David J J Waugh

Summary

Affiliation: Queen's University Belfast
Country: UK

Publications

  1. ncbi request reprint Multi-faceted roles for CXC-chemokines in prostate cancer progression
    David J J Waugh
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, 97 Lisburn Road, Belfast, BT9 7BL
    Front Biosci 13:4595-604. 2008
  2. pmc Constitutive and treatment-induced CXCL8-signalling selectively modulates the efficacy of anti-metabolite therapeutics in metastatic prostate cancer
    Catherine Wilson
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland
    PLoS ONE 7:e36545. 2012
  3. pmc Dexamethasone potentiates the antiangiogenic activity of docetaxel in castration-resistant prostate cancer
    C Wilson
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast BT9 7BL, Northern Ireland
    Br J Cancer 99:2054-64. 2008
  4. pmc The expression and prognostic impact of CXC-chemokines in stage II and III colorectal cancer epithelial and stromal tissue
    O Oladipo
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland
    Br J Cancer 104:480-7. 2011
  5. pmc Inhibition of constitutive and cxc-chemokine-induced NF-kappaB activity potentiates ansamycin-based HSP90-inhibitor cytotoxicity in castrate-resistant prostate cancer cells
    A Seaton
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland
    Br J Cancer 101:1620-9. 2009
  6. doi request reprint The interleukin-8 pathway in cancer
    David J J Waugh
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland
    Clin Cancer Res 14:6735-41. 2008
  7. doi request reprint Chemotherapy-induced CXC-chemokine/CXC-chemokine receptor signaling in metastatic prostate cancer cells confers resistance to oxaliplatin through potentiation of nuclear factor-kappaB transcription and evasion of apoptosis
    Catherine Wilson
    Centre for Cancer Research and Cell Biology, Queens University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Pharmacol Exp Ther 327:746-59. 2008
  8. doi request reprint Interleukin-8 signaling promotes androgen-independent proliferation of prostate cancer cells via induction of androgen receptor expression and activation
    Angela Seaton
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    Carcinogenesis 29:1148-56. 2008
  9. ncbi request reprint Interleukin-8 signaling promotes translational regulation of cyclin D in androgen-independent prostate cancer cells
    Christopher F MacManus
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast City Hospital, University Floor, Lisburn Road, Belfast BT9 7AB, Northern Ireland
    Mol Cancer Res 5:737-48. 2007
  10. ncbi request reprint Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells
    Catherine Wilson
    Centre for Cancer Research and Cell Biology, Queens University Belfast, 97 Lisburn Road, Belfast, Northern Ireland BT9 7BL, United Kingdom
    Mol Cancer Ther 7:2649-61. 2008

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Multi-faceted roles for CXC-chemokines in prostate cancer progression
    David J J Waugh
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, 97 Lisburn Road, Belfast, BT9 7BL
    Front Biosci 13:4595-604. 2008
    ....
  2. pmc Constitutive and treatment-induced CXCL8-signalling selectively modulates the efficacy of anti-metabolite therapeutics in metastatic prostate cancer
    Catherine Wilson
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland
    PLoS ONE 7:e36545. 2012
    ....
  3. pmc Dexamethasone potentiates the antiangiogenic activity of docetaxel in castration-resistant prostate cancer
    C Wilson
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast BT9 7BL, Northern Ireland
    Br J Cancer 99:2054-64. 2008
    ..001). Our data show that DEX potentiates the antiangiogenic activity of docetaxel, suggesting a putative mechanism for the palliative and survival benefits of these agents in metastatic CaP...
  4. pmc The expression and prognostic impact of CXC-chemokines in stage II and III colorectal cancer epithelial and stromal tissue
    O Oladipo
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland
    Br J Cancer 104:480-7. 2011
    ..The CXC-chemokine expression is linked with colorectal cancer (CRC) progression but their significance in resected CRC is unclear. We explored the prognostic impact of such expression in stage II and III CRC...
  5. pmc Inhibition of constitutive and cxc-chemokine-induced NF-kappaB activity potentiates ansamycin-based HSP90-inhibitor cytotoxicity in castrate-resistant prostate cancer cells
    A Seaton
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland
    Br J Cancer 101:1620-9. 2009
    ....
  6. doi request reprint The interleukin-8 pathway in cancer
    David J J Waugh
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland
    Clin Cancer Res 14:6735-41. 2008
    ..Therefore, inhibiting the effects of IL-8 signaling may be a significant therapeutic intervention in targeting the tumor microenvironment...
  7. doi request reprint Chemotherapy-induced CXC-chemokine/CXC-chemokine receptor signaling in metastatic prostate cancer cells confers resistance to oxaliplatin through potentiation of nuclear factor-kappaB transcription and evasion of apoptosis
    Catherine Wilson
    Centre for Cancer Research and Cell Biology, Queens University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Pharmacol Exp Ther 327:746-59. 2008
    ..Our results further support NF-kappaB activity as an important determinant of cancer cell sensitivity to oxaliplatin and identify the induction of autocrine CXCR2 signaling as a novel mode of resistance to this drug...
  8. doi request reprint Interleukin-8 signaling promotes androgen-independent proliferation of prostate cancer cells via induction of androgen receptor expression and activation
    Angela Seaton
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    Carcinogenesis 29:1148-56. 2008
    ..In addition, our data show that IL-8-promoted regulation of the AR attenuates the effectiveness of the AR antagonist bicalutamide in reducing CaP cell viability...
  9. ncbi request reprint Interleukin-8 signaling promotes translational regulation of cyclin D in androgen-independent prostate cancer cells
    Christopher F MacManus
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast City Hospital, University Floor, Lisburn Road, Belfast BT9 7AB, Northern Ireland
    Mol Cancer Res 5:737-48. 2007
    ..This study provides a molecular basis to support the correlation of IL-8 expression with that of cyclin D1 in human prostate cancer and suggests a mechanism by which this chemokine promotes cell proliferation...
  10. ncbi request reprint Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells
    Catherine Wilson
    Centre for Cancer Research and Cell Biology, Queens University Belfast, 97 Lisburn Road, Belfast, Northern Ireland BT9 7BL, United Kingdom
    Mol Cancer Ther 7:2649-61. 2008
    ..Therefore, targeted inhibition of IL-8 signaling or c-FLIP expression in prostate cancer may be an attractive therapeutic strategy to sensitize this stage of disease to chemotherapy...
  11. pmc Elevation of c-FLIP in castrate-resistant prostate cancer antagonizes therapeutic response to androgen receptor-targeted therapy
    Clare McCourt
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland
    Clin Cancer Res 18:3822-33. 2012
    ....
  12. pmc Potentiation of inflammatory CXCL8 signalling sustains cell survival in PTEN-deficient prostate carcinoma
    Pamela J Maxwell
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland
    Eur Urol 64:177-88. 2013
    ..Inactivation of the tumour suppressor gene phosphatase and tensin homolog (PTEN) is prevalent in early PCa. The relationship of PTEN deficiency to inflammatory signalling remains to be characterised...
  13. ncbi request reprint Nonapical and cytoplasmic expression of interleukin-8, CXCR1, and CXCR2 correlates with cell proliferation and microvessel density in prostate cancer
    Catherine Murphy
    Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Northern Ireland
    Clin Cancer Res 11:4117-27. 2005
    ..We characterized interleukin-8 (IL-8) and IL-8 receptor expression (CXCR1 and CXCR2) in prostate cancer to address their significance to this disease...
  14. ncbi request reprint The emerging role of CD44 in regulating skeletal micrometastasis
    Ashleigh Hill
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast City Hospital, Lisburn Road, Belfast, Northern Ireland, BT9 7AB, UK
    Cancer Lett 237:1-9. 2006
    ....
  15. pmc CD44 enhances invasion of basal-like breast cancer cells by upregulating serine protease and collagen-degrading enzymatic expression and activity
    Nicola Montgomery
    Centre for Cancer Research and Cell Biology, Queens University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland
    Breast Cancer Res 14:R84. 2012
    ..The purpose of this study was to establish the relation of CD44 to BL-BCa and to characterize how HA/CD44 signaling promotes a protease-dependent invasion of breast cancer (BrCa) cells...
  16. pmc FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism
    Andrea Valentine
    School of Pharmacy, Queen s University Belfast, Belfast, United Kingdom
    Clin Cancer Res 17:1044-56. 2011
    ..Antiangiogenic therapies can be an important adjunct to the management of many malignancies. Here we investigated a novel protein, FKBPL, and peptide derivative for their antiangiogenic activity and mechanism of action...
  17. pmc Tumor-derived CXCL8 signaling augments stroma-derived CCL2-promoted proliferation and CXCL12-mediated invasion of PTEN-deficient prostate cancer cells
    Pamela J Maxwell
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland
    Oncotarget 5:4895-908. 2014
    ..Combined chemokine targeting may be required to inhibit their multi-faceted actions in promoting the invasion and proliferation of aggressive CaP. ..
  18. ncbi request reprint CD44 potentiates the adherence of metastatic prostate and breast cancer cells to bone marrow endothelial cells
    Jayne E Draffin
    Department of Oncology, Centre for Cancer Research, Queen s University Belfast, Belfast City Hospital, Belfast, Northern Ireland
    Cancer Res 64:5702-11. 2004
    ....