R Karl Malcolm

Summary

Affiliation: Queen's University Belfast
Country: UK

Publications

  1. ncbi request reprint A dynamic mechanical method for determining the silicone elastomer solubility of drugs and pharmaceutical excipients in silicone intravaginal drug delivery rings
    R Karl Malcolm
    School of Pharmacy, The Queen s University of Belfast, Medical Biology Centre, Northern Ireland, UK
    Biomaterials 23:3589-94. 2002
  2. pmc Vaginal rings for delivery of HIV microbicides
    R Karl Malcolm
    School of Pharmacy, Queen s University Belfast, Belfast, UK
    Int J Womens Health 4:595-605. 2012
  3. pmc Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques
    R Karl Malcolm
    School of Pharmacy, Queen s University Belfast, Belfast BT9 7BL, UK
    J Antimicrob Chemother 68:678-83. 2013
  4. pmc Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques
    R Karl Malcolm
    School of Pharmacy, Queen s University Belfast, Belfast, United Kingdom
    Antimicrob Agents Chemother 56:2251-8. 2012
  5. doi request reprint Advances in microbicide vaginal rings
    R Karl Malcolm
    School of Pharmacy, Medical Biology Centre, Queen s University Belfast, Belfast, UK
    Antiviral Res 88:S30-9. 2010
  6. ncbi request reprint Vaginal microbicides for the prevention of HIV transmission
    Karl Malcolm
    School of Pharmacy, The Queen s University of Belfast, Belfast, BT9 7BL, Northern Ireland, UK
    Biotechnol Genet Eng Rev 21:81-121. 2004
  7. ncbi request reprint Long-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings
    R Karl Malcolm
    School of Pharmacy, Medical Biology Centre, Queen s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    J Antimicrob Chemother 56:954-6. 2005
  8. ncbi request reprint In vitro release of nonoxynol-9 from silicone matrix intravaginal rings
    Karl Malcolm
    School of Pharmacy, Medical Biology Centre, The Queen s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    J Control Release 91:355-64. 2003
  9. ncbi request reprint Influence of silicone elastomer solubility and diffusivity on the in vitro release of drugs from intravaginal rings
    Karl Malcolm
    School of Pharmacy, Queen s University of Belfast, 97 Lisburn Road, Belfast, Northern Ireland, BT9 7BL, UK
    J Control Release 90:217-25. 2003
  10. pmc Partial protection against multiple RT-SHIV162P3 vaginal challenge of rhesus macaques by a silicone elastomer vaginal ring releasing the NNRTI MC1220
    Susan M Fetherston
    School of Pharmacy, Queen s University Belfast, Belfast BT9 7BL, UK
    J Antimicrob Chemother 68:394-403. 2013

Collaborators

Detail Information

Publications29

  1. ncbi request reprint A dynamic mechanical method for determining the silicone elastomer solubility of drugs and pharmaceutical excipients in silicone intravaginal drug delivery rings
    R Karl Malcolm
    School of Pharmacy, The Queen s University of Belfast, Medical Biology Centre, Northern Ireland, UK
    Biomaterials 23:3589-94. 2002
    ..The study also demonstrates the effect of drug/excipient concentrations on the mechanical stiffness of the silicone devices it 37 degrees C...
  2. pmc Vaginal rings for delivery of HIV microbicides
    R Karl Malcolm
    School of Pharmacy, Queen s University Belfast, Belfast, UK
    Int J Womens Health 4:595-605. 2012
    ..The remainder of the article highlights the key developments in HIV microbicide-releasing vaginal rings, with a particular focus on the dapivirine ring that is presently in late-stage clinical testing...
  3. pmc Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques
    R Karl Malcolm
    School of Pharmacy, Queen s University Belfast, Belfast BT9 7BL, UK
    J Antimicrob Chemother 68:678-83. 2013
    ....
  4. pmc Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques
    R Karl Malcolm
    School of Pharmacy, Queen s University Belfast, Belfast, United Kingdom
    Antimicrob Agents Chemother 56:2251-8. 2012
    ..These observations have implications for designing macaque challenge experiments and also for ring performance during the human female menstrual cycle...
  5. doi request reprint Advances in microbicide vaginal rings
    R Karl Malcolm
    School of Pharmacy, Medical Biology Centre, Queen s University Belfast, Belfast, UK
    Antiviral Res 88:S30-9. 2010
    ..This article forms part of a special supplement on presentations covering intravaginal rings, based on the symposium "Trends in Microbicide Formulations", held on 25 and 26 January 2010, Arlington, VA...
  6. ncbi request reprint Vaginal microbicides for the prevention of HIV transmission
    Karl Malcolm
    School of Pharmacy, The Queen s University of Belfast, Belfast, BT9 7BL, Northern Ireland, UK
    Biotechnol Genet Eng Rev 21:81-121. 2004
  7. ncbi request reprint Long-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings
    R Karl Malcolm
    School of Pharmacy, Medical Biology Centre, Queen s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    J Antimicrob Chemother 56:954-6. 2005
    ....
  8. ncbi request reprint In vitro release of nonoxynol-9 from silicone matrix intravaginal rings
    Karl Malcolm
    School of Pharmacy, Medical Biology Centre, The Queen s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    J Control Release 91:355-64. 2003
    ..It has been demonstrated through release studies and surface microscopy that a drug depletion zone is not established in such liquid-loaded intravaginal ring systems, with implications for the release kinetics...
  9. ncbi request reprint Influence of silicone elastomer solubility and diffusivity on the in vitro release of drugs from intravaginal rings
    Karl Malcolm
    School of Pharmacy, Queen s University of Belfast, 97 Lisburn Road, Belfast, Northern Ireland, BT9 7BL, UK
    J Control Release 90:217-25. 2003
    ....
  10. pmc Partial protection against multiple RT-SHIV162P3 vaginal challenge of rhesus macaques by a silicone elastomer vaginal ring releasing the NNRTI MC1220
    Susan M Fetherston
    School of Pharmacy, Queen s University Belfast, Belfast BT9 7BL, UK
    J Antimicrob Chemother 68:394-403. 2013
    ..Here, we describe the pre-clinical development of an MC1220-releasing silicone elastomer vaginal ring (SEVR), including pharmacokinetic (PK) and efficacy studies in macaques...
  11. pmc Non-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc
    Claire J Forbes
    School of Pharmacy, Queen s University Belfast, Belfast BT9 7BL, UK
    J Control Release 156:161-9. 2011
    ..The results demonstrate that non-aqueous silicone gels have potential as a formulation platform for coitally independent vaginal HIV microbicides...
  12. doi request reprint Characterisation of protein stability in rod-insert vaginal rings
    Aditya Pattani
    Queen s University of Belfast, School of Pharmacy, Belfast BT9 7BL, UK
    Int J Pharm 430:89-97. 2012
    ..Establishing the mechanism of degradation, and finding that degradation is decelerated in the presence of trehalose, will help inform further development of RiRs specifically and polymer based freeze-dried systems in general...
  13. doi request reprint Development of liposome gel based formulations for intravaginal delivery of the recombinant HIV-1 envelope protein CN54gp140
    Prem N Gupta
    School of Pharmacy, The Queen s University of Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, United Kingdom
    Eur J Pharm Sci 46:315-22. 2012
    ..The freeze-dried liposome-HEC formulations represent a novel formulation strategy that could offer potential as stable and practical dosage form...
  14. pmc Microneedle mediated intradermal delivery of adjuvanted recombinant HIV-1 CN54gp140 effectively primes mucosal boost inoculations
    Aditya Pattani
    School of Pharmacy, Queen s University Belfast, Belfast BT9 7BL, UK
    J Control Release 162:529-37. 2012
    ..This work opens up the possibility for microneedle-based HIV vaccination strategies that, once fully developed, will greatly reduce risk for vaccinators and patients, with those in the developing world set to benefit most...
  15. pmc Intravaginal immunization using the recombinant HIV-1 clade-C trimeric envelope glycoprotein CN54gp140 formulated within lyophilized solid dosage forms
    Louise Donnelly
    The School of Pharmacy, The Queen s University of Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    Vaccine 29:4512-20. 2011
    ..vag administration indicates that LSDFs are viable mucosal vaccine delivery modalities promoting antigen stability and facilitating intimate exposure of CN54gp140 to the mucosal-associated lymphoid tissue of the female genital tract...
  16. ncbi request reprint Intravaginal ring delivery of the reverse transcriptase inhibitor TMC 120 as an HIV microbicide
    A David Woolfson
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Int J Pharm 325:82-9. 2006
    ..TMC 120 release profiles and the mechanical properties of rings could be modified by the physicochemical nature of hydrophobic and hydrophilic excipients incorporated into the IVRs...
  17. doi request reprint Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings
    Christopher Mc Conville
    School of Pharmacy, Medical Biology Centre, Queen s University of Belfast, Belfast, Northern Ireland
    J Biomed Mater Res B Appl Biomater 100:891-5. 2012
    ..This study demonstrates that by blending PLA and PEVA together it is possible to achieve a blend that has flexibility similar to native PEVA but also allows for the release of tenofovir...
  18. doi request reprint Selection of an analytical method for evaluating bovine serum albumin concentrations in pharmaceutical polymeric formulations
    Manish Umrethia
    School of Pharmacy, Medical Biology Centre, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    J Pharm Biomed Anal 51:1175-9. 2010
    ..Low % relative standard deviation values (0.8-1.39%) indicate the precision of the method. Furthermore, the method was used to quantify in vitro BSA release from polymeric freeze-dried formulations...
  19. doi request reprint Molecular investigations into vaginal immunization with HIV gp41 antigenic construct H4A in a quick release solid dosage form
    Aditya Pattani
    School of Pharmacy, The Queen s University of Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, Northern Ireland, United Kingdom
    Vaccine 30:2778-85. 2012
    ..In future mucosal vaccine studies, a more explicit focus on antigen stability in the dosage form and the immune potential of available antigen-responsive cells is recommended...
  20. pmc Vaginal delivery of the recombinant HIV-1 clade-C trimeric gp140 envelope protein CN54gp140 within novel rheologically structured vehicles elicits specific immune responses
    Rhonda M Curran
    The School of Pharmacy, The Queen s University of Belfast, Belfast, BT9 7BL, Northern Ireland, UK
    Vaccine 27:6791-8. 2009
    ..Vaginal administration to rabbits induced specific serum IgG, and IgG and IgA in genital tract secretions. The RSVs are a viable delivery modality for vaginal immunization...
  21. doi request reprint Pharmacokinetics of a CCR5 inhibitor in rhesus macaques following vaginal, rectal and oral application
    R Karl Malcolm
    School of Pharmacy, Queen s University Belfast, Belfast BT9 7BL, UK
    J Antimicrob Chemother 69:1325-9. 2014
    ..This study measured and compared the pharmacokinetics of CMPD167, a small molecule antiretroviral CCR5 inhibitor with potential as an HIV microbicide, following vaginal, rectal and oral administration in rhesus macaques...
  22. doi request reprint A modified SILCS contraceptive diaphragm for long-term controlled release of the HIV microbicide dapivirine
    Ian Major
    School of Pharmacy, Queen s University Belfast, Belfast BT9 7BL, UK
    Contraception 88:58-66. 2013
    ..This study describes an innovative barrier contraceptive device--based on the SILCS diaphragm--that also provides long-term controlled release of the lead candidate anti-HIV microbicide dapivirine...
  23. pmc Sustained release of proteins from a modified vaginal ring device
    Ryan J Morrow
    School of Pharmacy, Queen s University Belfast, Belfast, Northern Ireland, UK
    Eur J Pharm Biopharm 77:3-10. 2011
    ..Furthermore, the InVR was shown to deliver over 1 mg of the monoclonal antibody 2F5 from a single device, offering a potential means of protecting women against the transmission of HIV...
  24. doi request reprint Modified Silicone Elastomer Vaginal Gels for Sustained Release of Antiretroviral HIV Microbicides
    Claire J Forbes
    School of Pharmacy, Queen s University Belfast, Belfast, BT9 7BL, UK
    J Pharm Sci 103:1422-32. 2014
    ..h-SEGs have potential for use in vaginal drug delivery, particularly for ARV-based HIV-1 microbicides. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:1422-1432, 2014. ..
  25. doi request reprint Freeze-dried, mucoadhesive system for vaginal delivery of the HIV microbicide, dapivirine: optimisation by an artificial neural network
    A David Woolfson
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    Int J Pharm 388:136-43. 2010
    ....
  26. pmc Characterization of the rheological, mucoadhesive, and drug release properties of highly structured gel platforms for intravaginal drug delivery
    Gavin P Andrews
    Drug Delivery and Biomaterials Group, The School of Pharmacy, The Queen s University of Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, United Kingdom
    Biomacromolecules 10:2427-35. 2009
    ..It is considered that these semisolid drug delivery systems may be useful as site-retentive platforms for the sustained delivery of therapeutic agents to the vagina...
  27. ncbi request reprint Controlled-release vaginal ring drug-delivery systems: a key strategy for the development of effective HIV microbicides
    Susan M Fetherston
    School of Pharmacy, 97 Lisburn Road, Queen s University Belfast, Belfast, BT9 7BL, Northern Ireland, UK
    Ther Deliv 1:785-802. 2010
    ..This review examines the potential for using polymeric vaginal ring systems to provide controlled delivery of HIV microbicides in order to prevent heterosexual transmission of the virus...
  28. ncbi request reprint Characterization of silicone elastomer vaginal rings containing HIV microbicide TMC120 by Raman spectroscopy
    Steven E J Bell
    Innovative Molecular Materials Group, School of Chemistry and Chemical Engineering, Queen s University, Belfast BT9 5AG, UK
    J Pharm Pharmacol 59:203-7. 2007
    ..The extent of permeation was found to be similar in rings manufactured at 25 and 80 degrees C...
  29. ncbi request reprint High speed DSC (hyper-DSC) as a tool to measure the solubility of a drug within a solid or semi-solid matrix
    Daniela Gramaglia
    Department of Pharmaceutical Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy
    Int J Pharm 301:1-5. 2005
    ..At a heating rate of 400 degrees C/min (HDSC), metronidazole solubility was calculated to be 2.16 mg/g compared with 6.16 mg/g at 20 degrees C/min...