Michelangelo Campanella

Summary

Affiliation: Royal Veterinary College
Country: UK

Publications

  1. ncbi request reprint PK11195 inhibits mitophagy targeting the F1Fo-ATPsynthase in Bcl-2 knock-down cells
    M S D Seneviratne
    Royal Veterinary College, University of London, NW1 0TU, London, United Kingdom
    Curr Mol Med 12:476-82. 2012
  2. pmc Clonal characterization of rat muscle satellite cells: proliferation, metabolism and differentiation define an intrinsic heterogeneity
    Carlo A Rossi
    Stem Cell Processing Laboratory, Department of Pediatrics, University of Padua, Padova, Italy
    PLoS ONE 5:e8523. 2010
  3. pmc Molecular Regulation of the Mitochondrial F(1)F(o)-ATPsynthase: Physiological and Pathological Significance of the Inhibitory Factor 1 (IF(1))
    Danilo Faccenda
    The Royal Veterinary College, University of London and UCL Consortium for Mitochondrial Research, Royal College Street, London NW1 0TU, UK
    Int J Cell Biol 2012:367934. 2012
  4. pmc IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling
    D Faccenda
    Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, London, UK
    Cell Death Differ 20:686-97. 2013
  5. ncbi request reprint The 18 kDa translocator protein (TSPO): a new perspective in mitochondrial biology
    J Gatliff
    Royal Veterinary College, University of London, Royal College Street, NW1 0TU, London, United Kingdom
    Curr Mol Med 12:356-68. 2012
  6. doi request reprint IF1, the endogenous regulator of the F(1)F(o)-ATPsynthase, defines mitochondrial volume fraction in HeLa cells by regulating autophagy
    Michelangelo Campanella
    Department of Cell and Developmental Biology, University College London, UK
    Biochim Biophys Acta 1787:393-401. 2009
  7. pmc Modulation of intracellular Ca2+ signalling in HeLa cells by the apoptotic cell death enhancer PK11195
    Michelangelo Campanella
    Department of Veterinary Basic Science, Royal Veterinary College, Royal College Street, University of London, NW10TU London, UK
    Biochem Pharmacol 76:1628-36. 2008
  8. doi request reprint IF(1): setting the pace of the F(1)F(o)-ATP synthase
    Michelangelo Campanella
    Department of Cell and Developmental Biology, University College London, UK
    Trends Biochem Sci 34:343-50. 2009
  9. pmc Regulation of mitochondrial morphogenesis by annexin A6
    Marcin Chlystun
    Department of Cell Biology, University College London, Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 8:e53774. 2013
  10. pmc Cell metabolism sets the differences between subpopulations of satellite cells (SCs)
    Andrea Repele
    Stem Cells and Regenerative Medicine Lab, Department of Woman and Child Health, University of Padua, Padua, Italy
    BMC Cell Biol 14:24. 2013

Collaborators

Detail Information

Publications14

  1. ncbi request reprint PK11195 inhibits mitophagy targeting the F1Fo-ATPsynthase in Bcl-2 knock-down cells
    M S D Seneviratne
    Royal Veterinary College, University of London, NW1 0TU, London, United Kingdom
    Curr Mol Med 12:476-82. 2012
    ..Taken together, these data highlight a novel TSPO-independent biological effect for PK11195 and provide evidences for a hitherto uncovered Bcl-2-dependent role of the F1Fo-ATPsynthase in mitochondrial quality control...
  2. pmc Clonal characterization of rat muscle satellite cells: proliferation, metabolism and differentiation define an intrinsic heterogeneity
    Carlo A Rossi
    Stem Cell Processing Laboratory, Department of Pediatrics, University of Padua, Padova, Italy
    PLoS ONE 5:e8523. 2010
    ..By these means, novel insights on SCs heterogeneity are provided and evidences for biological readouts potentially relevant for diagnostic purposes described...
  3. pmc Molecular Regulation of the Mitochondrial F(1)F(o)-ATPsynthase: Physiological and Pathological Significance of the Inhibitory Factor 1 (IF(1))
    Danilo Faccenda
    The Royal Veterinary College, University of London and UCL Consortium for Mitochondrial Research, Royal College Street, London NW1 0TU, UK
    Int J Cell Biol 2012:367934. 2012
    ....
  4. pmc IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling
    D Faccenda
    Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, London, UK
    Cell Death Differ 20:686-97. 2013
    ..These data suggest that IF1 is an antiapoptotic and potentially tumorigenic factor and may be a valuable predictor of responsiveness to chemotherapy...
  5. ncbi request reprint The 18 kDa translocator protein (TSPO): a new perspective in mitochondrial biology
    J Gatliff
    Royal Veterinary College, University of London, Royal College Street, NW1 0TU, London, United Kingdom
    Curr Mol Med 12:356-68. 2012
    ..In essence, we hope to demonstrate the intimate involvement TSPO has in the regulation of mitochondrial homeostasis and muster attention towards this molecule, which is equally central for both cellular and mitochondrial biology...
  6. doi request reprint IF1, the endogenous regulator of the F(1)F(o)-ATPsynthase, defines mitochondrial volume fraction in HeLa cells by regulating autophagy
    Michelangelo Campanella
    Department of Cell and Developmental Biology, University College London, UK
    Biochim Biophys Acta 1787:393-401. 2009
    ..Variations in IF1 expression level may therefore play a significant role in defining both resting rates of ROS generation and cellular mitochondrial content...
  7. pmc Modulation of intracellular Ca2+ signalling in HeLa cells by the apoptotic cell death enhancer PK11195
    Michelangelo Campanella
    Department of Veterinary Basic Science, Royal Veterinary College, Royal College Street, University of London, NW10TU London, UK
    Biochem Pharmacol 76:1628-36. 2008
    ..This work provides evidence for a novel pharmacological effect of PK11195 on Ca2+ signalling which may be linked to its effect on Bcl-2 and account for its role in apoptotic cell death...
  8. doi request reprint IF(1): setting the pace of the F(1)F(o)-ATP synthase
    Michelangelo Campanella
    Department of Cell and Developmental Biology, University College London, UK
    Trends Biochem Sci 34:343-50. 2009
    ..Emerging research suggests that IF(1) has a wider ranging impact on mitochondrial structure and function than previously thought...
  9. pmc Regulation of mitochondrial morphogenesis by annexin A6
    Marcin Chlystun
    Department of Cell Biology, University College London, Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 8:e53774. 2013
    ..Our results suggest that anxA6 inhibits Drp1 activity, and that Ca(2+)-binding to anxA6 relieves this inhibition to permit Drp1-mediated mitochondrial fission...
  10. pmc Cell metabolism sets the differences between subpopulations of satellite cells (SCs)
    Andrea Repele
    Stem Cells and Regenerative Medicine Lab, Department of Woman and Child Health, University of Padua, Padua, Italy
    BMC Cell Biol 14:24. 2013
    ..Herewith, we have investigated their cell metabolism and individuated features that remark an intrinsic difference in basal physiology but that are retrievable also at the initial phases of their cloning...
  11. doi request reprint Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1
    Michelangelo Campanella
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Cell Metab 8:13-25. 2008
    ..Thus, IF(1) regulates mitochondrial function and structure under both physiological and pathological conditions...
  12. doi request reprint Ca 2+ -dependent autophagy is enhanced by the pharmacological agent PK11195
    Annallisa Gastaldello
    Royal Veterinary College, University of London, London UK
    Autophagy 6:607-13. 2010
    ..By these means, PK11195 is proposed as facilitator of Ca ( 2+) mediated autophagy and tool to ascertain the Bcl-2 contribution to the onset and unfolding of this essential catabolic process for cellular homeostasis...
  13. ncbi request reprint The compound BTB06584 is an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase
    Fabrice Ivanes
    Department of Cell and Developmental Biology, University College London, Gower street WC1E BT, London, UK INSERM UMR 1060, Carmen, Lyon, France Universit Lyon I, Facult de M decine Lyon Est, Lyon, France
    Br J Pharmacol . 2014
    ..We have sought to identify a molecule that can selectively inhibit this activity without affecting ATP synthesis, preserve ATP, and delay ischemic cell death...
  14. doi request reprint Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate
    Giordano Pula
    Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, United Kingdom
    Arterioscler Thromb Vasc Biol 30:2631-8. 2010
    ..In this study, we assessed whether the release of dRP by platelets stimulates endothelial cell migration and angiogenesis...