Susan J Duthie

..g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2]...

..The differences in effectiveness of these dietary compounds against oxidative DNA damage may be explained by differences in their chemical structure or location within the cell...

..Supplementation with synthetic folic acid increased expression of these proteins but did not substantially disrupt the balance of these pathways...

..Evidence for an anticarcinogenic effect in human studies is weak...

..Non-nutritive anthocyanins are present in significant amounts in the human diet. However, it is unclear whether they have health benefits in humans...

..Evidence from animal and human studies is presented here in support of folate acting to maintain genomic stability through both these mechanisms...

..Anthocyanins are found in significant concentrations in the human diet. However, it remains to be established whether they are bioactive in vivo...

..These results demonstrate that folic acid modulates DNA repair, DNA strand breakage, and uracil misincorporation in immortalized human colonocytes and that folate deficiency substantially decreases DNA stability in these cells...

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..Folate deficiency may increase the risk of malignant transformation by perturbing these pathways...

..Old age is associated with reduced cognitive performance. Nutritional factors may contribute to this association...

..Cryopreserved lymphocytes were unable to repair oxidant-induced DNA strand breaks. Frozen human lymphocytes can therefore be successfully used for most aspects of DNA damage biomonitoring, but not for repair...

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..The latter is a novel consequence of BNIPP-cell interactions which adds to the spectrum of therapeutically relevant activities that may be exploited for the design and development of naphthalimide-based therapeutics...

..We investigated the influence of suboptimal zinc intake in a Western-type diet on the development of vascular inflammation and arterial plaque in apoE knock-out (AEKO) mice...

..Folate deficiency induces and accelerates carcinogenesis by perturbing each of these processes. This review presents recent evidence describing how these mechanisms act, and interact, to modify colon cancer risk...

..This review describes how flavonoids and folates in the human diet alter DNA methylation and may modify the risk of human colon cancer and CVD...

..This heterogeneity of response may confound the disease-preventative role and pharmacological application of this flavonoid...

..Certain disease conditions may cause higher or lower PBMC counts and thus protein yields, or increased urinary protein levels...

..The relevance of induced DNA damage within a non-overtly oxidatively stressed environment to the disease preventative and therapeutic use of kaempferol is discussed...

..Cardiovascular disease is the major cause of death in the world. Low dietary folate, elevated homocysteine, and high circulating cholesterol are risk factors...

..To describe the discovery and development of the Aberdeen 1921 and 1936 birth cohort studies...

..The use of tricine in the running buffer for the second dimension appears to enhance the resolution of proteins especially in the high molecular weight range...

..05) increase in salicylic acid in plasma. The regular consumption of cranberry juice results in the increased absorption of salicylic acid, an anti-inflammatory compound that may benefit health...

..Our present findings are discussed with particular reference to mechanisms which may initiate fetal programming, and to the feasibility of dietary interventions aimed at reducing early pregnancy loss and pre-eclampsia in man...

..9 and 2.5 times higher than the background, respectively. We conclude that the ORO solubilisation technique applied to AA samples is a very useful and rapid method for atherosclerotic lesion quantification...