Research Topics
| Michelangelo CampanellaSummaryAffiliation: Royal Veterinary College Country: UK Publications
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Detail Information
Publications
PK11195 inhibits mitophagy targeting the F1Fo-ATPsynthase in Bcl-2 knock-down cellsM S D Seneviratne
Royal Veterinary College, University of London, NW1 0TU, London, United Kingdom
Curr Mol Med 12:476-82. 2012..Taken together, these data highlight a novel TSPO-independent biological effect for PK11195 and provide evidences for a hitherto uncovered Bcl-2-dependent role of the F1Fo-ATPsynthase in mitochondrial quality control...
The 18 kDa translocator protein (TSPO): a new perspective in mitochondrial biologyJ Gatliff
Royal Veterinary College, University of London, Royal College Street, NW1 0TU, London, United Kingdom
Curr Mol Med 12:356-68. 2012..In essence, we hope to demonstrate the intimate involvement TSPO has in the regulation of mitochondrial homeostasis and muster attention towards this molecule, which is equally central for both cellular and mitochondrial biology...
Modulation of intracellular Ca2+ signalling in HeLa cells by the apoptotic cell death enhancer PK11195Michelangelo Campanella
Department of Veterinary Basic Science, Royal Veterinary College, Royal College Street, University of London, NW10TU London, UK
Biochem Pharmacol 76:1628-36. 2008..This work provides evidence for a novel pharmacological effect of PK11195 on Ca2+ signalling which may be linked to its effect on Bcl-2 and account for its role in apoptotic cell death...
IF1, the endogenous regulator of the F(1)F(o)-ATPsynthase, defines mitochondrial volume fraction in HeLa cells by regulating autophagyMichelangelo Campanella
Department of Cell and Developmental Biology, University College London, UK
Biochim Biophys Acta 1787:393-401. 2009..Variations in IF1 expression level may therefore play a significant role in defining both resting rates of ROS generation and cellular mitochondrial content...
Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1Michelangelo Campanella
Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
Cell Metab 8:13-25. 2008..Thus, IF(1) regulates mitochondrial function and structure under both physiological and pathological conditions...
IF(1): setting the pace of the F(1)F(o)-ATP synthaseMichelangelo Campanella
Department of Cell and Developmental Biology, University College London, UK
Trends Biochem Sci 34:343-50. 2009..Emerging research suggests that IF(1) has a wider ranging impact on mitochondrial structure and function than previously thought...
Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphateGiordano Pula
Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, United Kingdom
Arterioscler Thromb Vasc Biol 30:2631-8. 2010..In this study, we assessed whether the release of dRP by platelets stimulates endothelial cell migration and angiogenesis...
