Clive Bate

Summary

Affiliation: Royal Veterinary College
Country: UK

Publications

  1. ncbi Temporal and spatial relationship between the death of PrP-damaged neurones and microglial activation
    Clive Bate
    Institute of Comparative Medicine, Department of Veterinary Pathology, Univeristy of Glasgow Veterinary School, Bearsden Road, Glasgow G61 IQH, UK
    Neuroreport 13:1695-700. 2002
  2. ncbi Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and Abeta 1-42
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, AL9 7TA North Mymms, Herts, UK
    Neuropharmacology 54:934-43. 2008
  3. ncbi Cholesterol esterification reduces the neurotoxicity of prions
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
    Neuropharmacology 54:1247-53. 2008
  4. ncbi Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, UK, AL9 7TA
    BMC Biol 6:39. 2008
  5. ncbi Polyunsaturated fatty acids protect against prion-mediated synapse damage in vitro
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, North Mymms, Herts, AL9 7TA, UK
    Neurotox Res 17:203-14. 2010
  6. ncbi Clustering of sialylated glycosylphosphatidylinositol anchors mediates PrP-induced activation of cytoplasmic phospholipase A 2 and synapse damage
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Herts, UK
    Prion 6:350-3. 2012
  7. ncbi Neurodegeneration induced by clustering of sialylated glycosylphosphatidylinositols of prion proteins
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, United Kingdom
    J Biol Chem 287:7935-44. 2012
  8. ncbi Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide
    Rona Wilson
    1Division of Immunology, Infection and Inflammation, Western Infirmary, University of Glasgow, G11 6NT, Glasgow
    BMC Neurosci 8:99. 2007
  9. ncbi Platelet-activating factor antagonists protect amyloid-beta damaged neurons from microglia-mediated death
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
    Neuropharmacology 51:173-81. 2006
  10. ncbi Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, North Mymms, Herts, UK
    J Neuroinflammation 4:5. 2007

Collaborators

Detail Information

Publications40

  1. ncbi Temporal and spatial relationship between the death of PrP-damaged neurones and microglial activation
    Clive Bate
    Institute of Comparative Medicine, Department of Veterinary Pathology, Univeristy of Glasgow Veterinary School, Bearsden Road, Glasgow G61 IQH, UK
    Neuroreport 13:1695-700. 2002
    ..Activation of microglia and microglia-mediated killing of PrP-treated neurones or scrapie-infected neuroblastoma cells were maximal only when microglia were in direct contact with neurones...
  2. ncbi Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and Abeta 1-42
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, AL9 7TA North Mymms, Herts, UK
    Neuropharmacology 54:934-43. 2008
    ..Such observations raise the possibility that some PUFA supplements may accelerate neuronal loss in the terminal stages of prion or Alzheimer's diseases...
  3. ncbi Cholesterol esterification reduces the neurotoxicity of prions
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
    Neuropharmacology 54:1247-53. 2008
    ..These results indicate that cholesterol esterification is an important cellular response that reduces PrP(Sc)-induced activation of PLA(2) and protects against cell death in ScGT1 cells...
  4. ncbi Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, UK, AL9 7TA
    BMC Biol 6:39. 2008
    ..Since polyunsaturated fatty acids also reduced cellular cholesterol levels we tested their effects on PrPSc formation in three prion-infected neuronal cell lines (ScGT1, ScN2a and SMB cells)...
  5. ncbi Polyunsaturated fatty acids protect against prion-mediated synapse damage in vitro
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, North Mymms, Herts, AL9 7TA, UK
    Neurotox Res 17:203-14. 2010
    ..Such observations raise the possibility that supplements containing PUFA may protect against the synapse damage and cognitive loss seen during the early stages of prion diseases...
  6. ncbi Clustering of sialylated glycosylphosphatidylinositol anchors mediates PrP-induced activation of cytoplasmic phospholipase A 2 and synapse damage
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Herts, UK
    Prion 6:350-3. 2012
    ....
  7. ncbi Neurodegeneration induced by clustering of sialylated glycosylphosphatidylinositols of prion proteins
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, United Kingdom
    J Biol Chem 287:7935-44. 2012
    ....
  8. ncbi Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide
    Rona Wilson
    1Division of Immunology, Infection and Inflammation, Western Infirmary, University of Glasgow, G11 6NT, Glasgow
    BMC Neurosci 8:99. 2007
    ....
  9. ncbi Platelet-activating factor antagonists protect amyloid-beta damaged neurons from microglia-mediated death
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
    Neuropharmacology 51:173-81. 2006
    ..At nanomolar concentrations PAF induces a change in neuronal phenotype that activates microglia via the CD14 molecule, these activated microglia then kill the amyloid-beta1-42 damaged neurons...
  10. ncbi Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, North Mymms, Herts, UK
    J Neuroinflammation 4:5. 2007
    ..Since some epidemiological studies demonstrate that statins, drugs that reduce cholesterol synthesis, have a beneficial effect on mild AD, we examined the effects of two cholesterol synthesis inhibitors on neuronal responses to PAF...
  11. ncbi Squalestatin protects neurons and reduces the activation of cytoplasmic phospholipase A2 by Abeta(1-42)
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts AL9 7TA, UK
    Neuropharmacology 53:222-31. 2007
    ..This process is dependent on the amounts of cholesterol in neuronal membranes and is susceptible to treatment with squalestatin or simvastatin...
  12. ncbi Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, AL9 7TA, UK
    Mol Neurodegener 3:1. 2008
    ....
  13. ncbi Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2 activation
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, AL9 7TA, UK
    BMC Biol 6:8. 2008
    ....
  14. ncbi Prostaglandin D2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, AL9 7TA, UK
    Neuropharmacology 50:229-37. 2006
    ....
  15. ncbi Microglial cells kill prion-damaged neurons in vitro by a CD14-dependent process
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts AL9 7TA, UK
    J Neuroimmunol 170:62-70. 2005
    ..None of the mabs affected the survival of HuPrP106-126-damaged neurons in the absence of monocytes...
  16. ncbi Amyloid-β-induced synapse damage is mediated via cross-linkage of cellular prion proteins
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, United Kingdom
    J Biol Chem 286:37955-63. 2011
    ..This hypothesis was supported by our observation that monoclonal antibody mediated cross-linkage of PrP(C) also activated synaptic cPLA(2) and caused synapse damage...
  17. ncbi Monoacylated cellular prion protein modifies cell membranes, inhibits cell signaling, and reduces prion formation
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, United Kingdom
    J Biol Chem 286:8752-8. 2011
    ..In addition, our observations raise the possibility that pharmacological modification of GPI anchors might constitute a novel therapeutic approach to prion diseases...
  18. ncbi α-synuclein induced synapse damage is enhanced by amyloid-β1-42
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, AL9 7TA, UK
    Mol Neurodegener 5:55. 2010
    ....
  19. ncbi Amyloid-β(1-40) inhibits amyloid-β(1-42) induced activation of cytoplasmic phospholipase A2 and synapse degeneration
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, North Mymms, Herts, UK
    J Alzheimers Dis 21:985-93. 2010
    ..Such observations raise the possibility that the amount of Aβ(1-40) produced within the brain is critical in determining the synapse damaging effects of Aβ(1-42) and possibly the cognitive loss seen during the early stages of AD...
  20. ncbi A glycosylphosphatidylinositol analogue reduced prion-derived peptide mediated activation of cytoplasmic phospholipase A2, synapse degeneration and neuronal death
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, North Mymms, Herts, UK
    Neuropharmacology 59:93-9. 2010
    ..We conclude that glucosamine-PI, or isolated GPI anchors, can modify local membrane micro-environments that are important in the initiation of signalling events that mediate PrP82-146 induced neurodegeneration...
  21. ncbi Phospholipase A2 inhibitors protect against prion and Abeta mediated synapse degeneration
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, AL9 7TA, UK
    Mol Neurodegener 5:13. 2010
    ..A pharmacological approach was used to screen cell signalling pathways involved in synapse degeneration...
  22. ncbi The glycosylphosphatidylinositol anchor is a major determinant of prion binding and replication
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts AL9 7TA, UK
    Biochem J 428:95-101. 2010
    ..We conclude that the nature of the GPI anchor attached to PrPSc affected the binding of PrPSc to neurons, its localization to lipid rafts and its ability to convert endogenous PrPC...
  23. ncbi Glimepiride reduces the expression of PrPc, prevents PrPSc formation and protects against prion mediated neurotoxicity in cell lines
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, North Mymms, United Kingdom
    PLoS ONE 4:e8221. 2009
    ..The accumulation of PrP(Sc) within the brain is associated with synapse loss and ultimately neuronal death. Novel therapeutics are desperately required to treat neurodegenerative diseases including the prion diseases...
  24. ncbi Ethanol protects cultured neurons against amyloid-β and α-synuclein-induced synapse damage
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts AL9 7TA, UK
    Neuropharmacology 61:1406-12. 2011
    ..These results may help explain epidemiological reports that moderate alcohol consumption protects against the development of dementia in Alzheimer's and Parkinson's diseases...
  25. ncbi PrP-specific camel antibodies with the ability to immunodetect intracellular prion protein
    Mourad Tayebi
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
    J Gen Virol 91:2121-31. 2010
    ....
  26. ncbi The cellular prion protein with a monoacylated glycosylphosphatidylinositol anchor modifies cell membranes, inhibits cell signaling and reduces prion formation
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, North Mymms, Herts, UK on protein PrP
    Prion 5:65-8. 2011
    ..In addition, such observations raise the possibility that the pharmacological modification of GPI anchors might constitute a novel therapeutic approach to prion diseases...
  27. ncbi Glycosylphosphatidylinositol anchor analogues sequester cholesterol and reduce prion formation
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts AL9 7TA, United Kingdom
    J Biol Chem 285:22017-26. 2010
    ..We propose that treatment with glucosamine-PI modifies local micro-environments that control PrP(C) expression and activation of PLA(2) and subsequently inhibits PrP(Sc) formation...
  28. ncbi A camelid anti-PrP antibody abrogates PrP replication in prion-permissive neuroblastoma cell lines
    Daryl Rhys Jones
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hertfordshire, United Kingdom
    PLoS ONE 5:e9804. 2010
    ..These findings demonstrate the potential use of anti-prion camelid antibodies for the treatment of prion and other related diseases via non-invasive means...
  29. ncbi Inhibition of phospholipase A2 increased the removal of the prion derived peptide PrP82-146 from cultured neurons
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts AL9 7TA, UK
    Neuropharmacology 60:365-72. 2011
    ..We conclude that activation of PLA(2) and the production of PAF control a cholesterol-sensitive pathway that affects the cellular localisation and hence the fate of PrP82-146 in neurons...
  30. ncbi A role for B lymphocytes in anti-infective prion therapies?
    Mourad Tayebi
    Department of Pathology and Infectious Diseases, The Royal Veterinary College, North Mymms, Hatfield, Hertfordshire, UK
    Expert Rev Anti Infect Ther 5:631-8. 2007
    ..Furthermore, in vivo stimulation of immune-competent cells to specifically recognize and neutralize the abnormally folded isoform should also be pursued...
  31. ncbi Cyclo-oxygenase inhibitors protect against prion-induced neurotoxicity in vitro
    Clive Bate
    Institute of Comparative Medicine, Glasglow University Veterinary School, Glasgow, UK
    Neuroreport 13:1933-8. 2002
    ..The cox-1 inhibitors also inhibited neuronal PGE production and protected both neuroblastoma cells and primary cortical neurones against prions. They also reduced microglia-mediated killing of prion-treated neurones...
  32. ncbi Neurones treated with cyclo-oxygenase-1 inhibitors are resistant to amyloid-beta1-42
    Clive Bate
    Institute of Comparative Medicine, Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Neuroreport 14:2099-103. 2003
    ..Although the production of neuronal prostaglandin E2 in response to amyloid-beta1-42 was reduced by the presence of COX-1 inhibitors, no neurotoxic effects of prostaglandin E2, or any other prostaglandin, were observed...
  33. ncbi Simvastatin treatment prolongs the survival of scrapie-infected mice
    Sarah Kempster
    Department of Obstetrics and Gynaecology, University of Cambridge, Rosie Hospital, Robinson Way, Cambridge, UK
    Neuroreport 18:479-82. 2007
    ..183 days). These results indicate that low-dosage simvastatin treatment affects the progression of experimental scrapie, and supports the concept that statin treatment may influence the prion pathogenesis...
  34. ncbi Squalestatin cures prion-infected neurons and protects against prion neurotoxicity
    Clive Bate
    Institute of Comparative Medicine, Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, United Kingdom
    J Biol Chem 279:14983-90. 2004
    ..These studies indicate a pivotal role for cholesterol-sensitive processes in controlling PrP(Sc) formation, and in the activation of signaling pathways associated with PrP-induced neuronal death...
  35. ncbi The role of platelet activating factor in prion and amyloid-beta neurotoxicity
    Clive Bate
    Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Neuroreport 15:509-13. 2004
    ....
  36. ncbi Microglia kill amyloid-beta1-42 damaged neurons by a CD14-dependent process
    Clive Bate
    Institute of Comparative Medicine, Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Neuroreport 15:1427-30. 2004
    ..These results indicate an important role for CD14 in the recognition and subsequent killing of amyloid-beta damaged neurons by microglia...
  37. ncbi Detoxified lipopolysaccharide reduces microglial cell killing of prion-infected neurons
    Clive Bate
    Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Neuroreport 15:2765-8. 2004
    ..These results suggest that some compounds that bind to CD14 might reduce microglial cell activation and increase neuronal survival in prion and Alzheimer's diseases...
  38. ncbi Phospholipase A2 inhibitors or platelet-activating factor antagonists prevent prion replication
    Clive Bate
    Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, Scotland, United Kingdom
    J Biol Chem 279:36405-11. 2004
    ..These data indicate a pivotal role for PLA(2) and PAF in controlling PrP(res) formation and identify them as potential therapeutic agents...
  39. ncbi Role of glycosylphosphatidylinositols in the activation of phospholipase A2 and the neurotoxicity of prions
    Clive Bate
    Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    J Gen Virol 85:3797-804. 2004
    ..These results implicate phospholipase A(2) activation by PrP-GPIs as an early event in prion-induced neurodegeneration...
  40. ncbi Manipulation of PrPres production in scrapie-infected neuroblastoma cells
    Clive Bate
    Department of Veterinary Pathology, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    J Neurosci Methods 138:217-23. 2004
    ..The production of interleukin-6 by microglia cultured with retinoic acid-treated ScN2a cells was significantly higher than that of microglia cultured with untreated ScN2a cells...