A Bush

Summary

Affiliation: Royal Brompton Hospital
Country: UK

Publications

  1. doi request reprint Primary ciliary dyskinesia: recent advances in epidemiology, diagnosis, management and relationship with the expanding spectrum of ciliopathy
    Andrew Bush
    Department of Paediatric Respirology, Imperial School of Medicine at National Heart and Lung Institute, London, UK
    Expert Rev Respir Med 6:663-82. 2012
  2. pmc Exhaled 8-isoprostane in childhood asthma
    Sukhbir K Shahid
    National Heart and Lung Institute, Imperial College London, London, UK
    Respir Res 6:79. 2005
  3. ncbi request reprint Paediatric problems of cough
    Andrew Bush
    Paediatric Respirology, Imperial School of Medicine at National Heart and Lung Institute, and Royal Brompton Hospital, London, UK
    Pulm Pharmacol Ther 15:309-15. 2002
  4. pmc Acute bronchiolitis
    Andrew Bush
    Imperial School of Medicine at National Heart and Lung Institute, London SW3 6NP
    BMJ 335:1037-41. 2007
  5. ncbi request reprint Asthma research: the real action is in children
    Andrew Bush
    Imperial School of Medicine, National Heart and Lung Institute, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Paediatr Respir Rev 6:101-10. 2005
  6. pmc Primary ciliary dyskinesia: current state of the art
    Andrew Bush
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Arch Dis Child 92:1136-40. 2007
  7. ncbi request reprint Inflammometry and asthma: onto the next level
    Andrew Bush
    Imperial School of Medicine at National Heart and Lung Institute, UK
    Pediatr Pulmonol 42:569-72. 2007
  8. ncbi request reprint Update in pediatric lung disease 2006
    Andrew Bush
    F R C P, Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 175:532-40. 2007
  9. ncbi request reprint Diagnosis of asthma in children under five
    Andrew Bush
    Imperial School of Medicine at the National Heart and Lung Institute, London, UK
    Prim Care Respir J 16:7-15. 2007
  10. ncbi request reprint Update in pediatrics 2005
    Andrew Bush
    Imperial School of Medicine, National Heart and Lung Institute, London, United Kingdom
    Am J Respir Crit Care Med 173:585-92. 2006

Collaborators

Detail Information

Publications135 found, 100 shown here

  1. doi request reprint Primary ciliary dyskinesia: recent advances in epidemiology, diagnosis, management and relationship with the expanding spectrum of ciliopathy
    Andrew Bush
    Department of Paediatric Respirology, Imperial School of Medicine at National Heart and Lung Institute, London, UK
    Expert Rev Respir Med 6:663-82. 2012
    ..The authors consider the clinical situations in which ciliary disease should be considered, and the implications for specialist respiratory practice...
  2. pmc Exhaled 8-isoprostane in childhood asthma
    Sukhbir K Shahid
    National Heart and Lung Institute, Imperial College London, London, UK
    Respir Res 6:79. 2005
    ..Exhaled breath condensate (EBC) is a non-invasive method to assess airway inflammation and oxidative stress and may be useful in the assessment of childhood asthma...
  3. ncbi request reprint Paediatric problems of cough
    Andrew Bush
    Paediatric Respirology, Imperial School of Medicine at National Heart and Lung Institute, and Royal Brompton Hospital, London, UK
    Pulm Pharmacol Ther 15:309-15. 2002
    ..It is important however, not to over-diagnose asthma in children who in fact have a chronic non-specific cough. Such children require no treatment, get better with time, and have normal long-term lung function...
  4. pmc Acute bronchiolitis
    Andrew Bush
    Imperial School of Medicine at National Heart and Lung Institute, London SW3 6NP
    BMJ 335:1037-41. 2007
  5. ncbi request reprint Asthma research: the real action is in children
    Andrew Bush
    Imperial School of Medicine, National Heart and Lung Institute, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Paediatr Respir Rev 6:101-10. 2005
    ..Finally, the ethical principles that must underpin future research in pre-school children is discussed, as well as the means we might use to further our understanding of the relevant early disease processes...
  6. pmc Primary ciliary dyskinesia: current state of the art
    Andrew Bush
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Arch Dis Child 92:1136-40. 2007
    ..Treatment is not evidence based and recommendations are largely extrapolated from cystic fibrosis and other suppurative lung diseases...
  7. ncbi request reprint Inflammometry and asthma: onto the next level
    Andrew Bush
    Imperial School of Medicine at National Heart and Lung Institute, UK
    Pediatr Pulmonol 42:569-72. 2007
  8. ncbi request reprint Update in pediatric lung disease 2006
    Andrew Bush
    F R C P, Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 175:532-40. 2007
  9. ncbi request reprint Diagnosis of asthma in children under five
    Andrew Bush
    Imperial School of Medicine at the National Heart and Lung Institute, London, UK
    Prim Care Respir J 16:7-15. 2007
    ..Prophylactic therapy on a long term basis with inhaled steroids in pre-school children does not reduce the likelihood of progression to asthma in mid-childhood, and the results of treatment in terms of symptoms are disappointing...
  10. ncbi request reprint Update in pediatrics 2005
    Andrew Bush
    Imperial School of Medicine, National Heart and Lung Institute, London, United Kingdom
    Am J Respir Crit Care Med 173:585-92. 2006
  11. ncbi request reprint Small is beautiful: but may be breathless
    Andrew Bush
    Royal Brompton Hospital, London, UK
    Chron Respir Dis 1:181-2. 2004
  12. ncbi request reprint Early detection of lung disease in preschool children with cystic fibrosis
    Andrew Bush
    Imperial School of Medicine at National Heart and Lung Institute, Royal Brompton Hospital, London, United Kingdom
    Curr Opin Pulm Med 11:534-8. 2005
    ..This is particularly urgent to select groups of children for new, phenotype-specific therapies, and monitor their effects...
  13. ncbi request reprint Bronchoscopy in paediatric intensive care
    Andrew Bush
    Imperial School of Medicine at National Heart and Lung Institute, London, UK
    Paediatr Respir Rev 4:67-73. 2003
    ..New iatrogenic complications are also likely to be discovered. The procedure is very safe if performed by experienced operators with back-up from doctors skilled in airway management and the monitoring of sick children...
  14. pmc How has research in the last five years changed my clinical practice?
    A Bush
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Arch Dis Child 90:832-6. 2005
    ..The first instruction to examination candidates is to read and answer the question actually set. Doing so in this case leads to the following..
  15. pmc Respiratory management of the infant with type 1 spinal muscular atrophy
    A Bush
    Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Arch Dis Child 90:709-11. 2005
    ..Here we offer a personal view, as a possible template for managing a vexed and emotional problem. The complex non-respiratory aspects of the holistic care of these infants will not be discussed...
  16. ncbi request reprint Phenotype specific treatment of asthma in childhood
    Andrew Bush
    Imperial School of Medicine at National Heart and Lung Institute, Royal Brompton Hospital, UK
    Paediatr Respir Rev 5:S93-101. 2004
    ..Asthma is not one disease but many, and attention to delineating clinical phenotypes, rather than being obsessed with guidelines based on large heterogeneous groups, may allow rational individual treatment...
  17. ncbi request reprint Classification of phenotypes
    Andrew Bush
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Pediatr Pulmonol Suppl 26:30-3. 2004
  18. doi request reprint How early do airway inflammation and remodeling occur?
    Andrew Bush
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Allergol Int 57:11-9. 2008
    ....
  19. ncbi request reprint Decisions facing the cystic fibrosis clinician at first isolation of Pseudomonas aeruginosa
    Andrew Bush
    Imperial School of Medicine and Royal Brompton Hospital, London, UK
    Paediatr Respir Rev 3:82-8. 2002
    ..In addition, the optimal treatment of patients at first isolation and early colonisation needs to be researched, including choice of antibiotic(s) and route, dosage and duration of antibiotic therapy...
  20. doi request reprint COPD: a pediatric disease
    Andrew Bush
    Imperial School of Medicine at National Heart and Lung Institute
    COPD 5:53-67. 2008
    ..Any model of COPD which does not take into account early life influences is likely to be fatally flawed...
  21. ncbi request reprint Congenital lung disease: a plea for clear thinking and clear nomenclature
    A Bush
    Department of Paediatric Respirology, Imperial School of Medicine at National Heart and Lung Institute and Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 32:328-37. 2001
    ..Thus, a complete reappraisal of the nomenclature of congenital lung disease is timely; this review does not discuss treatment options...
  22. doi request reprint Prenatal presentation and postnatal management of congenital thoracic malformations
    Andrew Bush
    Imperial School of Medicine at National Heart and Lung Institute, UK
    Early Hum Dev 85:679-84. 2009
    ..Different families will make different decisions about postnatal surgery in an asymptomatic baby. If surgery is performed, morbidity is low, particularly with a video-assisted thoracoscopic (VATS) procedure...
  23. pmc Management of severe asthma in children
    Andrew Bush
    Imperial School of Medicine, National Heart and Lung Institute, Royal Brompton Hospital, London, UK
    Lancet 376:814-25. 2010
    ..However, despite the interest in innovative approaches, getting the basics right in children with apparently severe asthma will remain the foundation of management for the foreseeable future...
  24. ncbi request reprint Primary ciliary dyskinesia
    A Bush
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Acta Otorhinolaryngol Belg 54:317-24. 2000
    ..Patients should be followed up by specialists familiar with the different ways of managing the upper and lower airway complications...
  25. doi request reprint Recurrent respiratory infections
    Andrew Bush
    Imperial School of Medicine at National Heart and Lung Institute, London, UK
    Pediatr Clin North Am 56:67-100, x. 2009
    ..It is hoped that, in the absence of good-quality evidence for most clinical scenarios, the experience-based approach described in this article may prove a useful guide to the clinician...
  26. doi request reprint The value of FeNO measurement in asthma management: the motion for Yes, it's NO--or, the wrong end of the Stick!
    Andrew Bush
    Imperial School of Medicine at National Heart and Lung Institute, London, UK
    Paediatr Respir Rev 9:127-31. 2008
    ....
  27. doi request reprint Phenotypes of refractory/severe asthma
    Andrew Bush
    Imperial School of Medicine at National Heart and Lung Institute, Royal Brompton Hospital, London, UK
    Paediatr Respir Rev 12:177-81. 2011
    ....
  28. doi request reprint Update in pediatric lung disease 2007
    Andrew Bush
    F R C P, Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 177:686-95. 2008
  29. ncbi request reprint Clinical trials research in pediatrics: strategies for effective collaboration between investigator sites and the pharmaceutical industry
    Andrew Bush
    Imperial School of Medicine at National Heart and Lung Institute, London, UK
    Paediatr Drugs 8:271-7. 2006
    ..The new UK initiative, 'Medicines for Children', should go a long way towards addressing the problem, and increase the evidence base for the utilization of medications in pediatric practice...
  30. doi request reprint Phenotypic differences between pediatric and adult asthma
    Andrew Bush
    Department of Paediatric Respiratory Medicine, Imperial School of Medicine at National Heart and Lung Institute, London, United Kingdom
    Proc Am Thorac Soc 6:712-9. 2009
    ..Retrospective recall of childhood events is of limited value. In conclusion, a full understanding the multifaceted phenotypes of asthma requires a thorough knowledge of early life events and their consequences over many decades...
  31. ncbi request reprint Comparison of hypertonic saline and alternate-day or daily recombinant human deoxyribonuclease in children with cystic fibrosis: a randomised trial
    R Suri
    Respiratory Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Lancet 358:1316-21. 2001
    ..Hypertonic saline improved lung function to the same degree as rhDNase in short-term studies. We compared the effectiveness of daily rhDNase, hypertonic saline, and alternate-day rhDNase in children with cystic fibrosis...
  32. ncbi request reprint Non-CF bronchiectasis: does knowing the aetiology lead to changes in management?
    A M Li
    Dept of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Eur Respir J 26:8-14. 2005
    ..Computed tomography scans do not contribute towards identifying the aetiology and, most importantly, a specific aetiological diagnosis frequently leads to a change in management...
  33. ncbi request reprint A comparative study of hypertonic saline, daily and alternate-day rhDNase in children with cystic fibrosis
    R Suri
    Respiratory Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Health Technol Assess 6:iii, 1-60. 2002
  34. ncbi request reprint Asthma severity and inflammation markers in children
    N M Wilson
    Department of Paediatrics, Royal Brompton and Harefield NHS Trust, Chelsea Wing, Sydney St, London SW3 6NP, UK
    Pediatr Allergy Immunol 12:125-32. 2001
    ..There was no significant correlation between the results of any..
  35. ncbi request reprint Normal nasal mucociliary clearance in CF children: evidence against a CFTR-related defect
    D McShane
    Dept of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK
    Eur Respir J 24:95-100. 2004
    ..Studies to explore this mechanism in the distal, more sparsely-ciliated airways could aid an understanding of pathogenesis and the development of new treatments...
  36. ncbi request reprint Investigation of young children with severe recurrent wheeze: any clinical benefit?
    S Saglani
    Dept of Respiratory Paediatrics, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Eur Respir J 27:29-35. 2006
    ..This hypothesis-generating work should form the basis of future interventional studies...
  37. doi request reprint Comparison of inhaled mannitol, daily rhDNase and a combination of both in children with cystic fibrosis: a randomised trial
    C Minasian
    Royal Brompton Hospital and Imperial College, London, UK
    Thorax 65:51-6. 2010
    ..This is the first therapeutic trial of inhaled mannitol in children with CF; it was compared with recombinant human deoxyribonuclease (rhDNase), the current best established mucolytic treatment...
  38. pmc Corticosteroid responsiveness and clinical characteristics in childhood difficult asthma
    C J Bossley
    Dept of Respiratory Paediatrics, Royal Brompton Hospital, London SW3 6NP, UK
    Eur Respir J 34:1052-9. 2009
    ..93, 95% CI 0.90-0.97). Only 11% of DA children exhibited complete corticosteroid responsiveness. The rarity of complete corticosteroid responsiveness suggests alternative therapies are needed for children with DA...
  39. pmc Evidence for different subgroups of difficult asthma in children
    D N Payne
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Thorax 56:345-50. 2001
    ..Both subgroups included patients with persistent symptoms, which suggests that different patterns of difficult asthma in children exist...
  40. ncbi request reprint Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone
    D N Payne
    Department of Paediatrics, Imperial College of Science, Technology and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, London, United Kingdom
    Am J Respir Crit Care Med 164:1376-81. 2001
    ..We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia...
  41. ncbi request reprint Safety of endobronchial biopsy in children with cystic fibrosis
    A Molina-Teran
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, United Kingdom
    Pediatr Pulmonol 41:1021-4. 2006
    ..Studies of such samples would allow us to determine the early pathological changes in the CF airway and possibly find new treatments to prevent the progression to bronchiectasis and end stage airway destruction...
  42. doi request reprint Blood eosinophil counts rarely reflect airway eosinophilia in children with severe asthma
    N Ullmann
    Respiratory Paediatrics, Royal Brompton Hospital London and NHLI Imperial College London, London, UK
    Allergy 68:402-6. 2013
    ..If this were true in children with severe therapy-resistant asthma (STRA), invasive tests could be avoided. At the moment there is no conclusive evidence in children...
  43. doi request reprint Mannose-binding lectin is present in the infected airway: a possible pulmonary defence mechanism
    K J Fidler
    Infectious Diseases and Microbiology Unit, Institute of Child Health, London, UK
    Thorax 64:150-5. 2009
    ..The mechanism is uncertain, and could relate either to systemic or local effects. The aim of this study was to determine, in a large cohort of children, whether MBL is present on the airway surface in health or disease...
  44. ncbi request reprint HRCT lung abnormalities are not a surrogate for exercise limitation in bronchiectasis
    E A Edwards
    Dept of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Eur Respir J 24:538-44. 2004
    ....
  45. pmc Safety and ethics of bronchoscopy and endobronchial biopsy in difficult asthma
    D Payne
    Department of Paediatrics, Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, UK
    Arch Dis Child 84:423-6. 2001
    ..The procedure is acceptable to the families involved...
  46. pmc Intravenous immunoglobulin for cystic fibrosis lung disease: a case series of 16 children
    I M Balfour-Lynn
    Department of Paediatric Respiratory Medicine, Royal Brompton and Harefield NHS Trust, Sydney Street, London, UK
    Arch Dis Child 89:315-9. 2004
    ..In an attempt to reduce the use of regular oral corticosteroids, we treated a group of such children with monthly courses of intravenous immunoglobulin (IVIG)...
  47. pmc Can HRCT be used as a marker of airway remodelling in children with difficult asthma?
    S Saglani
    Respiratory Paediatrics, Royal Brompton Hospital, London, UK
    Respir Res 7:46. 2006
    ..A similar relationship in children with difficult asthma (DA), in whom RBM thickening is a known feature, may allow the use of HRCT as a non-invasive marker of airway remodelling. We evaluated this relationship in children with DA...
  48. doi request reprint Lung Clearance Index and HRCT are complementary markers of lung abnormalities in young children with CF
    C M Owens
    Department of Paediatric Radiology, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Thorax 66:481-8. 2011
    ....
  49. ncbi request reprint Three-minute step test to assess exercise capacity in children with cystic fibrosis with mild lung disease
    I Narang
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 35:108-13. 2003
    ..The 15c did not discriminate between a maximal and a submaximal test, and was less useful than VAS. Important information may be missed by the step test which is detected by more complex exercise tests...
  50. pmc Cough frequency in children with stable asthma: correlation with lung function, exhaled nitric oxide, and sputum eosinophil count
    A M Li
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London SW3 6NP, UK
    Thorax 58:974-8. 2003
    ..A study was undertaken to assess the correlation between cough frequency in asthmatic children with lung function and two non-invasive markers of airway inflammation...
  51. ncbi request reprint Anti-inflammatory effects of macrolides in lung disease
    A Jaffe
    Department of Respiratory Medicine, Great Ormond Street Hospital for Children, National Health Service Trust, London, UK
    Pediatr Pulmonol 31:464-73. 2001
    ..The benefits and potential side effects need to be determined before routine use can be advised...
  52. ncbi request reprint Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction
    Sejal Saglani
    Lung Pathology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 171:722-7. 2005
    ..We hypothesized that the epithelial reticular basement membrane (RBM) thickening and eosinophilic inflammation characteristic of asthma would be present in symptomatic infants with reversible airflow obstruction...
  53. ncbi request reprint Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children
    Angela Zacharasiewicz
    Department of Respiratory Pediatrics, Clinical Trials and Evaluation Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 171:1077-82. 2005
    ..38; confidence interval, 1.06-1.81) were significant predictors of failed reduction. These findings suggest that monitoring airway inflammation may be useful in optimizing treatment in children with asthma...
  54. ncbi request reprint Routine ventilation scans in children with cystic fibrosis: diagnostic usefulness and prognostic value
    A Jaffe
    Department of Respiratory Paediatrics, Royal Brompton and Harefield NHS Trust, London, UK
    Eur J Nucl Med 28:1313-8. 2001
    ..VS at presentation gives prognostic information, which may be of use in early intervention studies. Whether using VS to guide treatment improves long-term prognosis requires a larger prospective trial...
  55. doi request reprint The complexities of defining atopy in severe childhood asthma
    J Frith
    Department of Respiratory Paediatrics, Royal Brompton Hospital, London, UK
    Clin Exp Allergy 41:948-53. 2011
    ..There is currently no gold standard test; both skin prick testing (SPT) and allergen-specific IgE (sIgE) are used. Furthermore, atopy is increasingly considered to be a spectrum, not an all-or-none phenomenon...
  56. pmc Use of cough swabs in a cystic fibrosis clinic
    A C Equi
    Department of Paediatric Respiratory Medicine, Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, UK
    Arch Dis Child 85:438-9. 2001
    ..A positive cough swab is a strong predictor of sputum culture. However, a negative cough swab does not rule out infection. Persistent symptoms should be further investigated...
  57. doi request reprint The importance of nurse-led home visits in the assessment of children with problematic asthma
    M Bracken
    Department of Paediatric Respirology, Royal Brompton Hospital, London, UK
    Arch Dis Child 94:780-4. 2009
    ..To evaluate and identify potentially modifiable factors in children with problematic asthma by a nurse-led assessment and home visit...
  58. ncbi request reprint An infant with pneumonia, failure to thrive and persistent radiographical changes
    N Thompson
    Dept of Paediatrics, Royal Brompton Hospital, Sydney Street, London SW10 9NH, UK
    Eur Respir J 30:172-6. 2007
  59. pmc A video questionnaire identifies upper airway abnormalities in preschool children with reported wheeze
    S Saglani
    Paediatric Respiratory Medicine, Airways Diseases Section of the National Heart and Lung Institute, Imperial College, London, UK
    Arch Dis Child 90:961-4. 2005
    ..Accurate characterisation of subjects is essential to interpret data from studies investigating preschool wheezing...
  60. pmc Multiple breath inert gas washout as a measure of ventilation distribution in children with cystic fibrosis
    P Aurora
    Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Institute of Child Health, London, UK
    Thorax 59:1068-73. 2004
    ....
  61. doi request reprint CT and histopathological correlation of congenital cystic pulmonary lesions: a common pathogenesis?
    N Griffin
    Royal Brompton and Harefield NHS Trust, London, UK
    Clin Radiol 63:995-1005. 2008
    ..To determine whether similarities exist in both the imaging and histopathological features of congenital cystic lung lesions and whether a more appropriate classification would be to adopt the theory of "malinosculation"...
  62. ncbi request reprint Mannitol as a mucolytic in cystic fibrosis
    C C Minasian
    Department of Paediatric Respiratory Medicine, Imperial College and Royal Brompton Hospital, London, UK
    J R Soc Med 100:53-6. 2007
  63. ncbi request reprint Multiresistant Pseudomonas aeruginosa in a pediatric cystic fibrosis center: natural history and implications for segregation
    G Davies
    Department of Paediatric Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, UK
    Pediatr Pulmonol 35:253-6. 2003
    ..The variability with time in isolation of MR strains from individuals demonstrates the potential difficulties in designing segregation policies based on antibiotic sensitivity patterns...
  64. doi request reprint Non-cystic fibrosis bronchiectasis in childhood: longitudinal growth and lung function
    C M Bastardo
    Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, UCL, Institute of Child Health, London, UK
    Thorax 64:246-51. 2009
    ..Little is known about disease progression through childhood and the effect on growth and spirometry. This study reviews longitudinal lung function and growth in children with non-CF bronchiectasis...
  65. ncbi request reprint Cystic fibrosis: review of the decade
    A Jaffe
    Department of Respiratory Paediatrics, Level 4, Chelsea Wing, Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, England
    Monaldi Arch Chest Dis 56:240-7. 2001
    ..It is important that patients continue to be referred early to tertiary CF centres...
  66. pmc Predicting hypoxaemia during flights in children with cystic fibrosis
    R M Buchdahl
    Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, UK
    Thorax 56:877-9. 2001
    ..This study reports on the results of measurements over 5 years...
  67. pmc Longitudinal study of grass pollen exposure, symptoms, and exhaled nitric oxide in childhood seasonal allergic asthma
    G Roberts
    Paediatric Allergy, Asthma and Immunology, Imperial College of St Mary s, London, UK
    Thorax 59:752-6. 2004
    ..Exhaled nitric oxide (NO) has been proposed as a marker of airway eosinophilic inflammation in asthma. There is currently a paucity of longitudinal data relating it to allergen exposure and asthma symptoms...
  68. ncbi request reprint Congenital lung abnormality in a 1-yr old
    R Ajitsaria
    Dept of Paediatric Respiratory Medicine, Royal Brompton and NHS Trust, Sydney Street, London, SW3 6NP, UK
    Eur Respir J 23:347-51. 2004
  69. ncbi request reprint Haemodynamics in children during rest and exercise: methods and normal values
    M Rosenthal
    Dept of Paediatric Respiratory Medicine, The Royal Brompton Hospital, London, UK
    Eur Respir J 11:854-65. 1998
    ..Normal values are provided for all haemodynamic parameters for rest and every exercise stage for all subgroups of children. This should allow accurate comparison of normal and disease groups in future...
  70. ncbi request reprint Should preschool wheezers ever be treated with inhaled corticosteroids?
    Sejal Saglani
    Imperial School of Medicine, National Heart and Lung Institute, and Department of Pediatric Respiratory Medicine, Royal Brompton Hospital, London, United Kingdom
    Semin Respir Crit Care Med 28:272-85. 2007
    ..There is an urgent need for better treatment of preschool wheeze...
  71. ncbi request reprint Breath condensate pH in children with cystic fibrosis and asthma: a new noninvasive marker of airway inflammation?
    Giovanna E Carpagnano
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, UK
    Chest 125:2005-10. 2004
    ..The pH of exhaled breath condensate (EBC) is a promising marker. Although pH has been measured in the EBC of adults with inflammatory airway diseases, no study has measured this in children...
  72. ncbi request reprint Quality, size, and composition of pediatric endobronchial biopsies in cystic fibrosis
    Nicolas Regamey
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Chest 131:1710-7. 2007
    ..We prospectively assessed how the quality of biopsy specimens obtained from children with CF compare with those from children with other airway diseases...
  73. ncbi request reprint Mucus properties in children with primary ciliary dyskinesia: comparison with cystic fibrosis
    Andrew Bush
    Pediatric Pulmonology, Imperial School of Medicine at National Heart and Lung Institute, London, UK
    Chest 129:118-23. 2006
    ..Our objective was to compare the biophysical and transport properties of CF and PCD sputa in subjects matched for age and degree of lung function impairment...
  74. doi request reprint Symptom-pattern phenotype and pulmonary function in preschool wheezers
    Samatha Sonnappa
    Portex Unit, Respiratory Medicine and Physiology, UCL Institute of Child Health, London, United Kingdom
    J Allergy Clin Immunol 126:519-26.e1-7. 2010
    ..Pulmonary function in preschool wheezing phenotypes based on wheeze onset and duration and atopic status has been extensively described but has not been studied in symptom-pattern phenotypes of episodic (viral) and multiple-trigger wheeze...
  75. ncbi request reprint Phenotype-specific treatment of difficult asthma in children
    Donald Payne
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Paediatr Respir Rev 5:116-23. 2004
    ..Multi-centre studies are required to test the utility of this approach...
  76. ncbi request reprint Ultrastructure of the reticular basement membrane in asthmatic adults, children and infants
    S Saglani
    Lung Pathology, Dept of Gene Therapy, Imperial College at the Royal Brompton Hospital, London, UK
    Eur Respir J 28:505-12. 2006
    ..49) versus 1.18 (0.31-2.6)). The ratio of fibril to matrix in the thickened reticular basement membrane of asthmatics is normal, and, contrary to what is expected in fibrosis, the fibrils do not resemble those of interstitial collagen...
  77. ncbi request reprint HRCT of paediatric lung disease
    S J Copley
    Department of Radiology, Royal Brompton Hospital, Sydney St London, SW3 6NP, UK
    Paediatr Respir Rev 1:141-7. 2000
    ..HRCT is also more specific than chest radiography for categorizing airway, airspace or interstitial processes in children. The current review will concentrate on the value of CT in airway diseases and diffuse interstitial lung disease...
  78. pmc Nitric oxide in chronic airway inflammation in children: diagnostic use and pathophysiological significance
    I Narang
    Department of Paediatrics, Royal Brompton Hospital, Imperial School of Medicine, London SW3 6NP, UK
    Thorax 57:586-9. 2002
    ..The levels of exhaled and nasal nitric oxide (eNO and nNO) in groups of patients with inflammatory lung diseases are well documented but the diagnostic use of these measurements in an individual is unknown...
  79. ncbi request reprint Pulmonary artery occlusion from tuberculous lymphadenopathy in a child
    A Equi
    Department of Paediatric Respiratory Medicine, Royal Brompton and Harefield National Health Service Trust, London, UK
    Pediatr Pulmonol 31:311-3. 2001
    ..Failure of medical therapy necessitated surgical reconstruction of her right pulmonary artery. Postoperatively she has normal perfusion of the right lung and normal lung function...
  80. ncbi request reprint Subcutaneous terbutaline in children with chronic severe asthma
    Donald N R Payne
    Department of Respiratory Medicine, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 33:356-61. 2002
    ..These initial findings support the need for further controlled studies to evaluate the use of CSIT in severe childhood asthma...
  81. pmc Pathophysiological features of asthma develop in parallel in house dust mite-exposed neonatal mice
    Sejal Saglani
    Leukocyte Biology Section, National Heart and Lung Institute, Sir Alexander Fleming Building, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Am J Respir Cell Mol Biol 41:281-9. 2009
    ..Importantly, all abnormalities developed in parallel, not sequentially, between 2 and 3 weeks of age...
  82. ncbi request reprint Alveolar, but not bronchial nitric oxide production is elevated in cystic fibrosis
    Ranjan Suri
    Department of Respiratory Paediatrics, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Pediatr Pulmonol 42:1215-21. 2007
    ..The distal airway is a major site of inflammation in CF, and measuring alveolar NO may be a marker of distal inflammation in this disease...
  83. ncbi request reprint Relative ability of full and partial forced expiratory maneuvers to identify diminished airway function in infants with cystic fibrosis
    Sarath C Ranganathan
    Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Institute of Child Health, London, United Kingdom
    Am J Respir Crit Care Med 166:1350-7. 2002
    ..In infants with CF, the raised volume technique identified diminished airway function more frequently than the tidal technique...
  84. ncbi request reprint Airway eosinophilia in children with severe asthma: predictive values of noninvasive tests
    Christiane Lex
    Department of Pediatric Respiratory Medicine, Imperial College of Science, Technology, and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 174:1286-91. 2006
    ....
  85. ncbi request reprint Is a two-week trial of oral prednisolone predictive of target lung function in pediatric asthma?
    Christiane Lex
    Department of Respiratory Paediatrics, Imperial College of Science, Technology and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, London, UK
    Pediatr Pulmonol 39:521-7. 2005
    ..5-39.9) vs. 1.4 (0.0-4.8) cells/mm2, P = 0.018). In conclusion, a 2-week course of prednisolone is not necessarily predictive of "target" lung function. Definitions such as PAL should be regularly reviewed on individual basis...
  86. ncbi request reprint Sputum induction in children with difficult asthma: safety, feasibility, and inflammatory cell pattern
    Christiane Lex
    Department of Respiratory Paediatrics, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 39:318-24. 2005
    ..Raised nitric oxide is only poorly predictive of sputum eosinophilia in these children...
  87. ncbi request reprint Symptoms, lung function, and beta2-adrenoceptor polymorphisms in a birth cohort followed for 10 years
    Nicola M Wilson
    Department of Paediatrics, National Heart and Lung Institute, London, UK
    Pediatr Pulmonol 38:75-81. 2004
    ..We also showed an influence of polymorphisms at both aa16 and aa27 on neonatal lung function. Wheezing beyond 4 years, typical of classical asthma, was unrelated to early measurements of lung function or bronchial responsiveness...
  88. ncbi request reprint Lung function in infants and young children with chronic lung disease of infancy: the next steps?
    Janet Stocks
    Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, UCL, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Pediatr Pulmonol 42:3-9. 2007
    ....
  89. doi request reprint Pro-con debate: Inhaled corticosteroids should not be prescribed in primary care to children under two years of age - the case for
    Andrew Bush
    Imperial School of Medicine at the National Heart and Lung Institute, London, UK
    Prim Care Respir J 17:176-80. 2008
    ....
  90. doi request reprint Bronchial provocation testing with dry powder mannitol in children with cystic fibrosis
    Caro Minasian
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital and Imperial College, London, UK
    Pediatr Pulmonol 43:1078-84. 2008
    ..To date there have been no studies exclusively in children with CF examining the effect of dry powder mannitol on the airways. The aim of this study was to determine acute tolerability of inhaled mannitol in children with CF...
  91. doi request reprint Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis
    Nicolas Regamey
    Department of Gene Therapy, National Heart and Lung Institute, 1B Manresa Road, London SW3 6LR, UK
    Am J Respir Crit Care Med 177:837-43. 2008
    ..Structural alterations to airway smooth muscle (ASM) are a feature of asthma and cystic fibrosis (CF) in adults...
  92. ncbi request reprint Treatment options of asthma in infancy
    Andrew Bush
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Pediatr Pulmonol Suppl 26:20-2. 2004
  93. ncbi request reprint Airway function measurements and the long-term follow-up of survivors of preterm birth with and without chronic lung disease
    Indra Narang
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 41:497-508. 2006
    ..This paper further considers the long-term implications of these studies for both future research and clinical practice...
  94. doi request reprint A large-scale, consortium-based genomewide association study of asthma
    Miriam F Moffatt
    National Heart and Lung Institute, Imperial College, London, United Kingdom
    N Engl J Med 363:1211-21. 2010
    ..Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease...
  95. ncbi request reprint Increased leukotrienes in exhaled breath condensate in childhood asthma
    Zsuzsanna Csoma
    Department of Thoracic Medicine and Department of Pediatric Respiratory Care, Imperial College School of Medicine, National Heart and Lung Institute, London, United Kingdom
    Am J Respir Crit Care Med 166:1345-9. 2002
    ..05). There was an inverse correlation between exhaled cys-LTs and LTB4 in patients with mild persistent asthma. We conclude that exhaled cys-LTs and LTB4 may be noninvasive markers of airway inflammation in pediatric asthma...
  96. ncbi request reprint Does sputum eosinophilia predict the response to systemic corticosteroids in children with difficult asthma?
    Christiane Lex
    Department of Paediatric Respiratory Medicine, Imperial College of Science, Technology and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, London, United Kingdom
    Pediatr Pulmonol 42:298-303. 2007
    ..25 [0-91]%) or the "non-eosinophilic" group (27.5 [0-96] vs. 44 [9-96]%). In conclusion children with difficult asthma may benefit clinically from high-dose systemic corticosteroids even in the absence of sputum eosinophilia...
  97. ncbi request reprint Antiasthmatic drug delivery in children
    Elizabeth Biggart
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, United Kingdom
    Paediatr Drugs 4:85-93. 2002
    ..Nebulizers are being used much less frequently, and in particular, all but the most severe exacerbations can be treated at least as effectively with equivalent dosages of beta(2)-adrenoceptor agonists from a large volume spacer...
  98. ncbi request reprint Correlation between cough frequency and airway inflammation in children with primary ciliary dyskinesia
    Nadwa Zihlif
    Department of Paediatric Respiratory Medicine, Imperial School of Medicine at National Heart and Lung Institute, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 39:551-7. 2005
    ..693, P < 0.002), but not percent FEV(1) or eNO. Stable PCD children have increased cough frequency and neutrophilic airway inflammation. In conclusion, cough frequency correlated with sputum neutrophils but not with FEV1 or eNO...
  99. ncbi request reprint Markers of airway inflammation in primary ciliary dyskinesia studied using exhaled breath condensate
    Nadwa Zihlif
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 41:509-14. 2006
    ..The mechanism of airway neutrophilia is unclear, but is unlikely to be related to increased production of LTB4, at least in stable PCD patients...
  100. doi request reprint Severe childhood asthma: a common international approach?
    Andrew Bush
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London SW3 6JJ, UK
    Lancet 372:1019-21. 2008
  101. ncbi request reprint Comparison of active cycle of breathing and high-frequency oscillation jacket in children with cystic fibrosis
    Gillian E Phillips
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 37:71-5. 2004
    ..Pulmonary function did not change at any time following HFCC. Compared with ACBT, HFCC by Hayek Cuirass is not an effective airway clearance treatment modality for children with CF during an infective exacerbation...