Genomes and Genes
Royal Hallamshire Hospital
Organization: Royal Hallamshire Hospital
- Common menstrual problems in adolescenceDiana J Fothergill
Sheffield Teaching Hospitals NHS Foundation Trust, Tree Root Walk, Sheffield, UK
Arch Dis Child Educ Pract Ed 95:199-203. 2010..This article focuses on a practical approach to managing menorrhagia, dysmenorrhoea, oligomenorrhoea and premenstrual syndrome (PMS) and reviews the literature on this topic...
- Drug treatment of delirium: past, present and futureRichard S Bourne
Department of Critical Care, Sheffield Teaching Hospitals, Sheffield, United Kingdom
J Psychosom Res 65:273-82. 2008..We also identified recent research developments and highlighted some ongoing clinical trials to explore future directions in drug treatment and prevention of delirium...
- Chickenpox in adults - clinical managementA J Tunbridge
Department of Infection and Tropical Medicine, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
J Infect 57:95-102. 2008..The accompanying flowchart has been formulated to guide emergency physicians and general practitioners through the decision-making process regarding treatment and admission for specialist care...
- Large-spot subthreshold infrared laser to treat diabetic macular edemaDavid M Squirrell
Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, United Kingdom
Retina 28:615-21. 2008..To evaluate the efficacy of a large-spot subthreshold infrared laser protocol to treat diabetic maculopathy...
- Ictal hiccup during absence seizure in a childAthi Ponnusamy
Department of Clinical Neurophysiology, Sheffield Teaching Hospitals NHS Foundation Trust, UK
Epileptic Disord 10:53-5. 2008..Childhood absence epilepsy (CAE) is the prototype IGE with typical absence seizures. We report a child who had prominent ictal hiccups during an absence seizure, and discuss the possible mechanisms. [Published with video sequences]...
- Diagnosis and management of motor neurone diseaseChristopher J McDermott
Sheffield Care and Research Centre for Motor Neurone Disorders/Academic Neurology Unit, Section of Neuroscience, University of Sheffield, Sheffield S10 2RX
BMJ 336:658-62. 2008
- Developmental care: does it make a difference?P C Bustani
Jessop Wing, Sheffield Teaching Hospitals, Sheffield S10 2SF, UK
Arch Dis Child Fetal Neonatal Ed 93:F317-21. 2008..The emergence of large well-conducted clinical trials may provide the evidence to support or refute the outcome-based assumptions of developmental care...
- Trials in palliative treatment--have the goal posts been moved?Peter Kirkbride
Weston Park Hospital, Sheffield, UK
Lancet Oncol 9:186-7. 2008
- The use of two-stage exchange arthroplasty with depot antibiotics in the absence of long-term antibiotic therapy in infected total hip replacementI Stockley
Sheffield Teaching Hospitals Trust, Herries Road, Sheffield, S5 7AU, UK
J Bone Joint Surg Br 90:145-8. 2008..Using the technique described, a prolonged course of systemic antibiotics does not appear to be essential and the high cost of the administration of antibiotics can be avoided...
- Assessment of surgical competenceJ D Beard
Sheffield Vascular Institute, Northern General Hospital, Sheffield S5 7AU, UK
Br J Surg 94:1315-6. 2007
- Dressings for venous leg ulcers: systematic review and meta-analysisSimon Palfreyman
Sheffield Vascular Institute, Northern General Hospital, Sheffield S5 7AU
BMJ 335:244. 2007..To review the evidence of effectiveness of dressings applied to venous leg ulcers...
- VZV infection in pregnancy: a retrospective review over 5 years in Sheffield and discussion on the potential utilisation of varicella vaccine in preventionM W McKendrick
Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, UK
J Infect 55:64-7. 2007..To study retrospectively the epidemiology, demography and clinical issues related to varicella in pregnancy in a UK city over a 5-year period and help inform the debate on the potential of varicella immunisation in prevention...
- Best practice in record-keepingRebecca McGeehan
Northern General Hospital, Sheffield
Nurs Stand 21:51-5; quiz 58. 2007..Accurate record-keeping is integral to professional practice. This article provides an overview of the importance of good record-keeping in nursing practice...
- Risk of malignancy after gamma knife stereotactic radiosurgeryJeremy Rowe
National Centre for Stereotactic Radiosurgery, Royal Hallamshire Hospital, Sheffield, England, UK
Neurosurgery 60:60-5; discussion 65-6. 2007..To assess the risk of radiosurgery to cause malignant transformation in benign tumors or to induce new malignancies...
- Radiosurgery for type II neurofibromatosisJeremy Rowe
National Centre for Stereotactic Radiosurgery, Royal Hallamshire Hospital, Glossop Road, Sheffield, UK
Prog Neurol Surg 21:176-82. 2008..It is important therefore that these patients are given advice specific for NF2. Considering this, we believe that radiosurgery remains a valuable minimally invasive treatment option for selected NF2 patients...
- Evaluation of a new venom-based clotting assay of protein CP C Cooper
Department of Coagulation, Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK
Int J Lab Hematol 30:437-43. 2008..The new assay is considered to be a suitable assay for the routine diagnosis of protein C deficiency...
- Coeliac diseaseJohn S Leeds
Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Room P39, P Floor, Glossop Road, Sheffield S102JF, UK
Br Med Bull 88:157-70. 2008..Compliance with a strict, lifelong gluten-free diet is the cornerstone of management, improving symptoms and reducing complications of the disease...
- Do older adults have equitable access to specialist epilepsy services?Markus Reuber
Academic Neurology Unit, University of Sheffield, Sheffield, United Kingdom
Epilepsia 51:2341-3. 2010..3% of people with epilepsy who were 85 and older had been referred. The results raise the possibility of inadvertent age discrimination, putting older adults with seizures at greater risk for misdiagnoses and suboptimal management...
- Feeding and boneJennifer S Walsh
Centre for Biomedical Research, Northern General Hospital, Sheffield S5 7AU, UK
Arch Biochem Biophys 503:11-9. 2010..We also discuss the results of clinical trials of analogues of ghrelin, amylin and GLP-2 in the treatment of low bone density, and the potential bone effects of GLP-1 mimetics that are used in the treatment of type 2 diabetes...
- Initial management of paediatric dento-alveolar trauma in the permanent dentition: a multi-centre evaluationH Zaitoun
Department of Paediatric Dentistry, Charles Clifford Dental Hospital, Wellesley Road, Sheffield, S10 2SZ
Br Dent J 208:E11; discussion 254-5. 2010..To investigate the time lapse prior to provision of emergency dental care and appropriateness of earliest treatment provided for children with dental trauma...
- Adjuvant trastuzumab in routine clinical practice and the impact of cardiac monitoring guidelines on treatment deliveryL J Murray
Department of Clinical Oncology, Weston Park Hospital, Sheffield, UK
Breast 19:339-44. 2010..Adjuvant trastuzumab was well tolerated overall. The new guidelines potentially allow more patients to complete trastuzumab on schedule but require higher levels of cardiological intervention...
- Perioperative role development: evaluating a fast-track approach to advanced scrub and/or dual role practitioner trainingMichaela D Timpany
Clinical Educator Site Lead, Operating Department, Northern General Hospital, Herries Road, Sheffield, S5 7AU
J Perioper Pract 20:13-8. 2010..A further aim is to establish if the fast-track route is adequately meeting the training and development needs of staff within the organisation and supporting service requirements...
- Paraneoplastic granulomatous vitritis and retinitis as a presentation of recurrent classical Hodgkin's lymphomaHardeep Singh Mudhar
National Specialist Ophthalmic Pathology Service NSOPS Sheffield Lab, Department of Histopathology, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, England, UK
Int Ophthalmol 30:341-3. 2010....
- Epidural analgesia and breastfeeding: a randomised controlled trial of epidural techniques with and without fentanyl and a non-epidural comparison groupM J A Wilson
Royal Hallamshire Hospital, Sheffield, UK
Anaesthesia 65:145-53. 2010..Mean duration for breastfeeding was similar across epidural groups (Control 13.3, Combined Spinal Epidural 15.5, Low Dose Infusion 15.0 weeks). Our data do not support an effect of epidural fentanyl on breastfeeding initiation...
- Clinical efficacy and cost-effectiveness of outpatient parenteral antibiotic therapy (OPAT): a UK perspectiveAnn L N Chapman
Department of Infection and Tropical Medicine, Royal Hallamshire Hospital, Sheffield, UK
J Antimicrob Chemother 64:1316-24. 2009..We examined the clinical efficacy and cost-effectiveness of an OPAT service based in a large UK teaching hospital, predominantly using the outpatient 'infusion centre' and patient/carer administration models of service delivery...
- Using interactional and linguistic analysis to distinguish between epileptic and psychogenic nonepileptic seizures: a prospective, blinded multirater studyMarkus Reuber
Academic Neurology Unit, University of Sheffield, Sheffield, UK
Epilepsy Behav 16:139-44. 2009..7% (71.4%) and a specificity of 84.6% (92.3%). This blinded, prospective multirater study confirms the diagnostic value of linguistic and interactional observations in the seizure clinic setting...
- Chloracne in seven organic chemists exposed to novel polycyclic halogenated chemical compounds (triazoloquinoxalines)D J Gawkrodger
Department of Dermatology, Royal Hallamshire Hospital, Sheffield, UK
Br J Dermatol 161:939-43. 2009..Chloracne can be a difficult diagnosis to make when it occurs in a novel setting: occupational physicians and dermatologists need to be vigilant when dealing with unusual eruptions in discovery chemists...
- Peritoneal Dialysis Access -- Results from a UK SurveyMartin Wilkie
Sheffield Kidney Institute Northern General Hospital, Sheffield Baxter Healthcare Compton, United Kingdom
Perit Dial Int 29:355-7. 2009..To obtain information about peritoneal dialysis (PD) access practices in the United Kingdom...
- Factors associated with abdominal discomfort during colonoscopy: a prospective analysisDavid A Elphick
Department of Gastroenterology, Northern General Hospital, Sheffield, UK
Eur J Gastroenterol Hepatol 21:1076-82. 2009..Colonoscopy can be uncomfortable. To increase safety, there is a trend, in the UK, towards reduced sedative use. We aimed to determine factors predictive of discomfort during colonoscopy...
- Prosthetic valve endocarditis caused by Pseudomonas mosseliiElizabeth McLellan
Department of Microbiology, Northern General Hospital, Herries Road, Sheffield S17 3QU, UK
J Med Microbiol 58:144-5. 2009..P. mosselii is a highly unusual cause of endocarditis and there are few case reports of curative treatment of pseudomonal prosthetic valve endocarditis with antibiotics alone...
- Magnesium depletion in patients receiving cisplatin-based chemotherapyE Hodgkinson
Pharmacy Department, Weston Park Hospital, Sheffield, UK
Clin Oncol (R Coll Radiol) 18:710-8. 2006..To assess the incidence of hypomagnesaemia, the influence of different cisplatin dosages on the degree of hypomagnesaemia and the effect of routine magnesium supplementation on magnesium levels...
- Ureteric embolization: an alternative treatment strategy for urinary fistulae complicating advanced pelvic malignancyVaithianathan Natarajan
Department of Urology, Royal Hallamshire Hospital, Sheffield, UK
BJU Int 99:147-9. 2007..To report experience with a minimally invasive technique for palliation of urinary fistula/incontinence complicating advanced pelvic malignancy or its treatment...
- General practitioners and the National Strategy on Sexual Health and HIVK E Rogstad
Department of Genitourinary Medicine, Royal Hallamshire Hospital, Sheffield, UK
Int J STD AIDS 15:169-72. 2004..Although 45% of GPs may provide Level 2 care, it is unlikely to include partner notification. Many GPs are too busy and require extra training and funding. These needs must be addressed if the Strategy is to be implemented...
- Sleep disruption in critically ill patients--pharmacological considerationsR S Bourne
Intensive Care Unit, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
Anaesthesia 59:374-84. 2004..Newer non-benzodiazepine hypnotics offer little practical advantage. Melatonin and atypical antipsychotics require further investigation before their routine use can be recommended...
- Aftercare in severe neurological impairmentM F Smith
Regional Neonatal Intensive Care Unit, The Jessop Wing, Royal Hallamshire Hospital, Sheffield, UK
Semin Neonatol 8:147-57. 2003..The recurrent admission of infants in this group for active resuscitation and/or intensive care may not always be the wisest management, and important medical, ethical and legal dilemmas are faced by families and carers of these infants...
- Neurovascular MRI with dynamic contrast-enhanced subtraction angiographyS C Coley
Department of Radiology, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
Neuroradiology 45:843-50. 2003..As time-resolved techniques become more sophisticated and 3D acquisitions can be obtained with high isotropic spatial resolution we may start to see the demise of catheter angiography as a diagnostic procedure...
- Breast cancer incidence and mortality trends in 16 European countriesJ L Botha
Trent Cancer Registry, Weston Park Hospital, Whitham Road, Sheffield S10 2SJ, UK
Eur J Cancer 39:1718-29. 2003....
- Introduction, audit and review of guidelines for delegated authorization of nuclear medicine investigations in compliance with the Ionising Radiation (Medical Exposure) Regulations 2000A M Harris
Department of Medical Physics and Clinical Technology, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK
Nucl Med Commun 24:939-42. 2003..Regular audit is essential. This study identified the need to improve the format of the request card and to obtain additional referral information from the referrer...
- Adrenal axis testing and corticosteroid replacement therapy in septic shock patients--local and national perspectivesR S Bourne
Intensive Care Unit, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, United Kingdom
Anaesthesia 58:591-6. 2003..Sixty per cent of intensive care units use corticosteroids in septic shock patients, but only 22% use a short synacthen test to guide therapy...
- Electrocardiographic artefact mimicking arrhythmic change on the ECGN C Samaniego
Department of Care of the Elderley, Northern General Hospital, Sheffield, UK
Emerg Med J 20:356-7. 2003..This article present two cases that illustrate this problem, and will briefly look at known internal and external causes of artefact...
- An evaluation of the evidence base related to critical care outreach teams--2 years on from Comprehensive Critical CareWayne P Robson
Critical Care Outreach Team, Intensive Care Unit, Royal Hallamshire Hospital, Sheffield 510 2JF, UK
Intensive Crit Care Nurs 18:211-8. 2002..We must remember however that some outreach teams have only been in post for 12 months and so it may therefore be far too early to reliably demonstrate any effect...
- An analysis of the pattern of pregnancy loss in women with recurrent miscarriageTin Chiu Li
The Jessop Wing, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom
Fertil Steril 78:1100-6. 2002..To describe the pattern of pregnancy loss in women with a history of recurrent miscarriage (RM)...
- External quality assessment in gynaecological cytology: The Trent Region experience. The Trent Regional Gynaecological Pathology Quality Assurance Group for the National Health Service Cervical Screening ProgrammeD N Slater
Quality Assurance Reference Centre for the Trent NHSCSP, Northern General Hospital, Sheffield, UK
Cytopathology 13:206-19. 2002..In particular this paper highlights the effectiveness of the scoring system contained within the Trent and National EQA protocols...
- Minister without portfolio?M Nelson
Department of Ophthalmology, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
Br J Ophthalmol 86:948-9. 2002
- Article 9. Change, committees, and the press want to speak to youJ Wardrope
Department of Accident and Emergency Medicine, Northern General Hospital, Sheffield, UK
Emerg Med J 19:333-6. 2002
- Differential diagnosis of stress urinary incontinenceS C Radley
Royal Hallamshire Hospital, Sheffield, UK
BJU Int 94:4-7. 2004
- Evaluation of a local anaesthesia regimen following mastectomyH Talbot
Department of Surgery, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
Anaesthesia 59:664-7. 2004..Bupivacaine irrigation used in this manner does not appear to offer an effective contribution to postoperative analgesia...
- Occupational skin cancersD J Gawkrodger
Department of Dermatology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
Occup Med (Lond) 54:458-63. 2004..g. for outdoor workers, the need to cover up in the sun and use sun protective creams and a campaign for earlier recognition of skin cancers, which are usually curable if treated in their early stages...
- A giant bladder stone as an unusual cause of pelviabdominal mass and postmenopausal bleedingM Metwally
Department of Obstetrics and Gynaecology, Rotherham General Hospital, Rotherham, UK
J Obstet Gynaecol 26:708-9. 2006
- Deep vein thrombosis among injecting drug users in SheffieldV A Cooke
The Northern General Hospital, Sheffield, UK corrected
Emerg Med J 23:777-9. 2006..To identify the proportion of patients testing positive for deep vein thrombosis (DVT) who are injecting drug users (IDUs), and examine differences in the investigation and management of this group compared with non-IDUs...
- Prognostic and predictive factors in endocrine tumoursT J Stephenson
Department of Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
Histopathology 48:629-43. 2006....
- Swimming against the stream: major changes to GMC's complaints procedure a concern for doctorsSuzie Bailey
Specialised Medicine and Rehabilitation, Sheffield Teaching Hospitals NHS Foundation Trust
Med Leg J 73:164-5. 2005
- Preoperative radiological assessment for vascular accessP W G Brown
Sheffield Teaching Hospitals NHS Trust, Sheffield, South Yorkshire, UK
Eur J Vasc Endovasc Surg 31:64-9. 2006..Traditional contrast venography is mandatory where there is suspicion of central vein stenosis. In predialysis patients where there is a risk of contrast nephropathy MR venography is emerging as a possible alternative...
- Optimizing the fluid management of ventilated patients with suspected hypovolaemiaPhilip Murch
General Intensive Therapy Unit, Northern General Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, S5 7AU, UK
Nurs Crit Care 10:279-88. 2005..In an attempt to optimize the fluid management of patients within the intensive therapy unit, this article outlines the development and implementation of a fluid prescription for ventilated patients with suspected hypovolaemia...
- Broadband measurements of the frequency dependence of attenuation coefficient and velocity in amniotic fluid, urine and human serum albumin solutionsPrashant K Verma
Department of Medical Physics, Sheffield Teaching Hospitals, Northern General Hospital, Sheffield, UK
Ultrasound Med Biol 31:1375-81. 2005....
- Developing assessments of surgical skills for the GMC Performance ProceduresJonathan D Beard
Sheffield Teaching Hospitals, Sheffield, UK
Ann R Coll Surg Engl 87:242-7. 2005....
- Tapping into talentHeather Tierney-Moore
Sheffield Teaching Hospitals NHS Foundation Trust
Nurs Manag (Harrow) 12:12-3. 2005
- Postoperative hypoxia in a woman with Down's syndrome: case outcomeA K Siotia
Northern General Hospital, Sheffield, S5 7AU
BMJ 330:1068; discussion 1069. 2005
- Painful diabetic neuropathyS Tesfaye
Diabetes Research Unit, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
Diabetologia 48:805-7. 2005
- Spurious leptomeningeal enhancement on immediate post-operative MRI for paediatric brain tumoursElysa Widjaja
Department of Radiology, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
Pediatr Radiol 35:334-8. 2005..The underlying cause of the enhancement remains to be elucidated, but it should be recognized that leptomeningeal enhancement may occur after surgery and that this does not necessarily imply tumour spread...
- Increasing hCG concentrations during storage at (+)4 degrees C with the Bayer Centaur Total hCG methodK Page
Department of Clinical Chemistry, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK
Ann Clin Biochem 41:479-81. 2004..We therefore attempted to determine the analytical imprecision of our total hCG method over a 4-week period at concentrations up to 20,000 IU/L...
- The role of intensity-modulated radiotherapy in the treatment of parotid tumorsChristopher M Bragg
Department of Clinical Oncology, Weston Park Hospital, Sheffield, South Yorkshire, United Kingdom
Int J Radiat Oncol Biol Phys 52:729-38. 2002..To compare intensity-modulated radiotherapy (IMRT) treatment plans with three-dimensional conformal radiotherapy (3D-CRT) plans to investigate the suitability of IMRT for the treatment of tumors of the parotid gland...
- Can dynamic pupillography and/or spectral analysis of heart rate variability provSolomon Tesfaye; Fiscal Year: 2007..Also, analysis of the results will provide the range of variation for the analysed parameters among the different groups of subjects studied and allow for refinement and standardisation of these techniques. ..