Bernadette McGuinness

Summary

Affiliation: Queen's University Belfast
Country: UK

Publications

  1. ncbi Systematic review: Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia
    B McGuinness
    Department of Geriatric Medicine, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 5HP, UK
    J Neurol Neurosurg Psychiatry 79:4-5. 2008
  2. doi Apolipoprotein epsilon4 and neuropsychological performance in Alzheimer's disease and vascular dementia
    Bernadette McGuinness
    Geriatric Medicine, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Whitla Medical Building, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom
    Neurosci Lett 483:62-6. 2010
  3. doi Can statins prevent or help treat Alzheimer's disease?
    Bernadette McGuinness
    Centre for Public Health, Queen s University Belfast, Belfast, UK
    J Alzheimers Dis 20:925-33. 2010
  4. doi Attention deficits in Alzheimer's disease and vascular dementia
    Bernadette McGuinness
    Department of Geriatric Medicine, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Neurol Neurosurg Psychiatry 81:157-9. 2010
  5. doi Executive functioning in Alzheimer's disease and vascular dementia
    B McGuinness
    Geriatric Medicine, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Whitla Medical Building, Queen s University Belfast, Belfast, UK
    Int J Geriatr Psychiatry 25:562-8. 2010
  6. pmc How useful is dual energy lateral vertebral assessment in a clinic setting?
    Bernadette McGuinness
    Department of Geriatric Medicine, Queen s University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, UK
    Ulster Med J 78:34-6. 2009
  7. doi Variation in RTN3 and PPIL2 genes does not influence platelet membrane beta-secretase activity or susceptibility to alzheimer's disease in the northern Irish population
    Robyn Carson
    Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK
    Neuromolecular Med 11:337-44. 2009
  8. pmc Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
    Paul Hollingworth
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 43:429-35. 2011
  9. doi The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease
    Amy Gerrish
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
    J Alzheimers Dis 28:377-87. 2012
  10. pmc Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease
    Lesley Jones
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom
    PLoS ONE 5:e13950. 2010

Detail Information

Publications18

  1. ncbi Systematic review: Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia
    B McGuinness
    Department of Geriatric Medicine, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 5HP, UK
    J Neurol Neurosurg Psychiatry 79:4-5. 2008
  2. doi Apolipoprotein epsilon4 and neuropsychological performance in Alzheimer's disease and vascular dementia
    Bernadette McGuinness
    Geriatric Medicine, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Whitla Medical Building, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom
    Neurosci Lett 483:62-6. 2010
    ..In AD and VaD groups epsilon4 present patients showed impairment in selective attention. These findings provide further support of the negative impact of the epsilon4 allele in cognition...
  3. doi Can statins prevent or help treat Alzheimer's disease?
    Bernadette McGuinness
    Centre for Public Health, Queen s University Belfast, Belfast, UK
    J Alzheimers Dis 20:925-33. 2010
    ..We need to await full results from the RCTs before we can be certain. In addition statins were not detrimental to cognition in either systematic review...
  4. doi Attention deficits in Alzheimer's disease and vascular dementia
    Bernadette McGuinness
    Department of Geriatric Medicine, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Neurol Neurosurg Psychiatry 81:157-9. 2010
    ..To compare the performance of patients with mild-moderate Alzheimer's disease (AD) and vascular dementia (VaD) on tests of information processing and attention...
  5. doi Executive functioning in Alzheimer's disease and vascular dementia
    B McGuinness
    Geriatric Medicine, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Whitla Medical Building, Queen s University Belfast, Belfast, UK
    Int J Geriatr Psychiatry 25:562-8. 2010
    ..To compare performance of patients with mild-moderate Alzheimer's disease (AD) and vascular dementia (VaD) on tests of executive functioning and working memory...
  6. pmc How useful is dual energy lateral vertebral assessment in a clinic setting?
    Bernadette McGuinness
    Department of Geriatric Medicine, Queen s University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, UK
    Ulster Med J 78:34-6. 2009
    ..We evaluated use of dual energy X-ray technology in patients with osteoporosis. We found this technology useful in the clinic setting and it has advantages in that less radiation is delivered to the patient...
  7. doi Variation in RTN3 and PPIL2 genes does not influence platelet membrane beta-secretase activity or susceptibility to alzheimer's disease in the northern Irish population
    Robyn Carson
    Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK
    Neuromolecular Med 11:337-44. 2009
    ..We conclude that common or potentially functional genetic variation in these BACE1 interacting proteins does not affect platelet membrane beta-secretase activity or contribute to risk of AD in this population...
  8. pmc Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
    Paul Hollingworth
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 43:429-35. 2011
    ..0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10))...
  9. doi The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease
    Amy Gerrish
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
    J Alzheimers Dis 28:377-87. 2012
    ..However, the gene-wide effect observed at MAPT indicates a possible contribution to disease risk which requires further study...
  10. pmc Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease
    Lesley Jones
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom
    PLoS ONE 5:e13950. 2010
    ..We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes...
  11. doi A novel reciprocal and biphasic relationship between membrane cholesterol and beta-secretase activity in SH-SY5Y cells and in human platelets
    Wei Wei Liu
    School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, 97 Lisburn Road, Belfast, Northern Ireland, UK
    J Neurochem 108:341-9. 2009
    ....
  12. doi Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease
    Robyn Carson
    Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK
    Neuromolecular Med 10:377-84. 2008
    ..A significant association between delusions and the T allele of rs6494223 (P = 0.014, OR = 1.63, CI = 1.22-2.17) was found. This suggests that the alpha 7 receptor may be a suitable target for the treatment of AD with psychosis...
  13. doi The development of effective biomarkers for Alzheimer's disease: a review
    Mark S Henry
    Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Belfast, UK
    Int J Geriatr Psychiatry 28:331-40. 2013
    ..This overview aims to summarise the utility of key neuroimaging and cerebrospinal fluid (CSF) biomarkers for AD, before focusing on the latest efforts to identify informative blood biomarkers...
  14. doi Encouraging lifestyle behaviour change in mild cognitive impairment patients: development of appropriate educational material
    Charlotte E Neville
    Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Institute of Clinical Science B, Queen s University Belfast, Belfast, United Kingdom
    Aging Ment Health 17:276-86. 2013
    ..The qualitative data were used to design, develop and pilot test educational material (EM) to help encourage lifestyle behaviour change...
  15. ncbi Plasma clusterin levels and the rs11136000 genotype in individuals with mild cognitive impairment and Alzheimer's disease
    Gemma M Mullan
    Centre for Public Health, Queen s University Belfast, Institute of Pathology, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland
    Curr Alzheimer Res 10:973-8. 2013
    ..The aim of this study was to investigate the relationship between plasma clusterin and the rs11136000 genotype in mild cognitive impairment (MCI) and AD...
  16. doi Reduced estimated glomerular filtration rate in Alzheimer's disease
    Enda Kerr
    Queen s University of Belfast, School of Medicine, Belfast BT9 7BL, UK
    Int J Geriatr Psychiatry 24:927-32. 2009
    ..We sought to examine estimates of glomerular filtration rate in AD and control groups...
  17. doi Inflammation and anti-inflammatory strategies for Alzheimer's disease--a mini-review
    Benjamin Brian Alexander McNaull
    Department of Geriatric Medicine, Queen s University Belfast, Belfast, UK
    Gerontology 56:3-14. 2010
    ..Based on this knowledge, new therapies aimed at limiting onset of neuroinflammation could arrest or even reverse the development of the disease...
  18. pmc Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    Denise Harold
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 41:1088-93. 2009
    ..5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86)...