A N Akbar
Affiliation: Royal Free and University College Medical School
- IFN-alpha and IFN-beta: a link between immune memory and chronic inflammationA N Akbar
Department of Clinical Immunology, Royal Free and University College Medical School, Hampstead, London, UK
Immunol Today 21:337-42. 2000..Although this enables memory T cells to persist without antigen, excessive IFN-alpha or IFN-gamma secretion might lead to chronic inflammation...
- Differential regulation of CD8+ T cell senescence in mice and menA N Akbar
Department of Clinical Immunology, Royal Free and University College Medical School, Pond Street, Hampstead, London NW3 2QG, UK
Mech Ageing Dev 121:69-76. 2000....
- Regulation of apoptosis and replicative senescence in CD8+ T cell following acute viral infectionF J Plunkett
Department of Clinical Immunology, Royal Free and University College of Medical School, London, UK
Apoptosis 5:431-4. 2000..For successful memory to be produced T cells must avoid apoptosis and avoid replicative senescence...
- The inhibition of cutaneous T cell apoptosis may prevent resolution of inflammation in atopic eczemaC H Orteu
Department of Clinical Immunology, The Royal Free and University College Medical School, London, UK
Clin Exp Immunol 122:150-6. 2000....
- Human tenon's fibroblast-produced ifnbeta and the prevention of t-cell apoptosisL Chang
Wound Healing Research and Glaucoma Units, Institute of Ophthalmology, University College, London, UK
Invest Ophthalmol Vis Sci 42:1531-8. 2001..This study was undertaken to determine whether normal and growth-arrested human Tenon's fibroblasts (HTF) can prevent cytokine deprivation-mediated T-cell apoptosis through the secretion of interferon (IFN)beta...
- Cellular environments and apoptosis: tissue microenvironments control activated T-cell deathA N Akbar
Dept of Clinical Immunology, Royal Free Hospital School of Medicine, Hampstead, London, UK
Immunol Today 18:72-6. 1997..Here, Arne Akbar and Mike Salmon describe how both death pathways interact in activated T cells and are profoundly influenced by different tissue microenvironments...
- Follicular dendritic cells share a membrane-bound protein with fibroblastsM Bofill
Department of Immunology, The Royal Free and University College Medical School, London, UK
J Pathol 191:217-26. 2000..These findings provide new evidence for a local differentiation pathway of fibroblasts to mature FDCs...
- Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone populationL S Taams
Department of Clinical Immunology, Royal Free and University College Medical School, London, GB
Eur J Immunol 31:1122-31. 2001..Further studies into their role in normal and pathological situations in humans are clearly essential...
- The use of the inhibitory receptors for modulating the immune responsesS M Henson
Immunology, Division of Infection and Immunity, UCL, 46 Cleveland Street, London, W1T 4JF, UK
Curr Pharm Des 14:2643-50. 2008..In this review, we examine the role of CTLA-4 and PD-1 in regulating immune response and discuss their therapeutic potential during aging...