Gina Brown

Summary

Affiliation: Royal Brompton Hospital
Country: UK

Publications

  1. ncbi request reprint Local radiological staging of rectal cancer
    G Brown
    Department of Diagnostic Radiology, The Royal Marsden Hospital NHS Trust, Downs Road, Sutton, Surrey, UK
    Clin Radiol 59:213-4. 2004
  2. pmc MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins?
    S Burton
    Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK
    Br J Cancer 94:351-7. 2006
  3. ncbi request reprint Preoperative staging of rectal cancer: the MERCURY research project
    G Brown
    Department of Radiology, The Royal Marsden Hospital, Downs Road, Sutton SM2 5PT, UK
    Recent Results Cancer Res 165:58-74. 2005
  4. pmc Effectiveness of preoperative staging in rectal cancer: digital rectal examination, endoluminal ultrasound or magnetic resonance imaging?
    G Brown
    Department of Radiology, University Hospital of Wales, Cardiff, Wales, UK
    Br J Cancer 91:23-9. 2004
  5. ncbi request reprint High-resolution MRI of the anatomy important in total mesorectal excision of the rectum
    Gina Brown
    Department of Radiology, Cardiff and the Vale NHS Trust, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XW, Wales
    AJR Am J Roentgenol 182:431-9. 2004
  6. ncbi request reprint Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histopathologic comparison
    Gina Brown
    University Hospital of Wales and Llandough Hospital NHS Trust, University of Wales College of Medicine, Cardiff, England
    Radiology 227:371-7. 2003
  7. ncbi request reprint CT detection of hydronephrosis in resected colorectal cancer: a predictor of recurrent disease
    G Brown
    Department of Diagnostic Radiology, Royal Marsden Hospital, London, UK
    Clin Radiol 58:137-42. 2003
  8. ncbi request reprint Preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging
    G Brown
    Cardiff and the Vale NHS Trust, University of Wales College of Medicine, Cardiff, UK
    Br J Surg 90:355-64. 2003
  9. doi request reprint Multicenter randomized phase II clinical trial comparing neoadjuvant oxaliplatin, capecitabine, and preoperative radiotherapy with or without cetuximab followed by total mesorectal excision in patients with high-risk rectal cancer (EXPERT-C)
    Alice Dewdney
    Department of Medicine, Royal Marsden Hospital, Surrey, UK
    J Clin Oncol 30:1620-7. 2012
  10. doi request reprint Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: a phase 2 trial
    Yu Jo Chua
    Department of Medicine, Royal Marsden Hospital, Sutton, Surrey, UK
    Lancet Oncol 11:241-8. 2010

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Local radiological staging of rectal cancer
    G Brown
    Department of Diagnostic Radiology, The Royal Marsden Hospital NHS Trust, Downs Road, Sutton, Surrey, UK
    Clin Radiol 59:213-4. 2004
  2. pmc MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins?
    S Burton
    Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK
    Br J Cancer 94:351-7. 2006
    ..In conclusion, MDT discussion of MRI and implementation of a preoperative treatment strategy results in significantly reduced positive CRM in rectal cancer patients...
  3. ncbi request reprint Preoperative staging of rectal cancer: the MERCURY research project
    G Brown
    Department of Radiology, The Royal Marsden Hospital, Downs Road, Sutton SM2 5PT, UK
    Recent Results Cancer Res 165:58-74. 2005
    ....
  4. pmc Effectiveness of preoperative staging in rectal cancer: digital rectal examination, endoluminal ultrasound or magnetic resonance imaging?
    G Brown
    Department of Radiology, University Hospital of Wales, Cardiff, Wales, UK
    Br J Cancer 91:23-9. 2004
    ..Magnetic resonance imaging dominated both DRE and EUS on cost and clinical effectiveness by selecting appropriate patients for neoadjuvant therapy and justifies its use for local staging of rectal cancer patients...
  5. ncbi request reprint High-resolution MRI of the anatomy important in total mesorectal excision of the rectum
    Gina Brown
    Department of Radiology, Cardiff and the Vale NHS Trust, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XW, Wales
    AJR Am J Roentgenol 182:431-9. 2004
    ..Anatomic dissections of sagitally sectioned hemipelves were compared with MRIs obtained in vivo to establish criteria for visualization of the structures relevant to anterior resection of the rectum...
  6. ncbi request reprint Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histopathologic comparison
    Gina Brown
    University Hospital of Wales and Llandough Hospital NHS Trust, University of Wales College of Medicine, Cardiff, England
    Radiology 227:371-7. 2003
    ..To evaluate signal intensity and border characteristics of lymph nodes at high-spatial-resolution magnetic resonance (MR) imaging in patients with rectal cancer and to compare these findings with size in prediction of nodal status...
  7. ncbi request reprint CT detection of hydronephrosis in resected colorectal cancer: a predictor of recurrent disease
    G Brown
    Department of Diagnostic Radiology, Royal Marsden Hospital, London, UK
    Clin Radiol 58:137-42. 2003
    ..To investigate the causes and significance of hydronephrosis in follow-up of colorectal cancer...
  8. ncbi request reprint Preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging
    G Brown
    Cardiff and the Vale NHS Trust, University of Wales College of Medicine, Cardiff, UK
    Br J Surg 90:355-64. 2003
    ..The aim was to determine the accuracy of preoperative magnetic resonance imaging (MRI) in the evaluation of pathological prognostic factors that influence local recurrence and survival in rectal cancer...
  9. doi request reprint Multicenter randomized phase II clinical trial comparing neoadjuvant oxaliplatin, capecitabine, and preoperative radiotherapy with or without cetuximab followed by total mesorectal excision in patients with high-risk rectal cancer (EXPERT-C)
    Alice Dewdney
    Department of Medicine, Royal Marsden Hospital, Surrey, UK
    J Clin Oncol 30:1620-7. 2012
    ..To evaluate the addition of cetuximab to neoadjuvant chemotherapy before chemoradiotherapy in high-risk rectal cancer...
  10. doi request reprint Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: a phase 2 trial
    Yu Jo Chua
    Department of Medicine, Royal Marsden Hospital, Sutton, Surrey, UK
    Lancet Oncol 11:241-8. 2010
    ....
  11. doi request reprint Diagnostic accuracy of nodal enhancement pattern of rectal cancer at MRI enhanced with ultrasmall superparamagnetic iron oxide: findings in pathologically matched mesorectal lymph nodes
    Dow Mu Koh
    Department of Radiology, Royal Marsden Hospital, Sutton, Surrey SM2 5PT, United Kingdom
    AJR Am J Roentgenol 194:W505-13. 2010
    ....
  12. doi request reprint Evaluating mesorectal lymph nodes in rectal cancer before and after neoadjuvant chemoradiation using thin-section T2-weighted magnetic resonance imaging
    Dow Mu Koh
    Academic Department of Radiology, The Royal Marsden Hospital, Sutton, United Kingdom
    Int J Radiat Oncol Biol Phys 71:456-61. 2008
    ....
  13. doi request reprint Preoperative magnetic resonance imaging assessment of circumferential resection margin predicts disease-free survival and local recurrence: 5-year follow-up results of the MERCURY study
    Fiona G M Taylor
    Fiona G M Taylor and Ian R Swift, Mayday University Hospital, Croydon Gina Brown, The Royal Marsden National Health Service NHS Foundation Trust, Sutton, Surrey Philip Quirke, Leeds Institute of Molecular Medicine, University of Leeds David Sebag Montefiore, St James s Institute of Oncology Bexley Wing, St James University Hospital, Leeds Richard J Heald and Brendan J Moran, Pelican Cancer Foundation, North Hampshire Hospital, Basingstoke, Hampshire Paris Tekkis, The Royal Marsden NHS Foundation Trust, London, United Kingdom and Lennart Blomqvist, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden
    J Clin Oncol 32:34-43. 2014
    ....
  14. doi request reprint Dose finding and early efficacy study of gemcitabine plus capecitabine in combination with bevacizumab plus erlotinib in advanced pancreatic cancer
    Naureen Starling
    Department of Medicine, Royal Marsden Hospital, Downs Rd, Sutton, Surrey SM2 5PT, United Kingdom
    J Clin Oncol 27:5499-505. 2009
    ....
  15. ncbi request reprint Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer
    Ian Chau
    Department of Medicine, Royal Marsden Hospital, London, United Kingdom
    J Clin Oncol 24:668-74. 2006
    ..To evaluate neoadjuvant capecitabine/oxaliplatin before chemoradiotherapy (CRT) and total mesorectal excision (TME) in newly diagnosed patients with magnetic resonance imaging (MRI) -defined poor-risk rectal cancer...
  16. doi request reprint Rectal cancer: primary staging and assessment after chemoradiotherapy
    Jessica Evans
    Royal Marsden Hospital, Surrey, England
    Semin Radiat Oncol 21:169-77. 2011
    ....
  17. doi request reprint Timing of surgery following preoperative therapy in rectal cancer: the need for a prospective randomized trial?
    Jessica Evans
    1 Departments of Surgery and Radiology, Royal Marsden Hospital, London, United Kingdom
    Dis Colon Rectum 54:1251-9. 2011
    ..In rectal cancer, the standard of care after the completion of radiotherapy is surgery at 6 to 8 weeks. However, there is variation regarding the timing of surgery...
  18. doi request reprint Indications and outcome of pelvic exenteration for locally advanced primary and recurrent rectal cancer
    Aneel Bhangu
    Department of Colorectal Surgery, The Royal Marsden Hospital, London Division of Surgery, Chelsea and Westminster Campus, Imperial College London, London Department of Radiology, The Royal Marsden Hospital, London and Division of Surgery, Imperial College, St Mary s Hospital, London
    Ann Surg 259:315-22. 2014
    ..The outcome of pelvic exenteration was compared in patients with locally advanced primary (LAP) cancer and recurrent rectal cancer (RRC)...
  19. doi request reprint Survival outcome of local excision versus radical resection of colon or rectal carcinoma: a Surveillance, Epidemiology, and End Results (SEER) population-based study
    Aneel Bhangu
    Department of Colorectal Surgery, Royal Marsden Hospital, Fulham Road, London, UK Division of Surgery, Imperial College, Chelsea and Westminster Campus, London, UK Department of Radiology, Royal Marsden Hospital, Fulham Road, London, UK Division of Surgery, Imperial College, St Mary s Hospital, London, UK Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Ann Surg 258:563-9; discussion 569-71. 2013
    ..To compare cancer-specific results of local excision with major resection...
  20. ncbi request reprint Comparison of magnetic resonance imaging and histopathological response to chemoradiotherapy in locally advanced rectal cancer
    Uday Bharat Patel
    Department of Radiology, The Royal Marsden Hospital, Sutton, UK
    Ann Surg Oncol 19:2842-52. 2012
    ..We compared these methods in identifying good versus poor responders with the histopathological standards of T stage (ypT) and tumor regression grading (TRG)...
  21. ncbi request reprint Survival after resection of colorectal cancer based on anatomical segment of involvement
    Aneel Bhangu
    Department of Colorectal Surgery, Royal Marsden Hospital, London, UK
    Ann Surg Oncol 20:4161-8. 2013
    ..To determine survival differences for patients undergoing colonic or rectal resection for cancer on the basis of the specific anatomical location of primary tumor...
  22. doi request reprint Nanoparticles in rectal cancer imaging
    Dow Mu Koh
    Department of Radiology, Royal Marsden Hospital, Surrey, UK
    Cancer Biomark 5:89-98. 2009
    ..In this article, we discuss the challenges to accurate nodal staging of patients with rectal cancer, and demonstrate how USPIO may be applied to rectal cancer imaging to identify nodal involvement...
  23. ncbi request reprint Diagnostic accuracy of rim and segmental MRI enhancement of colorectal hepatic metastasis after administration of mangafodipir trisodium
    Dow Mu Koh
    Academic Department of Radiology, Royal Marsden Hospital, Downs Rd, Sutton, Surrey, United Kingdom SM2 5PT
    AJR Am J Roentgenol 188:W154-61. 2007
    ..The purpose of this study was to determine the diagnostic accuracy of rim and segmental MRI enhancement of hepatic metastasis of colorectal cancer after administration of mangafodipir trisodium (MnDPDP)...
  24. ncbi request reprint Non-operative treatment after neoadjuvant chemoradiotherapy for rectal cancer
    Brian D P O'Neill
    Department of Clinical Oncology, Royal Marsden Hospital, Sutton, Surrey, UK
    Lancet Oncol 8:625-33. 2007
    ....
  25. doi request reprint Extended lymphadenectomy versus conventional surgery for rectal cancer: a meta-analysis
    Panagiotis Georgiou
    Department of Biosurgery and Surgical Technology, Imperial College, Chelsea and Westminster Campus, London, UK
    Lancet Oncol 10:1053-62. 2009
    ..A meta-analysis was undertaken to assess the value of extended lateral pelvic lymphadenectomy in the operative management of rectal cancer...
  26. ncbi request reprint MRI after treatment of locally advanced rectal cancer: how to report tumor response--the MERCURY experience
    Uday B Patel
    Department of Radiology, Royal Marsden Hospital, Downs Rd, Sutton SM2 5PT, United Kingdom
    AJR Am J Roentgenol 199:W486-95. 2012
    ....
  27. pmc Staging rectal cancer: endoscopic ultrasound and pelvic MRI
    Gina Brown
    The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK
    Cancer Imaging 8:S43-5. 2008
    ..Careful staging of rectal tumours results in selective pre-operative treatment strategies aimed at reducing local failure and distant failure in high risk patients...
  28. doi request reprint CT staging of colon cancer
    S Dighe
    Department of Radiology, Royal Marsden Hospital, Sutton SM5 2TT, UK
    Clin Radiol 63:1372-9. 2008
    ..The aim of this review is to explain the process of identifying high-risk features seen on the staging CT images. This will help to identify a cohort of patients that could truly benefit from neoadjuvant strategies...
  29. doi request reprint Chemoradiotherapy response in recurrent rectal cancer
    Stanley K T Yu
    Radiotherapy Department, Royal Marsden NHS Foundation Trust, Sutton, London, UK
    Cancer Med 3:111-7. 2014
    ..Recurrent rectal cancer appears radioresistant compared with primary tumors for tumor size after CRT. Further investigation into improving/intensifying chemotherapy and radiotherapy for locally recurrent rectal cancer is justified...
  30. doi request reprint Perfusion CT vascular parameters do not correlate with immunohistochemically derived microvessel density count in colorectal tumors
    Shwetal Dighe
    Department of Surgery, Mayday University Hospital NHS Trust, Croydon, London, England
    Radiology 268:400-10. 2013
    ....
  31. ncbi request reprint The value of routine serum carcino-embryonic antigen measurement and computed tomography in the surveillance of patients after adjuvant chemotherapy for colorectal cancer
    Ian Chau
    Department of Medicine, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK
    J Clin Oncol 22:1420-9. 2004
    ..This analysis aims to evaluate routine carcino-embryonic antigen (CEA) and computed tomography (CT) of thorax, abdomen, and pelvis as part of protocol-specified follow-up policy for colorectal cancer (CRC)...
  32. ncbi request reprint Development and implementation of a synoptic MRI report for preoperative staging of rectal cancer on a population-based level
    Erin D Kennedy
    1Department of Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada 2Zane Cohen Centre for Digestive Diseases, Toronto, Ontario, Canada 3Department of Medicine, University of Toronto, Toronto, Ontario, Canada 4Institute of the Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada 5Department of Medical Imaging, Sunnybrook Health Science Centre, Toronto, Ontario, Canada 6Department of Medical Imaging, Saint Joseph s Health Centre, Toronto, Ontario, Canada 7Department of Medical Imaging, The Royal Marsden Hospital, London, United Kingdom 8Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    Dis Colon Rectum 57:700-8. 2014
    ....
  33. pmc Laparoscopic surgery for rectal cancer
    Manish Chand
    Royal Marsden Hospital, Specialist Registrar Surgery, Sutton SM2 5PT, UK
    J R Soc Med 105:429-35. 2012
    ..We present the challenges associated with laparoscopic rectal cancer surgery and explain that appropriate patient selection, surgical planning and laparoscopic experience are the key to successful outcomes...
  34. ncbi request reprint Potential of surface-coil MRI for staging of esophageal cancer
    Angela M Riddell
    Department of Diagnostic Radiology, The Royal Marsden Hospital, Downs Road, Sutton, Surrey, London, United Kingdom, SM2 5PT
    AJR Am J Roentgenol 187:1280-7. 2006
    ..The aim of this pilot study was to assess the feasibility of external surface-coil MRI as a new method of imaging the esophagus and esophageal cancer...
  35. ncbi request reprint Thin section MRI in multidisciplinary pre-operative decision making for patients with rectal cancer
    G Brown
    Department of Radiology, The Royal Marsden NHS Foundation Trust, Downs Road, Sutton SM2 5PT, UK
    Br J Radiol 78:S117-27. 2005
    ..Use of standardized criteria for reporting is reproducible in the multicentre setting and pre-operative multidisciplinary discussion of the MRI features increases the number of operations performed with tumour-free resection margins...
  36. ncbi request reprint Nodal staging in rectal cancer
    D M Koh
    Academic Department of Radiology, Royal Marsden Hospital, Downs Road, Sutton SM2 5PT, UK
    Abdom Imaging 31:652-9. 2006
    ..The use of morphological criteria instead of size criteria has been shown to improve nodal staging by MRI. The potential role of magnetic resonance lymphography and PET imaging in further improving nodal staging accuracy is discussed...
  37. ncbi request reprint The use of 18F-FDG PET/CT in colorectal liver metastases--comparison with CT and liver MRI
    G Kong
    Department of Nuclear Medicine and PET, The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK
    Eur J Nucl Med Mol Imaging 35:1323-9. 2008
    ....
  38. doi request reprint Diagnostic accuracy and value of magnetic resonance imaging (MRI) in planning exenterative pelvic surgery for advanced colorectal cancer
    Panagiotis A Georgiou
    Department of Colorectal Surgery, The Royal Marsden NHS Foundation Trust, Fulham Road, London, UK
    Eur J Cancer 49:72-81. 2013
    ..To assess the diagnostic accuracy of magnetic resonance imaging (MRI) in detecting colorectal tumour invasion according to seven intrapelvic compartments for planning exenterative pelvic surgery...
  39. ncbi request reprint Preoperative High-resolution Magnetic Resonance Imaging Can Identify Good Prognosis Stage I, II, and III Rectal Cancer Best Managed by Surgery Alone: A Prospective, Multicenter, European Study
    Fiona G M Taylor
    Mayday University Hospital, 530 London Road, Croydon, Surrey, UK Pathology and Tumor Biology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK Pelican Cancer Foundation, North Hampshire Hospital, Basingstoke, Hampshire, UK Karolinska University Hospital, Stockholm, Sweden St James s Institute of Oncology, Saint James University Hospital, Leeds, UK The Royal Marsden NHS Foundation Trust, London, UK The Royal Marsden Hospital, Downs Road, Sutton, UK
    Ann Surg 253:711-9. 2011
    ..To assess local recurrence, disease-free survival, and overall survival in magnetic resonance imaging (MRI)-predicted good prognosis tumors treated by surgery alone...
  40. ncbi request reprint Rectal cancer: mesorectal lymph nodes at MR imaging with USPIO versus histopathologic findings--initial observations
    Dow Mu Koh
    Department of Academic Radiology and Medical Statistics, Royal Marsden Hospital, Downs Rd, Sutton SM2 5PT, England
    Radiology 231:91-9. 2004
    ..To compare histopathologic findings with appearances of mesorectal lymph nodes at magnetic resonance (MR) imaging with ultrasmall particles of iron oxide (USPIO) in rectal cancer...
  41. doi request reprint Diagnostic precision of CT in local staging of colon cancers: a meta-analysis
    S Dighe
    Department of Radiology, Royal Marsden Hospital, Sutton, UK
    Clin Radiol 65:708-19. 2010
    ..To determine the accuracy of computed tomography (CT) in detecting disease with invasion beyond the muscularis propria (MP) and malignant lymph nodes...
  42. pmc Defining patient outcomes in stage IV colorectal cancer: a prospective study with baseline stratification according to disease resectability status
    D J Watkins
    Department of Medicine, Royal Marsden Hospital, London and Surrey, UK
    Br J Cancer 102:255-61. 2010
    ..In a phase II study primarily designed to assess the efficacy of capecitabine and oxaliplatin, we were able to prospectively examine the outcomes of patients with stage IV colorectal cancer according to the baseline resectability status...
  43. ncbi request reprint A retrospective study comparing the individual modalities of triple assessment in the pre-operative diagnosis of invasive lobular breast carcinoma
    S M Tan
    Department of Surgery, Royal Marsden Hospital, London, UK
    Eur J Surg Oncol 28:203-8. 2002
    ..The aim of this study was to evaluate the accuracy of triple assessment in the pre-operative detection of patients identified to have ILC from their surgical pathology...
  44. ncbi request reprint Techniques and trouble-shooting in high spatial resolution thin slice MRI for rectal cancer
    G Brown
    Department of Radiology, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK
    Br J Radiol 78:245-51. 2005
    ....
  45. ncbi request reprint Sites of surgical wasting in the abdominoperineal specimen
    G Salerno
    Pelican Cancer Foundation, North Hampshire Hospital, Basingstoke, London, UK
    Br J Surg 95:1147-54. 2008
    ..This is associated with high positive margin rates. The aim of this study was to locate the site of surgical wasting, namely the least amount of tissue excised at APE...
  46. ncbi request reprint The appearances of oesophageal carcinoma demonstrated on high-resolution, T2-weighted MRI, with histopathological correlation
    A M Riddell
    Department of Radiology, Royal Marsden Hospital NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK
    Eur Radiol 17:391-9. 2007
    ....
  47. ncbi request reprint Diffusion MRI for prediction of response of rectal cancer to chemoradiation
    Andrzej Dzik-Jurasz
    UK Cancer Research Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Royal Marsden NHS Trust, Downs Road, Sutton SM2 5PT, UK
    Lancet 360:307-8. 2002
    ..67, p=0.01) and chemoradiation (r=-0.83, p=0.001). Persistence of low ADC in responders after chemotherapy could represent loss of a non-viable fraction of the treated tumour...
  48. ncbi request reprint Distribution of mesorectal lymph nodes in rectal cancer: in vivo MR imaging compared with histopathological examination. Initial observations
    D M Koh
    Academic Department of Radiology, Cancer Research UK Magnetic Resonance Group, Institute of Cancer Research, Royal Marsden Hospital, Downs Road, Sutton, SM2 5PT, UK
    Eur Radiol 15:1650-7. 2005
    ..Almost all mesorectal nodes visible on MR imaging were found at the level of tumour or within 5 cm proximal to the tumour. This has implications for the planning of MR imaging and the level of mesorectal transection at surgery...
  49. pmc Neoadjuvant systemic fluorouracil and mitomycin C prior to synchronous chemoradiation is an effective strategy in locally advanced rectal cancer
    I Chau
    Department of Medicine, Royal Marsden Hospital, Sutton, Surrey, UK
    Br J Cancer 88:1017-24. 2003
    ..Neoadjuvant systemic chemotherapy as a prelude to synchronous chemoradiation can be administered with negligible risk of disease progression and produces considerable symptomatic response with associated tumour regression...
  50. ncbi request reprint Phase II study of irinotecan and 5-fluorouracil/leucovorin in patients with primary refractory or relapsed advanced oesophageal and gastric carcinoma
    L Assersohn
    Royal Marsden Hospital, London and Sutton, Surrey, UK
    Ann Oncol 15:64-9. 2004
    ..The purpose of this study was to assess the efficacy and toxicity of irinotecan and 5-fluorouracil (5-FU) in primary refractory or relapsed locally advanced or metastatic oesophagogastric (O-G) carcinoma...
  51. doi request reprint A phase II trial evaluating capecitabine and irinotecan as second line treatment in patients with oesophago-gastric cancer who have progressed on, or within 3 months of platinum-based chemotherapy
    Alexandra Leary
    Department of Medicine, Royal Marsden Hospital, Sutton, London, Surrey, UK
    Cancer Chemother Pharmacol 64:455-62. 2009
    ..There is no standard second line therapy for relapsed oesophago-gastric (O-G) cancer...
  52. pmc Preoperative radiotherapy for rectal cancer
    Gisella Salerno
    J R Soc Med 97:361-2. 2004
  53. ncbi request reprint Management and imaging of low rectal carcinoma
    Gisella Salerno
    Pelican Cancer Foundation, Basingstoke, Hants, UK
    Surg Oncol 13:55-61. 2004
    ..Surface coil MRI is the most promising modality for patient selection, which can provide good views of the circumferential resection margin especially the presence or absence of tumour encroaching the intersphincteric plane...
  54. ncbi request reprint Endorectal ultrasound and magnetic resonance imaging in rectal cancer staging
    Clive Bartram
    Imperial College School of Medicine and St Mark s Hospital, Northwick Park, Harrow HA1 3UJ, UK
    Gastroenterol Clin North Am 31:827-39. 2002
    ..The assessment of residual tumor after chemoradiotherapy remains difficult; PET scanning has been used in this situation [32], but has not been compared with MRI and is unlikely to show only residual cells with extensive fibrosis...
  55. ncbi request reprint Circumferential resection margin assessment on MRI of rectal cancer
    Styliani Petroudi
    Dept of Eng Sci, Oxford Univ, UK
    Conf Proc IEEE Eng Med Biol Soc 1:4881-4. 2006
    ..Prior to this, we segment the rectum and mesorectum. Preliminary results are reported for 10 patient cases, and a further large set are currently being analysed and results will be available at the time of the conference...
  56. ncbi request reprint Preoperative staging of rectal cancer
    Neil Smith
    Royal Marsden Hospital Colorectal Cancer Network, Department of Colorectal Surgery, Croydon, Surrey, UK
    Acta Oncol 47:20-31. 2008
    ..The optimal pre-operative treatment regimes for these patients (radiotherapy alone, systemic chemotherapy alone or combination chemo-radiotherapy) is the subject of current and future trials...
  57. pmc MRI in predicting curative resection of rectal cancer: new dilemma in multidisciplinary team management
    R J Heald
    BMJ 333:808. 2006
  58. ncbi request reprint Colorectal cancer imaging
    Lennart Blomqvist
    AJR Am J Roentgenol 182:1600-1. 2004
  59. ncbi request reprint MRI identified prognostic features of tumors in distal sigmoid, rectosigmoid, and upper rectum: treatment with radiotherapy and chemotherapy
    Sarah Burton
    Division of Colorectal Surgery, Mayday University Hospital, Croydon, UK
    Int J Radiat Oncol Biol Phys 65:445-51. 2006
    ..The aim of this study was to determine whether magnetic resonance imaging (MRI) could accurately stage tumors of the distal sigmoid, rectosigmoid, and upper rectum and help direct preoperative treatment...