C A Sharp

Summary

Affiliation: Robert Jones and Agnes Hunt Orthopaedic Hospital
Country: UK

Publications

  1. ncbi A bio-assay for effectors of osteoclast differentiation in serum from patients with bone disease
    Marit Naomi Dugard
    Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust, Oswestry, Shropshire, SY10 7AG, United Kingdom
    Clin Chim Acta 356:154-63. 2005
  2. pmc Increased matrix concentrations of IGFBP-5 in cancellous bone in osteoarthritis
    C A Sharp
    Chalres Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust, Oswestry, Shropshire, UK
    Ann Rheum Dis 63:1162-5. 2004
  3. ncbi Analysis of human bone alkaline phosphatase isoforms: comparison of isoelectric focusing and ion-exchange high-performance liquid chromatography
    Christopher A Sharp
    Division of Clinical Chemistry, Department of Laboratory Medicine, Linkoping University Hospital, SE 581 85, Linkoping, Sweden
    Clin Chim Acta 379:105-12. 2007
  4. pmc Disc cell clusters in pathological human intervertebral discs are associated with increased stress protein immunostaining
    Christopher A Sharp
    Charles Salt Centre for Human Metabolism, Robert Jones and Agnes Hunt Orthopaedic and District Hospital NHS Trust, Oswestry, Shropshire SY10 7AG, UK
    Eur Spine J 18:1587-94. 2009
  5. ncbi Effect of chronic renal failure on bone turnover and bone alkaline phosphatase isoforms
    P Magnusson
    Bone and Mineral Metabolic Unit, Division of Clinical Chemistry, Department of Biomedicine and Surgery, Linkoping University Hospital, Linkoping, Sweden
    Kidney Int 60:257-65. 2001
  6. ncbi Regional differences in mechanical and material properties of femoral head cancellous bone in health and osteoarthritis
    S J Brown
    Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic, District Hospital NHS Trust, Oswestry, Shropshire, UK
    Calcif Tissue Int 71:227-34. 2002
  7. doi Health-related quality of life in patients with osteoporosis in the absence of vertebral fracture: a systematic review
    S Wilson
    Bone Health Service, Charles Salt Laboratories, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry, Shropshire, SY10 7AG, UK
    Osteoporos Int 23:2749-68. 2012
  8. ncbi Different distributions of human bone alkaline phosphatase isoforms in serum and bone tissue extracts
    Per Magnusson
    Department of Biomedicine and Surgery, Bone and Mineral Metabolic Unit, Division of Clinical Chemistry, Linkoping University Hospital, SE 581 85 Linkoping, Sweden
    Clin Chim Acta 325:59-70. 2002
  9. ncbi Differently cross-linked and uncross-linked carboxy-terminal telopeptides of type I collagen in human mineralised bone
    Heidi A Eriksen
    Department of Clinical Chemistry, University of Oulu, Finland
    Bone 34:720-7. 2004

Collaborators

Detail Information

Publications9

  1. ncbi A bio-assay for effectors of osteoclast differentiation in serum from patients with bone disease
    Marit Naomi Dugard
    Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust, Oswestry, Shropshire, SY10 7AG, United Kingdom
    Clin Chim Acta 356:154-63. 2005
    ..Our aim was to develop a functional assay for any factors present in human serum that can affect osteoclast differentiation and to assess whether any such factors vary in diseases in which bone loss occurs...
  2. pmc Increased matrix concentrations of IGFBP-5 in cancellous bone in osteoarthritis
    C A Sharp
    Chalres Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust, Oswestry, Shropshire, UK
    Ann Rheum Dis 63:1162-5. 2004
    ..In osteoarthritis cancellous bone adapts to meet altered mechanical loading. These changes may be mediated by insulin-like growth factors (IGF-I and IGF-II), but the matrix bound binding protein, IGFBP-5 has not been investigated...
  3. ncbi Analysis of human bone alkaline phosphatase isoforms: comparison of isoelectric focusing and ion-exchange high-performance liquid chromatography
    Christopher A Sharp
    Division of Clinical Chemistry, Department of Laboratory Medicine, Linkoping University Hospital, SE 581 85, Linkoping, Sweden
    Clin Chim Acta 379:105-12. 2007
    ..Several isoforms of alkaline phosphatase (ALP) can be identified in human tissues and serum after separation by anion-exchange HPLC and isoelectric focusing (IEF)...
  4. pmc Disc cell clusters in pathological human intervertebral discs are associated with increased stress protein immunostaining
    Christopher A Sharp
    Charles Salt Centre for Human Metabolism, Robert Jones and Agnes Hunt Orthopaedic and District Hospital NHS Trust, Oswestry, Shropshire SY10 7AG, UK
    Eur Spine J 18:1587-94. 2009
    ..A better understanding of the stress response in IVD cells may allow its utilization in disc cell therapies...
  5. ncbi Effect of chronic renal failure on bone turnover and bone alkaline phosphatase isoforms
    P Magnusson
    Bone and Mineral Metabolic Unit, Division of Clinical Chemistry, Department of Biomedicine and Surgery, Linkoping University Hospital, Linkoping, Sweden
    Kidney Int 60:257-65. 2001
    ..We have applied a comprehensive panel of markers to patients with chronic renal failure (CRF), with particular focus on the isoforms of bone alkaline phosphatase (BALP)...
  6. ncbi Regional differences in mechanical and material properties of femoral head cancellous bone in health and osteoarthritis
    S J Brown
    Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic, District Hospital NHS Trust, Oswestry, Shropshire, UK
    Calcif Tissue Int 71:227-34. 2002
    ..In conclusion, femoral head cancellous bone mass in end-stage osteoarthritis is increased but undermineralized, and is neither stiffer nor stronger than normal cancellous bone...
  7. doi Health-related quality of life in patients with osteoporosis in the absence of vertebral fracture: a systematic review
    S Wilson
    Bone Health Service, Charles Salt Laboratories, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry, Shropshire, SY10 7AG, UK
    Osteoporos Int 23:2749-68. 2012
    ..Future studies are needed to investigate HRQoL in patients with osteoporosis in the absence of fracture, controlling for co-morbidities and social and economic status...
  8. ncbi Different distributions of human bone alkaline phosphatase isoforms in serum and bone tissue extracts
    Per Magnusson
    Department of Biomedicine and Surgery, Bone and Mineral Metabolic Unit, Division of Clinical Chemistry, Linkoping University Hospital, SE 581 85 Linkoping, Sweden
    Clin Chim Acta 325:59-70. 2002
    ..Previous studies have shown that the relative abundance of these BALP isoforms in serum may be clinically useful for the diagnosis and management of metabolic bone disease...
  9. ncbi Differently cross-linked and uncross-linked carboxy-terminal telopeptides of type I collagen in human mineralised bone
    Heidi A Eriksen
    Department of Clinical Chemistry, University of Oulu, Finland
    Bone 34:720-7. 2004
    ..It also provides additional information regarding the extent and maturity of tissue type I collagen cross-linking in health and disease...