A McDowell

Summary

Affiliation: Queen's University Belfast
Country: UK

Publications

  1. pmc The opportunistic pathogen Propionibacterium acnes: insights into typing, human disease, clonal diversification and CAMP factor evolution
    Andrew McDowell
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, Belfast, United Kingdom
    PLoS ONE 8:e70897. 2013
  2. pmc An expanded multilocus sequence typing scheme for propionibacterium acnes: investigation of 'pathogenic', 'commensal' and antibiotic resistant strains
    Andrew McDowell
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, Belfast, United Kingdom
    PLoS ONE 7:e41480. 2012
  3. doi request reprint A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens
    Andrew McDowell
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, 97 Lisburn Road, Belfast BT9 7BL, UK
    Microbiology 157:1990-2003. 2011
  4. ncbi request reprint Epidemiology of Burkholderia cepacia complex species recovered from cystic fibrosis patients: issues related to patient segregation
    Andrew McDowell
    Department of Bacteriology, Northern Ireland Public Health Laboratory, Belfast, UK
    J Med Microbiol 53:663-8. 2004
  5. ncbi request reprint Autoantibodies to malondialdehyde-modified low-density lipoprotein in patients with angiographically confirmed coronary artery disease
    A McDowell
    School of Biology and Biochemistry, Queen s University, Belfast, BT9 7BL, Northern Ireland, UK
    J Pharm Pharmacol 54:1651-7. 2002
  6. pmc PCR-based detection and identification of Burkholderia cepacia complex pathogens in sputum from cystic fibrosis patients
    A McDowell
    Molecular Epidemiology Research Unit, Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom BT9 7AB
    J Clin Microbiol 39:4247-55. 2001
  7. ncbi request reprint Measurement of asialylated LDL in the blood of patients with coronary artery disease by antibody-lectin sandwich assay
    A McDowell
    School of Biology, Medical Biology Centre, The Queen s University of Belfast, Northern Ireland, UK
    Ann Clin Biochem 38:499-508. 2001
  8. doi request reprint A new phylogenetic group of Propionibacterium acnes
    Andrew McDowell
    School of Medicine and Dentistry, Queen s University, Belfast BT12 6BN, UK
    J Med Microbiol 57:218-24. 2008
  9. pmc Propionibacterium acnes types I and II represent phylogenetically distinct groups
    Andrew McDowell
    Department of Microbiology and Immunobiology, School of Medicine, Queen s University, Grosvenor Road, Belfast, BT12 6BN, United Kingdom
    J Clin Microbiol 43:326-34. 2005
  10. doi request reprint Association of airway cathepsin B and S with inflammation in cystic fibrosis
    S L Martin
    School of Pharmacy, Queen s University, Belfast, UK
    Pediatr Pulmonol 45:860-8. 2010

Collaborators

Detail Information

Publications17

  1. pmc The opportunistic pathogen Propionibacterium acnes: insights into typing, human disease, clonal diversification and CAMP factor evolution
    Andrew McDowell
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, Belfast, United Kingdom
    PLoS ONE 8:e70897. 2013
    ..These evolutionary insights may prove important for discussions surrounding camp2 as an immunotherapy target for acne, and the effect such treatments may have on commensal lineages...
  2. pmc An expanded multilocus sequence typing scheme for propionibacterium acnes: investigation of 'pathogenic', 'commensal' and antibiotic resistant strains
    Andrew McDowell
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, Belfast, United Kingdom
    PLoS ONE 7:e41480. 2012
    ..Collectively our data lends support to the view that pathogenic versus truly commensal lineages of P. acnes may exist. This is likely to have important therapeutic and diagnostic implications...
  3. doi request reprint A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens
    Andrew McDowell
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, 97 Lisburn Road, Belfast BT9 7BL, UK
    Microbiology 157:1990-2003. 2011
    ..The MLST scheme and database described in this study should provide a valuable platform for future epidemiological and evolutionary studies of P. acnes...
  4. ncbi request reprint Epidemiology of Burkholderia cepacia complex species recovered from cystic fibrosis patients: issues related to patient segregation
    Andrew McDowell
    Department of Bacteriology, Northern Ireland Public Health Laboratory, Belfast, UK
    J Med Microbiol 53:663-8. 2004
    ..It is therefore suggested that CF centres cohort patients based on the presence or absence of B. cepacia complex infection and not on the basis of transmissibility marker-positive B. cenocepacia as previously suggested...
  5. ncbi request reprint Autoantibodies to malondialdehyde-modified low-density lipoprotein in patients with angiographically confirmed coronary artery disease
    A McDowell
    School of Biology and Biochemistry, Queen s University, Belfast, BT9 7BL, Northern Ireland, UK
    J Pharm Pharmacol 54:1651-7. 2002
    ..In conclusion, this study could not establish any significant association between circulating autoantibody titres to MDA-LDL and coronary atherosclerosis. Therefore, the diagnostic value of autoantibodies to oxidised LDL remains unclear...
  6. pmc PCR-based detection and identification of Burkholderia cepacia complex pathogens in sputum from cystic fibrosis patients
    A McDowell
    Molecular Epidemiology Research Unit, Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom BT9 7AB
    J Clin Microbiol 39:4247-55. 2001
    ..cepacia complex genomovars directly from sputum. Where the sensitivity of the assay proves a limitation, sputum samples can be analyzed by selective culturing followed by recA-based analysis of the isolate...
  7. ncbi request reprint Measurement of asialylated LDL in the blood of patients with coronary artery disease by antibody-lectin sandwich assay
    A McDowell
    School of Biology, Medical Biology Centre, The Queen s University of Belfast, Northern Ireland, UK
    Ann Clin Biochem 38:499-508. 2001
    ..82). When expressed as a percentage of serum apo B-100, median (IQR) values were 18% (16-23%) and 19% (15-29%), respectively (P = 0.78). These results suggest asialo-LDL has little value as a risk factor for coronary atherosclerosis...
  8. doi request reprint A new phylogenetic group of Propionibacterium acnes
    Andrew McDowell
    School of Medicine and Dentistry, Queen s University, Belfast BT12 6BN, UK
    J Med Microbiol 57:218-24. 2008
    ..acnes types I and II. We now propose this new grouping as P. acnes type III. The prevalence and clinical importance of this novel recA lineage amongst isolates of P. acnes remains to be determined...
  9. pmc Propionibacterium acnes types I and II represent phylogenetically distinct groups
    Andrew McDowell
    Department of Microbiology and Immunobiology, School of Medicine, Queen s University, Grosvenor Road, Belfast, BT12 6BN, United Kingdom
    J Clin Microbiol 43:326-34. 2005
    ..acnes types I and II reflect deeper differences in their phylogeny. Furthermore, nucleotide sequencing provides an accurate method for identifying the type status of P. acnes isolates...
  10. doi request reprint Association of airway cathepsin B and S with inflammation in cystic fibrosis
    S L Martin
    School of Pharmacy, Queen s University, Belfast, UK
    Pediatr Pulmonol 45:860-8. 2010
    ..This data indicates that cathepsin B and S may have important roles in the pathophysiology of CF lung disease and could have potential as markers of inflammation in future studies...
  11. ncbi request reprint Clinical outcome of Burkholderia cepacia complex infection in cystic fibrosis adults
    J M Courtney
    Adult Cystic Fibrosis Centre, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, North Ireland, UK
    J Cyst Fibros 3:93-8. 2004
    ..The Burkholderia cepacia complex (BCC) is one of the most important groups of organisms infecting cystic fibrosis (CF) patients. The aim of the study was to examine how infection with BCC affects clinical outcome...
  12. ncbi request reprint Inhibition of Escherichia coli glucosamine synthetase by novel electrophilic analogues of glutamine--comparison with 6-diazo-5-oxo-norleucine
    B Walker
    Division of Biomedicinal Chemistry, School of Pharmacy, The Queen s University of Belfast, Medical Biology Centre, Northern Ireland, UK
    Bioorg Med Chem Lett 10:2795-8. 2000
    ..The gamma-dimethylsulphonium salt analogue of glutamine was found to be one of the most potent inactivators of this enzyme yet reported, with an apparent second order rate constant (k2/Ki) of 3.5 x 10(5) M(-1) min(-1)...
  13. doi request reprint Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis
    Michael M Tunney
    School of Pharmacy, Medical Biology Centre, Queen s University Belfast, Belfast, United Kingdom
    Am J Respir Crit Care Med 177:995-1001. 2008
    ..Pulmonary infection in cystic fibrosis (CF) is polymicrobial and it is possible that anaerobic bacteria, not detected by routine aerobic culture methods, reside within infected anaerobic airway mucus...
  14. ncbi request reprint CAMP factor homologues in Propionibacterium acnes: a new protein family differentially expressed by types I and II
    Susanna Valanne
    Department of Microbiology and Immunobiology, School of Medicine, Queen s University, Grosvenor Road, Belfast BT12 6BN, UK
    Microbiology 151:1369-79. 2005
    ..acnes used in much of the published literature is a type IA isolate and is, therefore, lacking in this attribute...
  15. ncbi request reprint Biofilm formation by bacteria isolated from retrieved failed prosthetic hip implants in an in vitro model of hip arthroplasty antibiotic prophylaxis
    M M Tunney
    Clinical and Practice Research Group, School of Pharmacy, Queen s University Belfast, Belfast BT9 7BL, United Kingdom
    J Orthop Res 25:2-10. 2007
    ....
  16. ncbi request reprint A study of the anti-invasive properties of N-alpha-phthalimidomethyl-ketomethylene tripeptide-based metalloprotease inhibitors
    S L Martin
    Division of Biomedicinal Chemistry, School of Pharmacy, The Queen s University of Belfast, Medical Biology Centre, Northern Ireland, UK
    J Pharm Pharmacol 53:333-43. 2001
    ....
  17. ncbi request reprint Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes
    Istvan Nagy
    Department of Dermatology and Allergology, University of Szeged, Koranyi fasor 6, 6720 Szeged, Hungary
    Microbes Infect 8:2195-205. 2006
    ..acnes vary in their capacity to stimulate an inflammatory response within the pilosebaceous follicle...