A R Collins

Summary

Affiliation: Rowett Research Institute
Country: UK

Publications

  1. pmc Oxidative damage to DNA: do we have a reliable biomarker?
    A R Collins
    Rowett Research Institute, Aberdeen, Scotland, United Kingdom
    Environ Health Perspect 104:465-9. 1996
  2. ncbi Carotenoids and genomic stability
    A R Collins
    Rowett Research Institute, DNA Instability Group, Greenburn Road, Bucksburn, AB21 9SB, Aberdeen, UK
    Mutat Res 475:21-8. 2001
  3. ncbi Detection of alkylation damage in human lymphocyte DNA with the comet assay
    A R Collins
    Rowett Research Institute, Aberdeen, UK
    Acta Biochim Pol 48:611-4. 2001
  4. ncbi Molecular epidemiology in cancer research
    A R Collins
    Rowett Research Institute, DNA Instability Group, Bucksburn, Aberdeen, UK
    Mol Aspects Med 19:359-432. 1998
  5. ncbi Oxidative DNA damage, antioxidants, and cancer
    A R Collins
    Rowett Research Institute, Scotland, UK
    Bioessays 21:238-46. 1999
  6. ncbi Serum carotenoids and oxidative DNA damage in human lymphocytes
    A R Collins
    Rowett Research Institute, Bucksburn, Aberdeen, UK
    Carcinogenesis 19:2159-62. 1998
  7. ncbi Comet assay in human biomonitoring studies: reliability, validation, and applications
    A Collins
    Rowett Research Institute, Bucksburn, Aberdeen, UK
    Environ Mol Mutagen 30:139-46. 1997
  8. ncbi UV-sensitive rodent mutant cell lines of complementation groups 6 and 8 differ phenotypically from their human counterparts
    A R Collins
    Rowett Research Institute and University of Aberdeen, Bucksburn, United Kingdom
    Environ Mol Mutagen 29:152-60. 1997
  9. ncbi Oxidative DNA damage, antioxidants and DNA repair: applications of the comet assay
    A R Collins
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, U K
    Biochem Soc Trans 29:337-41. 2001
  10. ncbi Antioxidant efficacy of phytoestrogens in chemical and biological model systems
    J H Mitchell
    Division of Micronutrients and Lipid Metabolism, Rowett Research Institute, Bucksburn, AB21 9SB, UK
    Arch Biochem Biophys 360:142-8. 1998

Detail Information

Publications20

  1. pmc Oxidative damage to DNA: do we have a reliable biomarker?
    A R Collins
    Rowett Research Institute, Aberdeen, Scotland, United Kingdom
    Environ Health Perspect 104:465-9. 1996
    ..It is still an open question whether 8-OHgua, measured by HPLC or by the comet assay, is a valid marker for oxidative damage...
  2. ncbi Carotenoids and genomic stability
    A R Collins
    Rowett Research Institute, DNA Instability Group, Greenburn Road, Bucksburn, AB21 9SB, Aberdeen, UK
    Mutat Res 475:21-8. 2001
    ..It seems clear that the carotenoids act as antioxidants in vivo, and yet this activity may not result in cancer prevention...
  3. ncbi Detection of alkylation damage in human lymphocyte DNA with the comet assay
    A R Collins
    Rowett Research Institute, Aberdeen, UK
    Acta Biochim Pol 48:611-4. 2001
    ..AlkA detects damage in the DNA of cells treated with low concentrations of methyl methanesulphonate. We also find low background levels of alkylated bases in normal human lymphocytes...
  4. ncbi Molecular epidemiology in cancer research
    A R Collins
    Rowett Research Institute, DNA Instability Group, Bucksburn, Aberdeen, UK
    Mol Aspects Med 19:359-432. 1998
    ..So far, interpretation of the growing databases is largely speculative. (ABSTRACT..
  5. ncbi Oxidative DNA damage, antioxidants, and cancer
    A R Collins
    Rowett Research Institute, Scotland, UK
    Bioessays 21:238-46. 1999
    ..It seems that efficient antioxidant defences together with DNA repair maintain a steady-state level of damage representing minimal risk to cell or organism...
  6. ncbi Serum carotenoids and oxidative DNA damage in human lymphocytes
    A R Collins
    Rowett Research Institute, Bucksburn, Aberdeen, UK
    Carcinogenesis 19:2159-62. 1998
    ..In this case, basal serum carotenoids may simply be markers of consumption of fruit and vegetables, they themselves having little or no protective value...
  7. ncbi Comet assay in human biomonitoring studies: reliability, validation, and applications
    A Collins
    Rowett Research Institute, Bucksburn, Aberdeen, UK
    Environ Mol Mutagen 30:139-46. 1997
    ..We applied the assay in investigations of human disease and occupational exposure of factory workers...
  8. ncbi UV-sensitive rodent mutant cell lines of complementation groups 6 and 8 differ phenotypically from their human counterparts
    A R Collins
    Rowett Research Institute and University of Aberdeen, Bucksburn, United Kingdom
    Environ Mol Mutagen 29:152-60. 1997
    ..In both complementation groups, expression of mutations in a gene involved in regulation of DNA repair takes very different forms in human and rodent cells...
  9. ncbi Oxidative DNA damage, antioxidants and DNA repair: applications of the comet assay
    A R Collins
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, U K
    Biochem Soc Trans 29:337-41. 2001
    ..The steady-state level of DNA oxidation is ultimately controlled by the process of DNA repair; the extent to which this varies between individuals has yet to be established...
  10. ncbi Antioxidant efficacy of phytoestrogens in chemical and biological model systems
    J H Mitchell
    Division of Micronutrients and Lipid Metabolism, Rowett Research Institute, Bucksburn, AB21 9SB, UK
    Arch Biochem Biophys 360:142-8. 1998
    ..As the concentrations of PEs used in this study exceed the estimated serum concentrations, their relatively poor antioxidant ability in vitro may indicate little significance as antioxidants in vivo...
  11. ncbi Inter-individual differences in repair of DNA base oxidation, measured in vitro with the comet assay
    A R Collins
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB, UK
    Mutagenesis 16:297-301. 2001
    ..This new DNA repair assay is simple, rapid and requires only small quantities of lymphocyte extract (obtainable from 10 ml blood)...
  12. ncbi Quercetin and myricetin protect against hydrogen peroxide-induced DNA damage (strand breaks and oxidised pyrimidines) in human lymphocytes
    S J Duthie
    Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK
    Mutat Res 393:223-31. 1997
    ..The differences in effectiveness of these dietary compounds against oxidative DNA damage may be explained by differences in their chemical structure or location within the cell...
  13. ncbi Kiwifruit protects against oxidative DNA damage in human cells and in vitro
    B H Collins
    Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK
    Nutr Cancer 39:148-53. 2001
    ..Our dual approach is appropriate for testing other fruit and vegetable products for potential antioxidant effects...
  14. ncbi Effects of age and dietary restriction on oxidative DNA damage, antioxidant protection and DNA repair in rats
    C M Gedik
    Rowett Research Institute, Greenburn Road, Aberdeen AB21 9SB, Scotland
    Eur J Nutr 44:263-72. 2005
    ..Experimentally imposed dietary restriction is known to extend the lifespan of rodents, perhaps by slowing the accumulation of oxidative damage that is thought to be one of the causes of aging...
  15. ncbi Anthocyanin-rich extract decreases indices of lipid peroxidation and DNA damage in vitamin E-depleted rats
    C Ramirez-Tortosa
    Antioxidants and DNA Damage Group, Rowett Research Institute, Aberdeen, Scotland, UK
    Free Radic Biol Med 31:1033-7. 2001
    ..These compounds are indices of lipid peroxidation and DNA damage, respectively. Dietary consumption of anthocyanin-rich foods may contribute to overall antioxidant status, particularly in areas of habitually low vitamin E intake...
  16. ncbi Effects of a soy milk supplement on plasma cholesterol levels and oxidative DNA damage in men--a pilot study
    J H Mitchell
    Rowett Research Institute, Bucksburn, UK Aberdeen, Great Britain
    Eur J Nutr 38:143-8. 1999
    ..They may also have antioxidant function in scavenging potentially harmful free radicals and thus decreasing oxidative attack on DNA...
  17. ncbi The effect of increased intakes of polyunsaturated fatty acids and vitamin E on DNA damage in human lymphocytes
    A M Jenkinson
    Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK
    FASEB J 13:2138-42. 1999
    ..Jenkinson, A. McE., Collins, A. R., Duthie, S. J., Wahle, K. W. J., Duthie, G. G. The effect of increased intakes of polyunsaturated fatty acids and vitamin E on DNA damage in human lymphocytes...
  18. ncbi Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study
    S P Boyle
    Rowett Research Institute, Bucksburn, Aberdeen, Scotland
    Eur J Clin Nutr 54:774-82. 2000
    ..To determine the potential antioxidant effect of rutin (quercetin-3-O-beta-rutinoside) supplementation...
  19. ncbi Dietary supplement use in old age: associations with childhood IQ, current cognition and health
    L J Whalley
    University of Aberdeen, Clinical Research Centre, Royal Cornhill Hospital, Aberdeen, UK
    Int J Geriatr Psychiatry 18:769-76. 2003
    ..Dietary supplement (DS) use is actively promoted among old people but there is little evidence in favour of DS use or information about the demographic, health and cognitive characteristics of DS users...
  20. ncbi Effect of a phytoestrogen food supplement on reproductive health in normal males
    J H Mitchell
    Division of Cellular Integrity, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
    Clin Sci (Lond) 100:613-8. 2001
    ..This is the first study to examine the effects of a phytoestrogen supplement on reproductive health in males. We conclude that the phytoestrogen dose consumed had no effect on semen quality...