Affiliation: Rowett Research Institute
- Escherichia coli K88 receptor expression in intestine of disease-susceptible weaned pigsM D Jeyasingham
Rowett Research Institute, Bucksburn, Aberdeen, UK
Vet Microbiol 68:219-34. 1999..These results suggest that genetic differences in the glycosyl moieties of the receptor complex provide the basis for disease susceptibility to K88-positive E. coli...
- Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelADenise Kelly
Gut Immunology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
Nat Immunol 5:104-12. 2004..thetaiotaomicron. This PPAR-gamma-dependent anti-inflammatory mechanism defines new cellular targets for therapeutic drug design and interventions for the treatment of chronic inflammation...
- Early nutrition and the development of immune function in the neonateD Kelly
Department of Intestinal Cell Biology and Immunology, Rowett Research Institute, Bucksburn, Aberdeen, UK
Proc Nutr Soc 59:177-85. 2000..One factor that has been proposed to contribute to the increase in the incidence of immune-based disorders, e.g. atopic diseases in Western countries, is thought to be the increased prevalence of formula-feeding...
- Bacterial modulation of mucosal innate immunityDenise Kelly
Gut Immunology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Mol Immunol 42:895-901. 2005..Hence, the possibility exists that bacterially derived effector molecules, with defined modes of action, may have clinical relevance and application...
- Importance of microbial colonization of the gut in early life to the development of immunityDenise Kelly
Rowett Research Institute, Aberdeen, Scotland
Mutat Res 622:58-69. 2007..However, much remains to be elucidated about how commensal bacteria influence the function of cells of both the innate and adaptive immune systems in health and disease...
- Inflammatory bowel disease, gut bacteria and probiotic therapyCaroline Reiff
Department of Gut Immunology, Rowett Institute of Nutrition and Health, Greenburn Road, Bucksburn, AB21 9SB Aberdeen, UK
Int J Med Microbiol 300:25-33. 2010..Bacterial-host events, including interactions with pattern recognition receptors (PRRs) expressed on epithelial cells and dendritic cells (DCs) and the resultant impact on immune responses at mucosal surfaces will be discussed...
- Novel immunostimulatory agent based on CpG oligodeoxynucleotide linked to the nontoxic B subunit of cholera toxinJenni Adamsson
Department of Medical Microbiology and Immunology, Göteborg University Vaccine Research Institute, Goteborg University, Goteborg, Sweden
J Immunol 176:4902-13. 2006..To our knowledge, CTB is the first nontoxic derivative of microbial toxins discovered that when chemically linked to CpG remarkably augments the CpG-mediated immune responses...
- Flagellin suppresses epithelial apoptosis and limits disease during enteric infectionMatam Vijay-Kumar
Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Pathol 169:1686-700. 2006..This notion is consistent with the emerging paradigm that specific TLR ligands may have a fundamental cytoprotective effect during inflammatory stress...