Genomes and Genes
Affiliation: Queen's University Belfast
- The role of hepatocyte growth factor/c-met interactions in the immune systemGrzegorz Skibinski
Respiratory Research Group, Department of Clinical Biochemistry, Institute of Clinical Science, Queen s University of Belfast, Belfast BT12 6BJ, Northern Ireland, UK
Arch Immunol Ther Exp (Warsz) 51:277-82. 2003..This paper discusses expression of HGF and c-met within the immune system and their interactions in the control of immune cell functions...
- The role of hepatocyte growth factor and its receptor c-met in interactions between lymphocytes and stromal cells in secondary human lymphoid organsG Skibinski
Department of Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, UK
Immunology 102:506-14. 2001..In this way HGF may indirectly influence immunoglobulin secretion by B cells...
- Hepatocyte growth factor (HGF) protects c-met-expressing Burkitt's lymphoma cell lines from apoptotic death induced by DNA damaging agentsG Skibinski
Department of Clinical and Surgical Sciences, University of Edinburgh, Royal Infirmary, Edinburgh EH3 9YW, UK
Eur J Cancer 37:1562-9. 2001..Overall, these studies suggest that the accumulation of HGF within the microenvironment of neoplastic cells may contribute to the development of a chemoresistant phenotype...
- Bronchial epithelial cell growth regulation in fibroblast cocultures: the role of hepatocyte growth factorGrzegorz Skibinski
Respiratory Medicine Research Cluster, School of Medicine and Dentistry, Queen s University Belfast, Belfast, Northern Ireland, United Kingdom
Am J Physiol Lung Cell Mol Physiol 293:L69-76. 2007....
- Chronic IL9 and IL-13 exposure leads to an altered differentiation of ciliated cells in a well-differentiated paediatric bronchial epithelial cell modelJeremy C Parker
Centre for Infection and Immunity, Queen s University Belfast, Belfast, Northern Ireland
PLoS ONE 8:e61023. 2013..This suggests an alternative role for IL-9 in airways remodelling and reaffirms IL-9 as a potential therapeutic target...
- A 3-D well-differentiated model of pediatric bronchial epithelium demonstrates unstimulated morphological differences between asthmatic and nonasthmatic cellsJeremy Parker
Centre for Infection and Immunity and School of Medicine, Queen s University Belfast, Belfast, BT12 6BN, Northern Ireland
Pediatr Res 67:17-22. 2010..A well-differentiated model of pediatric epithelium has been developed that will be useful for more in vivo like study of the mechanisms at play during asthma...
- Effects of IL-13 on mucociliary differentiation of pediatric asthmatic bronchial epithelial cellsSurendran Thavagnanam
Centre for Infection and Immunity, Queen s University Belfast, Belfast BT12 6BN, Northern Ireland, United Kingdom
Pediatr Res 69:95-100. 2011..05. IL-13 drives PBEC(N) toward an asthmatic phenotype and worsens the phenotype in PBEC(A) with reduced ciliated cell numbers and increased goblet cells...
- Cytopathogenesis of Sendai virus in well-differentiated primary pediatric bronchial epithelial cellsRemi Villenave
Queen s University Belfast, Medical Biology Centre, Belfast BT9 7BL, Northern Ireland
J Virol 84:11718-28. 2010..Alternatively, such robust responses might constitute appropriate normal host responses to viral infection and be a prerequisite for the induction of efficient immune responses...
- Differential cytopathogenesis of respiratory syncytial virus prototypic and clinical isolates in primary pediatric bronchial epithelial cellsRemi Villenave
Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queens University Belfast, Belfast BT9 7BL, Northern Ireland
Virol J 8:43. 2011..We hypothesized that such strains may be poorly representative of recent clinical isolates in terms of virus/host interactions in primary human bronchial epithelial cells (PBECs)...
- Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthmaClaire A Butler
Centre for Infection and Immunity, Queens University Belfast, Level 8, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, Northern Ireland, UK
Thorax 67:392-8. 2012....
- Wild-type measles virus infection of primary epithelial cells occurs via the basolateral surface without syncytium formation or release of infectious virusMartin Ludlow
Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University of Belfast, Belfast BT9 7BL, UK
J Gen Virol 91:971-9. 2010..o.i. The low numbers of MV-infected epithelial cells observed in vivo in conjunction with the absence of infectious virus release from infected primary cell cultures suggest that epithelial cells have a peripheral role in MV transmission...
- Staphylococcus aureus enterotoxins induce IL-8 secretion by human nasal epithelial cellsGarrett J O'Brien
Respiratory Research Group, School of Medicine and Dentistry, Queen s University Belfast, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, UK
Respir Res 7:115. 2006..Staphylococcus aureus produces a set of proteins which act both as superantigens and toxins. Although their mode of action as superantigens is well understood, little is known about their effects on airway epithelial cells...