    Fiona C Lampe
    Department of Infection and Population Health, University College London Medical School, London, UK
    J Acquir Immune Defic Syndr 54:500-5. 2010
    ..We examined the association of self-reported physical and psychological symptoms with subsequent virologic rebound among patients with viral suppression on combination antiretroviral therapy (cART)...
  27. ncbi Rate of AIDS diseases or death in HIV-infected antiretroviral therapy-naive individuals with high CD4 cell count
    Andrew N Phillips
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    AIDS 21:1717-21. 2007
    ..To assess the absolute rate of AIDS and death in antiretroviral therapy (ART)-naive patients with a high CD4 cell count. Such information would be helpful in the design of a trial investigating early initiation of ART...
  28. pmc CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK
    Mark Bower
    Research Department of Infection and Population Health, Division of Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
    Haematologica 94:875-80. 2009
    ..Earlier highly active anti-retroviral therapy initiation and wider access to HIV testing is advocated to reduce the risk of systemic non-Hodgkin's lymphoma...
  29. doi Behavioral surveillance study: sexual risk taking behaviour in UK HIV outpatient attendees
    Richard Harding
    Department of Palliative Care, Policy and Rehabilitation, King s College London, Cicely Saunders Institute, King s Health Partners, UK
    AIDS Behav 16:1708-15. 2012
    ..Psychological symptoms should be assessed and managed in the HIV outpatient setting to ensure integrated care that enhances prevention...
  30. ncbi Increased duration of viral suppression is associated with lower viral rebound rates in patients with previous treatment failures
    Andrew A Benzie
    St Mary s Hospital, London, UK
    AIDS 21:1423-30. 2007
    ....
  31. ncbi A randomized comparative trial of tenofovir DF or abacavir as replacement for a thymidine analogue in persons with lipoatrophy
    Graeme J Moyle
    Chelsea and Westminster Hospital, London, UK
    AIDS 20:2043-50. 2006
    ..Peripheral fat loss, lipoatrophy, appears most associated with prolonged therapy with thymidine nucleoside analogues...
  32. pmc Sexual behaviour, recreational drug use and hepatitis C co-infection in HIV-diagnosed men who have sex with men in the United Kingdom: results from the ASTRA study
    Marina Daskalopoulou
    University College London Royal Free Hospital, London, UK
    J Int AIDS Soc 17:19630. 2014
    ..We explore associations between self-reported sexual behaviours and drug use with cumulative HCV prevalence, as well as new HCV diagnosis...
  33. doi The effect of transmitted HIV-1 drug resistance on pre-therapy viral load
    Linda Harrison
    HIV and Infections Group, MRC Clinical Trials Unit, London, UK
    AIDS 24:1917-22. 2010
    ..Reduced replication capacity of viruses expressing drug resistant mutations implies that patients with transmitted drug resistance (TDR) could have lower HIV RNA viral load than those infected with wild-type virus...
  34. pmc Socio-economic factors and virological suppression among people diagnosed with HIV in the United Kingdom: results from the ASTRA study
    Lisa Burch
    Department of Infection and Population Health, University College London, London, UK
    J Int AIDS Soc 17:19533. 2014
    ..The impact of socio-economic factors on virological suppression has been little studied...
  35. pmc Laboratory adverse events and discontinuation of therapy according to CD4(+) cell count at the start of antiretroviral therapy
    Sophie Jose
    aResearch Department of Infection and Population Health, UCL bImperial College London Department of Medicine, London cThe Lothian University Hospitals NHS Trust, Edinburgh dSt George s Healthcare NHS Trust, London eBrighton and Sussex University Hospitals NHS Trust, Brighton fKings College Hospital NHS Foundation Trust and King s College London gChelsea and Westminster NHS Foundation Trust, London hNorth Bristol NHS Trust, Bristol iRoyal Free Hampstead NHS Trust, London jSouth Tees Hospital NHS Foundation Trust, Middlesbrough kMortimer Market Centre, University College Medical School, London, UK
    AIDS 28:1333-9. 2014
    ..We compared rates of laboratory-defined adverse events (LDAEs) according to CD4(+) cell count at ART initiation...
  36. doi Serious fatal and nonfatal non-AIDS-defining illnesses in Europe
    Amanda Mocroft
    Research Department of Infection and Population Health, University College Medical School, London, UK
    J Acquir Immune Defic Syndr 55:262-70. 2010
    ..Little is known about the incidence and risk factors for serious non-AIDS-defining events...
  37. ncbi Survival following HIV infection of a cohort followed up from seroconversion in the UK
    Fiona M Ewings
    MRC Clinical Trials Unit, London, UK
    AIDS 22:89-95. 2008
    ..To estimate changes over calendar time in survival following HIV seroconversion in the era of HAART and to provide updated survival estimates...
  38. doi The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapy
    C A Sabin
    Department of Primary Care and Population Science, Royal Free and UC Medical School, London, UK
    HIV Med 10:35-43. 2009
    ....
  39. doi Responses to highly active antiretroviral therapy and clinical events in patients with a low CD4 cell count: late presenters vs. late starters
    L Waters
    Department of GU HIV Medicine, Chelsea and Westminster Hospital Foundation Trust, London, UK
    HIV Med 12:289-98. 2011
    ..We investigated whether adverse responses to highly active antiretroviral therapy (HAART) associated with late HIV presentation are secondary to low CD4 cell count per se or other confounding factors...
  40. doi Responses to switching to maraviroc-based antiretroviral therapy in treated patients with suppressed plasma HIV-1-RNA load
    Paola Vitiello
    UCL Medical School, London, UK
    Intervirology 55:172-8. 2012
    ..The aim of this study was to evaluate patients on suppressive ART switching to an MVC-containing regimen (MVC-CR), and test the hypothesis that the switch may have an impact on T cell activation...
  41. doi Long-term trends in adherence to antiretroviral therapy from start of HAART
    Valentina Cambiano
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, London, UK
    AIDS 24:1153-62. 2010
    ..We aimed to investigate long-term trends in highly active antiretroviral therapy (HAART) adherence to identify the main predictors and to evaluate whether participants experience periods of low adherence (<or=60%)...
  42. doi Clinical epidemiology of HIV-associated end-stage renal failure in the UK
    Loveleen Bansi
    University College London Medical School, London, UK
    AIDS 23:2517-21. 2009
    ..To describe the clinical epidemiology of HIV-associated end-stage renal failure (HIV/ESRF) from 1998 to 2007 in the United Kingdom...
  43. ncbi An open-label, randomized comparative pilot study of a single-class quadruple therapy regimen versus a 2-class triple therapy regimen for individuals initiating antiretroviral therapy
    Graeme Moyle
    Chelsea and Westminster Hospital, London, UK
    Antivir Ther 11:73-8. 2006
    ..To examine the antiviral potency and tolerability profile of a single-class four drug (quadruple) nucleoside reverse transcriptase inhibitor (NRTI) regimen compared with a 2-class standard-of-care regimen...
  44. ncbi Successive switching of antiretroviral therapy is associated with high psychological and physical burden
    Lorraine Sherr
    Royal Free and University College Medical School, London, UK
    Int J STD AIDS 18:700-4. 2007
    ..A holistic approach is needed to understand the psychological effects of such switches if lifelong treatment is to be maintained and those on antiretroviral treatment are to attain good quality of life and minimize symptom burden...
  45. ncbi Saquinavir/low-dose ritonavir: its use in HIV infection
    Margaret Johnson
    Infection and Immunity Services, Royal Free Hospital, Pons Street, London NW3 2QG, UK
    AIDS Rev 5:44-51. 2003
    ..In addition, data suggest that "double-boosting" strategies, including the combination of saquinavir with lopinavir/ritonavir, provide valuable treatment options in the salvage setting...
  46. pmc Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy
    Margaret T May
    aUniversity of Bristol bNorth Bristol NHS Trust, Bristol cPublic Health England dMedical Research Council Clinical Trials Unit eBarts and The London NHS Trust fSouth London Healthcare NHS Trust gSt George s Healthcare NHS Trust hRoyal Free Hampstead NHS Trust, London iUniversity Hospitals of Leicester NHS Trust, Leicester jMortimer Market Centre, University College Medical School, London kSouth Tees Hospital NHS Foundation Trust, Middlesbrough lYork Teaching Hospital NHS Foundation Trust, York mResearch Department of Infection and Population Health, UCL nImperial College Healthcare NHS Foundation Trust oKings College Healthcare NHS Foundation Trust and Kings College London, London pBrighton and Sussex University Hospitals NHS Trust, Brighton qNorth Middlesex University Hospital NHS Trust, London rThe Lothian University Hospitals NHS Trust, Edinburgh sChelsea and Westminster NHS Foundation Trust tHomerton University Hospital NHS Trust, London, UK
    AIDS 28:1193-202. 2014
    ..The objective of this study is to estimate life expectancies of HIV-positive patients conditional on response to antiretroviral therapy (ART)...
  47. doi Failure to achieve a CD4+ cell count response on combination antiretroviral therapy despite consistent viral load suppression
    Jemma L O'Connor
    aResearch Department of Infection and Population Health, UCL, London bNorth Bristol NHS Trust, Bristol cSt George s Healthcare NHS Trust, London dSouth Tees Hospitals NHS Foundation Trust, Middlesbrough eBrighton and Sussex University Hospitals NHS Trust, Brighton fNorth Middlesex University Hospital NHS Trust gMortimer Market Centre, University College Medical School hImperial College Healthcare NHS Trust iHomerton University Hospital NHS Trust jBarts and The London NHS Trust kChelsea and Westminster Hospital NHS Foundation Trust lSouth London Healthcare NHS Trust, London mThe Lothian University Hospitals NHS Trust, Edinburgh nUniversity Hospitals of Leicester NHS Trust, Leicester oKings College Hospital NHS Foundation Trust, London, UK pRoyal Free Hampstead NHS Trust, London, UK
    AIDS 28:919-24. 2014
    ..To assess CD4 cell count recovery in people severely immunosuppressed at start of antiretroviral therapy (ART) who achieve and maintain viral load suppression...
  48. doi The challenges of testing for HIV in women: experience from the UK and other European countries
    Margaret Johnson
    Department of Thoracic Medicine, Royal Free Hospital, London, UK
    Antivir Ther 18:19-25. 2013
    ..Similarly, the consequences of a positive diagnosis for a woman need to be addressed in pre- and post-test discussions...
  49. doi Detection of low-frequency K103N mutants after unstructured discontinuation of efavirenz in the presence of the CYP2B6 516 TT polymorphism
    Ana Garcia-Diaz
    Royal Free Hospital and Royal Free and University College Medical School, London, UK
    J Antimicrob Chemother 62:1188-90. 2008
    ....
  50. ncbi Pneumocystis pneumonia revisited: delayed diagnosis in an HIV infected individual with high blood and low lung CD4 T cell counts
    Ben Killingley
    The Royal Free Centre for HIV Medicine, Royal Free Hospital, London, United Kingdom
    J Infect 53:e159-60. 2006
    ..On each occasion the possibility of PCP was discounted as he had a well-preserved blood CD4 count. Subsequent examination of his pulmonary T-lymphocyte subsets revealed marked CD4 lymphopenia...
  51. ncbi The changing pattern of bronchoscopy in an HIV-infected population
    Simon Taggart
    Royal Free Hospital HIV Centre, Hampstead, London, UK
    Chest 122:878-85. 2002
    ..This study was performed to identify any changes to our pattern of use of bronchoscopy over the last decade, and how this might relate to the introduction of more effective ARTs to our center in 1996...
  52. doi End-stage kidney disease and kidney transplantation in HIV-positive patients: an observational cohort study
    Esther Gathogo
    Department of Renal Sciences, King s College London, London, United Kingdom Research Department of Infection and Population Health, University College London, London, United Kingdom West London Centre for Sexual Health, Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom Imperial College Kidney and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom UCL Centre for Nephrology, Royal Free Hospital NHS Foundation Trust, London, United Kingdom Department of Infectious Diseases, The Lothian University Hospitals NHS Trust, Edinburgh, United Kingdom Department of Sexual Health and HIV, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom and Department of Sexual Health and HIV, King s College Hospital NHS Foundation Trust, London, United Kingdom
    J Acquir Immune Defic Syndr 67:177-80. 2014
    ..Survival was similar for KT recipients and those awaiting KT (85% and 89% at 5 years, respectively; P = 0.53). Our results endorse the use of KT to manage ESKD in HIV-positive patients...
  53. pmc Rate of viral load failure over time in people on ART in the UK Collaborative HIV Cohort (CHIC) study
    Jemma O'Connor
    Department of Infection and Population Health, UCL, London, UK
    J Int AIDS Soc 17:19527. 2014
    ..It is unclear whether those who have maintained VL suppression for several years will be able to continue to do so, or if rates of VL failure - due to poor adherence, ART interruption and/or resistance - remain at appreciable levels...
  54. doi Impaired antigen-specific CD4(+) T lymphocyte responses in cavitary tuberculosis
    Simon Barry
    Department of Respiratory Medicine, Royal Free Hospital, Pond Street, London, UK
    Tuberculosis (Edinb) 89:48-53. 2009
    ..It remains unclear whether neutrophilia is a cause, or a result of cavitation in pulmonary tuberculosis...
  55. ncbi Reconstitution of herpes simplex virus-specific T cell immunity in HIV-infected patients receiving highly active antiretroviral therapy
    Meghna Ramaswamy
    Department of Virology, Royal Free Hospital and Royal Free and University College Medical School, North Middlesex University Hospital, London, UK
    J Infect Dis 195:410-5. 2007
    ..6/month (95% confidence interval, 1.2-9.9 [P=.01]) and 21.3/100 CD4 cells/mm(3) gained (95% confidence interval, 13.8-28.7 [P<.0001]). Responses were correlated with LTNP status and CD4 cell count...
  56. ncbi CD4 cell count changes in individuals with counts above 500 cells/mm and viral loads below 50 copies/ml on antiretroviral therapy
    Andrew N Phillips
    Royal Free Centre for HIV Medicine, London, UK
    AIDS 16:1073-5. 2002
  57. pmc Minimal cognitive impairment in UK HIV-positive men who have sex with men: effect of case definitions and comparison with the general population and HIV-negative men
    Jeffrey McDonnell
    Research Department of Infection and Population Health, University College London, London, United Kingdom Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom National Institute for Infectious Diseases, Lazzaro Spallanzani, Rome, Italy CogState, Melbourne, Victoria, Australia Department of Sexual Health and HIV, Royal Free London NHS Foundation Trust, London, United Kingdom and HIV I Base, London, United Kingdom
    J Acquir Immune Defic Syndr 67:120-7. 2014
    ..To determine the prevalence of neurocognitive impairment (NCI) in UK HIV-positive and HIV-negative men who have sex with men (MSM)...
  58. pmc A clinically useful risk-score for chronic kidney disease in HIV infection
    Amanda Mocroft
    Department of Infection and Population Health, University College London, London, UK
    J Int AIDS Soc 17:19514. 2014
    ..Development of a simple, widely applicable risk score for chronic kidney disease (CKD) allows comparisons of risks or benefits of starting potentially nephrotoxic antiretrovirals (ARVs) as part of a treatment regimen...
  59. pmc Effects of age on symptom burden, mental health and quality of life amongst people with HIV in the UK
    Jennifer McGowan
    Infection and Population Health, University College London, London, UK
    J Int AIDS Soc 17:19511. 2014
    ..It has been suggested that adverse physical and psychological effects of HIV may be higher among older people. However, few studies have examined the effect of older age on well-being for people with HIV...
  60. ncbi Acetyl-l-carnitine: a pathogenesis based treatment for HIV-associated antiretroviral toxic neuropathy
    Andrew M Hart
    Blond McIndoe Centre, Royal Free and University College Medical School, London, UK
    AIDS 18:1549-60. 2004
    ..ALCAR enhances neurotrophic support of sensory neurons and promotes energy metabolism, potentially causing nerve regeneration and symptom relief...
  61. pmc Analysis of transmitted HIV-1 drug resistance using 454 ultra-deep-sequencing and the DeepChek(®)-HIV system
    Ana Garcia-Diaz
    Virology, Royal Free London NHS Foundation Trust, London, UK
    J Int AIDS Soc 17:19752. 2014
    ..DeepChek (ABL, TherapyEdge) is a CE-marked software that allows automated analysis and resistance interpretation of NGS data...
  62. doi Use of a prescription-based measure of antiretroviral therapy adherence to predict viral rebound in HIV-infected individuals with viral suppression
    V Cambiano
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, London, UK
    HIV Med 11:216-24. 2010
    ..The aim of the study was to assess whether a simple, routinely available measure of antiretroviral therapy (ART) adherence predicts viral rebound at the next HIV viral load (VL) measurement in virally suppressed patients...
  63. ncbi Gender differences in virologic response to treatment in an HIV-positive population: a cohort study
    A L Moore
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Hampstead, London, United Kingdom
    J Acquir Immune Defic Syndr 26:159-63. 2001
    ..To establish whether a gender difference in virologic response to highly active antiretroviral treatment (HAART) exists...
  64. ncbi Rash in an HIV-positive patient
    C Herzmann
    The Royal Free Centre for HIV Medicine, London, UK
    HIV Med 6:379. 2005
  65. doi Patterns and predictors of the use of different antiretroviral drug regimens at treatment initiation in the UK
    P J Easterbrook
    Department of HIV GU Medicine, Kings College London School of Medicine at Guy s, London, UK
    HIV Med 9:47-56. 2008
    ..We describe the patterns of antiretroviral drug use at treatment initiation from 1996 to 2005 in a large UK multicentre cohort...
  66. doi A systematic review of the use of atazanavir in women infected with HIV-1
    Margaret Johnson
    Royal Free Centre for HIV Medicine, Royal Free Hospital, London, UK
    Antivir Ther 19:293-307. 2014
    ..The purpose of this systematic review is to provide clinicians with an overview of available literature regarding the use of ritonavir-boosted atazanavir (ATV/r) in women...
  67. ncbi Practical strategies in case management
    Margaret Johnson
    Department of Thoracic Medicine, Royal Free Hospital, London, UK
    Int J STD AIDS 16:35-9; discussion 39-43. 2005
  68. pmc Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per microL in Europe and North America: a pooled cohort observational study
    Rebecca K Lodwick
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, London, UK
    Lancet 376:340-5. 2010
    ..We aimed to examine this by analysis of pooled data from industrialised countries...
  69. ncbi Multiple myeloma and human immunodeficiency virus-1 (HIV-1) infection
    T T Yee
    Department of Haematology, Royal Free and University College Medical School, University College, London, United Kingdom
    Am J Hematol 66:123-5. 2001
    ....
  70. pmc Human immunodeficiency virus (HIV) antibody avidity testing to identify recent infection in newly diagnosed HIV type 1 (HIV-1)-seropositive persons infected with diverse HIV-1 subtypes
    A Chawla
    Department of Virology, Royal Free Hospital, Royal Free and University College Medical School, London, UK
    J Clin Microbiol 45:415-20. 2007
    ..Results are affected by advanced disease and should therefore be interpreted in the context of other clinical parameters...
  71. ncbi British HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapy (2006)
    B Gazzard
    Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK
    HIV Med 7:487-503. 2006
  72. ncbi Use of a stochastic model to develop understanding of the impact of different patterns of antiretroviral drug use on resistance development
    A N Phillips
    Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, University College London, London, UK
    AIDS 15:2211-20. 2001
    ..CONCLUSIONS: This model helps to develop understanding of key principles concerning development of resistance under different patterns of treatment use...
  73. ncbi British HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapy
    A Pozniak
    Chelsea and Westminster Hospital, London, UK
    HIV Med 4:1-41. 2003
  74. ncbi Assessing the cost-effectiveness of HAART for adults with HIV in England
    A H Miners
    Royal Free Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    HIV Med 2:52-8. 2001
    ..To assess the cost-effectiveness of highly active antiretroviral therapy (HAART) compared with two nucleoside reverse transcriptase inhibitors (NRTIs) for HIV infected individuals...
  75. ncbi Cervical screening in HIV-positive women: characteristics of those who default and attitudes towards screening
    S Shah
    Department of Thoracic Medicine, Royal Free Centre for HIV Medicine, London, UK
    HIV Med 7:46-52. 2006
    ..To determine the characteristics of HIV-positive women who undergo cervical screening and to identify negative attitudes and experiences of these women to screening and the factors associated with these...
  76. pmc Long term recovery of IgG and IgM production during HIV infection in a patient with common variable immunodeficiency (CVID)
    S Jolles
    The National Institute for Medical Research, Division of Cellular Immunology, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    J Clin Pathol 54:713-5. 2001
    ..This paper describes the immunological consequences of human immunodeficiency virus (HIV) infection in a patient with familial CVID subsequently treated with highly active antiretroviral therapy (HAART)...
  77. ncbi Tuberculosis complicating treatment of hepatitis C in an HIV-infected haemophilia A patient
    B Killingley
    Royal Free Centre for HIV Medicine, Royal Free Hospital, London, UK
    Haemophilia 12:545-7. 2006
    ..The association of pegIFN and ribavirin therapy with tuberculosis (TB) has not been described previously...
  78. doi The prevalence of hepatitis C virus (HCV) infection in HIV-positive individuals in the UK - trends in HCV testing and the impact of HCV on HIV treatment outcomes
    J Turner
    Centre for Sexual Health and HIV Research, UCL Medical School and The Mortimer Market Centre, Camden Primary Care Trust, London, UK
    J Viral Hepat 17:569-77. 2010
    ..HCV infection had no impact on HIV virological outcomes or immunological response to HIV treatment. The long-term impact on morbidity and mortality remain to be determined...
  79. ncbi National review of first treatment change after starting highly active antiretroviral therapy in antiretroviral-naïve patients
    E Hart
    North Manchester General Hospital, Manchester, UK
    HIV Med 8:186-91. 2007
    ..Reference was made to the British HIV Association (BHIVA) guidelines on HIV management...
  80. doi Once-daily atazanavir/ritonavir versus twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 48 week efficacy and safety results of the CASTLE study
    Jean Michel Molina
    Department of Infectious Diseases, Saint Louis Hospital, AP HP, Paris University of Paris Diderot, Paris 7, France
    Lancet 372:646-55. 2008
    ..We compared these two combinations directly in treatment-naive patients...
  81. ncbi Multicenter study of human immunodeficiency virus-related germ cell tumors
    T Powles
    Chelsea and Westminster Hospital, London, United Kingdom
    J Clin Oncol 21:1922-7. 2003
    ..Testicular germ cell tumors (GCT) occur at increased frequency in men with human immunodeficiency virus (HIV). This multicenter study addresses the characteristics of these tumors...
  82. pmc Outcome of patients with HIV-related germ cell tumours: a case-control study
    T Powles
    Department of Oncology, Chelsea and Westminster Hospital, Fulham Road, London SW10 9NH, UK
    Br J Cancer 90:1526-30. 2004
    ..78). The overall survival has not improved since the introduction of highly active antiretroviral therapy (log rank P=0.4). Thus, HIV-related GCT is not more aggressive than GCT in the general population...
  83. ncbi Survey of HIV and hepatitis B or C co-infection management in the UK 2004
    S de Silva
    Mortimer Market Centre, Capper Street, London WC1E 5AU, UK
    Int J STD AIDS 17:799-801. 2006
    ..In conclusion, we identified several areas of concern in the diagnosis and management of HIV/hepatitis co-infection in several UK HIV treatment centres...
  84. ncbi Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia
    A Marutle
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research (NEUROTEC, Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, S-141 86, Stockholm, Sweden
    J Chem Neuroanat 22:115-26. 2001
    ....
  85. pmc Mechanisms involved in stimulation of human immunodeficiency virus type 1 replication by aminooxypentane RANTES
    A J Marozsan
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 75:8624-38. 2001
    ..MAPK/ERK1 and -2 appear to phosphorylate the HIV-1 preintegration complex, a step necessary for nuclear translocation and successful integration...
  86. ncbi Genotypic and epidemiologic characteristics of hepatitis C virus infections among recent injection drug user and nonuser populations
    L Krekulova
    Program in Infectious Diseases, School of Public Health, University of California, Berkeley 94720, USA
    Clin Infect Dis 33:1435-8. 2001
    ....
  87. pmc Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
    ....
  88. ncbi Effects of repeated anaesthesia on central cholinergic function in the rat cerebral cortex
    C D Hanning
    Leicester General Hospital, Department of Anaesthesia, Leicester, UK
    Eur J Anaesthesiol 20:93-7. 2003
    ..General anaesthesia may contribute to postoperative cognitive decline in the elderly. The aim was to determine the effects of repeated pentobarbital anaesthesia throughout life on central cholinergic function in the rat...
  89. ncbi Adenovirus viraemia and dissemination unresponsive to antiviral therapy in advanced HIV-1 infection
    G Nebbia
    AIDS 19:1339-40. 2005
  90. pmc Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke
    Ralph L Sacco
    Miller School of Medicine, University of Miami, Miami, USA
    N Engl J Med 359:1238-51. 2008
    ..Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel...