Affiliation: Royal Brompton Hospital
- Local radiological staging of rectal cancerG Brown
Department of Diagnostic Radiology, The Royal Marsden Hospital NHS Trust, Downs Road, Sutton, Surrey, UK
Clin Radiol 59:213-4. 2004
- Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histopathologic comparisonGina Brown
University Hospital of Wales and Llandough Hospital NHS Trust, University of Wales College of Medicine, Cardiff, England
Radiology 227:371-7. 2003..To evaluate signal intensity and border characteristics of lymph nodes at high-spatial-resolution magnetic resonance (MR) imaging in patients with rectal cancer and to compare these findings with size in prediction of nodal status...
- Preoperative staging of rectal cancer: the MERCURY research projectG Brown
Department of Radiology, The Royal Marsden Hospital, Downs Road, Sutton SM2 5PT, UK
Recent Results Cancer Res 165:58-74. 2005....
- Preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imagingG Brown
Cardiff and the Vale NHS Trust, University of Wales College of Medicine, Cardiff, UK
Br J Surg 90:355-64. 2003..The aim was to determine the accuracy of preoperative magnetic resonance imaging (MRI) in the evaluation of pathological prognostic factors that influence local recurrence and survival in rectal cancer...
- CT detection of hydronephrosis in resected colorectal cancer: a predictor of recurrent diseaseG Brown
Department of Diagnostic Radiology, Royal Marsden Hospital, London, UK
Clin Radiol 58:137-42. 2003..To investigate the causes and significance of hydronephrosis in follow-up of colorectal cancer...
- Effectiveness of preoperative staging in rectal cancer: digital rectal examination, endoluminal ultrasound or magnetic resonance imaging?G Brown
Department of Radiology, University Hospital of Wales, Cardiff, Wales, UK
Br J Cancer 91:23-9. 2004..Magnetic resonance imaging dominated both DRE and EUS on cost and clinical effectiveness by selecting appropriate patients for neoadjuvant therapy and justifies its use for local staging of rectal cancer patients...
- High-resolution MRI of the anatomy important in total mesorectal excision of the rectumGina Brown
Department of Radiology, Cardiff and the Vale NHS Trust, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XW, Wales
AJR Am J Roentgenol 182:431-9. 2004..Anatomic dissections of sagitally sectioned hemipelves were compared with MRIs obtained in vivo to establish criteria for visualization of the structures relevant to anterior resection of the rectum...
- Multicenter randomized phase II clinical trial comparing neoadjuvant oxaliplatin, capecitabine, and preoperative radiotherapy with or without cetuximab followed by total mesorectal excision in patients with high-risk rectal cancer (EXPERT-C)Alice Dewdney
Department of Medicine, Royal Marsden Hospital, Surrey, UK
J Clin Oncol 30:1620-7. 2012..To evaluate the addition of cetuximab to neoadjuvant chemotherapy before chemoradiotherapy in high-risk rectal cancer...
- Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: a phase 2 trialYu Jo Chua
Department of Medicine, Royal Marsden Hospital, Sutton, Surrey, UK
Lancet Oncol 11:241-8. 2010....
- Diagnostic accuracy of nodal enhancement pattern of rectal cancer at MRI enhanced with ultrasmall superparamagnetic iron oxide: findings in pathologically matched mesorectal lymph nodesDow Mu Koh
Department of Radiology, Royal Marsden Hospital, Sutton, Surrey SM2 5PT, United Kingdom
AJR Am J Roentgenol 194:W505-13. 2010....
- Timing of surgery following preoperative therapy in rectal cancer: the need for a prospective randomized trial?Jessica Evans
1 Departments of Surgery and Radiology, Royal Marsden Hospital, London, United Kingdom
Dis Colon Rectum 54:1251-9. 2011..In rectal cancer, the standard of care after the completion of radiotherapy is surgery at 6 to 8 weeks. However, there is variation regarding the timing of surgery...
- Rectal cancer: primary staging and assessment after chemoradiotherapyJessica Evans
Royal Marsden Hospital, Surrey, England
Semin Radiat Oncol 21:169-77. 2011....
- Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancerIan Chau
Department of Medicine, Royal Marsden Hospital, London, United Kingdom
J Clin Oncol 24:668-74. 2006..CONCLUSION: Capecitabine/oxaliplatin before synchronous CRT and TME results in substantial tumor regression, rapid symptomatic response, and achievement of R0 resection...
- Nanoparticles in rectal cancer imagingDow Mu Koh
Department of Radiology, Royal Marsden Hospital, Surrey, UK
Cancer Biomark 5:89-98. 2009..In this article, we discuss the challenges to accurate nodal staging of patients with rectal cancer, and demonstrate how USPIO may be applied to rectal cancer imaging to identify nodal involvement...
- Extended lymphadenectomy versus conventional surgery for rectal cancer: a meta-analysisPanagiotis Georgiou
Department of Biosurgery and Surgical Technology, Imperial College, Chelsea and Westminster Campus, London, UK
Lancet Oncol 10:1053-62. 2009..A meta-analysis was undertaken to assess the value of extended lateral pelvic lymphadenectomy in the operative management of rectal cancer...
- Non-operative treatment after neoadjuvant chemoradiotherapy for rectal cancerBrian D P O'Neill
Department of Clinical Oncology, Royal Marsden Hospital, Sutton, Surrey, UK
Lancet Oncol 8:625-33. 2007....
- MRI after treatment of locally advanced rectal cancer: how to report tumor response--the MERCURY experienceUday B Patel
Department of Radiology, Royal Marsden Hospital, Downs Rd, Sutton SM2 5PT, United Kingdom
AJR Am J Roentgenol 199:W486-95. 2012..CONCLUSION: In this article we report a validated systematic approach to the interpretation of MR images of patients with rectal cancer after chemoradiation...
- Staging rectal cancer: endoscopic ultrasound and pelvic MRIGina Brown
The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK
Cancer Imaging 8:S43-5. 2008..Careful staging of rectal tumours results in selective pre-operative treatment strategies aimed at reducing local failure and distant failure in high risk patients...
- CT staging of colon cancerS Dighe
Department of Radiology, Royal Marsden Hospital, Sutton SM5 2TT, UK
Clin Radiol 63:1372-9. 2008..The aim of this review is to explain the process of identifying high-risk features seen on the staging CT images. This will help to identify a cohort of patients that could truly benefit from neoadjuvant strategies...
- The value of routine serum carcino-embryonic antigen measurement and computed tomography in the surveillance of patients after adjuvant chemotherapy for colorectal cancerIan Chau
Department of Medicine, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK
J Clin Oncol 22:1420-9. 2004..1%) in the symptomatic group (CT v symptomatic, P <.001; CEA v symptomatic, P =.015). CONCLUSION: Surveillance CT and CEA are valuable components of postoperative follow-up in stage II and III colorectal cancer...
- Laparoscopic surgery for rectal cancerManish Chand
Royal Marsden Hospital, Specialist Registrar Surgery, Sutton SM2 5PT, UK
J R Soc Med 105:429-35. 2012..We present the challenges associated with laparoscopic rectal cancer surgery and explain that appropriate patient selection, surgical planning and laparoscopic experience are the key to successful outcomes...
- Potential of surface-coil MRI for staging of esophageal cancerAngela M Riddell
Department of Diagnostic Radiology, The Royal Marsden Hospital, Downs Road, Sutton, Surrey, London, United Kingdom, SM2 5PT
AJR Am J Roentgenol 187:1280-7. 2006..This study illustrates the potential of the technique as an alternative form of local staging for esophageal cancer...
- Nodal staging in rectal cancerD M Koh
Academic Department of Radiology, Royal Marsden Hospital, Downs Road, Sutton SM2 5PT, UK
Abdom Imaging 31:652-9. 2006..The use of morphological criteria instead of size criteria has been shown to improve nodal staging by MRI. The potential role of magnetic resonance lymphography and PET imaging in further improving nodal staging accuracy is discussed...
- The use of 18F-FDG PET/CT in colorectal liver metastases--comparison with CT and liver MRIG Kong
Department of Nuclear Medicine and PET, The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK
Eur J Nucl Med Mol Imaging 35:1323-9. 2008....
- Thin section MRI in multidisciplinary pre-operative decision making for patients with rectal cancerG Brown
Department of Radiology, The Royal Marsden NHS Foundation Trust, Downs Road, Sutton SM2 5PT, UK
Br J Radiol 78:S117-27. 2005..Use of standardized criteria for reporting is reproducible in the multicentre setting and pre-operative multidisciplinary discussion of the MRI features increases the number of operations performed with tumour-free resection margins...
- Rectal cancer: mesorectal lymph nodes at MR imaging with USPIO versus histopathologic findings--initial observationsDow Mu Koh
Department of Academic Radiology and Medical Statistics, Royal Marsden Hospital, Downs Rd, Sutton SM2 5PT, England
Radiology 231:91-9. 2004..To compare histopathologic findings with appearances of mesorectal lymph nodes at magnetic resonance (MR) imaging with ultrasmall particles of iron oxide (USPIO) in rectal cancer...
- Preoperative High-resolution Magnetic Resonance Imaging Can Identify Good Prognosis Stage I, II, and III Rectal Cancer Best Managed by Surgery Alone: A Prospective, Multicenter, European StudyFiona G M Taylor
Mayday University Hospital, 530 London Road, Croydon, Surrey, UK Pathology and Tumor Biology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK Pelican Cancer Foundation, North Hampshire Hospital, Basingstoke, Hampshire, UK Karolinska University Hospital, Stockholm, Sweden St James s Institute of Oncology, Saint James University Hospital, Leeds, UK The Royal Marsden NHS Foundation Trust, London, UK The Royal Marsden Hospital, Downs Road, Sutton, UK
Ann Surg 253:711-9. 2011..To assess local recurrence, disease-free survival, and overall survival in magnetic resonance imaging (MRI)-predicted good prognosis tumors treated by surgery alone...
- MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins?S Burton
Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK
Br J Cancer 94:351-7. 2006..In conclusion, MDT discussion of MRI and implementation of a preoperative treatment strategy results in significantly reduced positive CRM in rectal cancer patients...
- Diagnostic precision of CT in local staging of colon cancers: a meta-analysisS Dighe
Department of Radiology, Royal Marsden Hospital, Sutton, UK
Clin Radiol 65:708-19. 2010..To determine the accuracy of computed tomography (CT) in detecting disease with invasion beyond the muscularis propria (MP) and malignant lymph nodes...
- Diagnostic accuracy and value of magnetic resonance imaging (MRI) in planning exenterative pelvic surgery for advanced colorectal cancerPanagiotis A Georgiou
Department of Colorectal Surgery, The Royal Marsden NHS Foundation Trust, Fulham Road, London, UK Department of Surgery and Cancer, Imperial College, Chelsea and Westminster Campus, London, UK
Eur J Cancer 49:72-81. 2013..To assess the diagnostic accuracy of magnetic resonance imaging (MRI) in detecting colorectal tumour invasion according to seven intrapelvic compartments for planning exenterative pelvic surgery...
- Sites of surgical wasting in the abdominoperineal specimenG Salerno
Pelican Cancer Foundation, North Hampshire Hospital, Basingstoke, London, UK
Br J Surg 95:1147-54. 2008..This is associated with high positive margin rates. The aim of this study was to locate the site of surgical wasting, namely the least amount of tissue excised at APE...
- Defining patient outcomes in stage IV colorectal cancer: a prospective study with baseline stratification according to disease resectability statusD J Watkins
Department of Medicine, Royal Marsden Hospital, London and Surrey, UK
Br J Cancer 102:255-61. 2010..In a phase II study primarily designed to assess the efficacy of capecitabine and oxaliplatin, we were able to prospectively examine the outcomes of patients with stage IV colorectal cancer according to the baseline resectability status...
- Techniques and trouble-shooting in high spatial resolution thin slice MRI for rectal cancerG Brown
Department of Radiology, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK
Br J Radiol 78:245-51. 2005....
- The appearances of oesophageal carcinoma demonstrated on high-resolution, T2-weighted MRI, with histopathological correlationA M Riddell
Department of Radiology, Royal Marsden Hospital NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK
Eur Radiol 17:391-9. 2007....
- A retrospective study comparing the individual modalities of triple assessment in the pre-operative diagnosis of invasive lobular breast carcinomaS M Tan
Department of Surgery, Royal Marsden Hospital, London, UK
Eur J Surg Oncol 28:203-8. 2002..CONCLUSION: Triple assessment is useful in the diagnosis of ILC. As the features of ILC may be subtle, a high index of suspicion is required to facilitate early diagnosis...
- Diffusion MRI for prediction of response of rectal cancer to chemoradiationAndrzej Dzik-Jurasz
UK Cancer Research Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Royal Marsden NHS Trust, Downs Road, Sutton SM2 5PT, UK
Lancet 360:307-8. 2002..67, p=0.01) and chemoradiation (r=-0.83, p=0.001). Persistence of low ADC in responders after chemotherapy could represent loss of a non-viable fraction of the treated tumour...
- A phase II trial evaluating capecitabine and irinotecan as second line treatment in patients with oesophago-gastric cancer who have progressed on, or within 3 months of platinum-based chemotherapyAlexandra Leary
Department of Medicine, Royal Marsden Hospital, Sutton, London, Surrey, UK
Cancer Chemother Pharmacol 64:455-62. 2009..There is no standard second line therapy for relapsed oesophago-gastric (O-G) cancer...
- Neoadjuvant systemic fluorouracil and mitomycin C prior to synchronous chemoradiation is an effective strategy in locally advanced rectal cancerI Chau
Department of Medicine, Royal Marsden Hospital, Sutton, Surrey, UK
Br J Cancer 88:1017-24. 2003..Neoadjuvant systemic chemotherapy as a prelude to synchronous chemoradiation can be administered with negligible risk of disease progression and produces considerable symptomatic response with associated tumour regression...
- Phase II study of irinotecan and 5-fluorouracil/leucovorin in patients with primary refractory or relapsed advanced oesophageal and gastric carcinomaL Assersohn
Royal Marsden Hospital, London and Sutton, Surrey, UK
Ann Oncol 15:64-9. 2004..2% and diarrhoea 7.9%. Median failure-free survival was 3.7 months and median overall survival was 6.4 months. CONCLUSION: 5-FU/irinotecan is a valuable regimen for second-line treatment in 5-FU/platinum-resistant O-G carcinoma...
- Distribution of mesorectal lymph nodes in rectal cancer: in vivo MR imaging compared with histopathological examination. Initial observationsD M Koh
Academic Department of Radiology, Cancer Research UK Magnetic Resonance Group, Institute of Cancer Research, Royal Marsden Hospital, Downs Road, Sutton, SM2 5PT, UK
Eur Radiol 15:1650-7. 2005..Almost all mesorectal nodes visible on MR imaging were found at the level of tumour or within 5 cm proximal to the tumour. This has implications for the planning of MR imaging and the level of mesorectal transection at surgery...
- Endorectal ultrasound and magnetic resonance imaging in rectal cancer stagingClive Bartram
Imperial College School of Medicine and St Mark s Hospital, Northwick Park, Harrow HA1 3UJ, UK
Gastroenterol Clin North Am 31:827-39. 2002..The assessment of residual tumor after chemoradiotherapy remains difficult; PET scanning has been used in this situation , but has not been compared with MRI and is unlikely to show only residual cells with extensive fibrosis...
- Preoperative radiotherapy for rectal cancerGisella Salerno
J R Soc Med 97:361-2. 2004
- Evaluating mesorectal lymph nodes in rectal cancer before and after neoadjuvant chemoradiation using thin-section T2-weighted magnetic resonance imagingDow Mu Koh
Academic Department of Radiology, The Royal Marsden Hospital, Sutton, United Kingdom
Int J Radiat Oncol Biol Phys 71:456-61. 2008....
- Management and imaging of low rectal carcinomaGisella Salerno
Pelican Cancer Foundation, Basingstoke, Hants, UK
Surg Oncol 13:55-61. 2004..Surface coil MRI is the most promising modality for patient selection, which can provide good views of the circumferential resection margin especially the presence or absence of tumour encroaching the intersphincteric plane...
- Preoperative staging of rectal cancerNeil Smith
Royal Marsden Hospital Colorectal Cancer Network, Department of Colorectal Surgery, Croydon, Surrey, UK
Acta Oncol 47:20-31. 2008..The optimal pre-operative treatment regimes for these patients (radiotherapy alone, systemic chemotherapy alone or combination chemo-radiotherapy) is the subject of current and future trials...
- Circumferential resection margin assessment on MRI of rectal cancerStyliani Petroudi
Dept of Eng Sci, Oxford Univ, UK
Conf Proc IEEE Eng Med Biol Soc 1:4881-4. 2006..Prior to this, we segment the rectum and mesorectum. Preliminary results are reported for 10 patient cases, and a further large set are currently being analysed and results will be available at the time of the conference...
- Colorectal cancer imagingLennart Blomqvist
AJR Am J Roentgenol 182:1600-1. 2004
- MRI identified prognostic features of tumors in distal sigmoid, rectosigmoid, and upper rectum: treatment with radiotherapy and chemotherapySarah Burton
Division of Colorectal Surgery, Mayday University Hospital, Croydon, UK
Int J Radiat Oncol Biol Phys 65:445-51. 2006....
- Diagnostic accuracy of rim and segmental MRI enhancement of colorectal hepatic metastasis after administration of mangafodipir trisodiumDow Mu Koh
Academic Department of Radiology, Royal Marsden Hospital, Downs Rd, Sutton, Surrey, United Kingdom SM2 5PT
AJR Am J Roentgenol 188:W154-61. 2007..The purpose of this study was to determine the diagnostic accuracy of rim and segmental MRI enhancement of hepatic metastasis of colorectal cancer after administration of mangafodipir trisodium (MnDPDP)...
- MRI in predicting curative resection of rectal cancer: new dilemma in multidisciplinary team managementR J Heald
BMJ 333:808. 2006