Alan Stitt

Summary

Affiliation: Queen's University Belfast
Country: UK

Publications

  1. ncbi request reprint The maillard reaction in eye diseases
    Alan W Stitt
    Ophthalmic Research Centre, Queen s University Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland
    Ann N Y Acad Sci 1043:582-97. 2005
  2. pmc The 67-kd laminin receptor is preferentially expressed by proliferating retinal vessels in a murine model of ischemic retinopathy
    A W Stitt
    Department of Ophthalmology, The Queen s University of Belfast, United Kingdom
    Am J Pathol 152:1359-65. 1998
  3. ncbi request reprint Advanced glycation endproduct modified basement membrane attenuates endothelin-1 induced [Ca2+]i signalling and contraction in retinal microvascular pericytes
    Sarah Jane Hughes
    Centre of Vision Science, Institute of Clinical Sciences, The Royal Victoria Hospital, Belfast, Northern Ireland
    Mol Vis 10:996-1004. 2004
  4. ncbi request reprint Substrates modified by advanced glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet-derived growth factor
    A W Stitt
    Ophthalmic Research Centre, Ophthalmology and Vision Science, Queen s University Belfast, Royal Victoria Hospital, Belfast, Northern Ireland, UK
    Diabetologia 47:1735-46. 2004
  5. pmc The pleiotropic effects of simvastatin on retinal microvascular endothelium has important implications for ischaemic retinopathies
    Reinhold J Medina
    Centre for Vision Science, Queen s University Belfast, Belfast, United Kingdom
    PLoS ONE 3:e2584. 2008
  6. pmc Inhibition of advanced glycation and absence of galectin-3 prevent blood-retinal barrier dysfunction during short-term diabetes
    Paul Canning
    Centre for Vision Science, Queen s University Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK
    Exp Diabetes Res 2007:51837. 2007
  7. pmc Intervention with an erythropoietin-derived peptide protects against neuroglial and vascular degeneration during diabetic retinopathy
    Carmel M McVicar
    Centre for Vision and Vascular Science, Queen s University Belfast, Belfast, Northern Ireland, UK
    Diabetes 60:2995-3005. 2011
  8. pmc Advanced glycation of the Arg-Gly-Asp (RGD) tripeptide motif modulates retinal microvascular endothelial cell dysfunction
    Denise M McDonald
    Centre for Vision and Vascular Science, Queen s University Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland, UK
    Mol Vis 15:1509-20. 2009
  9. pmc Differential modulation of angiogenesis by erythropoiesis-stimulating agents in a mouse model of ischaemic retinopathy
    Carmel M McVicar
    Centre for Vision and Vascular Science, Queen s University Belfast, Belfast, Northern Ireland, United Kingdom
    PLoS ONE 5:e11870. 2010
  10. pmc RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization
    Mei Chen
    Centre for Experimental Medicine, Queen s University of Belfast, Belfast, United Kingdom
    PLoS ONE 9:e89548. 2014

Collaborators

Detail Information

Publications51

  1. ncbi request reprint The maillard reaction in eye diseases
    Alan W Stitt
    Ophthalmic Research Centre, Queen s University Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland
    Ann N Y Acad Sci 1043:582-97. 2005
    ..It also outlines recent pharmaceutical strategies to inhibit Maillard reaction products and provides links to how these may serve to limit ocular cell dysfunction...
  2. pmc The 67-kd laminin receptor is preferentially expressed by proliferating retinal vessels in a murine model of ischemic retinopathy
    A W Stitt
    Department of Ophthalmology, The Queen s University of Belfast, United Kingdom
    Am J Pathol 152:1359-65. 1998
    ..The differential expression of 67LR between proliferating and quiescent retinal vessels suggests that this laminin receptor is an important and novel target for future chemotherapeutic intervention during proliferative vasculopathies...
  3. ncbi request reprint Advanced glycation endproduct modified basement membrane attenuates endothelin-1 induced [Ca2+]i signalling and contraction in retinal microvascular pericytes
    Sarah Jane Hughes
    Centre of Vision Science, Institute of Clinical Sciences, The Royal Victoria Hospital, Belfast, Northern Ireland
    Mol Vis 10:996-1004. 2004
    ..To assess the effects of advanced glycation endproduct (AGE) modification of vascular basement membrane (BM) on endothelin-1 (Et-1) induced intracellular [Ca2+] ([Ca2+]i) homeostasis and contraction in retinal microvascular pericytes (RMP)...
  4. ncbi request reprint Substrates modified by advanced glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet-derived growth factor
    A W Stitt
    Ophthalmic Research Centre, Ophthalmology and Vision Science, Queen s University Belfast, Royal Victoria Hospital, Belfast, Northern Ireland, UK
    Diabetologia 47:1735-46. 2004
    ..The current study used an in vitro model, whereby retinal pericytes were exposed to AGE-modified substrate and the mechanisms underlying pericyte death explored...
  5. pmc The pleiotropic effects of simvastatin on retinal microvascular endothelium has important implications for ischaemic retinopathies
    Reinhold J Medina
    Centre for Vision Science, Queen s University Belfast, Belfast, United Kingdom
    PLoS ONE 3:e2584. 2008
    ..The objective of this study was to investigate the effects of clinically relevant concentrations of simvastatin on retinal endothelium in vitro and in vivo...
  6. pmc Inhibition of advanced glycation and absence of galectin-3 prevent blood-retinal barrier dysfunction during short-term diabetes
    Paul Canning
    Centre for Vision Science, Queen s University Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK
    Exp Diabetes Res 2007:51837. 2007
    ..Prevention of AGE formation or genetic deletion of Gal-3 can effectively prevent these acute diabetic retinopathy changes...
  7. pmc Intervention with an erythropoietin-derived peptide protects against neuroglial and vascular degeneration during diabetic retinopathy
    Carmel M McVicar
    Centre for Vision and Vascular Science, Queen s University Belfast, Belfast, Northern Ireland, UK
    Diabetes 60:2995-3005. 2011
    ..A peptide based on the EPO helix-B domain (helix B-surface peptide [pHBSP]) is nonerythrogenic but retains tissue-protective properties, and this study evaluates its therapeutic potential in diabetic retinopathy...
  8. pmc Advanced glycation of the Arg-Gly-Asp (RGD) tripeptide motif modulates retinal microvascular endothelial cell dysfunction
    Denise M McDonald
    Centre for Vision and Vascular Science, Queen s University Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland, UK
    Mol Vis 15:1509-20. 2009
    ....
  9. pmc Differential modulation of angiogenesis by erythropoiesis-stimulating agents in a mouse model of ischaemic retinopathy
    Carmel M McVicar
    Centre for Vision and Vascular Science, Queen s University Belfast, Belfast, Northern Ireland, United Kingdom
    PLoS ONE 5:e11870. 2010
    ..In the current study we have assessed the angiogenic potential of three ESAs; epoetin delta, darbepoetin alfa and epoetin beta using in vitro and in vivo models...
  10. pmc RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization
    Mei Chen
    Centre for Experimental Medicine, Queen s University of Belfast, Belfast, United Kingdom
    PLoS ONE 9:e89548. 2014
    ..This study has investigated if RAGE plays a role in immune cell mobilization and choroidal neovascular pathology that is associated with the neovascular form of age-related macular degeneration (nvAMD)...
  11. ncbi request reprint Advanced glycation end products and diabetic retinopathy
    M Chen
    Centre for Vision and Vascular Science, Queen s University Belfast, Northern Ireland, UK
    Curr Med Chem 20:3234-40. 2013
    ..In this review, AGE/ALE formation in the diabetic retina is discussed alongside their impact on retinal cell function. In addition, various inhibitors of the AGE-RAGE system and their therapeutic utility for DR will also be evaluated. ..
  12. doi request reprint Advances in our understanding of diabetic retinopathy
    Alan W Stitt
    Centre for Vision and Vascular Science, Queen s University of Belfast, The Royal Victoria Hospital, Belfast BT12 6BA, UK
    Clin Sci (Lond) 125:1-17. 2013
    ..We assess these findings and discuss how they could eventually lead to new therapeutic options for diabetic retinopathy...
  13. pmc Eyes open to stem cells: safety trial may pave the way for cell therapy to treat retinal disease in patients
    Reinhold J Medina
    Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Science, Queen s University Belfast, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, UK
    Stem Cell Res Ther 2:47. 2011
    ..While there are some hurdles to clear, the ACT trial is a fine example of translational research that could eventually pave the way for a range of stem cell therapies for the retina and other tissues...
  14. pmc Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities
    Reinhold J Medina
    Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Science, Queen s University Belfast, Belfast, BT12 6BA, UK
    BMC Med Genomics 3:18. 2010
    ..This study provides a detailed molecular fingerprint for two EPC subtypes: early EPCs (eEPCs) and outgrowth endothelial cells (OECs)...
  15. doi request reprint AGEs and diabetic retinopathy
    Alan W Stitt
    Centre for Vision and Vascular Science, Queens University Belfast, Northern Ireland, UK
    Invest Ophthalmol Vis Sci 51:4867-74. 2010
    ....
  16. doi request reprint Vascular stem cells and ischaemic retinopathies
    Alan W Stitt
    Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Science, Queen s University Belfast, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, UK
    Prog Retin Eye Res 30:149-66. 2011
    ..When some of the remaining questions surrounding the clinical use of EPCs are addressed, they may provide an exciting new therapeutic option for treating ischaemic retinopathies...
  17. doi request reprint A new advanced glycation inhibitor, LR-90, prevents experimental diabetic retinopathy in rats
    A Bhatwadekar
    Centre for Vision Science, Queen s University Belfast, Royal Victoria Hospital, Grosvenor Road Belfast BT 126BA, Northern Ireland, UK
    Br J Ophthalmol 92:545-7. 2008
    ..Diabetic retinopathy is associated with accumulation of advanced glycation end products in the retinal microvasculature. LR-90 is an effective multistage inhibitor of advanced glycation with renoprotective and anti-inflammatory properties...
  18. ncbi request reprint Advanced glycation and retinal pathology during diabetes
    Alan W Stitt
    Centre for Vision Science, Queen s University of Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland, UK
    Pharmacol Rep 57:156-68. 2005
    ..It will also describe how ongoing pharmaceutical strategies to inhibit AGE formation and thereby attenuate their pathogenic influence during chronic hyperglycemia may play a significant role in the treatment of diabetic retinopathy...
  19. ncbi request reprint Impaired retinal angiogenesis in diabetes: role of advanced glycation end products and galectin-3
    Alan W Stitt
    Ophthalmic and Vision Science Research Centre, Queens University Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland
    Diabetes 54:785-94. 2005
    ..The data suggest a significant suppression of angiogenesis by the retinal microvasculature during diabetes and implicate AGEs and AGE-receptor interactions in its causation...
  20. ncbi request reprint Expression of vascular endothelial growth factor (VEGF) and its receptors is regulated in eyes with intra-ocular tumours
    A W Stitt
    Department of Ophthalmology, Queen s University of Belfast, Northern Ireland, U K
    J Pathol 186:306-12. 1998
    ..Retinal vascular endothelia may respond to high intra-ocular levels of VEGF by increasing expression of their VEGF receptors, a phenomenon which could have relevance to neoplasm-related ocular neovascularization...
  21. ncbi request reprint The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes
    Alan Stitt
    Department of Ophthalmology, Institute of Clinical Science, The Royal Victoria Hospital, Queen s University of Belfast, Belfast, Northern Ireland
    Diabetes 51:2826-32. 2002
    ..These results indicate that the AGE/ALE inhibitor PM protected against a range of pathological changes in the diabetic retina and may be useful for treating diabetic retinopathy...
  22. ncbi request reprint Advanced glycation end-product receptor interactions on microvascular cells occur within caveolin-rich membrane domains
    A W Stitt
    Department of Ophthalmology, The Queen s University of Belfast, Northern Ireland, UK
    FASEB J 14:2390-2. 2000
    ..It is significant that the AGE-R complex localizes to these organelles, because this may have implications for AGE binding, internalization, signal transduction, and the modulation of AGE-receptor-mediated vascular cell dysfunction...
  23. ncbi request reprint Characterization of the advanced glycation end-product receptor complex in human vascular endothelial cells
    A W Stitt
    Department of Opthalmology, Queen s University of Belfast, Royal Victoria Hospital, Belfast, BT12 6BA, Northern Ireland, United Kingdom
    Biochem Biophys Res Commun 256:549-56. 1999
    ..In response to AGE-modified molecules, this complex is subject to upregulation, while the AGE-R2 component also displays increased phosphorylation possibly leading to enhanced signal transduction...
  24. ncbi request reprint Ocular wounding prevents pre-retinal neovascularization and upregulates PEDF expression in the inner retina
    Alan W Stitt
    Ophthalmic Research Centre, Queen s University Belfast, Institute of Clinical Sciences, Royal Victoria Hospital, Belfast, Northern Ireland, UK
    Mol Vis 10:432-8. 2004
    ....
  25. ncbi request reprint Role of vascular endothelial growth factor and placental growth factors during retinal vascular development and hyaloid regression
    Susan A Feeney
    Department of Ophthalmology, The Queen s University of Belfast, The Royal Victoria Hospital, Belfast, Northern Ireland, United Kingdom
    Invest Ophthalmol Vis Sci 44:839-47. 2003
    ..This study has sought to elucidate the expression patterns and modulatory role of these growth factors during retinal vascular development and hyaloid regression in the neonatal mouse...
  26. ncbi request reprint Recombinant alpha2(IV)NC1 domain of type IV collagen is an effective regulator of retinal capillary endothelial cell proliferation and inhibits pre-retinal neovascularisation
    Gary Coleman
    Centre for Vision Science, School of Biomedical Science, Queen s University Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland, UK
    Graefes Arch Clin Exp Ophthalmol 245:581-7. 2007
    ..In the current investigation we examined the potential for alpha2(IV)NC1 to regulate retinal microvascular endothelial cell function using a range of in vitro and in vivo assay systems...
  27. ncbi request reprint Retinopathy is reduced during experimental diabetes in a mouse model of outer retinal degeneration
    Tanyth E de Gooyer
    Centre for Vision Science, Queens University Belfast, Institute of Clinical Science Block A, Royal Victoria Hospital, Belfast, Northern Ireland
    Invest Ophthalmol Vis Sci 47:5561-8. 2006
    ..The study was designed to investigate whether degeneration of the outer retina has any impact on hypoxia, to examine diabetes-related retinal gene expression responses, and to assess lesions of diabetic retinopathy...
  28. ncbi request reprint The role of advanced glycation end products in retinal microvascular leukostasis
    Tara C B Moore
    Department of Ophthalmology, Royal Victoria Hospital, The Queen s University of Belfast, Northern Ireland
    Invest Ophthalmol Vis Sci 44:4457-64. 2003
    ....
  29. pmc Retinal endothelial cell apoptosis stimulates recruitment of endothelial progenitor cells
    Ashay D Bhatwadekar
    Centre for Vision Science, Queen s University Belfast, Royal Victoria Hospital, Belfast, Northern Ireland, United Kingdom
    Invest Ophthalmol Vis Sci 50:4967-73. 2009
    ..This study was conducted to determine how the presence of apoptotic bodies at sites of endothelial damage may influence participation of EPCs in retinal microvascular repair...
  30. doi request reprint Outgrowth endothelial cells: characterization and their potential for reversing ischemic retinopathy
    Reinhold J Medina
    Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Science, Queen s University Belfast, Belfast, United Kingdom
    Invest Ophthalmol Vis Sci 51:5906-13. 2010
    ....
  31. pmc Inhibition of tumor necrosis factor-alpha improves physiological angiogenesis and reduces pathological neovascularization in ischemic retinopathy
    Tom A Gardiner
    Ophthalmology and Vision Science, Queen s University Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK
    Am J Pathol 166:637-44. 2005
    ..HP provides a useful tool for mapping and quantifying tissue hypoxia in experimental ischemic retinopathy...
  32. ncbi request reprint Rod photoreceptor loss in Rho-/- mice reduces retinal hypoxia and hypoxia-regulated gene expression
    Tanyth E de Gooyer
    Centre for Vision Science, Queen s University Belfast, Royal Victoria Hospital, Belfast, Northern Ireland, United Kingdom
    Invest Ophthalmol Vis Sci 47:5553-60. 2006
    ..This study was conducted to evaluate whether regions of the retinal neuropile become hypoxic during periods of high oxygen consumption and whether depletion of the outer retina reduces hypoxia and related changes in gene expression...
  33. ncbi request reprint Advanced glycation and advanced lipoxidation: possible role in initiation and progression of diabetic retinopathy
    Alan W Stitt
    Ophthalmic Research Centre, Queen s University of Belfast, BT12 6BA Northern Ireland, UK
    Curr Pharm Des 10:3349-60. 2004
    ..It will also outline how recent pharmaceutical strategies to inhibit AGE/ALE formation or limit their pathogenic influence during chronic hyperglycaemia may play a significant role in the treatment of diabetic retinopathy...
  34. doi request reprint Advanced glycation end product (AGE) accumulation on Bruch's membrane: links to age-related RPE dysfunction
    Josephine V Glenn
    Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Science, Queen s University, Northern Ireland, United Kingdom
    Invest Ophthalmol Vis Sci 50:441-51. 2009
    ..In the present study the impact of AGEs at the RPE-Bruch's membrane interface was evaluated, to establish how these modifications may contribute to age-related disease...
  35. pmc Proteomic profiling of the retinal dysplasia and degeneration chick retina
    Sorcha Finnegan
    Centre for Vision Sciences, Institute of Clinical Science, Queen s University of Belfast, Belfast, Northern Ireland, UK
    Mol Vis 16:7-17. 2010
    ..The pathology displayed by the rdd chick resembles that observed in some of the more severe forms of human retinitis pigmentosa...
  36. doi request reprint The role of advanced glycation end products in retinal ageing and disease
    Josephine V Glenn
    Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Belfast, BT12 6BA, Northern Ireland, UK
    Biochim Biophys Acta 1790:1109-16. 2009
    ..The therapeutic potential for novel agents that can ameliorate AGE formation of attenuate RAGE signalling in the retina is also discussed...
  37. doi request reprint Effects of an endothelin receptor antagonist on a model of hypertensive retinopathy
    Louise McDonald
    Centre for Vision and Vascular Science, Queen s University Belfast, Belfast, Northern Ireland
    Ophthalmic Res 43:99-107. 2010
    ..ET-mediated vasoregulation abnormalities in the retinal microvasculature could play an associative role in lesion formation during hypertensive retinopathy...
  38. ncbi request reprint Upregulation of oxidative stress markers in human microvascular endothelial cells by complexes of serum albumin and digestion products of glycated casein
    Permal Deo
    Human Nutrition and Health Group, School of Biological Sciences, Queen s University Belfast, Belfast, Northern Ireland
    J Biochem Mol Toxicol 23:364-72. 2009
    ..In conclusion, in an in vitro cell system, digested dietary AGEs complexed with serum albumin play a role in the regulation of RAGE and downstream inflammatory pathways. AGE-R3 may protect against these effects...
  39. ncbi request reprint Advanced glycation as a basis for understanding retinal aging and noninvasive risk prediction
    Anna M Pawlak
    Centre for Vision Science, School of Biomedical Science, Queen s University Belfast, Belfast, UK
    Ann N Y Acad Sci 1126:59-65. 2008
    ....
  40. ncbi request reprint The role of advanced glycation in the pathogenesis of diabetic retinopathy
    Alan W Stitt
    Department of Ophthalmology, Queen s University of Belfast, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, UK
    Exp Mol Pathol 75:95-108. 2003
    ..It will also outline how recent strategies to inhibit AGE formation or limit their pathogenic influence during chronic diabetes may have an important role to play in the treatment of retinopathy...
  41. doi request reprint Advanced glycation of fibronectin impairs vascular repair by endothelial progenitor cells: implications for vasodegeneration in diabetic retinopathy
    Ashay D Bhatwadekar
    Centre for Vision Science, Queen s University Belfast, Royal Victoria Hospital, Northern Ireland, UK
    Invest Ophthalmol Vis Sci 49:1232-41. 2008
    ..The hypothesis for the study was that progressive basement membrane (BM) modification by advanced glycation end products (AGEs) contributes to impairment of EPC reparative function after diabetes-related endothelial injury...
  42. ncbi request reprint Sources of PDGF expression in murine retina and the effect of short-term diabetes
    Orla T Cox
    Ophthalmology Vision Science, Queen s University of Belfast, Institute of Clinical Science, Royal Victoria Hospital Belfast, Northern Ireland
    Mol Vis 9:665-72. 2003
    ..The retinal cell source(s) of PDGF remain unknown. It is important to understand how diabetes alters expression of this important growth factor...
  43. ncbi request reprint Advanced glycation end products and diabetic complications
    Alan W Stitt
    Dept of Ophthalmology, Royal Victoria Hospital, Queen s University of Belfast, Northern Ireland
    Expert Opin Investig Drugs 11:1205-23. 2002
    ....
  44. pmc Synthetic peptides interacting with the 67-kd laminin receptor can reduce retinal ischemia and inhibit hypoxia-induced retinal neovascularization
    Dorota Gebarowska
    Centre of Ophthalmology and Vision Science and the School of Biology and Biochemistry, The Queen s University of Belfast, Royal Victoria Hospital, Belfast, Northern Ireland, United Kingdom
    Am J Pathol 160:307-13. 2002
    ..Agonism of this receptor may be valuable in reducing the hypoxia-stimulated release of angiogenic growth factors which drives retinal angiogenesis...
  45. ncbi request reprint Distribution of the receptor for advanced glycation end products in the human male reproductive tract: prevalence in men with diabetes mellitus
    Con Mallidis
    Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, School of Medicine, Queen s University of Belfast, Grosvenor Road, Belfast, UK
    Hum Reprod 22:2169-77. 2007
    ..As the receptor for AGEs (RAGE) is important to oxidative stress and cell dysfunction, we hypothesise, that it may be involved in sperm nDNA damage...
  46. ncbi request reprint Arteriolar involvement in the microvascular lesions of diabetic retinopathy: implications for pathogenesis
    Tom A Gardiner
    Centre for Vision Science, The Queen s University of Belfast, The Royal Victoria Hospital, Institute of Clinical Science, Belfast, Northern Ireland
    Microcirculation 14:25-38. 2007
    ..In particular, an emphasis will be placed on the relatively unappreciated role of arteriolar dysfunction in the clinical manifestations and pathology of this disease...
  47. ncbi request reprint Confocal Raman microscopy can quantify advanced glycation end product (AGE) modifications in Bruch's membrane leading to accurate, nondestructive prediction of ocular aging
    Josephine V Glenn
    Centre for Vision Science, School of Biomedical Science, Faculty of Medicine and Health Sciences, Queen s University Belfast, Belfast BT12 6BA, Northern Ireland
    FASEB J 21:3542-52. 2007
    ..000001). With further development, this Raman-based approach has the potential for noninvasive examination of AGE adducts in living eyes and ultimately to assess their precise pathogenic role in age-related diseases...
  48. pmc Multiplex analysis of age-related protein and lipid modifications in human Bruch's membrane
    J Renwick Beattie
    Centre for Vision and Vascular Science, School of Medicine and Dentistry, Queen s University Belfast, Belfast, UK
    FASEB J 24:4816-24. 2010
    ..We present the first directly recorded evidence of the key role of heme in AGE/ALE formation...
  49. pmc Homodimerization is essential for the receptor for advanced glycation end products (RAGE)-mediated signal transduction
    Hongliang Zong
    Centre for Vision and Vascular Science, Queen s University Belfast, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, United Kingdom
    J Biol Chem 285:23137-46. 2010
    ..Thus, the data indicate that dimerization of RAGE represents an important component of RAGE-mediated cell signaling...
  50. pmc Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy
    Jennifer L Wilkinson-Berka
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Am J Pathol 164:1263-73. 2004
    ..In conclusion, PDGF is required for pericyte viability and the subsequent prevention of VEGF/VEGFR-2 overexpression and angiogenesis in ROP...
  51. ncbi request reprint Involvement of MAPKs in endostatin-mediated regulation of blood-retinal barrier function
    Matthew Campbell
    UCD School of Biomolecular Biomedical Sciences, Conway Institute, University College Dublin, Dublin, Ireland
    Curr Eye Res 31:1033-45. 2006
    ..In order to determine the mechanism of endostatin action on BRB integrity, we have examined the effects of endostatin on a number of intracellular pathways implicated in endothelial cell physiology...