B Damato

Summary

Affiliation: Royal Liverpool University Hospital
Country: UK

Publications

  1. ncbi request reprint Proton beam radiotherapy of choroidal melanoma: the Liverpool-Clatterbridge experience
    Bertil Damato
    Ocular Oncology Service, St Paul s Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Int J Radiat Oncol Biol Phys 62:1405-11. 2005
  2. doi request reprint Choroidal melanoma endoresection, dandelions and allegory-based medicine
    Bertil Damato
    Br J Ophthalmol 92:1013-4. 2008
  3. pmc Personalized treatment of uveal melanoma
    B Damato
    Department of Molecular and Clinical Cancer Medicine, Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, UK
    Eye (Lond) 27:172-9. 2013
  4. doi request reprint Whole anterior segment proton beam radiotherapy for diffuse iris melanoma
    Lazaros Konstantinidis
    Ocular Oncology Service, Liverpool Ocular Oncology Centre, Royal Liverpool University Hospital, Liverpool, UK
    Br J Ophthalmol 97:471-4. 2013
  5. pmc Progress in the management of patients with uveal melanoma. The 2012 Ashton Lecture
    B Damato
    Department of Molecular and Clinical Cancer Medicine, Ocular Oncology Service, Royal Liverpool University Hospital, Prescot St, Liverpool, UK
    Eye (Lond) 26:1157-72. 2012
  6. pmc Differences in uveal melanomas between men and women from the British Isles
    B E Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, UK
    Eye (Lond) 26:292-9. 2012
  7. ncbi request reprint Developments in the management of uveal melanoma
    Bertil Damato
    Liverpool Ocular Oncology Centre, Royal Liverpool University Hospital, Liverpool, UK
    Clin Experiment Ophthalmol 32:639-47. 2004
  8. doi request reprint Genotypic profiling of 452 choroidal melanomas with multiplex ligation-dependent probe amplification
    Bertil Damato
    Liverpool Ocular Oncology Centre, St Paul s Eye Clinic, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Clin Cancer Res 16:6083-92. 2010
  9. pmc Does ocular treatment of uveal melanoma influence survival?
    B Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Prescot St, Liverpool L7 8XP, UK
    Br J Cancer 103:285-90. 2010
  10. doi request reprint Management of conjunctival melanoma
    Bertil Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
    Expert Rev Anticancer Ther 9:1227-39. 2009

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Proton beam radiotherapy of choroidal melanoma: the Liverpool-Clatterbridge experience
    Bertil Damato
    Ocular Oncology Service, St Paul s Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Int J Radiat Oncol Biol Phys 62:1405-11. 2005
    ..To report on outcomes after proton beam radiotherapy of choroidal melanoma using a 62-MeV cyclotron in patients considered unsuitable for other forms of conservative therapy...
  2. doi request reprint Choroidal melanoma endoresection, dandelions and allegory-based medicine
    Bertil Damato
    Br J Ophthalmol 92:1013-4. 2008
  3. pmc Personalized treatment of uveal melanoma
    B Damato
    Department of Molecular and Clinical Cancer Medicine, Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, UK
    Eye (Lond) 27:172-9. 2013
    ..Personalized treatment enhances not only the patient's satisfaction but also the 'job satisfaction' of all members of the multidisciplinary team, improving quality of care...
  4. doi request reprint Whole anterior segment proton beam radiotherapy for diffuse iris melanoma
    Lazaros Konstantinidis
    Ocular Oncology Service, Liverpool Ocular Oncology Centre, Royal Liverpool University Hospital, Liverpool, UK
    Br J Ophthalmol 97:471-4. 2013
    ..To report the results of whole anterior segment proton beam radiotherapy (PBR) for diffuse iris melanoma...
  5. pmc Progress in the management of patients with uveal melanoma. The 2012 Ashton Lecture
    B Damato
    Department of Molecular and Clinical Cancer Medicine, Ocular Oncology Service, Royal Liverpool University Hospital, Prescot St, Liverpool, UK
    Eye (Lond) 26:1157-72. 2012
    ..Patient management has been enhanced by the formation of multidisciplinary teams in specialised ocular oncology centres...
  6. pmc Differences in uveal melanomas between men and women from the British Isles
    B E Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, UK
    Eye (Lond) 26:292-9. 2012
    ..The purpose of this study is to compare uveal melanomas (UMs) in men and women...
  7. ncbi request reprint Developments in the management of uveal melanoma
    Bertil Damato
    Liverpool Ocular Oncology Centre, Royal Liverpool University Hospital, Liverpool, UK
    Clin Experiment Ophthalmol 32:639-47. 2004
    ..Cytogenetic studies suggest that some melanomas may never develop any metastatic potential and if these impressions are confirmed by further studies, then in these patients the main priority of treatment would be to conserve vision...
  8. doi request reprint Genotypic profiling of 452 choroidal melanomas with multiplex ligation-dependent probe amplification
    Bertil Damato
    Liverpool Ocular Oncology Centre, St Paul s Eye Clinic, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Clin Cancer Res 16:6083-92. 2010
    ..The purpose of this study was to correlate our MLPA results with other risk factors and metastatic death...
  9. pmc Does ocular treatment of uveal melanoma influence survival?
    B Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Prescot St, Liverpool L7 8XP, UK
    Br J Cancer 103:285-90. 2010
    ..Randomised trials of treatment vs non-treatment of asymptomatic tumours are desirable but would be controversial, difficult, expensive and possibly inconclusive. Strategies for coping with uncertainty are needed to avoid unethical care...
  10. doi request reprint Management of conjunctival melanoma
    Bertil Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
    Expert Rev Anticancer Ther 9:1227-39. 2009
    ..We anticipate that these measures will improve outcomes after treatment of conjunctival melanoma in situ and invasive melanoma...
  11. doi request reprint An audit of conjunctival melanoma treatment in Liverpool
    B Damato
    St Paul s Eye Unit, Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, UK
    Eye (Lond) 23:801-9. 2009
    ..To evaluate treatment of conjunctival melanomas at the Ocular Oncology Service in Liverpool...
  12. doi request reprint Translating uveal melanoma cytogenetics into clinical care
    Bertil Damato
    Liverpool Ocular Oncology Centre, St Paul s Eye Clinic, Royal Liverpool University Hospital, Liverpool, England
    Arch Ophthalmol 127:423-9. 2009
    ..To report our experience in translating uveal melanoma cytogenetics to routine clinical practice...
  13. ncbi request reprint Legacy of the collaborative ocular melanoma study
    Bertil Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, England
    Arch Ophthalmol 125:966-8. 2007
  14. ncbi request reprint Cytogenetics of uveal melanoma: a 7-year clinical experience
    Bertil Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Ophthalmology 114:1925-31. 2007
    ..Since 1999, we have offered cytogenetic analysis to patients treated by local resection or enucleation. This study correlated our cytogenetic results with clinical and histologic predictors and disease-specific mortality...
  15. doi request reprint Artificial neural networks estimating survival probability after treatment of choroidal melanoma
    Bertil Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Ophthalmology 115:1598-607. 2008
    ..e., any uveal melanoma involving choroid) and to demonstrate the value of entering age, sex, clinical stage, cytogenetic type, and histologic grade into the predictive model...
  16. doi request reprint Multiplex ligation-dependent probe amplification of uveal melanoma: correlation with metastatic death
    Bertil Damato
    Liverpool Ocular Oncology Centre, St Paul s Eye Clinic, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Invest Ophthalmol Vis Sci 50:3048-55. 2009
    ..To evaluate multiplex ligation-dependent probe amplification (MLPA) of uveal melanoma as a predictive tool for metastatic death...
  17. doi request reprint Conjunctival melanoma and melanosis: a reappraisal of terminology, classification and staging
    Bertil Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, UK
    Clin Experiment Ophthalmol 36:786-95. 2008
    ....
  18. ncbi request reprint Treatment of primary intraocular melanoma
    Bertil Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Prescot St, Liverpool, L7 8XP, UK
    Expert Rev Anticancer Ther 6:493-506. 2006
    ..Uveal melanomas develop characteristic chromosomal abnormalities, such as loss of chromosome 3. This is associated with a reduction in the 5-year survival from approximately 95% to less than 50%...
  19. doi request reprint Estimating prognosis for survival after treatment of choroidal melanoma
    Bertil Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Prescot St, Liverpool L7 8XP, UK
    Prog Retin Eye Res 30:285-95. 2011
    ....
  20. ncbi request reprint Conservation of eyes with choroidal melanoma by a multimodality approach to treatment: an audit of 1632 patients
    Bertil Damato
    St Paul s Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Ophthalmology 111:977-83. 2004
    ..To report on conservation of eyes with choroidal melanoma with a multimodality approach to treatment...
  21. doi request reprint A reappraisal of the significance of largest basal diameter of posterior uveal melanoma
    B Damato
    Liverpool Ocular Oncology Centre, St Paul s Eye Clinic, Royal Liverpool University Hospital, Liverpool, UK
    Eye (Lond) 23:2152-60; quiz 2161-2. 2009
    ..To evaluate the significance of the largest tumour diameter (LTD) of posterior uveal melanomas (ie, involving choroid), correlating this feature with histological and cytogenetic predictors and mortality...
  22. doi request reprint Local resection of uveal melanoma
    Bertil E Damato
    Royal Liverpool University Hospital, Liverpool, UK
    Dev Ophthalmol 49:66-80. 2012
    ....
  23. ncbi request reprint Uveal melanoma: resection techniques
    Bertil Damato
    Ocular Oncology Service and Department of Anaesthesia, St Paul s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
    Ophthalmol Clin North Am 18:119-28, ix. 2005
    ..Outcomes of surgery and the indications, contraindications, and controversies of resecting uveal melanoma are discussed...
  24. ncbi request reprint Local tumor control after 106Ru brachytherapy of choroidal melanoma
    Bertil Damato
    Ocular Oncology Service, St Paul s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool, United Kingdom
    Int J Radiat Oncol Biol Phys 63:385-91. 2005
    ..To report on local tumor control after (106)Ru brachytherapy for choroidal melanoma...
  25. ncbi request reprint Visual acuity after Ruthenium(106) brachytherapy of choroidal melanomas
    Bertil Damato
    Ocular Oncology Service, St Paul s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool, United Kingdom
    Int J Radiat Oncol Biol Phys 63:392-400. 2005
    ..To report on conservation of visual acuity after Ruthenium(106) (Ru-106) brachytherapy of choroidal melanoma...
  26. doi request reprint Clinical mapping of conjunctival melanomas
    B Damato
    Liverpool Ocular Oncology Centre, St Paul s Eye Clinic, Royal Liverpool University Hospital, Liverpool, UK
    Br J Ophthalmol 92:1545-9. 2008
    ..To develop a system for clinically mapping conjunctival melanomas, taking into account the tumour's stage of development, location and extent...
  27. doi request reprint Treatment selection for uveal melanoma
    Bertil E Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, UK
    Dev Ophthalmol 49:16-26. 2012
    ..Finally, I discuss challenges and shortcomings in this aspect of patient care, also providing suggestions for further research in this field...
  28. ncbi request reprint Proton beam radiotherapy of iris melanoma
    Bertil Damato
    St Paul s Eye Unit, Royal Liverpool University Hospital, Liverpool, UK
    Int J Radiat Oncol Biol Phys 63:109-15. 2005
    ..To report on outcomes after proton beam radiotherapy of iris melanoma...
  29. doi request reprint Psychological aspects of cytogenetic testing of uveal melanoma: preliminary findings and directions for future research
    S A Cook
    St Paul s Eye Unit, The Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK
    Eye (Lond) 23:581-5. 2009
    ..To determine the proportion of uveal melanoma patients who accept cytogenetic prognostication and to understand the reasons for their decision and the psychological impact of an adverse prognosis...
  30. ncbi request reprint The Liverpool uveal melanoma liver metastases pathway: Outcome following liver resection
    D Gomez
    North Western Hepatobiliary Unit, Aintree University Hospital NHS Foundation Trust, Liverpool, UK
    J Surg Oncol 109:542-7. 2014
    ..To determine the outcome of patients that underwent liver resection for metastases from uveal melanoma...
  31. ncbi request reprint Continuous and discrete time survival analysis: neural network approaches
    A Eleuteri
    Department of Clinical Engineering, Royal Liverpool University Hospital, Liverpool, UK
    Conf Proc IEEE Eng Med Biol Soc 2007:5420-3. 2007
    ..093) at year 1, to 0.75 (SE=0.034) at year 7 for the continuous time model; from 0.81 (SE=0.07) at year 1, to 0.75 (SE=0.033) at year 7 for the discrete time model. For both models the calibration was good (p<0.05) up to 7 years...
  32. doi request reprint Routes of extraocular extension of uveal melanoma: risk factors and influence on survival probability
    Sarah E Coupland
    Department of Pathology, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
    Ophthalmology 115:1778-85. 2008
    ..To correlate extraocular spread with other survival predictors and with metastatic death and determine whether there was any relationship between the size of the extraocular tumor and survival...
  33. pmc Imaging of retinal and choroidal vascular tumours
    H Heimann
    Ocular Oncology Unit, Royal Liverpool University Hospital, Liverpool, UK
    Eye (Lond) 27:208-16. 2013
    ....
  34. ncbi request reprint Detection of uveal melanoma by optometrists in the United Kingdom
    B Damato
    Liverpool Ocular Oncology Centre, Royal Liverpool University Hospital, UK
    Ophthalmic Physiol Opt 21:268-71. 2001
    ..Failure of tumour detection in symptomatic patients was associated with absence of tumour extension posterior to equator (p < 0.0001)...
  35. ncbi request reprint Double-blind evaluation and benchmarking of survival models in a multi-centre study
    A Taktak
    Department of Clinical Engineering, Royal Liverpool University Hospital, Liverpool, UK
    Comput Biol Med 37:1108-20. 2007
    ..It was concluded that powerful, recent flexible modelling algorithms show a comparative predictive performance to that of more established methods from the medical and biological literature, for the reference data set...
  36. doi request reprint Ciliary body melanoma with partial deletion of chromosome 3 detected with multiplex ligation-dependent probe amplification
    E M Damato
    Department of Ophthalmology, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, Wales, UK
    Graefes Arch Clin Exp Ophthalmol 246:1637-40. 2008
    ..We report a case of ciliary body melanoma with partial deletion of chromosome 3, which was missed with fluorescence in situ hybridization (FISH) but detected with multiplex ligation-dependent probe amplification (MLPA)...
  37. doi request reprint Congenital vascular malformations of the retina and choroid
    H Heimann
    Ocular Oncology Unit, Royal Liverpool University Hospital, Liverpool, UK
    Eye (Lond) 24:459-67. 2010
    ..To review recent advances in the diagnosis and treatment of congenital vascular malformations of the retina and choroid...
  38. ncbi request reprint Time to treatment of uveal melanoma in the United Kingdom
    B Damato
    Liverpool Ocular Oncology Centre, Royal Liverpool University Hospital, UK
    Eye (Lond) 15:155-8. 2001
    ..To measure delay before treatment of uveal melanoma...
  39. ncbi request reprint The role of eyewall resection in uveal melanoma management
    Bertil Damato
    FRCOphth, St Paul s Eye Unit, Royal Liverpool University Hospital, UK
    Int Ophthalmol Clin 46:81-93. 2006
  40. ncbi request reprint Rhegmatogenous retinal detachment after transscleral local resection of choroidal melanoma
    Bertil Damato
    St Paul s Eye Unit, Royal Liverpool University Hospital, Liverpool, England, United Kingdom
    Ophthalmology 109:2137-43. 2002
    ..To report on the incidence and outcome of rhegmatogenous retinal detachment after transscleral local resection of choroidal melanoma...
  41. doi request reprint Proteomics of uveal melanomas suggests HSP-27 as a possible surrogate marker of chromosome 3 loss
    Sarah E Coupland
    Department of Pathology, School of Cancer Studies, University of Liverpool, Liverpool, United Kingdom
    Invest Ophthalmol Vis Sci 51:12-20. 2010
    ..To compare the proteomic profiles of primary uveal melanomas, with and without loss of chromosome 3...
  42. ncbi request reprint Photodynamic therapy for recurrent hyphema after proton beam radiotherapy of iris melanoma
    Nikolaos Trichopoulos
    St Paul s Eye Unit, Oncology Service, Royal Liverpool University Hospital, Liverpool, UK
    Graefes Arch Clin Exp Ophthalmol 245:1573-5. 2007
    ..Recurrent hemorrhage with secondary glaucoma is a rare but serious complication following proton beam irradiation (PBI) of iris melanoma. We report a case in which photodynamic therapy (PDT) was successfully used to treat this complication...
  43. doi request reprint Understanding intraocular lymphomas
    Sarah E Coupland
    Department of Cellular and Molecular Pathology, University of Liverpool, Liverpool, UK
    Clin Experiment Ophthalmol 36:564-78. 2008
    ..It would be preferable to refer to the various forms of intraocular lymphoma according to whether they are retinal, choroidal, ciliary or iridal and whether they are primary or secondary in these locations...
  44. pmc Effects of radiotherapy on uveal melanomas and adjacent tissues
    C Groenewald
    Ocular Oncology Service, St Paul s Eye Unit, Royal Liverpool University Hospital, Liverpool, UK
    Eye (Lond) 27:163-71. 2013
    ..The decision to treat a uveal melanoma with radiotherapy requires the ability to manage iatrogenic side effects and complications...
  45. pmc A nurse-led ocular oncology clinic in Liverpool: results of a 6-month trial
    T Sandinha
    Liverpool Ocular Oncology Centre, St Paul s Eye Unit, Liverpool, UK
    Eye (Lond) 26:937-43. 2012
    ..To describe the design and implementation of a nurse-led clinic in a tertiary adult ocular oncology service and to assess its feasibility and patient satisfaction...
  46. doi request reprint P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma
    Lyndsay Davies
    Unit of Ophthalmology, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
    J Cell Mol Med 13:1995-2007. 2009
    ..The findings underline the apoptotic pathway mediated by PERP as a critical mechanism employed by UM tumours to modulate susceptibility to apoptosis...
  47. ncbi request reprint Choroidal neovascular membrane in a series of cases of malignant melanoma of the choroid
    Eoin Guerin
    Department of Clinical Sciences, Unit of Ophthalmology, University of Liverpool, Liverpool, UK
    Acta Ophthalmol Scand 84:323-7. 2006
    ....
  48. ncbi request reprint The subjective experience of early postoperative pain following retrobulbar anaesthesia for enucleation and primary orbital implant
    J Bowyer
    St Paul s Eye Unit, Royal Liverpool University Hospital, Liverpool, U K
    Orbit 22:271-7. 2003
    ..75% with 1:100,000 adrenaline...
  49. ncbi request reprint Lymphomas involving the eye and the ocular adnexa
    Sarah E Coupland
    Department of Pathology, Royal Liverpool Hospital, Liverpool, England, UK
    Curr Opin Ophthalmol 17:523-31. 2006
    ..To describe recent advances in the understanding of the pathogenesis of the most common malignant lymphomas that occur as primary and secondary tumors in ocular tissues...
  50. ncbi request reprint Cathepsin S and its inhibitor cystatin C: imbalance in uveal melanoma
    Luminita Paraoan
    Unit of Ophthalmology, School of Clinical Science, University of Liverpool, Liverpool, UK
    Front Biosci (Landmark Ed) 14:2504-13. 2009
    ..The results indicate that the shift in the balance between cathepsin S and cystatin C may be part of deregulated proteolytic pathways contributing to the invasive phenotype of uveal melanoma...
  51. doi request reprint Iridocyclectomy for neovascular glaucoma caused by proton-beam radiotherapy of pigmented ciliary adenocarcinoma
    Ann Schalenbourg
    St Paul s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, UK
    Graefes Arch Clin Exp Ophthalmol 246:1499-501. 2008
    ..To report neovascular glaucoma after proton-beam radiotherapy of an adenocarcinoma of the pigmented ciliary epithelium and its successful treatment by iridocyclectomy...
  52. ncbi request reprint Transscleral resection versus iodine brachytherapy for choroidal malignant melanomas 6 millimeters or more in thickness: a matched case-control study
    Tero Kivela
    Oncology and Vitreoretinal Service, Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland
    Ophthalmology 110:2235-44. 2003
    ..To assess differences in treatment outcome after transscleral resection (TSR) and iodine brachytherapy (IBT) of choroidal melanomas too thick for ruthenium brachytherapy...
  53. ncbi request reprint Uveal melanoma: genetic aspects
    Arun D Singh
    Department of Ophthalmic Oncology, Cole Eye Institute i3 129, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Ophthalmol Clin North Am 18:85-97, viii. 2005
    ..This article reviews the clinical genetics, cytogenetics, and molecular genetic aspects of uveal melanoma...
  54. ncbi request reprint Transscleral local resection versus iodine brachytherapy for uveal melanomas that are large because of tumour height
    Ilkka Puusaari
    Department of Ophthalmology, Helsinki University Central Hospital, PL 220, Haartmaninkatu 4 C, FI 00029 HUS, Helsinki, Finland
    Graefes Arch Clin Exp Ophthalmol 245:522-33. 2007
    ..To compare visual outcome and ocular complications of transscleral local resection (TSR) with those of iodine-125 plaque brachytherapy (IBT) for uveal melanomas categorised as large because of tumour height...
  55. ncbi request reprint Intraocular melanocytoma in association with bone formation
    Paul Hiscott
    Arch Ophthalmol 121:1791-4. 2003
  56. ncbi request reprint Differential expression of angioregulatory matricellular proteins in posterior uveal melanoma
    Jose L Ordonez
    Unit of Ophthalmology, School of Clinical Sciences, University of Liverpool, UK
    Melanoma Res 15:495-502. 2005
    ..Interventions inducing TSP1 expression and/or inhibiting SPARC expression may be candidates for therapies directed towards the inhibition of angiogenesis in posterior uveal melanoma...
  57. ncbi request reprint Expression of p53-induced apoptosis effector PERP in primary uveal melanomas: downregulation is associated with aggressive type
    Luminita Paraoan
    Unit of Ophthalmology, School of Clinical Sciences, University of Liverpool, UCD Building, Daulby Street, Liverpool L69 3GA, UK
    Exp Eye Res 83:911-9. 2006
    ....