Nigel Price

Summary

Affiliation: Rowett Research Institute
Country: UK

Publications

  1. ncbi request reprint A novel brain-expressed protein related to carnitine palmitoyltransferase I
    Nigel Price
    Hannah Research Institute, Ayr, KA6 5HL, UK
    Genomics 80:433-42. 2002
  2. pmc Cloning and expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: residues within the N-terminus of the muscle isoform influence the kinetic properties of the enzyme
    Nigel T Price
    Hannah Research Institute, Ayr KA6 5HL, UK
    Biochem J 372:871-9. 2003
  3. ncbi request reprint Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals
    Feike R van der Leij
    Department of Pediatrics, Groningen University Institute for Drug Exploration, University of Groningen and Beatrix Children s Hospital, Groningen 9700RB, The Netherlands
    J Biol Chem 277:26994-7005. 2002
  4. ncbi request reprint The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity
    Karen Borthwick
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital Coventry and Warwick Campus, Coventry CV2 2DX, UK
    J Biol Chem 281:32946-52. 2006
  5. ncbi request reprint Characterisation of an N-terminal variant of acetyl-CoA carboxylase-alpha: expression in human tissues and evolutionary aspects
    Maureen T Travers
    Cell Biochemistry Group, Hannah Research Institute, Hannah Research Park, Ayr, Scotland KA6 5HL, UK
    Biochim Biophys Acta 1634:97-106. 2003
  6. ncbi request reprint Localization of messenger RNAs encoding enzymes associated with malonyl-CoA metabolism in mouse brain
    Annette Sorensen
    Hannah Research Institute, Ayr KA6 5HL, UK
    Brain Res Gene Expr Patterns 1:167-73. 2002
  7. pmc Demonstration of N- and C-terminal domain intramolecular interactions in rat liver carnitine palmitoyltransferase 1 that determine its degree of malonyl-CoA sensitivity
    Audrey Faye
    Departement d Endocrinologie, Institut Cochin, INSERM U567, CNRS Unité Mixte de Recherche 8104, Universite Rene Descartes, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    Biochem J 387:67-76. 2005
  8. ncbi request reprint Structure and regulation of acetyl-CoA carboxylase genes of metazoa
    Michael C Barber
    Hannah Research Institute, Ayr, KA6 5HL, Scotland, United Kingdom
    Biochim Biophys Acta 1733:1-28. 2005
  9. ncbi request reprint Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines
    Ana Paula B Vintém
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, UK
    Bioorg Med Chem 13:3487-95. 2005
  10. ncbi request reprint Distinct ontogenic patterns of overt and latent DGAT activities of rat liver microsomes
    Ian J Waterman
    Hannah Research Institute, Ayr, Scotland, United Kingdom
    J Lipid Res 43:1555-62. 2002

Collaborators

  • Richard G Vernon
  • Victor A Zammit
  • R R Ramsay
  • J Girard
  • Audrey Faye
  • Michael C Barber
  • Maureen T Travers
  • Karen Borthwick
  • Vicky N Jackson
  • Carina Prip-Buus
  • Catherine Esnous
  • Ana Paula B Vintém
  • Ian J Waterman
  • Annette Sorensen
  • Feike R van der Leij
  • Marie Anne Onfray
  • Stephanie Gobin
  • Richard B Silverman
  • Roger A Clegg
  • Ross Thomson
  • Amanda J Vallance
  • Jaap R G Kuipers
  • Trijnie Dijkhuizen
  • Peter Terpstra
  • Nicolette C A Huijkman
  • Philip A Wood
  • Beatrijs Bartelds
  • Keith B Cox

Detail Information

Publications11

  1. ncbi request reprint A novel brain-expressed protein related to carnitine palmitoyltransferase I
    Nigel Price
    Hannah Research Institute, Ayr, KA6 5HL, UK
    Genomics 80:433-42. 2002
    ..Thus this new CPT I related protein may be specialized for the metabolism of a distinct class of fatty acids involved in brain function...
  2. pmc Cloning and expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: residues within the N-terminus of the muscle isoform influence the kinetic properties of the enzyme
    Nigel T Price
    Hannah Research Institute, Ayr KA6 5HL, UK
    Biochem J 372:871-9. 2003
    ..The ovine N-terminal segment influences the kinetics of the enzyme for both its substrates, such that the K (m) for palmitoyl-CoA is decreased and that for carnitine is increased for the chimaera, relative to the parental ovine M-CPT 1...
  3. ncbi request reprint Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals
    Feike R van der Leij
    Department of Pediatrics, Groningen University Institute for Drug Exploration, University of Groningen and Beatrix Children s Hospital, Groningen 9700RB, The Netherlands
    J Biol Chem 277:26994-7005. 2002
    ..Therefore, the involvement of splice variation of M-CPT I in the modulation of malonyl-CoA inhibition of fatty acid oxidation may be less relevant than hitherto assumed...
  4. ncbi request reprint The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity
    Karen Borthwick
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital Coventry and Warwick Campus, Coventry CV2 2DX, UK
    J Biol Chem 281:32946-52. 2006
    ..The data suggest that the sequence spanning the loop-TM2 boundary determines the disposition of this TM in the membrane so as to alter the conformation of the C-terminal segment and thus affect its interaction with malonyl-CoA...
  5. ncbi request reprint Characterisation of an N-terminal variant of acetyl-CoA carboxylase-alpha: expression in human tissues and evolutionary aspects
    Maureen T Travers
    Cell Biochemistry Group, Hannah Research Institute, Hannah Research Park, Ayr, Scotland KA6 5HL, UK
    Biochim Biophys Acta 1634:97-106. 2003
    ....
  6. ncbi request reprint Localization of messenger RNAs encoding enzymes associated with malonyl-CoA metabolism in mouse brain
    Annette Sorensen
    Hannah Research Institute, Ayr KA6 5HL, UK
    Brain Res Gene Expr Patterns 1:167-73. 2002
    ..Localization of transcripts encoding enzymes involved in fatty acid synthesis and beta-oxidation in distinct nuclei of the hypothalamus supports a role for malonyl-CoA as a potential effector of satiety...
  7. pmc Demonstration of N- and C-terminal domain intramolecular interactions in rat liver carnitine palmitoyltransferase 1 that determine its degree of malonyl-CoA sensitivity
    Audrey Faye
    Departement d Endocrinologie, Institut Cochin, INSERM U567, CNRS Unité Mixte de Recherche 8104, Universite Rene Descartes, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    Biochem J 387:67-76. 2005
    ....
  8. ncbi request reprint Structure and regulation of acetyl-CoA carboxylase genes of metazoa
    Michael C Barber
    Hannah Research Institute, Ayr, KA6 5HL, Scotland, United Kingdom
    Biochim Biophys Acta 1733:1-28. 2005
    ..This review focuses on the structure of ACC genes and the putative individual roles of their gene products in fatty acid metabolism, taking an evolutionary viewpoint provided by data in genome databases...
  9. ncbi request reprint Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines
    Ana Paula B Vintém
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, UK
    Bioorg Med Chem 13:3487-95. 2005
    ..The data suggest that mutation of Cys374 influences MAO A catalysis, which has implications for MAO susceptibility to redox damage. These results are compared with previous work on the equivalent residue in MAO B, namely, cysteine 365...
  10. ncbi request reprint Distinct ontogenic patterns of overt and latent DGAT activities of rat liver microsomes
    Ian J Waterman
    Hannah Research Institute, Ayr, Scotland, United Kingdom
    J Lipid Res 43:1555-62. 2002
    ..We conclude that post-translational modification may play an important role in the overt and latent distribution of DGAT activity in the liver microsomal membrane...
  11. ncbi request reprint Rat liver carnitine palmitoyltransferase 1 forms an oligomeric complex within the outer mitochondrial membrane
    Audrey Faye
    Institut Cochin, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Universite Paris Descartes, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    J Biol Chem 282:26908-16. 2007
    ..Based on these findings, we proposed that the oligomeric structure of CPT1A would allow the newly formed acylcarnitines to gain direct access into the intermembrane space, hence facilitating substrate channeling...