G G Duthie

Summary

Affiliation: Rowett Research Institute
Country: UK

Publications

  1. ncbi request reprint Increased salicylate concentrations in urine of human volunteers after consumption of cranberry juice
    Garry G Duthie
    Rowett Research Institute, Aberdeen AB21 9SB, Scotland, UK
    J Agric Food Chem 53:2897-900. 2005
  2. ncbi request reprint Plant polyphenols: are they the new magic bullet?
    Garry G Duthie
    Rowett Research Institute, Aberdeen AB21 9SB, UK
    Proc Nutr Soc 62:599-603. 2003
  3. ncbi request reprint Determination of activity of antioxidants in human subjects
    G G Duthie
    Rowett Research Institute, Aberdeen, UK
    Proc Nutr Soc 58:1015-24. 1999
  4. ncbi request reprint Antioxidant efficacy of phytoestrogens in chemical and biological model systems
    J H Mitchell
    Division of Micronutrients and Lipid Metabolism, Rowett Research Institute, Bucksburn, AB21 9SB, UK
    Arch Biochem Biophys 360:142-8. 1998
  5. ncbi request reprint Quercetin and myricetin protect against hydrogen peroxide-induced DNA damage (strand breaks and oxidised pyrimidines) in human lymphocytes
    S J Duthie
    Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK
    Mutat Res 393:223-31. 1997
  6. ncbi request reprint The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers
    S J Duthie
    Phytochemicals and Genomic Stability Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen Sco AB21 9SB, UK
    Eur J Nutr 45:113-22. 2006
  7. ncbi request reprint Anthocyanin-rich extract decreases indices of lipid peroxidation and DNA damage in vitamin E-depleted rats
    C Ramirez-Tortosa
    Antioxidants and DNA Damage Group, Rowett Research Institute, Aberdeen, Scotland, UK
    Free Radic Biol Med 31:1033-7. 2001
  8. ncbi request reprint Antioxidant enzyme activities, lipid peroxidation, and DNA oxidative damage: the effects of short-term voluntary wheel running
    Colin Selman
    Aberdeen Centre for Energy Expenditure and Obesity ACERO, Department of Zoology, Aberdeen University, Aberdeen AB24 2TZ, Scotland, UK
    Arch Biochem Biophys 401:255-61. 2002
  9. doi request reprint Bound phytophenols from ready-to-eat cereals: comparison with other plant-based foods
    M Neacsu
    Natural Products Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB21 9SB, UK
    Food Chem 141:2880-6. 2013
  10. ncbi request reprint Erythrocyte vitamin E and plasma ascorbate concentrations in relation to erythrocyte peroxidation in smokers and nonsmokers: dose response to vitamin E supplementation
    K M Brown
    Rowett Research Institute, Bucksburn, Scotland, United Kingdom
    Am J Clin Nutr 65:496-502. 1997

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Increased salicylate concentrations in urine of human volunteers after consumption of cranberry juice
    Garry G Duthie
    Rowett Research Institute, Aberdeen AB21 9SB, Scotland, UK
    J Agric Food Chem 53:2897-900. 2005
    ..05) increase in salicylic acid in plasma. The regular consumption of cranberry juice results in the increased absorption of salicylic acid, an anti-inflammatory compound that may benefit health...
  2. ncbi request reprint Plant polyphenols: are they the new magic bullet?
    Garry G Duthie
    Rowett Research Institute, Aberdeen AB21 9SB, UK
    Proc Nutr Soc 62:599-603. 2003
    ....
  3. ncbi request reprint Determination of activity of antioxidants in human subjects
    G G Duthie
    Rowett Research Institute, Aberdeen, UK
    Proc Nutr Soc 58:1015-24. 1999
    ..Until more is known about the activity and metabolic fate of antioxidants, caution should be exercised in the consumption of large amounts of commercially-available antioxidant preparations...
  4. ncbi request reprint Antioxidant efficacy of phytoestrogens in chemical and biological model systems
    J H Mitchell
    Division of Micronutrients and Lipid Metabolism, Rowett Research Institute, Bucksburn, AB21 9SB, UK
    Arch Biochem Biophys 360:142-8. 1998
    ..As the concentrations of PEs used in this study exceed the estimated serum concentrations, their relatively poor antioxidant ability in vitro may indicate little significance as antioxidants in vivo...
  5. ncbi request reprint Quercetin and myricetin protect against hydrogen peroxide-induced DNA damage (strand breaks and oxidised pyrimidines) in human lymphocytes
    S J Duthie
    Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK
    Mutat Res 393:223-31. 1997
    ..The differences in effectiveness of these dietary compounds against oxidative DNA damage may be explained by differences in their chemical structure or location within the cell...
  6. ncbi request reprint The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers
    S J Duthie
    Phytochemicals and Genomic Stability Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen Sco AB21 9SB, UK
    Eur J Nutr 45:113-22. 2006
    ..Non-nutritive anthocyanins are present in significant amounts in the human diet. However, it is unclear whether they have health benefits in humans...
  7. ncbi request reprint Anthocyanin-rich extract decreases indices of lipid peroxidation and DNA damage in vitamin E-depleted rats
    C Ramirez-Tortosa
    Antioxidants and DNA Damage Group, Rowett Research Institute, Aberdeen, Scotland, UK
    Free Radic Biol Med 31:1033-7. 2001
    ..These compounds are indices of lipid peroxidation and DNA damage, respectively. Dietary consumption of anthocyanin-rich foods may contribute to overall antioxidant status, particularly in areas of habitually low vitamin E intake...
  8. ncbi request reprint Antioxidant enzyme activities, lipid peroxidation, and DNA oxidative damage: the effects of short-term voluntary wheel running
    Colin Selman
    Aberdeen Centre for Energy Expenditure and Obesity ACERO, Department of Zoology, Aberdeen University, Aberdeen AB24 2TZ, Scotland, UK
    Arch Biochem Biophys 401:255-61. 2002
    ..There was no evidence of any significant increase in any oxidative stress parameter in running individuals, despite having significantly elevated energy expenditures compared to sedentary controls...
  9. doi request reprint Bound phytophenols from ready-to-eat cereals: comparison with other plant-based foods
    M Neacsu
    Natural Products Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB21 9SB, UK
    Food Chem 141:2880-6. 2013
    ..The increased amount of these phenolic metabolites may, in part, explain the evidence for the protective effects of whole-grain cereals. ..
  10. ncbi request reprint Erythrocyte vitamin E and plasma ascorbate concentrations in relation to erythrocyte peroxidation in smokers and nonsmokers: dose response to vitamin E supplementation
    K M Brown
    Rowett Research Institute, Bucksburn, Scotland, United Kingdom
    Am J Clin Nutr 65:496-502. 1997
    ..001), and in nonsmokers receiving 1050 mg, the susceptibility to peroxidation also increased (P < 0.001). Thus, vitamin E may have prooxidant activity in nonsmokers at high and prolonged intakes...
  11. ncbi request reprint The effect of increased intakes of polyunsaturated fatty acids and vitamin E on DNA damage in human lymphocytes
    A M Jenkinson
    Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK
    FASEB J 13:2138-42. 1999
    ..Jenkinson, A. McE., Collins, A. R., Duthie, S. J., Wahle, K. W. J., Duthie, G. G. The effect of increased intakes of polyunsaturated fatty acids and vitamin E on DNA damage in human lymphocytes...
  12. ncbi request reprint Effects of infusion time and addition of milk on content and absorption of polyphenols from black tea
    Janet A M Kyle
    Rowett Research Institute, Aberdeen AB21 9SB, Scotland, U K
    J Agric Food Chem 55:4889-94. 2007
    ..Observational studies assessing the health benefits of tea consumption require recording of brewing methods as well as frequency of consumption...
  13. doi request reprint Anti-inflammatory implications of the microbial transformation of dietary phenolic compounds
    Wendy R Russell
    Molecular Nutrition Group, Rowett Research Institute, Aberdeen, United Kingdom
    Nutr Cancer 60:636-42. 2008
    ..This suggests that the microbial transformation of dietary compounds will have important inflammatory implications in the chemoprevention of colon cancer...
  14. ncbi request reprint Novel sites of cytosolic glutathione peroxidase expression in colon
    Janice E Drew
    Gut Health Division, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
    FEBS Lett 579:6135-9. 2005
    ..These results support the potential for Gpx1 and Gpx2 redundancy in lymphatic tissue, but not in epithelial cells of the colon crypt or in the lamina propria, sub-mucosa, muscularis or serosa...
  15. ncbi request reprint Salicylate modulates oxidative stress in the rat colon: a proteomic approach
    Janice E Drew
    Gut Health Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB Scotland, UK
    Biochem Pharmacol 72:204-16. 2006
    ....
  16. ncbi request reprint A proteomics approach to identify changes in protein profiles in pre-cancerous colon
    Janice E Drew
    Cellular Integrity Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB Scotland, UK
    Biochem Biophys Res Commun 330:81-7. 2005
    ..These changes may have a potential role in the identification of pre-pathological features preceding colon tumorigenesis...
  17. ncbi request reprint Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy
    Donald B McPhail
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland
    J Agric Food Chem 51:1684-90. 2003
    ..However, rates and stoichiometries did not always correlate and the data suggest that kinetic factors may be of greater importance within a biological context...
  18. ncbi request reprint DNA stability and lipid peroxidation in vitamin E-deficient rats in vivo and colon cells in vitro--modulation by the dietary anthocyanin, cyanidin-3-glycoside
    Susan J Duthie
    Phytochemicals and Genomic Stability Group, Rowett Research Institute, Aberdeen SCO, UK
    Eur J Nutr 44:195-203. 2005
    ..Anthocyanins are found in significant concentrations in the human diet. However, it remains to be established whether they are bioactive in vivo...
  19. doi request reprint Selective bio-availability of phenolic acids from Scottish strawberries
    Wendy R Russell
    Molecular Nutrition Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK
    Mol Nutr Food Res 53:S85-91. 2009
    ..If selective absorption of phenolic acids is observed with consumption of other plant-based foods, this is likely to have implications for the bioactive role of these compounds in chronic disease prevention...
  20. ncbi request reprint Salicylic acid modulates oxidative stress and glutathione peroxidase activity in the rat colon
    Janice E Drew
    Gut Health Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
    Biochem Pharmacol 70:888-93. 2005
    ..The ability of salicylic acid to modulate antioxidant enzymes in colon tissue may be an important mechanism in inhibiting colon cancer development...
  21. ncbi request reprint Assessment of the antioxidant potential of scotch whiskeys by electron spin resonance spectroscopy: relationship to hydroxyl-containing aromatic components
    D B McPhail
    Rowett Research Institute, Aberdeen, Scotland
    J Agric Food Chem 47:1937-41. 1999
    ..There was no evidence for synergistic interaction between the phenols investigated...
  22. ncbi request reprint Oxidative stress in colon tissue induced by vitamin E depletion
    J E Drew
    Cellular Integrity, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
    Biochem Soc Trans 32:979-81. 2004
    ..These changes in colon tissue are potentially important in disease pathogenesis of the colon linked with oxidative stress or other direct consequences of inadequate levels of vitamin E...
  23. ncbi request reprint Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation
    Christopher J Bennett
    OxyProTec Research Team, Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Bioorg Med Chem 12:2079-98. 2004
    ..The alkyl tails are introduced by Suzuki or Negishi palladium-catalysed cross-coupling or by cross-metathesis catalysed by first generation Grubbs catalyst, which tolerate phenolic hydroxyl and ketone groups...
  24. doi request reprint Impact of dietary polyphenols on human platelet function--a critical review of controlled dietary intervention studies
    Luisa M Ostertag
    Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK
    Mol Nutr Food Res 54:60-81. 2010
    ....
  25. doi request reprint Dietary flavonoid intake and colorectal cancer: a case-control study
    Janet A M Kyle
    Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB21 9SB, UK
    Br J Nutr 103:429-36. 2010
    ..5; 95 % CI 0.3, 0.8; P(trend) < 0.01). We concluded that flavonols, specifically quercetin, obtained from non-tea components of the diet may be linked with reduced risk of developing colon cancer...
  26. ncbi request reprint Effects of organic and inorganic selenium supplementation on selenoenzyme activity in blood lymphocytes, granulocytes, platelets and erythrocytes
    K M Brown
    Rowett Research Institute, Division of Micronutrient and Lipid Metabolism, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, U K
    Clin Sci (Lond) 98:593-9. 2000
    ..The different and contrasting effects that Se supplementation had on blood selenoenzyme activities may be indicative of a difference in metabolic need for Se regulated at the level of Se-dependent cell function...
  27. ncbi request reprint Inhibition of cytokine-induced prostanoid biogenesis by phytochemicals in human colonic fibroblasts
    Wendy R Russell
    Gut Health Division, Molecular Nutrition Group, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
    Biochim Biophys Acta 1762:124-30. 2006
    ..Common structural features of the inhibitors were the presence of 4-hydroxyl and 3-methoxyl substituents on the aromatic ring and/or the presence of a three-carbon side-chain on C1...
  28. doi request reprint Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids
    Wendy R Russell
    Molecular Nutrition Group, Rowett Research Institute, Aberdeen, AB21 9SB, Scotland, UK
    Bioorg Med Chem 16:4589-93. 2008
    ..No correlation was observed with the ability to act as reductants, supporting the hypothesis that their mode of inhibition may not be by a direct redox effect on the non-haem iron...
  29. ncbi request reprint Insulin, leptin, and adiponectin receptors in colon: regulation relative to differing body adiposity independent of diet and in response to dimethylhydrazine
    Janice E Drew
    Gut Health Division, Rowett Research Institute, Greenburn Rd, Bucksburn, Aberdeen, AB21 9SB, Scotland, UK
    Am J Physiol Gastrointest Liver Physiol 293:G682-91. 2007
    ..These findings do not support a direct link between the deregulation of insulin and adipokine levels observed in obese rats and an increased risk of colon carcinogenesis...
  30. doi request reprint Lifelong alpha-tocopherol supplementation increases the median life span of C57BL/6 mice in the cold but has only minor effects on oxidative damage
    Colin Selman
    Integrative Physiology, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom
    Rejuvenation Res 11:83-96. 2008
    ..However, these signaling pathways now require further investigation to establish their exact role in life span extension following alpha-tocopherol supplementation...
  31. ncbi request reprint The bioavailability of raspberry anthocyanins and ellagitannins in rats
    Gina Borges
    Institute of Biomedical and Life Science, University of Glasgow, Glasgow, UK
    Mol Nutr Food Res 51:714-25. 2007
    ..Ellagitannins disappeared in the stomach without accumulation of ellagic acid...
  32. ncbi request reprint Berry fruits
    Garry G Duthie
    Mol Nutr Food Res 51:643. 2007
  33. ncbi request reprint Life-long vitamin C supplementation in combination with cold exposure does not affect oxidative damage or lifespan in mice, but decreases expression of antioxidant protection genes
    Colin Selman
    Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Mech Ageing Dev 127:897-904. 2006
    ....
  34. ncbi request reprint Effect of freezing and storage on the phenolics, ellagitannins, flavonoids, and antioxidant capacity of red raspberries
    William Mullen
    Plant Products and Human Nutrition Group, Graham Kerr Building, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, United Kingdom
    J Agric Food Chem 50:5197-201. 2002
    ..It is concluded, therefore, that freshly picked, fresh commercial, and frozen raspberries all contain similar levels of phytochemicals and antioxidants per serving...
  35. ncbi request reprint The influence of moderate red wine consumption on antioxidant status and indices of oxidative stress associated with CHD in healthy volunteers
    Catherine Tsang
    Plant Products and Human Nutrition Group, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, UK
    Br J Nutr 93:233-40. 2005
    ..05) following red wine consumption. The findings from the present study provide some evidence for potential protective effects of moderate consumption of red wine in healthy volunteers...
  36. ncbi request reprint Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties
    William Mullen
    Plant Products and Human Nutrition Group, Graham Kerr Building, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, United Kingdom
    J Agric Food Chem 50:5191-6. 2002
    ..Vasodilation activity was restricted to fractions containing lambertianin C and sanguiin H-6...
  37. ncbi request reprint Determination of flavonol metabolites in plasma and tissues of rats by HPLC-radiocounting and tandem mass spectrometry following oral ingestion of [2-(14)C]quercetin-4'-glucoside
    William Mullen
    Plant Products and Human Nutrition Group, Graham Kerr Building, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    J Agric Food Chem 50:6902-9. 2002
    ....
  38. ncbi request reprint Biphasic effect of falcarinol on caco-2 cell proliferation, DNA damage, and apoptosis
    Jette F Young
    Danish Institute of Agricultural Sciences, Department of Food Science, Research Centre Foulum, P O Box 50, DK 8830 Tjele, Denmark
    J Agric Food Chem 55:618-23. 2007
    ..Thus, the effects of falcarinol on CaCo-2 cells appear to be biphasic, inducing pro-proliferative and apoptotic characteristics at low and high concentrations of falcarinol, respectively...
  39. pmc The impact of experimentally elevated energy expenditure on oxidative stress and lifespan in the short-tailed field vole Microtus agrestis
    Colin Selman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Proc Biol Sci 275:1907-16. 2008
    ..These data suggest that in captive animals physiologically mediated costs on life history do not result from increased energy expenditure and consequent elevations in oxidative stress and reduced survival...
  40. ncbi request reprint Disposition and metabolism of [2-14C]quercetin-4'-glucoside in rats
    Brigitte A Graf
    Plant Products and Human Nutrition Group, Division of Developmental Medicine, University of Glasgow, Glasgow G3 8SJ, UK
    Drug Metab Dispos 33:1036-43. 2005
    ..The main site of quercetin metabolism seemed to be the gastrointestinal tract. Quercetin metabolites may have a major influence on the gut mucosal epithelium and on colonic disease...