Harpal S Randeva

Summary

Country: UK

Publications

  1. ncbi request reprint Exercise decreases plasma total homocysteine in overweight young women with polycystic ovary syndrome
    Harpal S Randeva
    The Sir Quinton Hazel Molecular Medicine Research Centre, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 87:4496-501. 2002
  2. doi request reprint Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Cardiovasc Res 83:566-74. 2009
  3. doi request reprint The signalling profile of recombinant human orexin-2 receptor
    Jiyou Tang
    Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Cell Signal 20:1651-61. 2008
  4. doi request reprint Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity
    Manjunath Ramanjaneya
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    Endocrinology 151:3169-80. 2010
  5. doi request reprint Metformin increases the novel adipokine cartonectin/CTRP3 in women with polycystic ovary syndrome
    Bee K Tan
    Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 98:E1891-900. 2013
  6. doi request reprint Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose
    Bee K Tan
    MBChB, FRCP, Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Diabetes 57:801-8. 2008
  7. doi request reprint In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    Endocrinology 150:3530-9. 2009
  8. doi request reprint Decreased cerebrospinal fluid/plasma ratio of the novel satiety molecule, nesfatin-1/NUCB-2, in obese humans: evidence of nesfatin-1/NUCB-2 resistance and implications for obesity treatment
    Bee K Tan
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 96:E669-73. 2011
  9. doi request reprint Adiponectin (15-36) stimulates steroidogenic acute regulatory (StAR) protein expression and cortisol production in human adrenocortical cells: role of AMPK and MAPK kinase pathways
    Manjunath Ramanjaneya
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Biochim Biophys Acta 1813:802-9. 2011
  10. doi request reprint Metformin increases the novel adipokine adipolin/CTRP12: role of the AMPK pathway
    Bee K Tan
    Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    J Endocrinol 219:101-8. 2013

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Exercise decreases plasma total homocysteine in overweight young women with polycystic ovary syndrome
    Harpal S Randeva
    The Sir Quinton Hazel Molecular Medicine Research Centre, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 87:4496-501. 2002
    ..The precise mechanism by which exercise is associated with a reduction in homocysteine remains to be elucidated...
  2. doi request reprint Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Cardiovasc Res 83:566-74. 2009
    ....
  3. doi request reprint The signalling profile of recombinant human orexin-2 receptor
    Jiyou Tang
    Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Cell Signal 20:1651-61. 2008
    ....
  4. doi request reprint Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity
    Manjunath Ramanjaneya
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    Endocrinology 151:3169-80. 2010
    ..05) and showed positive correlation with body mass index in human. We report that nesfatin-1 is a novel depot specific adipokine preferentially produced by sc tissue, with obesity- and food deprivation-regulated expression...
  5. doi request reprint Metformin increases the novel adipokine cartonectin/CTRP3 in women with polycystic ovary syndrome
    Bee K Tan
    Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 98:E1891-900. 2013
    ..Polycystic ovary syndrome (PCOS) is a proinflammatory state associated with obesity, diabetes, dyslipidemia, and cardiovascular complications...
  6. doi request reprint Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose
    Bee K Tan
    MBChB, FRCP, Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Diabetes 57:801-8. 2008
    ..Ex vivo and in vivo regulation of adipose tissue omentin-1 was also studied...
  7. doi request reprint In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    Endocrinology 150:3530-9. 2009
    ..Thus, leptin increases visfatin production in AT in vivo and ex vivo via pathways involving MAPK and phosphatidylinositol 3-kinase signaling. The pleiotropic effects of leptin may be partially mediated by visfatin...
  8. doi request reprint Decreased cerebrospinal fluid/plasma ratio of the novel satiety molecule, nesfatin-1/NUCB-2, in obese humans: evidence of nesfatin-1/NUCB-2 resistance and implications for obesity treatment
    Bee K Tan
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 96:E669-73. 2011
    ..The novel adipokine, nesfatin-1/NUCB-2, reduces food intake, levels of which are elevated in overweight individuals...
  9. doi request reprint Adiponectin (15-36) stimulates steroidogenic acute regulatory (StAR) protein expression and cortisol production in human adrenocortical cells: role of AMPK and MAPK kinase pathways
    Manjunath Ramanjaneya
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Biochim Biophys Acta 1813:802-9. 2011
    ..This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
  10. doi request reprint Metformin increases the novel adipokine adipolin/CTRP12: role of the AMPK pathway
    Bee K Tan
    Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    J Endocrinol 219:101-8. 2013
    ..Importantly, metformin's effects appear to be via the AMP-activated protein kinase signaling pathway. ..
  11. doi request reprint Metformin treatment exerts antiinvasive and antimetastatic effects in human endometrial carcinoma cells
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 96:808-16. 2011
    ..We sought to study the effects of metformin treatment (widely used in the management of PCOS women) on human endometrial adenocarcinoma cells...
  12. doi request reprint Diurnal variation and effect of insulin on circulating high molecular weight (HMW) adiponectin and NF-κB activity in human endothelial cells
    Bee K Tan
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Atherosclerosis 214:174-7. 2011
    ..To study the diurnal variation and the effect of insulin on adiponectin multimers and nuclear factor-kappaB (NF-κB) activity in human endothelial cells...
  13. pmc Cardiometabolic aspects of the polycystic ovary syndrome
    Harpal S Randeva
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Endocr Rev 33:812-41. 2012
    ..Further insight into this network of factors may facilitate finding therapeutic targets that should ameliorate not only ovarian dysfunction but also the various cardiometabolic alterations related to the syndrome...
  14. doi request reprint The anti-atherogenic aspect of metformin treatment in insulin resistant women with the polycystic ovary syndrome: role of the newly established pro-inflammatory adipokine Acute-phase Serum Amyloid A; evidence of an adipose tissue-monocyte axis
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Atherosclerosis 216:402-8. 2011
    ....
  15. pmc Orexins stimulate steroidogenic acute regulatory protein expression through multiple signaling pathways in human adrenal H295R cells
    Manjunath Ramanjaneya
    Warwick Medical School, Warwick University, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Endocrinology 149:4106-15. 2008
    ..This is the first study linking orexin action on StAR expression and comprehensively describes the signaling pathways involved in regulating the complexity of hormone biosynthesis...
  16. pmc Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts
    Vanlata Patel
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, United Kingdom
    PLoS ONE 9:e87102. 2014
    ..We therefore investigated the direct effect of FGF21 on cardio-protection in obese and lean hearts in response to ischemia...
  17. ncbi request reprint Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis
    Raghu Adya
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Cardiovasc Res 78:356-65. 2008
    ..We therefore investigated the effect of visfatin on vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP-2, MMP-9) production and the potential signalling cascades...
  18. ncbi request reprint G-protein coupled estrogen receptor 1 expression in rat and human heart: Protective role during ischaemic stress
    Vanlata H Patel
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Int J Mol Med 26:193-9. 2010
    ..42+/-1.3%). The results suggest that GPER under cardiac stress exerts direct protection in the heart and may serve as a potential therapeutic target for cardiac drug therapy...
  19. ncbi request reprint Insulin regulates the novel adipokine adipolin/CTRP12: in vivo and ex vivo effects
    Bee K Tan
    Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK Department of Obstetrics and Gynaecology, Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, Birmingham, UK Department of Endocrinology and Metabolic Diseases, Polish Mother s Memorial Research Institute, The Medical University of Lodz, Lodz, Poland
    J Endocrinol 221:111-9. 2014
    ..05 and P<0.01). This effect was inhibited by the PPARγ antagonist, GW9662 (P<0.05). Our data provide novel insights into adipolin physiology in human subjects. ..
  20. doi request reprint Nuclear factor-kappaB induction by visfatin in human vascular endothelial cells: its role in MMP-2/9 production and activation
    Raghu Adya
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Diabetes Care 31:758-60. 2008
    ..We investigated the activation of nuclear factor-kappaB (NF-kappaB), a well-known proinflammatory transcription factor, by visfatin in endothelial cells...
  21. ncbi request reprint Raised serum, adipocyte, and adipose tissue retinol-binding protein 4 in overweight women with polycystic ovary syndrome: effects of gonadal and adrenal steroids
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 92:2764-72. 2007
    ..Recent studies have shown that serum retinol-binding protein 4 (RBP4) levels increase with obesity. Currently, no data exist on the relative expression of RBP4 in either serum or adipose tissue of PCOS women...
  22. ncbi request reprint Increased visfatin messenger ribonucleic acid and protein levels in adipose tissue and adipocytes in women with polycystic ovary syndrome: parallel increase in plasma visfatin
    Bee K Tan
    Endocrinology and Metabolism Group, Department of Biological Sciences, Warwick Medical School, The University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 91:5022-8. 2006
    ..Recent studies have shown that plasma levels of the insulin-mimetic adipokine visfatin increase with obesity. Currently, no data exist on the relative expression of visfatin in either plasma or adipose tissue of PCOS women...
  23. doi request reprint Identification of brown adipose tissue using MR imaging in a human adult with histological and immunohistochemical confirmation
    Narendra L Reddy
    Clinical Sciences Research Laboratories N L R, T A J, S S, G T, P G M, H S R, S K, C E H, T M B, Warwick Medical School, University of Warwick, and Departments of Medical Physics S C W, Radiology O A, C E H, and Histopathology Y C Y, University Hospitals of Coventry and Warwickshire, Coventry CV2 2DX, United Kingdom
    J Clin Endocrinol Metab 99:E117-21. 2014
    ..The aim of our study was to develop and test a novel magnetic resonance (MR) imaging-based method to identify human BAT, delineate it from white adipose tissue, and validate it through immunohistochemistry...
  24. ncbi request reprint Possible role of NUCB2/nesfatin-1 in adipogenesis
    Manjunath Ramanjaneya
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Curr Pharm Des 19:6976-80. 2013
    ..Moreover, we highlight the importance of NUCB2 and nesfatin-1 in adipose tissue, its regulation of adipogenesis and obesity-associated metabolic diseases. ..
  25. pmc Lower cerebrospinal fluid/plasma fibroblast growth factor 21 (FGF21) ratios and placental FGF21 production in gestational diabetes
    Bee K Tan
    Divisions of Metabolic and Vascular Health and Reproduction, Warwick Medical School, University of Warwick, Coventry, United Kingdom
    PLoS ONE 8:e65254. 2013
    ..We also assessed FGF21 secretion from GDM and control human placental explants...
  26. ncbi request reprint Circadian rhythmicity of salivary leptin in healthy subjects
    Harpal S Randeva
    Molecular Medicine Research Group, Biomedical Research Institute, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK
    Mol Genet Metab 78:229-35. 2003
    ..Our findings suggest that there may be differential regulation of leptin (salivary) between men and women. Finally, measurement of leptin in saliva is a simple, non-invasive and may be an acceptable alternative to plasma sampling...
  27. ncbi request reprint Protein kinase A-induced negative regulation of the corticotropin-releasing hormone R1alpha receptor-extracellularly regulated kinase signal transduction pathway: the critical role of Ser301 for signaling switch and selectivity
    Nikolleta Papadopoulou
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, The University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Mol Endocrinol 18:624-39. 2004
    ..Phosphorylation by PKA prevents maximal coupling of the CRH-R1alpha to Gq-protein, and thereby reduces activation of ERK 1/2...
  28. ncbi request reprint Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants
    Jing Chen
    Molecular Medicine Research Group, Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK
    Mol Endocrinol 18:2790-804. 2004
    ..Moreover, food deprivation led to a greater increase in hypothalamic mOX2 beta R gene expression, compared with both mOX1R and mOX2 alpha R. This potentially implicates a fundamental physiological role for these splice variants...
  29. ncbi request reprint Adiponectin and resistin serum levels in women with polycystic ovary syndrome during oral glucose tolerance test: a significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices
    Krzysztof C Lewandowski
    Department of Endocrinology and Isotope Therapy, Medical University of Lodz, Poland Polish Mother s Memorial Hospital Research Institute in Lodz, Poland
    Mol Genet Metab 85:61-9. 2005
    ..The observed increase in adiponectin during OGTT requires further study...
  30. ncbi request reprint Obesity and prostate cancer: a role for adipokines
    Tina Mistry
    Molecular Medicine Research Group, Biomedical Research Institute, University of Warwick Medical School, Coventry, UK
    Eur Urol 52:46-53. 2007
    ..This review provides an overview of current evidence that supports such a role for adipokines...
  31. pmc Cardiometabolic aspects of polycystic ovarian syndrome
    Li Wei Cho
    Department of Medicine, University of Hull, UK
    Vasc Health Risk Manag 3:55-63. 2007
    ..This article will address the current evidence for the adverse cardiovascular risk in PCOS and the other factors that may be implicated. Finally the therapeutic options for treatment will be discussed...
  32. ncbi request reprint Visfatin levels do not change after the oral glucose tolerance test and after a dexamethasone-induced increase in insulin resistance in humans
    Magdalena Marcinkowska
    Department of Endocrinology and Metabolic Diseases, Medical University of Łódź and Polish Mother Memorial Hospital Research Institute, Łódź
    Endokrynol Pol 58:188-94. 2007
    ..Insulin resistance was assessed according to the HOMA method in non-diabetic individuals (n = 15)...
  33. doi request reprint Leptin and adiponectin interact in the regulation of prostate cancer cell growth via modulation of p53 and bcl-2 expression
    Tina Mistry
    Department of Urology, University Hospital Coventry and Warwickshire, Coventry, UK
    BJU Int 101:1317-22. 2008
    ..To investigate the effects of leptin, full-length adiponectin (fAd) and globular adiponectin (gAd), alone and in combination, on LNCaP and PC3 prostate cancer cell proliferation, and on the expression of p53 and bcl-2 gene expression...
  34. doi request reprint Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance
    Bee K Tan
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes 57:1501-7. 2008
    ..Ex vivo regulation of adipose tissue vaspin and the effects of metformin treatment on circulating vaspin levels in PCOS subjects were also studied...
  35. ncbi request reprint Plasma total homocysteine concentrations in adults with growth hormone (GH) deficiency: effects of GH replacement
    Krzysztof C Lewandowski
    Molecular Medicine Research Group, Biomedical Research Institute, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK
    Mol Genet Metab 80:330-7. 2003
    ..Before firm conclusions can be drawn about the contribution of changes in plasma homocysteine concentrations to cardiovascular prognosis in adult GHD patients receiving GH replacement, further controlled studies are required...