Affiliation: Queen's University Belfast
McVeigh P, Cwiklinski K, Garcia Campos A, Mulcahy G, O Neill S, Maule A, et al
. In silico analyses of protein glycosylating genes in the helminth Fasciola hepatica (liver fluke) predict protein-linked glycan simplicity and reveal temporally-dynamic expression profiles. Sci Rep. 2018;8:11700 pubmed publisher
..These data provide a foundation for functional genomic interrogation of these pathways with the view towards novel parasite intervention strategies. ..
McVeigh P, Leech S, Mair G, Marks N, Geary T, Maule A. Analysis of FMRFamide-like peptide (FLP) diversity in phylum Nematoda. Int J Parasitol. 2005;35:1043-60 pubmed
..Moreover, individual FLPs and FLP motifs are highly conserved across the nematodes with little evidence for inter-clade or inter-lifestyle variation, supporting their fundamental role in free-living and parasitic species. ..
McCammick E, McVeigh P, McCusker P, Timson D, Morphew R, Brophy P, et al
. Calmodulin disruption impacts growth and motility in juvenile liver fluke. Parasit Vectors. 2016;9:46 pubmed publisher
McVeigh P, McCammick E, McCusker P, Wells D, Hodgkinson J, Paterson S, et al
. Profiling G protein-coupled receptors of Fasciola hepatica identifies orphan rhodopsins unique to phylum Platyhelminthes. Int J Parasitol Drugs Drug Resist. 2018;8:87-103 pubmed publisher
..This catalogue of liver fluke GPCRs provides a platform for new avenues into our understanding of flatworm biology and anthelmintic discovery. ..
Zamanian M, Kimber M, McVeigh P, Carlson S, Maule A, Day T. The repertoire of G protein-coupled receptors in the human parasite Schistosoma mansoni and the model organism Schmidtea mediterranea. BMC Genomics. 2011;12:596 pubmed publisher
..The recent availability of genomic data for the human blood fluke Schistosoma mansoni and the model planarian Schmidtea mediterranea paves the way for the first comprehensive effort to identify and analyze GPCRs in this important phylum...
McVeigh P, Mair G, Atkinson L, Ladurner P, Zamanian M, Novozhilova E, et al
. Discovery of multiple neuropeptide families in the phylum Platyhelminthes. Int J Parasitol. 2009;39:1243-52 pubmed publisher
..Our dataset provides a springboard for investigation of the functional biology and therapeutic potential of neuropeptides in flatworms, simultaneously launching flatworm neurobiology into the post-genomic era. ..
McVeigh P, Mair G, Novozhilova E, Day A, Zamanian M, Marks N, et al
. Schistosome I/Lamides--a new family of bioactive helminth neuropeptides. Int J Parasitol. 2011;41:905-13 pubmed publisher
..NPP-1-like peptides are a new family of helminth peptides with a cell-specific expression pattern distinct from FLPs and a modulatory effect on schistosome muscular activity. ..