Cyril Fisher

Summary

Affiliation: Royal Brompton Hospital
Country: UK

Publications

  1. ncbi request reprint Myofibrosarcoma
    Cyril Fisher
    Royal Marsden Hospital, Fulham Road, SW3 6JJ London, UK
    Virchows Arch 445:215-23. 2004
  2. ncbi request reprint Expression profile and molecular genetic regulation of cyclin D1 expression in epithelioid sarcoma
    Lin Lin
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mod Pathol 18:705-9. 2005
  3. ncbi request reprint Myofibroblastic malignancies
    Cyril Fisher
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Adv Anat Pathol 11:190-201. 2004
  4. doi request reprint Role of palliative chemotherapy in advanced epithelioid sarcoma
    Robin L Jones
    Sarcoma Unit, Royal Marsden Hospital, London, UK
    Am J Clin Oncol 35:351-7. 2012
  5. doi request reprint Metastatic angiomatoid fibrous histiocytoma of the scalp, with EWSR1-CREB1 gene fusions in primary tumor and nodal metastasis
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, SW3 6JJ London, UK
    Hum Pathol 44:289-93. 2013
  6. doi request reprint Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors
    Khin Thway
    Sarcoma Unit, Department of Histopathology, Drug Development and Medical Oncology Units, The Royal Marsden NHS Foundation Trust, London, UK
    Am J Surg Pathol 36:462-9. 2012
  7. doi request reprint Oncocytic adrenal cortical carcinosarcoma with pleomorphic rhabdomyosarcomatous metastases
    Khin Thway
    Sarcoma Unit, Department of Histopathology, The Royal Marsden NHS Foundation Trust, London, UK
    Am J Surg Pathol 36:470-7. 2012
  8. doi request reprint Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion: a new tumor entity
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Am J Surg Pathol 35:1722-32. 2011
  9. doi request reprint Tumors with EWSR1-CREB1 and EWSR1-ATF1 fusions: the current status
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Am J Surg Pathol 36:e1-e11. 2012
  10. doi request reprint Endobronchial pulmonary angiomatoid fibrous histiocytoma: two cases with EWSR1-CREB1 and EWSR1-ATF1 fusions
    Khin Thway
    Department of Histopathology, Royal Marsden NHS Foundation Trust, 203 Fulham Road, London, UK
    Am J Surg Pathol 36:883-8. 2012

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Myofibrosarcoma
    Cyril Fisher
    Royal Marsden Hospital, Fulham Road, SW3 6JJ London, UK
    Virchows Arch 445:215-23. 2004
    ..This article describes the low- and high-grade variants of myofibrosarcoma and other malignant tumours with myofibroblastic differentiation...
  2. ncbi request reprint Expression profile and molecular genetic regulation of cyclin D1 expression in epithelioid sarcoma
    Lin Lin
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mod Pathol 18:705-9. 2005
    ..The high level of cyclin D1 protein expression in epithelioid sarcoma appears to be regulated by translational and/or post-translational mechanisms...
  3. ncbi request reprint Myofibroblastic malignancies
    Cyril Fisher
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Adv Anat Pathol 11:190-201. 2004
    ..This article reviews the concept of myofibrosarcoma and describes its variants...
  4. doi request reprint Role of palliative chemotherapy in advanced epithelioid sarcoma
    Robin L Jones
    Sarcoma Unit, Royal Marsden Hospital, London, UK
    Am J Clin Oncol 35:351-7. 2012
    ..The aim of this study was to investigate the response rate and progression-free survival in a series of epithelioid sarcoma patients treated with chemotherapy at a single referral center...
  5. doi request reprint Metastatic angiomatoid fibrous histiocytoma of the scalp, with EWSR1-CREB1 gene fusions in primary tumor and nodal metastasis
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, SW3 6JJ London, UK
    Hum Pathol 44:289-93. 2013
    ..Angiomatoid fibrous histiocytoma can mimic both benign and malignant lesions, and although most behave indolently, it is important to recognize their metastatic potential...
  6. doi request reprint Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors
    Khin Thway
    Sarcoma Unit, Department of Histopathology, Drug Development and Medical Oncology Units, The Royal Marsden NHS Foundation Trust, London, UK
    Am J Surg Pathol 36:462-9. 2012
    ..p16 was the most sensitive and specific marker for detecting WDL/DDL, and the combination of CDK4 and p16 is of more discriminatory value than the combination of either with MDM2, the least sensitive and specific of the 3 markers...
  7. doi request reprint Oncocytic adrenal cortical carcinosarcoma with pleomorphic rhabdomyosarcomatous metastases
    Khin Thway
    Sarcoma Unit, Department of Histopathology, The Royal Marsden NHS Foundation Trust, London, UK
    Am J Surg Pathol 36:470-7. 2012
    ..Here, we discuss the clinical, radiologic, and pathologic findings and review the literature on adrenal cortical carcinosarcomas...
  8. doi request reprint Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion: a new tumor entity
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Am J Surg Pathol 35:1722-32. 2011
    ....
  9. doi request reprint Tumors with EWSR1-CREB1 and EWSR1-ATF1 fusions: the current status
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Am J Surg Pathol 36:e1-e11. 2012
    ..We review the clinicopathologic and molecular features of this group of neoplasms unified by the presence of EWSR1-CREB1 and EWSR1-ATF1 genetic fusions...
  10. doi request reprint Endobronchial pulmonary angiomatoid fibrous histiocytoma: two cases with EWSR1-CREB1 and EWSR1-ATF1 fusions
    Khin Thway
    Department of Histopathology, Royal Marsden NHS Foundation Trust, 203 Fulham Road, London, UK
    Am J Surg Pathol 36:883-8. 2012
    ..It is likely that cases of AFH in the lung may have been previously missed because of their morphologic and genetic overlap with other pulmonary lesions...
  11. doi request reprint Unusual myoid, perivascular, and postradiation lesions, with emphasis on atypical vascular lesion, postradiation cutaneous angiosarcoma, myoepithelial tumors, myopericytoma, and perivascular epithelioid cell tumor
    Cyril Fisher
    Department of Histopathology, Royal Marsden Hospital, London, UK Electronic address
    Semin Diagn Pathol 30:73-84. 2013
    ..This article reviews the clinical and pathologic features and differential diagnoses of atypical vascular lesion, postradiation cutaneous angiosarcoma, myoepithelioma, myopericytoma, and perivascular epithelioid cell tumor...
  12. doi request reprint Malignancies confined to disused arteriovenous fistulae in renal transplant patients: an important differential diagnosis
    Philip Webster
    Imperial College Healthcare NHS Trust, London, UK
    Am J Nephrol 34:42-8. 2011
    ..Swelling in an arteriovenous fistula (AVF) is commonly caused by thrombosis, aneurysm and infection. However, due to the increased risk of malignancy after transplantation, this should also be considered...
  13. doi request reprint Primary cardiac sarcomas may develop from resident or bone marrow-derived mesenchymal stem cells: use of immunohistochemistry including CD44 and octamer binding protein 3/4
    Laszlo Hegyi
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Histopathology 61:966-73. 2012
    ..To provide evidence that cardiac sarcomas 'not otherwise specified' express markers that might indicate their cellular origin or identify any lines of differentiation...
  14. doi request reprint Metastatic renal mucinous tubular and spindle cell carcinoma. Atypical behavior of a rare, morphologically bland tumor
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Ann Diagn Pathol 16:407-10. 2012
    ....
  15. doi request reprint Pediatric fibroblastic and myofibroblastic lesions
    Khin Thway
    Department of Histopathology, The Royal Marsden NHS Foundation Trust, London, UK
    Adv Anat Pathol 19:54-65. 2012
    ..In this review, we discuss the clinicopathologic spectrum of fibroblastic and myofibroblastic lesions of childhood and adolescence...
  16. doi request reprint Anatomic distribution of cervical lymph node spread in parotid carcinoma
    Edward J Chisholm
    Head and Neck Unit, Royal Marsden Hospital, London, UK
    Head Neck 33:513-5. 2011
    ..The pattern of distribution of cervical nodal involvement from primary parotid carcinomas has not been extensively described...
  17. doi request reprint Primary cutaneous epithelioid angiosarcoma: a clinicopathologic study of 13 cases of a rare neoplasm occurring outside the setting of conventional angiosarcomas and with predilection for the limbs
    Ravi Suchak
    Department of Dermatopathology, St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Am J Surg Pathol 35:60-9. 2011
    ..These findings suggest that primary cutaneous epithelioid angiosarcoma occurring outside the conventional settings of angiosarcoma is a highly aggressive malignant tumor with mortality rates in excess of 55% after 3 years...
  18. doi request reprint Chemotherapy in clear cell sarcoma
    Robin L Jones
    Royal Marsden Hospital, London, UK
    Med Oncol 28:859-63. 2011
    ..These data provide a reference for response and outcome in the assessment of novel agents in this histological subtype...
  19. doi request reprint Carcinoma arising from pharyngeal diverticula
    Afroze Shah Khan
    Head and Neck Unit, Royal Marsden Hospital, London, SW3 6JJ, United Kingdom
    Head Neck 33:135-7. 2011
    ..We report 2 patients with pharyngeal diverticulum carcinoma exhibiting an unusual presentation and good long-term, disease-free survival with normal speech and swallowing...
  20. doi request reprint Clinical benefit of early phase clinical trial participation for advanced sarcoma patients
    Robin L Jones
    Royal Marsden Hospital, London, SW3 6JJ, UK
    Cancer Chemother Pharmacol 68:423-9. 2011
    ..The aim of this study was to evaluate the clinical benefit for sarcoma patients treated within the Phase I Unit of a single referral centre...
  21. doi request reprint Chondroid lipoma: an update and review
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Ann Diagn Pathol 16:230-4. 2012
    ..We review the literature on chondroid lipoma, discussing tumor histology, immunohistochemistry, ultrastructure, and differential diagnosis, and summarize the molecular genetic features so far known...
  22. doi request reprint Utility of sarcoma-specific fusion gene analysis in paraffin-embedded material for routine diagnosis at a specialist centre
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London, UK
    J Clin Pathol 63:508-12. 2010
    ..It can be aided by detection of specific genetic aberrations in many cases. This study assessed the utility of a molecular genetics/cytogenetics service as part of the routine diagnostic service at the Royal Marsden Hospital...
  23. doi request reprint Dedifferentiated liposarcoma with meningothelial-like whorls, metaplastic bone formation, and CDK4, MDM2, and p16 expression: a morphologic and immunohistochemical study
    Khin Thway
    Department of Histopathology, Royal Marsden NHS Foundation Trust, Institute of Cancer Research, London, UK
    Am J Surg Pathol 35:356-63. 2011
    ..The CDK4, MDM2, and p16 expression in the whorls suggests that they share a similar genetic background to well-differentiated and dedifferentiated liposarcoma, and that additional genetic events are causal to their distinct morphology...
  24. doi request reprint Claudin-1 is expressed in perineurioma-like low-grade fibromyxoid sarcoma
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London SW3 6JJ, UK
    Hum Pathol 40:1586-90. 2009
    ..Although positivity for claudin-1 remains useful as an adjunct marker for perineurioma, it should be taken in context with clinical findings, morphology, and the additional immunoprofile...
  25. doi request reprint Immunohistochemistry in diagnosis of soft tissue tumours
    Cyril Fisher
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Histopathology 58:1001-12. 2011
    ..This article reviews selected applications of immunohistochemistry in the diagnosis of each of the principal morphological groups, concentrating on areas of most use in daily practice...
  26. doi request reprint Angiosarcoma developing in a non-functioning arteriovenous fistula post-renal transplant
    Yassar A Qureshi
    The Royal Marsden Hospital, Soft Tissue Sarcoma Unit, London, UK
    J Surg Oncol 101:520-3. 2010
    ..We describe a further case and review the relevant literature with specific emphasis on a possible mechanism for the development of angiosarcoma in the post-transplant patient...
  27. doi request reprint Endobronchial fibrosarcoma presenting as recurrent left-sided pneumonia
    Atul Gupta
    Department of Paediatric Respiratory Medicine, Royal Brompton and Harefield NHS Foundation Trust, London, UK
    Pediatr Pulmonol 46:610-3. 2011
    ....
  28. doi request reprint Epithelial-stromal tumor of seminal vesicle in a patient with chromophobe renal cell carcinoma and small lymphocytic lymphoma
    Khin Thway
    Royal Marsden Hospital, London SW36JJ, UK
    Ann Diagn Pathol 12:433-9. 2008
    ....
  29. doi request reprint Significant clinical benefit of first-line palliative chemotherapy in advanced soft-tissue sarcoma: retrospective analysis and identification of prognostic factors in 488 patients
    Vasilios Karavasilis
    Royal Marsden Hospital, London, England, United Kingdom
    Cancer 112:1585-91. 2008
    ..The efficacy of palliative chemotherapy was investigated in a large group of patients with advanced soft-tissue sarcomas (STS) treated on routine palliative protocols...
  30. ncbi request reprint Anaplastic lymphoma kinase (ALK 1) staining and molecular analysis in inflammatory myofibroblastic tumours of the bladder: a preliminary clinicopathological study of nine cases and review of the literature
    Alex Freeman
    Department of Histopathology, University College Hospital, London
    Mod Pathol 17:765-71. 2004
    ..In conclusion, ALK 1 staining may be of value in the distinction of vesical IMFT from morphologically similar entities, and often reflects ALK gene translocations in these lesions...
  31. ncbi request reprint Low-grade sarcomas with CD34-positive fibroblasts and low-grade myofibroblastic sarcomas
    Cyril Fisher
    Royal Marsden Hospital, London, UK
    Ultrastruct Pathol 28:291-305. 2004
    ..Many IMT have clonal chromosomal abnormalities involving 2p22-24, and fusion of the ALK gene with tropomyosin 3 (TPM3-ALK) or tropomyosin 4 (TPM4-ALK) is found in a subset...
  32. ncbi request reprint Epithelioid sarcoma of Enzinger
    Cyril Fisher
    Royal Marsden Hospital, London SW3 6JJ, UK
    Adv Anat Pathol 13:114-21. 2006
    ..Thirty-six years after Enzinger's original account, epithelioid sarcoma remains a clinically and pathologically distinct, indolent but aggressive sarcoma of indeterminate lineage...
  33. ncbi request reprint Low-grade fibromyxoid sarcoma and hyalinizing spindle cell tumor with giant rosettes share a common t(7;16)(q34;p11) translocation
    Robin Reid
    University Department of Pathology Scottish Bone Tumour Registry Western Infirmary, Glasgow, United Kingdom
    Am J Surg Pathol 27:1229-36. 2003
    ..Demonstration of the t(7;16)(q34;p11) translocation will help to diagnose difficult cases with unusual histologic features...
  34. ncbi request reprint Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene
    Fredrik Mertens
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Lab Invest 85:408-15. 2005
    ..Taken together, the results indicate that virtually all LGFMS are characterized by a chimeric FUS/CREB3L2 gene, and that rare cases may display a variant FUS/CREB3L1 fusion...
  35. ncbi request reprint Detection of SS18-SSX fusion transcripts in formalin-fixed paraffin-embedded neoplasms: analysis of conventional RT-PCR, qRT-PCR and dual color FISH as diagnostic tools for synovial sarcoma
    Maria Fernanda C Amary
    Santa Casa School of Medical Sciences and University of Sao Paulo, Sao Paulo, Brazil
    Mod Pathol 20:482-96. 2007
    ....
  36. ncbi request reprint Chromosomal imbalances in pleomorphic rhabdomyosarcomas and identification of the alveolar rhabdomyosarcoma-associated PAX3-FOXO1A fusion gene in one case
    Anthony Gordon
    Section of Molecular Carcinogenesis, Molecular Cytogenetics Laboratory, Institute of Cancer Research, Sutton, UK SM2 5NG, Surrey, UK
    Cancer Genet Cytogenet 140:73-7. 2003
    ..In addition, one of the cases classified as PRMS showed evidence for the presence of a PAX3-FOXO1A fusion gene, which is characteristic of the alveolar subtype of RMS...
  37. ncbi request reprint Immunophenotype of desmoplastic small round cell tumors as detected in cases with EWS-WT1 gene fusion product
    Paul J Zhang
    Anatomic Pathology, 6 Founders Pavilion, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19147, USA
    Mod Pathol 16:229-35. 2003
    ..Detection of EWS-WT1 fusion becomes critical for the diagnosis when the characteristic divergent phenotype cannot be detected immunohistochemically...
  38. ncbi request reprint Epithelioid sarcoma: an immunohistochemical analysis evaluating the utility of cytokeratin 5/6 in distinguishing superficial epithelioid sarcoma from spindled squamous cell carcinoma
    Lin Lin
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Cutan Pathol 30:114-7. 2003
    ....
  39. ncbi request reprint Myxofibrosarcomas contain large numbers of infiltrating immature dendritic cells
    Elizabeth J Soilleux
    Medical Research Council Cancer Cell Unit, Hutchison Medical Research Council Research Centre, Department of Histopathology, Addenbrooke s Hospital, Cambridge, England
    Am J Clin Pathol 119:540-5. 2003
    ..The DC-SIGN--positive DCs that we have identified in myxofibrosarcoma may, therefore, be involved in the induction of ineffective immune responses or even tolerance to tumor antigens...
  40. ncbi request reprint Loss of 13q14-q21 and gain of 5p14-pter in the progression of leiomyosarcoma
    Rubin Wang
    Molecular Cytogenetics, Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Mod Pathol 16:778-85. 2003
    ..These results suggest that 13q14-q21 loss and 5p14-pter gain at diagnosis could be used to identify patients with leiomyosarcoma who are likely to have a shorter survival time and who might benefit from early treatment intensification...
  41. ncbi request reprint Mediastinal synovial sarcoma: report of two cases with molecular genetic analysis
    Jacqueline K Trupiano
    Department of Anatomic Pathology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 73:628-30. 2002
    ..Detection of this translocation is of paramount importance to confirm this diagnosis, particularly when this neoplasm arises in atypical locations outside the extremities...
  42. ncbi request reprint Minichromosome maintenance protein in myxofibrosarcoma
    James D Sington
    Department of Molecular Histopathology, University of Cambridge, Cambridge, UK
    Mod Pathol 17:235-40. 2004
    ..We therefore suggest that assessment of cell cycle state may be a useful diagnostic adjunct in the histopathological assessment of myxofibrosarcoma, by enabling more accurate determination of grade and prediction of outcome...
  43. pmc Detection of TMPRSS2-ERG translocations in human prostate cancer by expression profiling using GeneChip Human Exon 1.0 ST arrays
    Sameer Jhavar
    Institute of Cancer Research, Male Urological Cancer Research Centre, Sutton, Surrey SM2 5NG, UK
    J Mol Diagn 10:50-7. 2008
    ..These studies demonstrate that expression analyses using exon arrays represent a valuable approach for detecting ETS gene translocation in prostate cancer, in parallel with analyses of gene expression profiles...
  44. ncbi request reprint Changing concepts in the pathological basis of soft tissue and bone sarcoma treatment
    Pancras C W Hogendoorn
    Departments of Pathology, Leiden University Medical Centre, Building 1, L1 Q, P O Box 9600, Leiden, The Netherlands
    Eur J Cancer 40:1644-54. 2004
    ..These changes in concepts, classification, and processing of soft tissue sarcomas have had impact on patient selection and treatment and formats of multi-institute trials...
  45. ncbi request reprint Intra-abdominal metastases from soft tissue sarcoma
    Kasim A Behranwala
    Sarcoma and Melanoma Unit, Royal Marsden NHS Trust, United Kingdom
    J Surg Oncol 87:116-20. 2004
    ..To define the clinical features and prognosis of patients with abdominal metastasis from primary soft tissue sarcoma (STS) at other sites...
  46. ncbi request reprint Adult rhabdomyosarcoma: cross-sectional imaging findings including histopathologic correlation
    Steven D Allen
    Department of Imaging, Royal Marsden Hospital, Downs Rd, Sutton, Surrey, SM2 5PT, United Kingdom
    AJR Am J Roentgenol 189:371-7. 2007
    ....
  47. ncbi request reprint Malignant perivascular epithelioid cell tumour ("PEComa") of soft tissue: a unique case
    Gavin C Harris
    Canterbury Health Laboratories, Christchurch, New Zealand
    Am J Surg Pathol 28:1655-8. 2004
    ..The light microscopic appearance and immunohistochemical profile (HMB-45, smooth muscle actin positive) and electron microscopic appearance support perivascular epithelioid cell differentiation...
  48. ncbi request reprint Nuclear beta-catenin expression distinguishes deep fibromatosis from other benign and malignant fibroblastic and myofibroblastic lesions
    Baishali Bhattacharya
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 29:653-9. 2005
    ..Most fibromatoses have diffuse nuclear staining although occasional examples only focally label...
  49. ncbi request reprint A gene expression signature associated with metastatic outcome in human leiomyosarcomas
    Yin Fai Lee
    The Male Urological Cancer Research Centre, Institute of Cancer Research, Surrey, United Kingdom
    Cancer Res 64:7201-4. 2004
    ..001). Our finding may aid the tailoring of therapy for individual sarcoma patients, where the aggressiveness of treatment is affected by the predicted outcome of disease...