Research Topics
Genomes and Genes | J E DrewSummaryAffiliation: Rowett Research Institute Country: UK Publications
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Detail Information
Publications
A proteomics approach to identify changes in protein profiles in pre-cancerous colonJanice E Drew
Cellular Integrity Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB Scotland, UK
Biochem Biophys Res Commun 330:81-7. 2005..These changes may have a potential role in the identification of pre-pathological features preceding colon tumorigenesis...- Identification and characterisation of 2-[125I]iodomelatonin binding and Mel1a melatonin receptor expression in the human fetal leptomeningesJ E Drew
Molecular Neuroendocrinology Group, Rowett Research Institute, Bucksburn, Aberdeen, UK
Brain Res 761:87-92. 1997..The identification of 2-[125I]iodomelatonin and Mel1a melatonin receptor expression in the fetal leptomeninges implies that melatonin may play a role in the early growth and development of the human brain... - Novel sites of cytosolic glutathione peroxidase expression in colonJanice E Drew
Gut Health Division, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
FEBS Lett 579:6135-9. 2005..These results support the potential for Gpx1 and Gpx2 redundancy in lymphatic tissue, but not in epithelial cells of the colon crypt or in the lamina propria, sub-mucosa, muscularis or serosa... - Salicylate modulates oxidative stress in the rat colon: a proteomic approachJanice E Drew
Gut Health Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB Scotland, UK
Biochem Pharmacol 72:204-16. 2006.... - Differential coupling of the extreme C-terminus of G protein alpha subunits to the G protein-coupled melatonin receptorsJanice E Drew
Phytochemicals and Genomic Stability, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
Biochim Biophys Acta 1592:185-92. 2002..Recognition of the C-terminal five amino acids of the Galpha subunit is a requisite for coupling to a receptor, but it is not the sole determinant... - Localization of the melatonin-related receptor in the rodent brain and peripheral tissuesJ E Drew
Molecular Neuroendocrinology Group, Rowett Research Institute, Bucksburn, Aberdeen, UK
J Neuroendocrinol 13:453-8. 2001..These results suggest a conserved function in neuroendocrine regulation and a potential role in coordinating physiological responses in the central nervous system and peripheral tissues... - Chimeric melatonin mt1 and melatonin-related receptors. Identification of domains and residues participating in ligand binding and receptor activation of the melatonin mt1 receptorS Conway
Molecular Neuroendocrinology Group, Division of Appetite and Energy Balance, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, United Kingdom
J Biol Chem 275:20602-9. 2000..This identified Gly(258) (Gly(6.55)) as a critical residue required for high affinity ligand binding and receptor function... - Characterisation of human melatonin mt(1) and MT(2) receptors by CRE-luciferase reporter assayS Conway
Molecular Neuroendocrinology Unit, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, UK
Eur J Pharmacol 390:15-24. 2000..We conclude that the CRE-luciferase reporter gene assay provides an effective functional screening method for the pharmacological characterisation of human melatonin receptor subtypes... - Serine residues 110 and 114 are required for agonist binding but not antagonist binding to the melatonin MT(1) receptorS Conway
Molecular Neuroendocrinology Group, Division of Appetite and Energy Balance, Rowett Research Institute, Bucksburn, Aberdeen, AB21 9SB, United Kingdom
Biochem Biophys Res Commun 282:1229-36. 2001..35) and Ser(3.39), in transmembrane domain 3, are critical for the formation of the high-affinity ligand binding site for agonists and partial agonists but not for the antagonist luzindole... - Identification of Mel1a melatonin receptors in the human embryonic kidney cell line HEK293: evidence of G protein-coupled melatonin receptors which do not mediate the inhibition of stimulated cyclic AMP levelsS Conway
Molecular Neuroendocrinology Group, Rowett Research Institute, Bucksburn, Aberdeen, UK
FEBS Lett 407:121-6. 1997..7 pM). These data may indicate that certain tissues, expressing low levels of G protein-coupled melatonin receptors, do not display melatonin mediated inhibition of cAMP... - Characterization of an antibody to the human melatonin mt1 receptorL M Williams
Molecular Physiology Group, The Rowett Research Institute, Aberdeen, UK
J Neuroendocrinol 13:94-101. 2001..Thus, Y31 antibody is suitable for use in detecting the human mt1 receptor subtype in tissues and in transfected cells... - The ovine melatonin-related receptor: cloning and preliminary distribution and binding studiesJ E Drew
Molecular Neuroendocrinology Unit, Rowett Research Institute, Bucksburn, Aberdeen, UK
J Neuroendocrinol 10:651-61. 1998..Expression patterns and similarity with the melatonin receptor gene family suggest a role for this novel G protein-coupled receptor in control and regulation of endocrine function and retinal physiology... 
Anti-inflammatory implications of the microbial transformation of dietary phenolic compoundsWendy R Russell
Molecular Nutrition Group, Rowett Research Institute, Aberdeen, United Kingdom
Nutr Cancer 60:636-42. 2008..This suggests that the microbial transformation of dietary compounds will have important inflammatory implications in the chemoprevention of colon cancer...- Oxidative stress in colon tissue induced by vitamin E depletionJ E Drew
Cellular Integrity, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
Biochem Soc Trans 32:979-81. 2004..These changes in colon tissue are potentially important in disease pathogenesis of the colon linked with oxidative stress or other direct consequences of inadequate levels of vitamin E... - Salicylic acid modulates oxidative stress and glutathione peroxidase activity in the rat colonJanice E Drew
Gut Health Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
Biochem Pharmacol 70:888-93. 2005..The ability of salicylic acid to modulate antioxidant enzymes in colon tissue may be an important mechanism in inhibiting colon cancer development... - Melatonin receptors in human fetal brain: 2-[(125)I]iodomelatonin binding and MT1 gene expressionLouise Thomas
Molecular Neuroendocrinology and Phytochemical and Genome Stability Groups, Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK
J Pineal Res 33:218-24. 2002.... - Inhibition of cytokine-induced prostanoid biogenesis by phytochemicals in human colonic fibroblastsWendy R Russell
Gut Health Division, Molecular Nutrition Group, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
Biochim Biophys Acta 1762:124-30. 2006..Common structural features of the inhibitors were the presence of 4-hydroxyl and 3-methoxyl substituents on the aromatic ring and/or the presence of a three-carbon side-chain on C1... - Complex regulation of mucosal pentraxin (Mptx) revealed by discrete micro-anatomical locations in colonJanice E Drew
Molecular Nutrition, Gut Health, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
Biochim Biophys Acta 1762:844-8. 2006..This study demonstrates that consideration of regional differences in Mptx gene expression and micro-anatomical location is necessary in the interpretation and deciphering of its regulation in colon... - Profiling of mitochondrial associated proteins from rat colonSara Padidar
Gut Health Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
J Cell Biochem 103:78-97. 2008.... - Influence of increased adiposity on mitochondrial-associated proteins of the rat colon: a proteomic and transcriptomic analysisSara Padidar
Molecular Nutrition, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB, Scotland, UK
Biochim Biophys Acta 1782:532-41. 2008..The changes in these mitochondrial protein profiles were not correlated with changes at the gene expression level assessed using real-time PCR arrays... - Insulin, leptin, and adiponectin receptors in colon: regulation relative to differing body adiposity independent of diet and in response to dimethylhydrazineJanice E Drew
Gut Health Division, Rowett Research Institute, Greenburn Rd, Bucksburn, Aberdeen, AB21 9SB, Scotland, UK
Am J Physiol Gastrointest Liver Physiol 293:G682-91. 2007..These findings do not support a direct link between the deregulation of insulin and adipokine levels observed in obese rats and an increased risk of colon carcinogenesis...