A N Akbar

Summary

Affiliation: Royal Free and University College Medical School
Country: UK

Publications

  1. ncbi request reprint IFN-alpha and IFN-beta: a link between immune memory and chronic inflammation
    A N Akbar
    Department of Clinical Immunology, Royal Free and University College Medical School, Hampstead, London, UK
    Immunol Today 21:337-42. 2000
  2. ncbi request reprint Differential regulation of CD8+ T cell senescence in mice and men
    A N Akbar
    Department of Clinical Immunology, Royal Free and University College Medical School, Pond Street, Hampstead, London NW3 2QG, UK
    Mech Ageing Dev 121:69-76. 2000
  3. ncbi request reprint Regulation of apoptosis and replicative senescence in CD8+ T cell following acute viral infection
    F J Plunkett
    Department of Clinical Immunology, Royal Free and University College of Medical School, London, UK
    Apoptosis 5:431-4. 2000
  4. pmc The inhibition of cutaneous T cell apoptosis may prevent resolution of inflammation in atopic eczema
    C H Orteu
    Department of Clinical Immunology, The Royal Free and University College Medical School, London, UK
    Clin Exp Immunol 122:150-6. 2000
  5. ncbi request reprint Human tenon's fibroblast-produced ifnbeta and the prevention of t-cell apoptosis
    L Chang
    Wound Healing Research and Glaucoma Units, Institute of Ophthalmology, University College, London, UK
    Invest Ophthalmol Vis Sci 42:1531-8. 2001
  6. ncbi request reprint Cellular environments and apoptosis: tissue microenvironments control activated T-cell death
    A N Akbar
    Dept of Clinical Immunology, Royal Free Hospital School of Medicine, Hampstead, London, UK
    Immunol Today 18:72-6. 1997
  7. ncbi request reprint Follicular dendritic cells share a membrane-bound protein with fibroblasts
    M Bofill
    Department of Immunology, The Royal Free and University College Medical School, London, UK
    J Pathol 191:217-26. 2000
  8. ncbi request reprint Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population
    L S Taams
    Department of Clinical Immunology, Royal Free and University College Medical School, London, GB
    Eur J Immunol 31:1122-31. 2001
  9. ncbi request reprint The use of the inhibitory receptors for modulating the immune responses
    S M Henson
    Immunology, Division of Infection and Immunity, UCL, 46 Cleveland Street, London, W1T 4JF, UK
    Curr Pharm Des 14:2643-50. 2008

Collaborators

Detail Information

Publications9

  1. ncbi request reprint IFN-alpha and IFN-beta: a link between immune memory and chronic inflammation
    A N Akbar
    Department of Clinical Immunology, Royal Free and University College Medical School, Hampstead, London, UK
    Immunol Today 21:337-42. 2000
    ..Although this enables memory T cells to persist without antigen, excessive IFN-alpha or IFN-gamma secretion might lead to chronic inflammation...
  2. ncbi request reprint Differential regulation of CD8+ T cell senescence in mice and men
    A N Akbar
    Department of Clinical Immunology, Royal Free and University College Medical School, Pond Street, Hampstead, London NW3 2QG, UK
    Mech Ageing Dev 121:69-76. 2000
    ....
  3. ncbi request reprint Regulation of apoptosis and replicative senescence in CD8+ T cell following acute viral infection
    F J Plunkett
    Department of Clinical Immunology, Royal Free and University College of Medical School, London, UK
    Apoptosis 5:431-4. 2000
    ..For successful memory to be produced T cells must avoid apoptosis and avoid replicative senescence...
  4. pmc The inhibition of cutaneous T cell apoptosis may prevent resolution of inflammation in atopic eczema
    C H Orteu
    Department of Clinical Immunology, The Royal Free and University College Medical School, London, UK
    Clin Exp Immunol 122:150-6. 2000
    ....
  5. ncbi request reprint Human tenon's fibroblast-produced ifnbeta and the prevention of t-cell apoptosis
    L Chang
    Wound Healing Research and Glaucoma Units, Institute of Ophthalmology, University College, London, UK
    Invest Ophthalmol Vis Sci 42:1531-8. 2001
    ..This study was undertaken to determine whether normal and growth-arrested human Tenon's fibroblasts (HTF) can prevent cytokine deprivation-mediated T-cell apoptosis through the secretion of interferon (IFN)beta...
  6. ncbi request reprint Cellular environments and apoptosis: tissue microenvironments control activated T-cell death
    A N Akbar
    Dept of Clinical Immunology, Royal Free Hospital School of Medicine, Hampstead, London, UK
    Immunol Today 18:72-6. 1997
    ..Here, Arne Akbar and Mike Salmon describe how both death pathways interact in activated T cells and are profoundly influenced by different tissue microenvironments...
  7. ncbi request reprint Follicular dendritic cells share a membrane-bound protein with fibroblasts
    M Bofill
    Department of Immunology, The Royal Free and University College Medical School, London, UK
    J Pathol 191:217-26. 2000
    ..These findings provide new evidence for a local differentiation pathway of fibroblasts to mature FDCs...
  8. ncbi request reprint Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population
    L S Taams
    Department of Clinical Immunology, Royal Free and University College Medical School, London, GB
    Eur J Immunol 31:1122-31. 2001
    ..Further studies into their role in normal and pathological situations in humans are clearly essential...
  9. ncbi request reprint The use of the inhibitory receptors for modulating the immune responses
    S M Henson
    Immunology, Division of Infection and Immunity, UCL, 46 Cleveland Street, London, W1T 4JF, UK
    Curr Pharm Des 14:2643-50. 2008
    ..In this review, we examine the role of CTLA-4 and PD-1 in regulating immune response and discuss their therapeutic potential during aging...