T Cowen

Summary

Affiliation: Royal Free and University College Medical School
Country: UK

Publications

  1. pmc Restricted diet rescues rat enteric motor neurones from age related cell death
    T Cowen
    Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill St, London NW3 2PF, UK
    Gut 47:653-60. 2000
  2. ncbi request reprint Differential regulation of survival and growth in adult sympathetic neurons: an in vitro study of neurotrophin responsiveness
    N Orike
    Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    J Neurobiol 47:295-305. 2001
  3. ncbi request reprint Responsiveness of sympathetic and sensory iridial nerves to NGF treatment in young and aged rats
    I Gavazzi
    Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, NW3 2PF, London, UK
    Neurobiol Aging 22:287-96. 2001
  4. ncbi request reprint Serum-free culture of dissociated, purified adult and aged sympathetic neurons and quantitative assays of growth and survival
    N Orike
    Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill St, London NW3 2PF, UK
    J Neurosci Methods 106:153-60. 2001
  5. ncbi request reprint Reactive oxygen species, dietary restriction and neurotrophic factors in age-related loss of myenteric neurons
    C Thrasivoulou
    Department of Anatomy and Developmental Biology, University College London, Royal Free Campus, London NW3 2PF, UK
    Aging Cell 5:247-57. 2006
  6. pmc Role of PI 3-kinase, Akt and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons
    N Orike
    Department of Anatomy and Developmental Biology, Royal Free Hospital School of Medicine, London NW3 2PF, United Kingdom
    J Cell Biol 154:995-1005. 2001
  7. ncbi request reprint Reduced age-related plasticity of neurotrophin receptor expression in selected sympathetic neurons of the rat
    T Cowen
    Department of Anatomy and Developmental Biology, University College London, UK
    Aging Cell 2:59-69. 2003
  8. ncbi request reprint A heady message for lifespan regulation
    T Cowen
    Dept of Anatomy and Developmental Biology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill St, London, UK NW3 2PF
    Trends Genet 17:109-13. 2001
  9. ncbi request reprint Selective vulnerability in adult and ageing mammalian neurons
    T Cowen
    Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, London, UK
    Auton Neurosci 96:20-4. 2002

Collaborators

Detail Information

Publications9

  1. pmc Restricted diet rescues rat enteric motor neurones from age related cell death
    T Cowen
    Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill St, London NW3 2PF, UK
    Gut 47:653-60. 2000
    ..A previous study demonstrated unexpectedly that neurones of the myenteric plexus from rats fed a restricted diet appeared not to suffer from extensive cell death in contrast with previous studies of ad libitum fed animals...
  2. ncbi request reprint Differential regulation of survival and growth in adult sympathetic neurons: an in vitro study of neurotrophin responsiveness
    N Orike
    Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    J Neurobiol 47:295-305. 2001
    ..Our results indicate that maturing neurons acquire protection against cell death, induced in the absence of neurotrophin, while retaining their growth responsiveness to these factors...
  3. ncbi request reprint Responsiveness of sympathetic and sensory iridial nerves to NGF treatment in young and aged rats
    I Gavazzi
    Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, NW3 2PF, London, UK
    Neurobiol Aging 22:287-96. 2001
    ..NGF treatment had no effect on receptor staining in young rats but restored 'young' levels of p75 staining in old rats. Our results do not support the hypothesis of a primary role for NGF in maintenance or atrophy of nerves in ageing...
  4. ncbi request reprint Serum-free culture of dissociated, purified adult and aged sympathetic neurons and quantitative assays of growth and survival
    N Orike
    Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill St, London NW3 2PF, UK
    J Neurosci Methods 106:153-60. 2001
    ..A novel semiautomated assay of neurite outgrowth is outlined using image analysis of composite images of immunofluorescence-stained single neurons...
  5. ncbi request reprint Reactive oxygen species, dietary restriction and neurotrophic factors in age-related loss of myenteric neurons
    C Thrasivoulou
    Department of Anatomy and Developmental Biology, University College London, Royal Free Campus, London NW3 2PF, UK
    Aging Cell 5:247-57. 2006
    ..We hypothesize that CR enhances antioxidant defence through neurotrophic factor signalling, thereby reducing age-related increases in neuronal ROS levels and in ROS-induced cell death...
  6. pmc Role of PI 3-kinase, Akt and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons
    N Orike
    Department of Anatomy and Developmental Biology, Royal Free Hospital School of Medicine, London NW3 2PF, United Kingdom
    J Cell Biol 154:995-1005. 2001
    ..These results demonstrate that PI 3-kinase/Akt signaling and the expression of antiapoptotic members of the Bcl-2 family are required to sustain the survival of adult sympathetic neurons...
  7. ncbi request reprint Reduced age-related plasticity of neurotrophin receptor expression in selected sympathetic neurons of the rat
    T Cowen
    Department of Anatomy and Developmental Biology, University College London, UK
    Aging Cell 2:59-69. 2003
    ..We conclude that lifelong exposure to low levels of NTs combined with impaired plasticity of NT receptor expression are predictors of neuronal vulnerability to age-related atrophy...
  8. ncbi request reprint A heady message for lifespan regulation
    T Cowen
    Dept of Anatomy and Developmental Biology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill St, London, UK NW3 2PF
    Trends Genet 17:109-13. 2001
    ..Here we discuss the new work and several hypotheses to explain this apparent contradiction...
  9. ncbi request reprint Selective vulnerability in adult and ageing mammalian neurons
    T Cowen
    Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, London, UK
    Auton Neurosci 96:20-4. 2002
    ....