C C Patterson

Summary

Affiliation: Queen's University Belfast
Country: UK

Publications

  1. pmc Haplotype association analysis of genes within the WNT signalling pathways in diabetic nephropathy
    David H Kavanagh
    Nephrology Research Group, Centre for Public Health, Queen s University Belfast, Belfast BT12 6BJ, UK
    BMC Nephrol 14:126. 2013
  2. doi request reprint Trends in childhood type 1 diabetes incidence in Europe during 1989-2008: evidence of non-uniformity over time in rates of increase
    C C Patterson
    Centre for Public Health, Queen s University Belfast, Institute of Clinical Science Block B, Grosvenor Road, Belfast, BT12 6BJ, UK
    Diabetologia 55:2142-7. 2012
  3. pmc Lack of MEF2A Delta7aa mutation in Irish families with early onset ischaemic heart disease, a family based study
    Paul G Horan
    Regional Medical Cardiology Centre, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland, UK
    BMC Med Genet 7:65. 2006
  4. pmc Genetic variants of complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population
    Weihua Meng
    Centre for Clinical and Population Sciences, Queen s University Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland, UK
    BMC Med Genet 8:62. 2007
  5. pmc Resequencing of genes for transforming growth factor beta1 (TGFB1) type 1 and 2 receptors (TGFBR1, TGFBR2), and association analysis of variants with diabetic nephropathy
    Amy Jayne McKnight
    Nephrology Research Group, Queen s University of Belfast, Belfast, UK
    BMC Med Genet 8:5. 2007
  6. ncbi request reprint Early mortality in EURODIAB population-based cohorts of type 1 diabetes diagnosed in childhood since 1989
    C C Patterson
    Department of Epidemiology and Public Health, Queen s University Belfast, Belfast, UK
    Diabetologia 50:2439-42. 2007
  7. pmc A cluster randomised intervention trial of asthma clubs to improve quality of life in primary school children: the School Care and Asthma Management Project (SCAMP)
    E E Patterson
    Belvoir Health Clinic, South and East Belfast Health and Social Services Trust, Belfast BT8 4ET, UK
    Arch Dis Child 90:786-91. 2005
  8. doi request reprint Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study
    Christopher C Patterson
    Epidemiology Research Group, Centre for Public Health, Queen s University Belfast, Belfast, UK
    Lancet 373:2027-33. 2009
  9. ncbi request reprint Polymorphisms of the macrophage migration inhibitory factor gene in a UK population with Type 1 diabetes mellitus
    R J L Martin
    Nephrology, Queen s University of Belfast, Belfast, UK
    Diabet Med 27:143-9. 2010
  10. doi request reprint Birthweight and the risk of childhood-onset type 1 diabetes: a meta-analysis of observational studies using individual patient data
    C R Cardwell
    Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Grosvenor Road, Belfast BT12 6BJ, UK
    Diabetologia 53:641-51. 2010

Detail Information

Publications74

  1. pmc Haplotype association analysis of genes within the WNT signalling pathways in diabetic nephropathy
    David H Kavanagh
    Nephrology Research Group, Centre for Public Health, Queen s University Belfast, Belfast BT12 6BJ, UK
    BMC Nephrol 14:126. 2013
    ..This study comprehensively examined common genetic variation within the WNT pathway for association with DN...
  2. doi request reprint Trends in childhood type 1 diabetes incidence in Europe during 1989-2008: evidence of non-uniformity over time in rates of increase
    C C Patterson
    Centre for Public Health, Queen s University Belfast, Institute of Clinical Science Block B, Grosvenor Road, Belfast, BT12 6BJ, UK
    Diabetologia 55:2142-7. 2012
    ..The aim of the study was to describe 20-year incidence trends for childhood type 1 diabetes in 23 EURODIAB centres and compare rates of increase in the first (1989-1998) and second (1999-2008) halves of the period...
  3. pmc Lack of MEF2A Delta7aa mutation in Irish families with early onset ischaemic heart disease, a family based study
    Paul G Horan
    Regional Medical Cardiology Centre, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland, UK
    BMC Med Genet 7:65. 2006
    ..We investigated this region of the MEF2A gene using an Irish family-based study, where affected individuals had early-onset IHD...
  4. pmc Genetic variants of complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population
    Weihua Meng
    Centre for Clinical and Population Sciences, Queen s University Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland, UK
    BMC Med Genet 8:62. 2007
    ..This study was designed to investigate if, using a family-based approach, there was an association between genetic variants of the CFH gene and risk of early-onset coronary heart disease...
  5. pmc Resequencing of genes for transforming growth factor beta1 (TGFB1) type 1 and 2 receptors (TGFBR1, TGFBR2), and association analysis of variants with diabetic nephropathy
    Amy Jayne McKnight
    Nephrology Research Group, Queen s University of Belfast, Belfast, UK
    BMC Med Genet 8:5. 2007
    ..Transforming growth factor (TGFbeta1) is a crucial mediator in the pathogenesis of diabetic nephropathy...
  6. ncbi request reprint Early mortality in EURODIAB population-based cohorts of type 1 diabetes diagnosed in childhood since 1989
    C C Patterson
    Department of Epidemiology and Public Health, Queen s University Belfast, Belfast, UK
    Diabetologia 50:2439-42. 2007
    ....
  7. pmc A cluster randomised intervention trial of asthma clubs to improve quality of life in primary school children: the School Care and Asthma Management Project (SCAMP)
    E E Patterson
    Belvoir Health Clinic, South and East Belfast Health and Social Services Trust, Belfast BT8 4ET, UK
    Arch Dis Child 90:786-91. 2005
    ..To evaluate the effectiveness of a programme of asthma clubs in improving quality of life in primary school children with asthma...
  8. doi request reprint Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study
    Christopher C Patterson
    Epidemiology Research Group, Centre for Public Health, Queen s University Belfast, Belfast, UK
    Lancet 373:2027-33. 2009
    ..We aimed to establish 15-year incidence trends for childhood type 1 diabetes in European centres, and thereby predict the future burden of childhood diabetes in Europe...
  9. ncbi request reprint Polymorphisms of the macrophage migration inhibitory factor gene in a UK population with Type 1 diabetes mellitus
    R J L Martin
    Nephrology, Queen s University of Belfast, Belfast, UK
    Diabet Med 27:143-9. 2010
    ....
  10. doi request reprint Birthweight and the risk of childhood-onset type 1 diabetes: a meta-analysis of observational studies using individual patient data
    C R Cardwell
    Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Grosvenor Road, Belfast BT12 6BJ, UK
    Diabetologia 53:641-51. 2010
    ..We investigated whether children who are heavier at birth have an increased risk of type 1 diabetes...
  11. ncbi request reprint Paraoxonase activity and coronary heart disease risk in healthy middle-aged males: the PRIME study
    J A Troughton
    Faculty of Medicine, Queen s University Belfast, Belfast, Northern Ireland, UK
    Atherosclerosis 197:556-63. 2008
    ..We tested the hypotheses that (1) higher paraoxonase activity is associated with decreased CHD risk and (2) PON55 LL genotype is associated with increased CHD risk...
  12. ncbi request reprint The intercellular adhesion molecule-1 (ICAM-1) gene K469E polymorphism is not associated with ischaemic heart disease: an investigation using family-based tests of association
    P G McGlinchey
    Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast, UK
    Eur J Immunogenet 31:201-6. 2004
    ..Our data demonstrate that, in an Irish population, the ICAM-1 K469E polymorphism is not associated with IHD...
  13. doi request reprint Do lifestyle behaviours explain socioeconomic differences in all-cause mortality, and fatal and non-fatal cardiovascular events? Evidence from middle aged men in France and Northern Ireland in the PRIME Study
    J V Woodside
    Queen s University Belfast, Belfast, United Kingdom
    Prev Med 54:247-53. 2012
    ..To examine the contribution of lifestyle behaviours to the socioeconomic gradient in all-cause mortality, and fatal and non-fatal cardiovascular events...
  14. doi request reprint Investigation of DNA polymorphisms in SMAD genes for genetic predisposition to diabetic nephropathy in patients with type 1 diabetes mellitus
    A J McKnight
    Nephrology Research Group, Queen s University of Belfast, c o Regional Genetics Centre, Belfast City Hospital, Belfast, Northern Ireland, UK
    Diabetologia 52:844-9. 2009
    ..SMAD proteins are involved in multiple signalling pathways and are key modulators of gene expression. We hypothesised that genetic variation in selected SMAD genes contributes to susceptibility to diabetic nephropathy...
  15. ncbi request reprint Investigation of the association of BMP gene variants with nephropathy in Type 1 diabetes mellitus
    A J McKnight
    Nephrology Research Group, Queen s University of Belfast, Belfast, UK
    Diabet Med 27:624-30. 2010
    ..The BMP2, BMP4 and BMP7 genes are located near linkage peaks for renal dysfunction, and we hypothesize that genetic polymorphisms in these biological and positional candidate genes may be risk factors for diabetic kidney disease...
  16. doi request reprint Contribution of lifetime smoking habit in France and Northern Ireland to country and socioeconomic differentials in mortality and cardiovascular incidence: the PRIME Study
    J W G Yarnell
    Centre for Public Health, Queens University of Belfast, ICS Block B, RVH Site, Grosvenor Road, Belfast BT12 6BJ, UK
    J Epidemiol Community Health 66:599-604. 2012
    ..This study examines the contribution of lifetime smoking habit to the socioeconomic gradient in all-cause and smoking-related mortality and in cardiovascular incidence in two countries...
  17. doi request reprint Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies
    C R Cardwell
    Department of Epidemiology and Public Health, School of Medicine and Dentistry, Queen s University Belfast, Grosvenor Road, Belfast, BT12 6BJ, UK
    Diabetologia 51:726-35. 2008
    ....
  18. ncbi request reprint Lack of association between the -2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation
    P G McGlinchey
    Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast, UK
    Tissue Antigens 64:199-203. 2004
    ..Our data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is not strongly associated with IHD...
  19. ncbi request reprint Prevalence and awareness of excess weight in 13 and 14 year olds in Northern Ireland using recent international guidelines
    J W Yarnell
    Department of Epidemiology and Public Health, Queen s University Belfast, UK
    Acta Paediatr 90:1435-9. 2001
    ..Only 15% of obese boys compared with 38% of obese girls stated that they were on weight-reducing diets...
  20. doi request reprint Investigation of ACE, ACE2 and AGTR1 genes for association with nephropathy in Type 1 diabetes mellitus
    D Currie
    Nephrology, Queen s University of Belfast, Belfast, UK
    Diabet Med 27:1188-94. 2010
    ..The ACE2 gene has not been studied extensively for association with diabetic nephropathy...
  21. ncbi request reprint Association of serum AACT levels and AACT signal polymorphism with late-onset Alzheimer's disease in Northern Ireland
    S P McIlroy
    Department of Geriatric Medicine, The Queen s University of Belfast, Belfast, Northern Ireland, UK
    Int J Geriatr Psychiatry 15:260-6. 2000
    ..We report allelic association of the AACT signal polymorphism with AD (chi(2)=3.70, df=1, p=0.04) but we failed to show any correlation between AACT serum levels and genotype...
  22. pmc Genetic association analyses of non-synonymous single nucleotide polymorphisms in diabetic nephropathy
    D A Savage
    Nephrology Research Laboratory, Queen s University, Belfast, BT9 7AB, Northern Ireland, UK
    Diabetologia 51:1998-2002. 2008
    ..The objective of this study was to investigate whether nsSNPs are involved in susceptibility to diabetic nephropathy using a case-control design...
  23. doi request reprint Genetic polymorphisms in nitric oxide synthase 3 gene and implications for kidney disease: a meta-analysis
    A J McKnight
    Nephrology Research Group, Centre for Public Health, Queen s University of Belfast, Belfast, UK
    Am J Nephrol 32:476-81. 2010
    ..However, the relationship between NOS3 polymorphisms and renal disease is inconclusive. This study aimed to clarify the association of NOS3 variants with nephropathy in individuals with type 1 diabetes...
  24. ncbi request reprint Common polymorphisms of the PAI1 gene do not play a major role in the development of diabetic nephropathy in Type 1 diabetes
    R J L Martin
    Nephrology Research Group, The Queen s University of Belfast, Belfast, UK
    Diabet Med 24:259-65. 2007
    ..Genotyping of the htSNPs was performed in 583 Type 1 diabetic patients (222 with nephropathy, 361 without nephropathy)using Pyrosequencing...
  25. ncbi request reprint Is childhood-onset type I diabetes a wealth-related disease? An ecological analysis of European incidence rates
    C C Patterson
    Department of Epidemiology and Public Health, Queen s University Belfast, Northern Ireland
    Diabetologia 44:B9-16. 2001
    ..A total of 16,362 cases were registered by 44 centres during the period 1989-1994. The registers cover a population of approximately 28 million children with most European countries represented...
  26. pmc Diabetes care provision and glycaemic control in Northern Ireland: a UK regional audit
    C R Cardwell
    Department of Epidemiology and Public Health, The Queen s University of Belfast, UK
    Arch Dis Child 90:468-73. 2005
    ..To assess the care received, compared to national guidelines, and to investigate factors associated with glycaemic control in children and adolescents with type 1 diabetes attending clinics in Northern Ireland...
  27. ncbi request reprint Homocysteine and coronary heart disease risk in the PRIME study
    J A Troughton
    Faculty of Medicine, Queen s University Belfast, Belfast, Northern Ireland, UK
    Atherosclerosis 191:90-7. 2007
    ..We investigated: (1) whether higher homocysteine is associated with increased CHD risk in the PRIME case-control cohort; (2) whether homocysteine interacts synergistically with pre-existing CHD risk factors...
  28. ncbi request reprint Do polymorphisms of apoB, LPL or apoE affect the hypocholesterolemic response to weight loss?
    F Kee
    Department of Epidemiology and Public Health, The Queen s University of Belfast QUB, Mulhouse Building, Grosvenor Rd, Northern Ireland BT12 6BJ, Belfast, UK
    Atherosclerosis 153:119-28. 2000
    ..Although, this study is one of the largest of its kind, it has not replicated the findings of other smaller studies. These findings do not provide support for the use of genotype-targeted dietary advice in routine practice...
  29. doi request reprint Association analysis of Notch pathway signalling genes in diabetic nephropathy
    D Kavanagh
    Nephrology Research Group, Centre for Public Health, Queen s University Belfast, Belfast, UK
    Diabetologia 54:334-8. 2011
    ..We assessed single-nucleotide polymorphisms (SNPs; n = 42) in four of these key genes (JAG1, HES1, NOTCH3 and ADAM10) for association with diabetic nephropathy using a case-control design...
  30. ncbi request reprint Do total and high density lipoprotein cholesterol and triglycerides act independently in the prediction of ischemic heart disease? Ten-year follow-up of Caerphilly and Speedwell Cohorts
    J W Yarnell
    Department of Epidemiology and Public Health, Queen s University of Belfast, Belfast, UK
    Arterioscler Thromb Vasc Biol 21:1340-5. 2001
    ..There was no evidence that men with low HDL/raised TGs were at significantly greater risk than that predicted from the independent effects of the 2 lipids considered individually...
  31. ncbi request reprint Cardiovascular and metabolic abnormalities in the offspring of diabetic pregnancy
    J G Manderson
    Royal Jubilee Maternity Hospital, Royal Victoria Hospital, Belfast, UK
    Diabetologia 45:991-6. 2002
    ..The aim of this study was to identify whether markers for fuel-related cardiovascular programming exist for the offspring of diabetic pregnancy...
  32. doi request reprint No association between routinely recorded infections in early life and subsequent risk of childhood-onset Type 1 diabetes: a matched case-control study using the UK General Practice Research Database
    C R Cardwell
    School of Medicine and Dentistry, The Queen s University of Belfast, Belfast, UK
    Diabet Med 25:261-7. 2008
    ..To determine whether children with infections in early life (recorded routinely in general practice) have a reduced risk of Type 1 diabetes, as would be expected from the hygiene hypothesis...
  33. ncbi request reprint Higher incidence of childhood-onset type 1 diabetes mellitus in remote areas: a UK regional small-area analysis
    C R Cardwell
    School of Medicine and Dentistry, The Queen s University of Belfast, Belfast, UK
    Diabetologia 49:2074-7. 2006
    ..We investigated the association between the incidence of type 1 diabetes mellitus and remoteness (a proxy measure for exposure to infections) using recently developed techniques for statistical analysis of small-area data...
  34. ncbi request reprint Secular trends, disease maps and ecological analyses of the incidence of childhood onset Type 1 diabetes in Northern Ireland, 1989-2003
    C R Cardwell
    School of Medicine and Dentistry, The Queen s University of Belfast, Belfast, UK
    Diabet Med 24:289-95. 2007
    ..To highlight geographical variations in the incidence of Type 1 diabetes by producing disease maps and to compare incidence rates by relevant area characteristics...
  35. ncbi request reprint Central obesity: predictive value of skinfold measurements for subsequent ischaemic heart disease at 14 years follow-up in the Caerphilly Study
    J W Yarnell
    Department of Epidemiology and Public Health, Queen s University of Belfast, Belfast, UK
    Int J Obes Relat Metab Disord 25:1546-9. 2001
    ..To assess the predictive value of central obesity for risk of ischaemic heart disease (IHD) in a long-term follow-up, measured by skinfold thickness in comparison to general measures of overweight and obesity such as Quetelet's index...
  36. ncbi request reprint Parental age at delivery, birth order, birth weight and gestational age are associated with the risk of childhood Type 1 diabetes: a UK regional retrospective cohort study
    C R Cardwell
    Department of Epidemiology and Public Health, The Queen s University of Belfast, Belfast, UK
    Diabet Med 22:200-6. 2005
    ..To investigate perinatal risk factors for childhood Type 1 diabetes in a UK population cohort...
  37. pmc Infections in early life and childhood leukaemia risk: a UK case-control study of general practitioner records
    C R Cardwell
    Department of Epidemiology and Public Health, School of Medicine and Dentistry, The Queen s University of Belfast, Belfast, UK
    Br J Cancer 99:1529-33. 2008
    ..05, 95%CI 0.64-1.74; P=0.84). Our study provides no support for the Greaves hypothesis, which proposes that reduced or delayed exposure to infections in early life increases the risk of childhood ALL...
  38. ncbi request reprint Season and outdoor ambient temperature: effects on birth weight
    L J Murray
    Department of Epidemiology and Public Health, The Queens University of Belfast, Belfast, United Kingdom
    Obstet Gynecol 96:689-95. 2000
    ..To determine the extent to which meteorologic factors explain seasonality in birth weight in a developed country...
  39. ncbi request reprint An investigation of susceptibility loci in benign, aggressive and primary progressive multiple sclerosis in Northern Irish population
    O M Gray
    Department of Neurology, Royal Victoria Hospital, and Epidemiology Research Group, Queen s University, Grosvenor Road, Belfast, N Ireland BT12 6BA
    Mult Scler 15:299-303. 2009
    ..To investigate the possibility that susceptibility loci in multiple sclerosis (MS) have a role in determining the disease outcome in Northern Ireland population...
  40. ncbi request reprint Improved survival for melanoma in Northern Ireland: a comparison of two 5-year periods (1984-88 and 1994-98)
    E A McMullen
    The Department of Dermatology, The Royal Victoria Hospital, Belfast, Northern Ireland, UK
    Br J Dermatol 151:587-93. 2004
    ..An increase in incidence of about 5% per year has been reported in most Caucasian populations since the early 1960s...
  41. doi request reprint A meta-analysis of the association between pre-eclampsia and childhood-onset Type 1 diabetes mellitus
    E B Henry
    Centre for Public Health, School of Medicine, Dentistry and Biomedical Science, The Queen s University of Belfast, Belfast, UK
    Diabet Med 28:900-5. 2011
    ..To review and synthesize the evidence for an increased risk of childhood Type 1 diabetes mellitus in children born to mothers diagnosed with pre-eclampsia during pregnancy...
  42. pmc Alcohol increases homocysteine and reduces B vitamin concentration in healthy male volunteers--a randomized, crossover intervention study
    A Gibson
    Centre for Clinical and Population Science, Queen s University Belfast, Belfast, UK
    QJM 101:881-7. 2008
    ..Few studies have examined the effect of alcohol consumption on total homocysteine (tHcy) concentrations...
  43. ncbi request reprint Risk of Alzheimer's disease is associated with a very low-density lipoprotein receptor genotype in Northern Ireland
    S P McIlroy
    Department of Geriatric Medicine, Queen s University of Belfast, Northern Ireland
    Am J Med Genet 88:140-4. 1999
    ..008; Pcorr = 0.047). The results from this study suggest that individuals who have the 9,9 genotype of the VLDL-R gene are at increased risk of AD in Northern Ireland...
  44. ncbi request reprint Common polymorphisms in LRP and A2M do not affect genetic risk for Alzheimer disease in Northern Ireland
    S P McIlroy
    Department of Geriatric Medicine, The Queen s University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland
    Am J Med Genet 105:502-6. 2001
    ..The results from this study indicate that polymorphisms in LRP and A2M are not associated with increased risk for AD in Northern Ireland...
  45. ncbi request reprint Interleukin 18 promoter polymorphisms are not strongly associated with type I diabetes in a UK population
    R J L Martin
    Department of Medical Genetics, The Queen s University of Belfast, Belfast City Hospital, Belfast, Northern Ireland
    Genes Immun 6:171-4. 2005
    ..In conclusion, our data do not support the strong positive associations of IL18 promoter polymorphisms with type I diabetes reported in previous smaller studies...
  46. ncbi request reprint An evaluation of protocolised weaning on the duration of mechanical ventilation
    B Blackwood
    Nursing and Midwifery Research Unit, Queen s University Belfast, 21 Stranmillis Road, Belfast, N Ireland
    Anaesthesia 61:1079-86. 2006
    ..Protocolised weaning did not reduce the duration of mechanical ventilation and was not associated with an increased rate of re-intubation or intensive care unit mortality...
  47. ncbi request reprint Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: a double-blind, randomized, factorial-design, controlled trial
    J V Woodside
    School of Clinical Medicine, The Queen s University of Belfast, United Kingdom
    Am J Clin Nutr 67:858-66. 1998
    ..Supplementation with the B-group vitamins with or without antioxidants reduced homocysteine in the men with mildly elevated concentrations, and hence may be effective in reducing cardiovascular risk...
  48. ncbi request reprint A multicenter, randomized open study of early corticosteroid treatment (OSECT) in preterm infants with respiratory illness: comparison of early and late treatment and of dexamethasone and inhaled budesonide
    H L Halliday
    Regional Neonatal Unit, Royal Maternity Hospital, Belfast, Northern Ireland
    Pediatrics 107:232-40. 2001
    ..To compare early (<3 days) with late (>15 days) steroid therapy and dexamethasone with inhaled budesonide in very preterm infants at risk of developing chronic lung disease...
  49. doi request reprint Association analysis of proopiomelanocortin (POMC) haplotypes in type 1 diabetes in a UK population
    R J L Martin
    Nephrology Research Group, Queen s University of Belfast, c o Regional Genetics Centre, A Floor Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, Northern Ireland, United Kingdom
    Diabetes Metab 37:298-304. 2011
    ..To assess the association of POMC haplotype-tagged single nucleotide polymorphisms (htSNPs) with the development of type 1 diabetes (T1D) in a Caucasian population...
  50. doi request reprint Chronic kidney disease and diabetes in the National Health Service: a cross-sectional survey of the U.K. National Diabetes Audit
    C J Hill
    Centre for Public Health, Queen s University Belfast, Belfast, UK Regional Nephrology Unit, Belfast City Hospital, Belfast, UK
    Diabet Med 31:448-54. 2014
    ..We investigated the prevalence of chronic kidney disease and attainment of therapeutic targets for HbA1c and blood pressure in a large U.K.-based diabetes population...
  51. ncbi request reprint Investigation of the C242T polymorphism of NAD(P)H oxidase p22 phox gene and ischaemic heart disease using family-based association methods
    M S Spence
    Regional Medical Cardiology Centre, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, UK
    Clin Sci (Lond) 105:677-82. 2003
    ....
  52. doi request reprint Intra-uterine growth restriction and increased risk of hypertension in adult life: a follow-up study of 50-year-olds
    D Spence
    School of Nursing and Midwifery, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
    Public Health 126:561-5. 2012
    ....
  53. ncbi request reprint Smoking, atopy and certain furry pets are major determinants of respiratory symptoms in children: the International Study of Asthma and Allergies in Childhood Study (Ireland)
    J W G Yarnell
    Department of Epidemiology, Queen s University Belfast, Belfast, Northern Ireland
    Clin Exp Allergy 33:96-100. 2003
    ..Environmental, cultural and health care differences may account for variation among countries in the prevalence of asthma and respiratory symptoms in teenagers...
  54. ncbi request reprint Haemostatic/inflammatory markers predict 10-year risk of IHD at least as well as lipids: the Caerphilly collaborative studies
    J W G Yarnell
    Department of Epidemiology and Public Health, Queen s University Belfast, Belfast BT12 6BJ, UK
    Eur Heart J 25:1049-56. 2004
    ..We compare the predictive values of plasma lipids (total and HDL-cholesterol, triglycerides) and three haemostatic/inflammatory risk markers for subsequent ischaemic heart disease (IHD)...
  55. doi request reprint General practice-recorded depression and antidepressant use in young people with newly diagnosed Type 1 diabetes: a cohort study using the Clinical Practice Research Datalink
    E Morgan
    UKCRC Centre of Excellence for Public Health NI Centre for Public Health, Queen s University Belfast, Belfast, UK
    Diabet Med 31:241-5. 2014
    ....
  56. ncbi request reprint Haplotype analysis of the preprotachykinin-1 (TAC1) gene in multiple sclerosis
    S Cunningham
    Applied Genomics Research Group, School of Pharmacy, Queen s University of Belfast, Belfast, UK
    Genes Immun 6:265-70. 2005
    ..While independent reproduction of these data in other data sets is indicated, our work is suggestive for a role of the TAC1 gene in MS. Genes and Immunity (2005) 6, 265-270. doi:10.1038/sj.gene.6364175 Published online 24 February 2005...
  57. pmc Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial
    David R McCance
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK
    Lancet 376:259-66. 2010
    ..We aimed to assess whether supplementation with vitamins C and E reduced incidence of pre-eclampsia in women with type 1 diabetes...
  58. ncbi request reprint The IL12B 3' untranslated region DNA polymorphism is not associated with early-onset type 1 diabetes
    R M McCormack
    Department of Medical Genetics, Queen s University Belfast, Belfast, Northern Ireland
    Genes Immun 3:433-5. 2002
    ..8% vs 80.8%; P=0.98) or family-based (49.7% transmissions; P=0.94) studies. Our results do not support earlier reports of an association between allele 1 in the 3'UTR of the IL12B gene and type 1 diabetes...
  59. pmc Cancer incidence and mortality in patients with insulin-treated diabetes: a UK cohort study
    A J Swerdlow
    Section of Epidemiology, Brookes Lawley Building, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Br J Cancer 92:2070-5. 2005
    ..Risks of cancer at other major sites were not substantially raised for type I patients. The excesses of obesity- and alcohol-related cancers in type II diabetes may be due to confounding rather than diabetes per se...
  60. ncbi request reprint Worldwide childhood type 1 diabetes incidence--what can we learn from epidemiology?
    G Soltesz
    Department of Pediatrics, University of Pecs, Hungary
    Pediatr Diabetes 8:6-14. 2007
    ..Some of these environmental risk factors such as viruses may initiate autoimmunity toward the beta cell, other exposures may put on overload on the already affected beta cell and thus accelerate the disease process...
  61. ncbi request reprint Association between polymorphism in regulatory region of gene encoding tumour necrosis factor alpha and risk of Alzheimer's disease and vascular dementia: a case-control study
    S M McCusker
    Department of Geriatric Medicine, Queen s University of Belfast, UK
    Lancet 357:436-9. 2001
    ..We postulated that genetic variation in the regulatory region of the gene for the proinflammatory cytokine tumour necrosis factor alpha (TNF-alpha) leads to increased risk of Alzheimer's disease and vascular dementia...
  62. ncbi request reprint The CTLA4+49A/G and CT60 polymorphisms and chronic inflammatory arthropathies in Northern Ireland
    V Suppiah
    Applied Genomics Research Group, School of Pharmacy, McClay Research Centre, The Queen s University of Belfast, Belfast BT9 7BL, Northern Ireland, UK
    Exp Mol Pathol 80:141-6. 2006
    ..00001 and 0.030 for comparison of RA and JIA patients with controls, respectively). Our results suggest that the CTLA-4 gene is involved in predisposition to inflammatory arthropathies in the Northern Irish population...
  63. ncbi request reprint The PAX4 gene variant A1168C is not associated with early onset Type 1 diabetes in a UK population
    R J L Martin
    Diabet Med 23:927-8. 2006
  64. ncbi request reprint Association of functional heme oxygenase-1 gene promoter polymorphism with renal transplantation outcomes
    A E Courtney
    Nephrology Research Group, Queen s University of Belfast, and Regional Nephrology Unit, Belfast City Hospital, Belfast BT9 7AB, UK
    Am J Transplant 7:908-13. 2007
    ..There is no evidence of a protective effect for the S-allele of the HO-1 gene promoter polymorphism on graft or recipient survival in clinical renal transplantation...
  65. ncbi request reprint Sleep complaints and risk factors for excessive daytime sleepiness in adult males in Northern Ireland
    A M Nugent
    Department of Respiratory Medicine, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, N. Ireland
    J Sleep Res 10:69-74. 2001
    ..Recognition of risk factors for EDS may help to identify and treat those affected...
  66. ncbi request reprint Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes
    S P Laing
    Section of Epidemiology, Brookes Lawley Building, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
    Diabetologia 46:760-5. 2003
    ..The Diabetes UK cohort, essentially one of patients with Type 1 diabetes, now has sufficient follow-up to report all heart disease, and specifically ischaemic heart disease, mortality rates by age...
  67. ncbi request reprint Acute asthma exacerbations and air pollutants in children living in Belfast, Northern Ireland
    A J Thompson
    Department of Child Health, The Queen's University of Belfast, Northern Ireland
    Arch Environ Health 56:234-41. 2001
    ..Benzene may be a more reliable method of measuring exposure to vehicle exhaust emissions than measurements of other pollutants...
  68. ncbi request reprint Geographical variation of presentation at diagnosis of type I diabetes in children: the EURODIAB study. European and Dibetes
    C Levy-Marchal
    INSERM U457, Robert Debre Hospital, Paris, France
    Diabetologia 44:B75-80. 2001
    ....
  69. ncbi request reprint Trends in the incidence of childhood-onset diabetes in Europe 1989-1998
    A Green
    Department of Epidemiology and Social Medicine, University of Aarhus, Denmark
    Diabetologia 44:B3-8. 2001
    ..The incidence rate is generally increasing but is more pronounced in some regions than in others. Seasonality at disease onset is apparent even in the youngest age-group...
  70. ncbi request reprint Mortality of South Asian patients with insulin-treated diabetes mellitus in the United Kingdom: a cohort study
    A J Swerdlow
    Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK
    Diabet Med 21:845-51. 2004
    ..To investigate mortality in South Asian patients with insulin-treated diabetes and compare it with mortality in non South Asian patients and in the general population...
  71. ncbi request reprint Possible association between CTLA4 DNA polymorphisms and early onset type 1 diabetes in a UK population
    R M McCormack
    Department of Medical Genetics, The Queen s University of Belfast, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, Northern Ireland
    Genes Immun 2:233-5. 2001
    ..02) and C/T (P = 0.01) polymorphisms employing 297 nuclear families. Our results suggest that the CTLA4 gene may play a minor role in the overall genetic predisposition to type 1 diabetes in this UK population...
  72. ncbi request reprint Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene
    L M Maier
    JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Genes Immun 4:469-75. 2003
    ..001 in the combined and P=0.02 in the Finnish data set). We, therefore, cannot rule out a genetic effect of IL4RA in T1D, but it is not a major one...
  73. doi request reprint A prospective clinical trial of a real-time polymerase chain reaction assay for the diagnosis of candidemia in nonneutropenic, critically ill adults
    R McMullan
    Department of Medical Microbiology, The Royal Hospitals, Belfast, Northern Ireland
    Clin Infect Dis 46:890-6. 2008
    ..A rapid, reliable diagnostic test could have a substantial impact on therapeutic practice in this patient population...
  74. pmc The connexin 37 gene polymorphism and coronary artery disease in Ireland
    P G Horan
    Heart 92:395-6. 2006