Susan J Duthie

Summary

Affiliation: Rowett Research Institute
Country: UK

Publications

  1. doi request reprint The response of human colonocytes to folate deficiency in vitro: functional and proteomic analyses
    Susan J Duthie
    Rowett Research Institute, Bucksburn, Aberdeen, UK
    J Proteome Res 7:3254-66. 2008
  2. ncbi request reprint Quercetin and myricetin protect against hydrogen peroxide-induced DNA damage (strand breaks and oxidised pyrimidines) in human lymphocytes
    S J Duthie
    Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK
    Mutat Res 393:223-31. 1997
  3. doi request reprint Blood folate status and expression of proteins involved in immune function, inflammation, and coagulation: biochemical and proteomic changes in the plasma of humans in response to long-term synthetic folic acid supplementation
    Susan J Duthie
    Aberdeen University Rowett Institute of Nutrition and Health, Aberdeen, U K
    J Proteome Res 9:1941-50. 2010
  4. ncbi request reprint Berry phytochemicals, genomic stability and cancer: evidence for chemoprotection at several stages in the carcinogenic process
    Susan J Duthie
    Nutrition and Epigenetics Group, Rowett Research Institute, Aberdeen, Scotland, UK
    Mol Nutr Food Res 51:665-74. 2007
  5. ncbi request reprint The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers
    S J Duthie
    Phytochemicals and Genomic Stability Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen Sco AB21 9SB, UK
    Eur J Nutr 45:113-22. 2006
  6. ncbi request reprint Folate, DNA stability and colo-rectal neoplasia
    Susan J Duthie
    Division of Cellular Integrity, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Proc Nutr Soc 63:571-8. 2004
  7. ncbi request reprint DNA stability and lipid peroxidation in vitamin E-deficient rats in vivo and colon cells in vitro--modulation by the dietary anthocyanin, cyanidin-3-glycoside
    Susan J Duthie
    Phytochemicals and Genomic Stability Group, Rowett Research Institute, Aberdeen SCO, UK
    Eur J Nutr 44:195-203. 2005
  8. ncbi request reprint Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells
    S J Duthie
    Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK
    Nutr Cancer 37:245-51. 2000
  9. ncbi request reprint Impact of folate deficiency on DNA stability
    Susan J Duthie
    Rowett Research Institute, Aberdeen, United Kingdom
    J Nutr 132:2444S-2449S. 2002
  10. ncbi request reprint DNA stability and genomic methylation status in colonocytes isolated from methyl-donor-deficient rats
    S J Duthie
    Rowett Research Institute, Aberdeen, UK
    Eur J Nutr 39:106-11. 2000

Collaborators

Detail Information

Publications27

  1. doi request reprint The response of human colonocytes to folate deficiency in vitro: functional and proteomic analyses
    Susan J Duthie
    Rowett Research Institute, Bucksburn, Aberdeen, UK
    J Proteome Res 7:3254-66. 2008
    ..g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2]...
  2. ncbi request reprint Quercetin and myricetin protect against hydrogen peroxide-induced DNA damage (strand breaks and oxidised pyrimidines) in human lymphocytes
    S J Duthie
    Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK
    Mutat Res 393:223-31. 1997
    ..The differences in effectiveness of these dietary compounds against oxidative DNA damage may be explained by differences in their chemical structure or location within the cell...
  3. doi request reprint Blood folate status and expression of proteins involved in immune function, inflammation, and coagulation: biochemical and proteomic changes in the plasma of humans in response to long-term synthetic folic acid supplementation
    Susan J Duthie
    Aberdeen University Rowett Institute of Nutrition and Health, Aberdeen, U K
    J Proteome Res 9:1941-50. 2010
    ..Supplementation with synthetic folic acid increased expression of these proteins but did not substantially disrupt the balance of these pathways...
  4. ncbi request reprint Berry phytochemicals, genomic stability and cancer: evidence for chemoprotection at several stages in the carcinogenic process
    Susan J Duthie
    Nutrition and Epigenetics Group, Rowett Research Institute, Aberdeen, Scotland, UK
    Mol Nutr Food Res 51:665-74. 2007
    ..Evidence for an anticarcinogenic effect in human studies is weak...
  5. ncbi request reprint The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers
    S J Duthie
    Phytochemicals and Genomic Stability Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen Sco AB21 9SB, UK
    Eur J Nutr 45:113-22. 2006
    ..Non-nutritive anthocyanins are present in significant amounts in the human diet. However, it is unclear whether they have health benefits in humans...
  6. ncbi request reprint Folate, DNA stability and colo-rectal neoplasia
    Susan J Duthie
    Division of Cellular Integrity, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Proc Nutr Soc 63:571-8. 2004
    ..Evidence from animal and human studies is presented here in support of folate acting to maintain genomic stability through both these mechanisms...
  7. ncbi request reprint DNA stability and lipid peroxidation in vitamin E-deficient rats in vivo and colon cells in vitro--modulation by the dietary anthocyanin, cyanidin-3-glycoside
    Susan J Duthie
    Phytochemicals and Genomic Stability Group, Rowett Research Institute, Aberdeen SCO, UK
    Eur J Nutr 44:195-203. 2005
    ..Anthocyanins are found in significant concentrations in the human diet. However, it remains to be established whether they are bioactive in vivo...
  8. ncbi request reprint Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells
    S J Duthie
    Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK
    Nutr Cancer 37:245-51. 2000
    ..These results demonstrate that folic acid modulates DNA repair, DNA strand breakage, and uracil misincorporation in immortalized human colonocytes and that folate deficiency substantially decreases DNA stability in these cells...
  9. ncbi request reprint Impact of folate deficiency on DNA stability
    Susan J Duthie
    Rowett Research Institute, Aberdeen, United Kingdom
    J Nutr 132:2444S-2449S. 2002
    ....
  10. ncbi request reprint DNA stability and genomic methylation status in colonocytes isolated from methyl-donor-deficient rats
    S J Duthie
    Rowett Research Institute, Aberdeen, UK
    Eur J Nutr 39:106-11. 2000
    ..Folate deficiency may increase the risk of malignant transformation by perturbing these pathways...
  11. ncbi request reprint Homocysteine, B vitamin status, and cognitive function in the elderly
    Susan J Duthie
    Rowett Research Institute, Aberdeen, United Kingdom
    Am J Clin Nutr 75:908-13. 2002
    ..Old age is associated with reduced cognitive performance. Nutritional factors may contribute to this association...
  12. ncbi request reprint Cryopreserved versus freshly isolated lymphocytes in human biomonitoring: endogenous and induced DNA damage, antioxidant status and repair capability
    S J Duthie
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Mutagenesis 17:211-4. 2002
    ..Cryopreserved lymphocytes were unable to repair oxidant-induced DNA strand breaks. Frozen human lymphocytes can therefore be successfully used for most aspects of DNA damage biomonitoring, but not for repair...
  13. ncbi request reprint Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo
    Sabrina Narayanan
    Division of Cellular Integrity, Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
    Cancer Epidemiol Biomarkers Prev 13:1436-43. 2004
    ....
  14. doi request reprint The influence of bisnaphthalimidopropyl polyamines on DNA instability and repair in Caco-2 colon epithelial cells
    Charles Stuart Bestwick
    Rowett Institute of Nutrition and Health, University of Aberdeen, Scotland, UK
    Cell Biol Toxicol 27:455-63. 2011
    ..The latter is a novel consequence of BNIPP-cell interactions which adds to the spectrum of therapeutically relevant activities that may be exploited for the design and development of naphthalimide-based therapeutics...
  15. doi request reprint Homocysteine, antioxidant micronutrients and late onset dementia
    Lawrence J Whalley
    Institute of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, Scotland, AB25 2ZH, UK
    Eur J Nutr 53:277-85. 2014
    ..To distinguish between contributions to dementia made by homocysteine, folate, B12 and antioxidant micronutrients...
  16. doi request reprint Suboptimal dietary zinc intake promotes vascular inflammation and atherogenesis in a mouse model of atherosclerosis
    John H Beattie
    Division of Lifelong Health, Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen, Scotland, UK
    Mol Nutr Food Res 56:1097-105. 2012
    ..We investigated the influence of suboptimal zinc intake in a Western-type diet on the development of vascular inflammation and arterial plaque in apoE knock-out (AEKO) mice...
  17. doi request reprint Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis
    Susan J Duthie
    Nutrition and Epigenetics Group, Division of Vascular Health, Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen, UK
    J Inherit Metab Dis 34:101-9. 2011
    ..Folate deficiency induces and accelerates carcinogenesis by perturbing each of these processes. This review presents recent evidence describing how these mechanisms act, and interact, to modify colon cancer risk...
  18. doi request reprint Epigenetic modifications and human pathologies: cancer and CVD
    Susan J Duthie
    Nutrition and Epigenetics Group, Division of Vascular Health, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK
    Proc Nutr Soc 70:47-56. 2011
    ..This review describes how flavonoids and folates in the human diet alter DNA methylation and may modify the risk of human colon cancer and CVD...
  19. ncbi request reprint Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations
    Charles S Bestwick
    Molecular Nutrition Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Chem Biol Interact 170:76-85. 2007
    ..This heterogeneity of response may confound the disease-preventative role and pharmacological application of this flavonoid...
  20. pmc Variation in protein levels obtained from human blood cells and biofluids for platelet, peripheral blood mononuclear cell, plasma, urine and saliva proteomics
    L Katie Crosley
    Rowett Institute of Nutrition and Health, University of Aberdeen, Greenburn Road, Bucksburn, Aberdeen, AB51 7HJ, UK
    Genes Nutr 4:95-102. 2009
    ..Certain disease conditions may cause higher or lower PBMC counts and thus protein yields, or increased urinary protein levels...
  21. ncbi request reprint The effect of short-term kaempferol exposure on reactive oxygen levels and integrity of human (HL-60) leukaemic cells
    Charles S Bestwick
    Phytochemical and Genomic Stability Group, Cellular Integrity Programme, Rowett Research Institute, Bucksburn, Aberdeen, UK
    Biochim Biophys Acta 1740:340-9. 2005
    ..The relevance of induced DNA damage within a non-overtly oxidatively stressed environment to the disease preventative and therapeutic use of kaempferol is discussed...
  22. doi request reprint Nutritional B vitamin deficiency disrupts lipid metabolism causing accumulation of proatherogenic lipoproteins in the aorta adventitia of ApoE null mice
    Christopher J McNeil
    Division of Lifelong Health, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, United Kingdom
    Mol Nutr Food Res 56:1122-30. 2012
    ..Cardiovascular disease is the major cause of death in the world. Low dietary folate, elevated homocysteine, and high circulating cholesterol are risk factors...
  23. doi request reprint How the 1932 and 1947 mental surveys of Aberdeen schoolchildren provide a framework to explore the childhood origins of late onset disease and disability
    Lawrence J Whalley
    Institute of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    Maturitas 69:365-72. 2011
    ..To describe the discovery and development of the Aberdeen 1921 and 1936 birth cohort studies...
  24. doi request reprint Proteomic methodological recommendations for studies involving human plasma, platelets, and peripheral blood mononuclear cells
    Baukje de Roos
    Rowett Research Institute, Aberdeen, United Kingdom
    J Proteome Res 7:2280-90. 2008
    ..The use of tricine in the running buffer for the second dimension appears to enhance the resolution of proteins especially in the high molecular weight range...
  25. ncbi request reprint Increased salicylate concentrations in urine of human volunteers after consumption of cranberry juice
    Garry G Duthie
    Rowett Research Institute, Aberdeen AB21 9SB, Scotland, UK
    J Agric Food Chem 53:2897-900. 2005
    ..05) increase in salicylic acid in plasma. The regular consumption of cranberry juice results in the increased absorption of salicylic acid, an anti-inflammatory compound that may benefit health...
  26. ncbi request reprint Serum concentrations of homocysteine are elevated during early pregnancy in rodent models of fetal programming
    Linda Petrie
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Br J Nutr 88:471-7. 2002
    ..Our present findings are discussed with particular reference to mechanisms which may initiate fetal programming, and to the feasibility of dietary interventions aimed at reducing early pregnancy loss and pre-eclampsia in man...
  27. doi request reprint Rapid quantification of aortic lesions in apoE(-/-) mice
    John H Beattie
    Division of Vascular Health, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK
    J Vasc Res 46:347-52. 2009
    ..9 and 2.5 times higher than the background, respectively. We conclude that the ORO solubilisation technique applied to AA samples is a very useful and rapid method for atherosclerotic lesion quantification...