- Rahman S, Ibrahim K, Larvin M, Kingsnorth A, McMahon M. Association of antioxidant enzyme gene polymorphisms and glutathione status with severe acute pancreatitis. Gastroenterology. 2004;126:1312-22 pubmed..The functional GSTT-1*A genotype was associated with severe attacks of pancreatitis. Heightened oxidative stress characterized by glutathione depletion may be of importance in mediating the progression from mild to severe pancreatitis. ..