Research Topics
| A R CollinsSummaryAffiliation: Rowett Research Institute Country: UK Publications
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Detail Information
Publications
Oxidative damage to DNA: do we have a reliable biomarker?A R Collins
Rowett Research Institute, Aberdeen, Scotland, United Kingdom
Environ Health Perspect 104:465-9. 1996..It is still an open question whether 8-OHgua, measured by HPLC or by the comet assay, is a valid marker for oxidative damage...
Carotenoids and genomic stabilityA R Collins
Rowett Research Institute, DNA Instability Group, Greenburn Road, Bucksburn, AB21 9SB, Aberdeen, UK
Mutat Res 475:21-8. 2001..It seems clear that the carotenoids act as antioxidants in vivo, and yet this activity may not result in cancer prevention...- Detection of alkylation damage in human lymphocyte DNA with the comet assayA R Collins
Rowett Research Institute, Aberdeen, UK
Acta Biochim Pol 48:611-4. 2001..AlkA detects damage in the DNA of cells treated with low concentrations of methyl methanesulphonate. We also find low background levels of alkylated bases in normal human lymphocytes... - Molecular epidemiology in cancer researchA R Collins
Rowett Research Institute, DNA Instability Group, Bucksburn, Aberdeen, UK
Mol Aspects Med 19:359-432. 1998..So far, interpretation of the growing databases is largely speculative. (ABSTRACT.. - Oxidative DNA damage, antioxidants, and cancerA R Collins
Rowett Research Institute, Scotland, UK
Bioessays 21:238-46. 1999..It seems that efficient antioxidant defences together with DNA repair maintain a steady-state level of damage representing minimal risk to cell or organism... - Serum carotenoids and oxidative DNA damage in human lymphocytesA R Collins
Rowett Research Institute, Bucksburn, Aberdeen, UK
Carcinogenesis 19:2159-62. 1998..In this case, basal serum carotenoids may simply be markers of consumption of fruit and vegetables, they themselves having little or no protective value... - Comet assay in human biomonitoring studies: reliability, validation, and applicationsA Collins
Rowett Research Institute, Bucksburn, Aberdeen, UK
Environ Mol Mutagen 30:139-46. 1997..We applied the assay in investigations of human disease and occupational exposure of factory workers... - UV-sensitive rodent mutant cell lines of complementation groups 6 and 8 differ phenotypically from their human counterpartsA R Collins
Rowett Research Institute and University of Aberdeen, Bucksburn, United Kingdom
Environ Mol Mutagen 29:152-60. 1997..In both complementation groups, expression of mutations in a gene involved in regulation of DNA repair takes very different forms in human and rodent cells... - Oxidative DNA damage, antioxidants and DNA repair: applications of the comet assayA R Collins
Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, U K
Biochem Soc Trans 29:337-41. 2001..The steady-state level of DNA oxidation is ultimately controlled by the process of DNA repair; the extent to which this varies between individuals has yet to be established... - Antioxidant efficacy of phytoestrogens in chemical and biological model systemsJ H Mitchell
Division of Micronutrients and Lipid Metabolism, Rowett Research Institute, Bucksburn, AB21 9SB, UK
Arch Biochem Biophys 360:142-8. 1998..As the concentrations of PEs used in this study exceed the estimated serum concentrations, their relatively poor antioxidant ability in vitro may indicate little significance as antioxidants in vivo... - Inter-individual differences in repair of DNA base oxidation, measured in vitro with the comet assayA R Collins
Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB, UK
Mutagenesis 16:297-301. 2001..This new DNA repair assay is simple, rapid and requires only small quantities of lymphocyte extract (obtainable from 10 ml blood)... - Quercetin and myricetin protect against hydrogen peroxide-induced DNA damage (strand breaks and oxidised pyrimidines) in human lymphocytesS J Duthie
Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK
Mutat Res 393:223-31. 1997..The differences in effectiveness of these dietary compounds against oxidative DNA damage may be explained by differences in their chemical structure or location within the cell... - Kiwifruit protects against oxidative DNA damage in human cells and in vitroB H Collins
Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK
Nutr Cancer 39:148-53. 2001..Our dual approach is appropriate for testing other fruit and vegetable products for potential antioxidant effects... - Effects of age and dietary restriction on oxidative DNA damage, antioxidant protection and DNA repair in ratsC M Gedik
Rowett Research Institute, Greenburn Road, Aberdeen AB21 9SB, Scotland
Eur J Nutr 44:263-72. 2005..Restricted diets (including protein and calorie restriction) have no effect on any of these markers of genetic stability... - Anthocyanin-rich extract decreases indices of lipid peroxidation and DNA damage in vitamin E-depleted ratsC Ramirez-Tortosa
Antioxidants and DNA Damage Group, Rowett Research Institute, Aberdeen, Scotland, UK
Free Radic Biol Med 31:1033-7. 2001..These compounds are indices of lipid peroxidation and DNA damage, respectively. Dietary consumption of anthocyanin-rich foods may contribute to overall antioxidant status, particularly in areas of habitually low vitamin E intake... - Effects of a soy milk supplement on plasma cholesterol levels and oxidative DNA damage in men--a pilot studyJ H Mitchell
Rowett Research Institute, Bucksburn, UK Aberdeen, Great Britain
Eur J Nutr 38:143-8. 1999..They may also have antioxidant function in scavenging potentially harmful free radicals and thus decreasing oxidative attack on DNA... - The effect of increased intakes of polyunsaturated fatty acids and vitamin E on DNA damage in human lymphocytesA M Jenkinson
Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK
FASEB J 13:2138-42. 1999..Jenkinson, A. McE., Collins, A. R., Duthie, S. J., Wahle, K. W. J., Duthie, G. G. The effect of increased intakes of polyunsaturated fatty acids and vitamin E on DNA damage in human lymphocytes... - Bioavailability and efficiency of rutin as an antioxidant: a human supplementation studyS P Boyle
Rowett Research Institute, Bucksburn, Aberdeen, Scotland
Eur J Clin Nutr 54:774-82. 2000..To determine the potential antioxidant effect of rutin (quercetin-3-O-beta-rutinoside) supplementation... - Dietary supplement use in old age: associations with childhood IQ, current cognition and healthL J Whalley
University of Aberdeen, Clinical Research Centre, Royal Cornhill Hospital, Aberdeen, UK
Int J Geriatr Psychiatry 18:769-76. 2003..Dietary supplement (DS) use is actively promoted among old people but there is little evidence in favour of DS use or information about the demographic, health and cognitive characteristics of DS users... - Effect of a phytoestrogen food supplement on reproductive health in normal malesJ H Mitchell
Division of Cellular Integrity, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
Clin Sci (Lond) 100:613-8. 2001..This is the first study to examine the effects of a phytoestrogen supplement on reproductive health in males. We conclude that the phytoestrogen dose consumed had no effect on semen quality...