Gang Li

Summary

Affiliation: Queen's University Belfast
Country: UK

Publications

  1. ncbi request reprint Rapid new bone tissue remodeling during distraction osteogenesis is associated with apoptosis
    Gang Li
    Trauma Research Group, Department of Trauma and Orthopaedic Surgery, Queen s University Belfast, Musgrave Park Hospital, Stockman s Lane, Belfast BT9 7JB, UK
    J Orthop Res 21:28-35. 2003
  2. ncbi request reprint rhBMP-2, rhVEGF(165), rhPTN and thrombin-related peptide, TP508 induce chemotaxis of human osteoblasts and microvascular endothelial cells
    Gang Li
    The Department of Orthopaedic Surgery, School of Medicine, Queen s University Belfast, Musgrave Park Hospital, UK
    J Orthop Res 23:680-5. 2005
  3. ncbi request reprint Effects of pleiotrophin (PTN) over-expression on mouse long bone development, fracture healing and bone repair
    G Li
    Department of Trauma and Orthopaedic Surgery, Queen s University Belfast, Musgrave Park Hospital, Belfast, Northern Ireland, UK
    Calcif Tissue Int 76:299-306. 2005
  4. ncbi request reprint A reliable externally fixated murine femoral fracture model that accounts for variation in movement between animals
    Chris K Connolly
    Trauma Research Group, Department of Trauma and Orthopaedic Surgery, Queen s University Belfast, Musgrave Park Hospital, Belfast, BT9 7JB, Northern Ireland, UK
    J Orthop Res 21:843-9. 2003
  5. ncbi request reprint Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesis
    Gang Li
    The Department of Trauma and Orthopaedic Surgery, Queen s University of Belfast, Musgrave Park Hospital, UK
    J Orthop Res 20:779-88. 2002
  6. ncbi request reprint Effect of lengthening rate on angiogenesis during distraction osteogenesis
    G Li
    Nuffield Department of Orthopaedic Surgery, University of Oxford, Headington, England
    J Orthop Res 17:362-7. 1999
  7. pmc Thrombin related peptide TP508 promoted fracture repair in a mouse high energy fracture model
    Brain M Hanratty
    Department of Orthopaedic Surgery, School of Biomedical Sciences, Queen s University Belfast, 97 Lisburn Road, Belfast, BT9 7B, UK
    J Orthop Surg Res 4:1. 2009
  8. ncbi request reprint Chondrogenic differentiation alters the immunosuppressive property of bone marrow-derived mesenchymal stem cells, and the effect is partially due to the upregulated expression of B7 molecules
    Xi Chen
    Department of Orthopaedic Surgery, Center for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, United Kingdom
    Stem Cells 25:364-70. 2007
  9. ncbi request reprint Bone formation is enhanced by thrombin-related peptide TP508 during distraction osteogenesis
    Gang Li
    Department of Trauma and Orthopaedic Surgery, Queen s University Belfast, Musgrave Park Hospital, Belfast BT9 7JB, UK
    J Orthop Res 23:196-202. 2005
  10. ncbi request reprint Osteoclastogenesis in the nonadherent cell population of human bone marrow is inhibited by rhBMP-2 alone or together with rhVEGF
    Chao Wan
    Department of Trauma and Orthopaedic Surgery, Centre for Cancer Research and Cell Biology, School of Medicine, Queen s University Belfast, Musgrave Park Hospital, Belfast, BT9 7JB, UK
    J Orthop Res 24:29-36. 2006

Collaborators

Detail Information

Publications73

  1. ncbi request reprint Rapid new bone tissue remodeling during distraction osteogenesis is associated with apoptosis
    Gang Li
    Trauma Research Group, Department of Trauma and Orthopaedic Surgery, Queen s University Belfast, Musgrave Park Hospital, Stockman s Lane, Belfast BT9 7JB, UK
    J Orthop Res 21:28-35. 2003
    ..The localization of apoptotic cells at the different regions of the regenerate, accompanied by the osteoclast activities, suggest that apoptosis is closely related to bone formation and remodeling during distraction osteogenesis...
  2. ncbi request reprint rhBMP-2, rhVEGF(165), rhPTN and thrombin-related peptide, TP508 induce chemotaxis of human osteoblasts and microvascular endothelial cells
    Gang Li
    The Department of Orthopaedic Surgery, School of Medicine, Queen s University Belfast, Musgrave Park Hospital, UK
    J Orthop Res 23:680-5. 2005
    ....
  3. ncbi request reprint Effects of pleiotrophin (PTN) over-expression on mouse long bone development, fracture healing and bone repair
    G Li
    Department of Trauma and Orthopaedic Surgery, Queen s University Belfast, Musgrave Park Hospital, Belfast, Northern Ireland, UK
    Calcif Tissue Int 76:299-306. 2005
    ..Fracture healing was impaired in the adult PTN mice and this may be due to inhibitory effects of PTN over-expression on BMP-2 mediated bone induction...
  4. ncbi request reprint A reliable externally fixated murine femoral fracture model that accounts for variation in movement between animals
    Chris K Connolly
    Trauma Research Group, Department of Trauma and Orthopaedic Surgery, Queen s University Belfast, Musgrave Park Hospital, Belfast, BT9 7JB, Northern Ireland, UK
    J Orthop Res 21:843-9. 2003
    ..Models such as this, employed to determine the effect of experimental interventions, will yield more information if the natural variation in animal motion is measured and included in the analysis...
  5. ncbi request reprint Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesis
    Gang Li
    The Department of Trauma and Orthopaedic Surgery, Queen s University of Belfast, Musgrave Park Hospital, UK
    J Orthop Res 20:779-88. 2002
    ..In Summary, both injection of rhBMP-2/buffer and implantation of rhBMP-2/ACS enhanced the consolidation stage of distraction osteogenesis in this rabbit model...
  6. ncbi request reprint Effect of lengthening rate on angiogenesis during distraction osteogenesis
    G Li
    Nuffield Department of Orthopaedic Surgery, University of Oxford, Headington, England
    J Orthop Res 17:362-7. 1999
    ..7 mm/day) appeared to impair this response. In this model of distraction osteogenesis, the vascularization process in the central fibrous zone was maximally stimulated at distraction rates of 0.7 and 1.3 mm/day...
  7. pmc Thrombin related peptide TP508 promoted fracture repair in a mouse high energy fracture model
    Brain M Hanratty
    Department of Orthopaedic Surgery, School of Biomedical Sciences, Queen s University Belfast, 97 Lisburn Road, Belfast, BT9 7B, UK
    J Orthop Surg Res 4:1. 2009
    ..abstract:..
  8. ncbi request reprint Chondrogenic differentiation alters the immunosuppressive property of bone marrow-derived mesenchymal stem cells, and the effect is partially due to the upregulated expression of B7 molecules
    Xi Chen
    Department of Orthopaedic Surgery, Center for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, United Kingdom
    Stem Cells 25:364-70. 2007
    ..The upregulated expression of B7 molecules on the chondrogenic-differentiated MSCs may be partially responsible for this event...
  9. ncbi request reprint Bone formation is enhanced by thrombin-related peptide TP508 during distraction osteogenesis
    Gang Li
    Department of Trauma and Orthopaedic Surgery, Queen s University Belfast, Musgrave Park Hospital, Belfast BT9 7JB, UK
    J Orthop Res 23:196-202. 2005
    ..The findings indicate that TP508 may be useful in promoting osteogenesis in situations when augmentative treatment for bone formation and consolidation are needed...
  10. ncbi request reprint Osteoclastogenesis in the nonadherent cell population of human bone marrow is inhibited by rhBMP-2 alone or together with rhVEGF
    Chao Wan
    Department of Trauma and Orthopaedic Surgery, Centre for Cancer Research and Cell Biology, School of Medicine, Queen s University Belfast, Musgrave Park Hospital, Belfast, BT9 7JB, UK
    J Orthop Res 24:29-36. 2006
    ..These findings suggested that an interactive regulation may exist between BMPs and VEGF signaling pathways during osteoclastogenesis; exact mechanisms are yet to be elucidated...
  11. doi request reprint Comparison of multipotent differentiation potentials of murine primary bone marrow stromal cells and mesenchymal stem cell line C3H10T1/2
    Li Zhao
    Centre for Cancer Research and Cell Biology, School of Biomedical Sciences, Queen s University Belfast, 97 Lisburn Road, Belfast BT71BL, UK
    Calcif Tissue Int 84:56-64. 2009
    ..Caution is needed when using C3H10T1/2 cells for adipogenic studies as they appear to have lower adipogenic potential than BM-MSCs...
  12. ncbi request reprint Survival of bone marrow-derived mesenchymal stem cells in a xenotransplantation model
    Yan Wang
    Department of Orthopaedic Surgery, General Hospital of Chinese People s Liberation Army, Beijing 100853, PR China, and Department of Orthopaedic Surgery, School of Biomedical Sciences, Queen s University Belfast, UK
    J Orthop Res 25:926-32. 2007
    ..The data suggested that rat MSCs survived the 11 weeks of xenotransplantation in the MF1 mice, but the increased host immune sensitization led to the impaired in vivo osteogenesis potential of MSCs...
  13. ncbi request reprint Systemic recruitment of osteoblastic cells in fracture healing
    Denise Shirley
    Department of Trauma and Orthopaedic Surgery, Queen s University Belfast, Musgrave Park Hospital, Belfast BT9 7JB, UK
    J Orthop Res 23:1013-21. 2005
    ..This investigation supports the hypothesis that some osteoblasts involved in fracture healing were systemically mobilised and recruited to the fracture from remote bone marrow sites...
  14. ncbi request reprint Nonsteroidal anti-inflammatory drug-induced fracture nonunion: an inhibition of angiogenesis?
    Mark Murnaghan
    SpR in Department of Trauma and Orthopaedic Surgery, Queen s University Belfast, Musgrave Park Hospital, 20 Stockman s Lane, Belfast BT9 7JB, Northern Ireland, United Kingdom
    J Bone Joint Surg Am 88:140-7. 2006
    ..It is proposed that a similar mechanism occurs in the induction of NSAID-induced nonunions. This hypothesis was investigated in a randomized placebo-controlled trial of the NSAID rofecoxib with use of a murine femoral fracture model...
  15. ncbi request reprint Time for treating bone fracture using rhBMP-2: a randomised placebo controlled mouse fracture trial
    Mark Murnaghan
    The Department of Trauma and Orthopaedic Surgery, School of Medicine, Queen s University of Belfast, Musgrave Park Hospital, Northern Ireland, UK
    J Orthop Res 23:625-31. 2005
    ..Data presented herein indicates that there is a time after fracture when rhBMP administration is most effective, and this may be at the time of surgery as well as in the early fracture healing phases...
  16. ncbi request reprint Allogenic peripheral blood derived mesenchymal stem cells (MSCs) enhance bone regeneration in rabbit ulna critical-sized bone defect model
    Chao Wan
    Musculoskeletal Education and Research Unit, Centre for Cancer Research and Cell Biology, School of Biomedical Sciences, Queen s University Belfast, Musgrave Park Hospital, Belfast, BT9 7JB, United Kingdom
    J Orthop Res 24:610-8. 2006
    ....
  17. ncbi request reprint Production of consistent crush lesions in murine quadriceps muscle--a biomechanical, histomorphological and immunohistochemical study
    Jonathan R Bunn
    Trauma Research Group, Department of Trauma and Orthopaedic Surgery, Queen s University Belfast, Musgrave Park Hospital, Stockman s Lane, BT9 7JB, Northern Ireland, UK
    J Orthop Res 22:1336-44. 2004
    ....
  18. ncbi request reprint Bioreactor expansion of human adult bone marrow-derived mesenchymal stem cells
    Xi Chen
    Department of Orthopaedic Surgery, School of Biomedical Sciences, Queen s University Belfast, Musgrave Park Hospital, Belfast, BT9 7JB, United Kingdom
    Stem Cells 24:2052-9. 2006
    ..We conclude that the rotary bioreactor with the modified Myelocult medium reported in this study may be used to rapidly expand MSCs...
  19. doi request reprint Mesenchymal stem cells as a gene therapy carrier for treatment of fibrosarcoma
    Juanjuan Xiang
    Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Belfast, UK
    Cytotherapy 11:516-26. 2009
    ..Emerging evidence suggests that mesenchymal stem cells (MSC) are able to migrate to sites of tissue injury and have immunosuppressive properties that may be useful in targeted gene therapy for sustained specific tissue engraftment...
  20. ncbi request reprint Expression of BMP-4 mRNA during distraction osteogenesis in rabbits
    G Li
    Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, U K
    Acta Orthop Scand 69:420-5. 1998
    ..Our observations suggest that the BMP-4 gene product is one of the local contributing factors in regulating bone and cartilage formation in distraction osteogenesis...
  21. doi request reprint SOX9 directly binds CREB as a novel synergism with the PKA pathway in BMP-2-induced osteochondrogenic differentiation
    Li Zhao
    Department of Orthopaedic Surgery, Center for Cancer Research and Cell Biology, School of Biomedical Sciences, Queen s University Belfast, Belfast, United Kingdom
    J Bone Miner Res 24:826-36. 2009
    ..The action of SOX9 was enhanced by overexpressing CREB. These results suggest that PKA signaling synergizes with SOX9 at the nuclear and cytoplasmic levels to promote BMP-2-induced osteochondrogenic differentiation...
  22. ncbi request reprint Concise review: multipotent mesenchymal stromal cells in blood
    Qiling He
    Centre for Cancer Research and Cell Biology, Musculoskeletal Education and Research Unit, School of Biomedical Sciences, Queen s University of Belfast, Musgrave Park Hospital, Belfast, United Kingdom
    Stem Cells 25:69-77. 2007
    ..In this review, current studies/knowledge about peripheral blood-derived multipotent mesenchymal stromal cells is summarized, and the above-mentioned topics are discussed...
  23. doi request reprint Advanced glycation of fibronectin impairs vascular repair by endothelial progenitor cells: implications for vasodegeneration in diabetic retinopathy
    Ashay D Bhatwadekar
    Centre for Vision Science, Queen s University Belfast, Royal Victoria Hospital, Northern Ireland, UK
    Invest Ophthalmol Vis Sci 49:1232-41. 2008
    ..The hypothesis for the study was that progressive basement membrane (BM) modification by advanced glycation end products (AGEs) contributes to impairment of EPC reparative function after diabetes-related endothelial injury...
  24. ncbi request reprint Mesenchymal stem cells in immunoregulation
    Xi Chen
    Department of Orthopaedic Surgery, Musgrave Park Hospital, Queen s University Belfast, Belfast, UK
    Immunol Cell Biol 84:413-21. 2006
    ....
  25. ncbi request reprint Nonadherent cell population of human marrow culture is a complementary source of mesenchymal stem cells (MSCs)
    Chao Wan
    Department of Trauma and Orthopaedic Surgery, Institute of Medical Research, Queen s University Belfast, Musgrave Park Hospital, Belfast BT9 7JB, United Kingdom
    J Orthop Res 24:21-8. 2006
    ....
  26. ncbi request reprint Assessment of cell proliferation in regenerating bone during distraction osteogenesis at different distraction rates
    G Li
    Nuffield Department of Orthopaedic Surgery, University of Oxford, England
    J Orthop Res 15:765-72. 1997
    ..3 mm/day) of distraction studied. Higher rates of distraction caused tissue damage. A distraction rate of 0.7 mm/day appeared optimal for cell proliferation and histological characteristics...
  27. ncbi request reprint Cell proliferation and apoptosis during fracture healing
    Gang Li
    Department of Trauma and Orthopedic Surgery, Queen s University of Belfast, Musgrave Park Hospital, United Kingdom
    J Bone Miner Res 17:791-9. 2002
    ..This study indicated that cell proliferation and apoptosis are coupled events during fracture repair, cell proliferation is active at the early stages, and apoptosis is active during the phase of callus remodeling...
  28. ncbi request reprint Cells seeded on MBG scaffold survive impaction grafting technique: Potential application of cell-seeded biomaterials for revision arthroplasty
    Moses T Mushipe
    Musculoskeletal Education and Research Unit, School of Medicine and Dentistry, Queen s University Belfast, Musgrave Park Hospital, Belfast, BT9 7JB, United Kingdom
    J Orthop Res 24:501-7. 2006
    ..Compared to allograft bone that is not osteogenic, a cell-seeded biomaterial might also be a suitable substitute for allograft bone for major joint reconstruction at revision arthroplasty...
  29. pmc Effect of thrombin peptide 508 (TP508) on bone healing during distraction osteogenesis in rabbit tibia
    Lisa R Amir
    Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam ACTA, Universiteit van Amsterdam and Vrije Universiteit Amsterdam, Van der Boechorststr 7, 1081BT, Amsterdam, The Netherlands
    Cell Tissue Res 330:35-44. 2007
    ..Clinically, TP508 may shorten the healing time during DO; this might be of benefit when bone regeneration is slow...
  30. ncbi request reprint Local injection of thrombin-related peptide (TP508) in PPF/PLGA microparticles-enhanced bone formation during distraction osteogenesis
    Yan Wang
    Department of Orthopaedic Surgery, General Hospital of Chinese People s Liberation Army, Beijing 100853, People s Republic of China
    J Orthop Res 26:539-46. 2008
    ....
  31. ncbi request reprint [Inhibition of EBV-encoded LMP-1 by DNA-based RNA interference affects metastatic ability of nasopharyngeal carcinoma cells]
    Gang Li
    Department of Otolaryngology Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Zhonghua Zhong Liu Za Zhi 28:724-7. 2006
    ....
  32. ncbi request reprint Enhanced antitumor effect of the combination of tumstatin gene therapy and gemcitabine in murine models
    Bin Yao
    National Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, People s Republic of China
    Hum Gene Ther 16:1075-86. 2005
    ..A combination of these agents could be used in future studies and translated into the clinical setting...
  33. ncbi request reprint The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth
    Ronald P C Wong
    Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Cancer Ther 6:1692-700. 2007
    ..This study highlights the importance of ILK in melanoma progression and provides an attractive target for the treatment of melanoma...
  34. ncbi request reprint Pilus-mediated epithelial cell death in response to infection with Burkholderia cenocepacia
    K John Cheung
    Division of Infectious Diseases, Immunology and Rheumatology, Children s Hospital and Regional Medical Center, 307 Westlake Avenue N, Seattle, WA 98109, USA
    Microbes Infect 9:829-37. 2007
    ..Understanding the role of cbl pili in the pathogenesis of B. cenocepacia infections offers the potential for decreasing the virulence of these potentially life-threatening organisms in CF patients...
  35. ncbi request reprint Does normothermic normokalemic simultaneous antegrade/retrograde perfusion improve myocardial oxygenation and energy metabolism for hypertrophied hearts?
    Jian Wang
    Institute for Biodiagnostics, National Research Council, Winnipeg, Manitoba, Canada
    Ann Thorac Surg 83:1751-8. 2007
    ..The present study was to determine whether NNSP improved myocardial oxygenation and energy metabolism of hypertrophied hearts relative to normothermic normokalemic antegrade perfusion (NNAP)...
  36. ncbi request reprint The tumour suppressor p33ING1 does not regulate migration and angiogenesis in melanoma cells
    K John Cheung
    Division of Dermatology, Department of Medicine, University of British Columbia, and Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia V6H 3Z6, Canada
    Int J Oncol 21:1361-5. 2002
    ..In conclusion, we demonstrate in vitro that p33ING1, unlike p53, does not play a role in angiogenesis and migration in melanoma cells...
  37. ncbi request reprint Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice
    Claus J Gruss
    The Wistar Institute, Philadelphia, PA Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute, Leuven, Belgium
    J Invest Dermatol 120:683-92. 2003
    ..The overall results suggest that adenoviral vectors can effectively remodel the architecture of human skin for studies in morphogenesis, inflammatory skin disorders, wound healing, and cancer development...
  38. ncbi request reprint Establishment of a hypertrophic scar model by transplanting full-thickness human skin grafts onto the backs of nude mice
    Dong Y Yang
    Department of Plastic and Reconstructive Surgery, Southwest Hospital, The Third Military Medical University, Chongqing, China
    Plast Reconstr Surg 119:104-9; discussion 110-1. 2007
    ..This study was designed to investigate whether hypertrophic scars could be reproduced by transplanting full-thickness human skin grafts onto the backs of nude mice...
  39. ncbi request reprint Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats
    Gang Li
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida, USA
    Diabetes 52:1951-7. 2003
    ..The mechanisms may involve the sustained hypophagia and the augmentation of thermogenesis in BAT...
  40. ncbi request reprint Familial partial lipodystrophy phenotype resulting from a single-base mutation in deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma
    Houshang Monajemi
    Academic Medical Center, Department of Vascular Medicine, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Clin Endocrinol Metab 92:1606-12. 2007
    ..The LMNA form is called FPLD2 (MIM 151660) and the PPARG form is called FPLD3 (MIM 604367)...
  41. ncbi request reprint Indomethacin enhances the cytotoxicity of recombinant human lymphotoxin alpha on tumor cells by suppressing NFkappaB signaling
    Yijun Shen
    Department of Genetic Engineering Development, Shanghai Fudan Zhangjiang Bio pharmaceutical Co, Ltd, Shanghai, China
    Cancer Biol Ther 6:1428-33. 2007
    ....
  42. ncbi request reprint DNA cleavage by aromatic amines
    Philip M Warner
    Department of Chemistry, Northeastern University, 360 Huntington Ave, Boston, MA 02115, USA
    Bioorg Med Chem Lett 12:1-4. 2002
    ..Initial investigations suggest this is an unprecedented mode of DNA cleavage, which may be ultimately applied to the development of sequence-specific agents...
  43. pmc Ku86 is essential in human somatic cells
    Gang Li
    Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912, USA gt
    Proc Natl Acad Sci U S A 99:832-7. 2002
    ..These cells were capable of undergoing only a limited number of cell divisions, after which they underwent apoptosis. These experiments demonstrate that the Ku86 locus is essential in human somatic tissue culture cells...
  44. ncbi request reprint The inhibition of lung cancer cell growth by intracellular immunization with LC-1 ScFv
    Liang Chen
    Laboratory of Cellular Immunology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
    Cell Res 12:47-54. 2002
    ....
  45. pmc 1,25-dihydroxyvitamin D(3) regulates LPS-induced cytokine production and reduces mortality in rats
    Xiao ping Qi
    School of Medicine, Nanjing University, Department of General Surgery, Jinling Hospital, Jiangsu Province, Nanjing, China
    World J Gastroenterol 14:3897-902. 2008
    ..To study the immunoregulatory effect of 1,25-dihydroxyvitamin-D(3) Von dominant Th1 response in rats...
  46. doi request reprint Evaluation of the viability and osteogenic differentiation of cryopreserved human adipose-derived stem cells
    Guangpeng Liu
    Shanghai Tissue Engineering Research and Development Center, Shanghai 200235, China
    Cryobiology 57:18-24. 2008
    ..These results demonstrate that cryopreservation has no effect on the phenotype, proliferation or osteogenic differentiation of human ASCs, showing cryopreserved human ASCs might be applied for bone tissue engineering...
  47. doi request reprint Role of ING4 in human melanoma cell migration, invasion and patient survival
    Jun Li
    Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia V6H 3Z6, Canada
    Carcinogenesis 29:1373-9. 2008
    ..Taken together, this study highlights the importance of ING4 in melanoma pathogenesis and ING4 may serve as a promising prognostic marker and a potential therapeutic target for human melanoma...
  48. doi request reprint A chaperone protein-enriched tumor cell lysate vaccine generates protective humoral immunity in a mouse breast cancer model
    Gang Li
    Department of Pediatrics, University of Arizona, Tucson, AZ 85724, USA
    Mol Cancer Ther 7:721-9. 2008
    ..These results suggest that tumor-derived CRCL vaccine has a wider applicability as a cancer vaccine because it can target both T-cell- and B-cell-specific responses and may represent a promising approach for the immunotherapy of cancer...
  49. ncbi request reprint Design, simulation, and optimization of a miniaturized device for size-fractioned DNA extraction
    Gang Li
    Nanotechnology Laboratory, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, PR China
    Electrophoresis 28:4661-7. 2007
    ..The simulations and the experimental results are in good agreement and confirm that with the optimized device design a high-efficiency DNA extraction is achieved...
  50. ncbi request reprint Reciprocal regulation of MelCAM and AKT in human melanoma
    Gang Li
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Oncogene 22:6891-9. 2003
    ..These data link AKT activation with MelCAM expression, and implicate that intervention of MelCAM-AKT signaling axis in melanoma is a potential therapeutical approach...
  51. ncbi request reprint [A pleiotrophin-specific siRNA and its effect on PTEN-/- MEF241 cells]
    Ying Chun Hu
    Beijing Institute of Radiation Medicine, Beijing, 100850, P R China
    Ai Zheng 25:1210-5. 2006
    ..Studies have showed that rRibozyme targeting Ptn suppresses the growth, angiogenesis, and metastasis of melanoma and pancreatic cancer cells. This study was to produce a small interfering RNA (siRNA) to inhibit Ptn expression...
  52. ncbi request reprint Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma
    Zheng Jiang
    Laboratory of Neurosurgery, Qilu Hospital of Shandong University, Jinan, China
    Neurosci Res 56:450-8. 2006
    ..The methylation and mRNA expression of LATS1 and LATS2 may provide useful clues to the development of the diagnostic assays for astrocytoma. Our results also suggested that LATS1 and LATS2 may be a useful target for astrocytoma therapy...
  53. ncbi request reprint Reversal of melanocytic malignancy by keratinocytes is an E-cadherin-mediated process overriding beta-catenin signaling
    Gang Li
    The Wistar Institute, Philadelphia, PA 19104, USA
    Exp Cell Res 297:142-51. 2004
    ..The results indicate that E-cadherin-mediated cell adhesion is required for keratinocyte-mediated control of melanocytic cells, which can override proliferative activity of beta-catenin...
  54. ncbi request reprint Rh2, a compound extracted from ginseng, hypersensitizes multidrug-resistant tumor cells to chemotherapy
    William W G Jia
    Department of Surgery, University of British Columbia, Vancouver, Canada
    Can J Physiol Pharmacol 82:431-7. 2004
    ..These results suggest that Rh2 possesses strong tumor-inhibiting properties, and potentially can be used in treatments for multidrug-resistant cancers, especially when it is used in combination with conventional chemotherapy agents...
  55. ncbi request reprint Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice
    Sheng Ding
    Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, China
    Cell 122:473-83. 2005
    ..These data provide a first and critical step toward a highly efficient transposon system for a variety of genetic manipulations including transgenesis and insertional mutagenesis in mice and other vertebrates...
  56. pmc Effects of alpha fetoprotein on escape of Bel 7402 cells from attack of lymphocytes
    Mengsen Li
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China
    BMC Cancer 5:96. 2005
    ..However, the molecular events of immune escape mechanisms are still unknown. The major observations reported here relate to a possible mechanism by which heptoloma Bel 7402 cells escape immune surveillance in vitro...
  57. ncbi request reprint [Adeno-associated virus-mediated expression of human endostatin and its biological activity in vitro]
    Xiao Hua Li
    Department of Otolaryngology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 25:651-4. 2005
    ..To construct the recombinant adeno-associated viral vector containing human endostatin gene (rAAV-hEndo) and observe the biological activity of the expressed human endostatin in vitro...
  58. ncbi request reprint Improved therapeutic effectiveness by combining recombinant CXC chemokine ligand 10 with Cisplatin in solid tumors
    Gang Li
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, The People s Republic of China
    Clin Cancer Res 11:4217-24. 2005
    ..CXC chemokine ligand 10 (CXCL10) is a potent inhibitor of angiogenesis. We wonder whether the combination of CXCL10 with cisplatin would improve the therapeutic antitumor efficacy...
  59. ncbi request reprint Effects of c-myb antisense RNA on TGF-beta1 and beta1-I collagen expression in cultured hepatic stellate cells
    Hui Hui Ma
    Department of Infectious Diseases, The 3rd Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, Guangdong Province, China
    World J Gastroenterol 10:3662-5. 2004
    ..To investigate the effects of c-myb antisense RNA on cell proliferation and the expression of c-myb, TGF-beta1 and beta1-I collagen in cultured hepatic stellate cells (HSC) from rats...
  60. ncbi request reprint XAF1 expression is significantly reduced in human melanoma
    Kin Cheung P Ng
    Department of Medicine, Division of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada
    J Invest Dermatol 123:1127-34. 2004
    ..Further studies are required to understand the molecular mechanisms governing the selective loss of XAF1 expression in the tumor tissue...
  61. ncbi request reprint Development of a PAN-specific, affinity-purified anti-acetylated lysine antibody for detection, identification, isolation, and intracellular localization of acetylated protein
    Liping Qiang
    Department of Medicine, ImmuneChem Pharmaceuticals Inc, Burnaby, British Columbia, Canada
    J Immunoassay Immunochem 26:13-23. 2005
    ..The isolated antibody was tested to be useful for ELISA, immunoblotting detection, immunofluorescent localization, and affinity isolation of the acetylated proteins...
  62. ncbi request reprint Morphine-promoted survival of CEMx174 cells in early stages of SIV infection in vitro: involvement of the multiple molecular mechanisms
    Ping Feng Li
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Xueyuan Rd 38, Beijing 100083, China
    Toxicol In Vitro 18:449-56. 2004
    ..Therefore, it is implicated that the calcium-PKC-MAPK cascade is involved in morphine-prolonged survival of SIV-infected cells in the early stages of virus infection...
  63. ncbi request reprint Expression and switching of TH1/TH2 type cytokines gene in human gliomas
    Gang Li
    Department of Neurosurgery, Qilu Hospital, Shandong University, Jinan 250012
    Chin Med Sci J 20:268-72. 2005
    ..To study the expression and switching of Th1/Th2 cytokines gene in human gliomas and its effects on occurring and developing of human gliomas...
  64. ncbi request reprint Natural killer cells play a key role in the antitumor immunity generated by chaperone-rich cell lysate vaccination
    Yi Zeng
    Department of Pediatrics, Steele Children s Research Center, University of Arizona, Tucson, AZ 85724 5073, USA
    Int J Cancer 119:2624-31. 2006
    ..Thus, this report provides further insight into the function of CRCL as an immunostimulant against cancer...
  65. ncbi request reprint How fast does the GluR1Qflip channel open?
    Gang Li
    Department of Chemistry and the Center for Neuroscience Research, State University of New York, Albany, New York 12222, USA
    J Biol Chem 279:3990-7. 2004
    ..93 +/- 0.10. These findings identify GluR1Qflip as one of the temporally efficient receptors that transduce the binding of chemical signals (i.e. glutamate) into an electrical impulse...
  66. ncbi request reprint Prognostic significance of nuclear factor-kappaB p105/p50 in human melanoma and its role in cell migration
    Kai Gao
    Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Cancer Res 66:8382-8. 2006
    ..Taken together, our data indicate that NF-kappaB p105/p50 may be an important marker for human melanoma progression and prognosis as well as a potentially selective therapeutic target...
  67. ncbi request reprint Ubiquitous expression of mRFP1 in transgenic mice
    Huaxing Zhu
    Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, Shanghai, P R China
    Genesis 42:86-90. 2005
    ..The intensity of mRFP1 signals can be used to distinguish homozygous and heterozygous transgenic mice. Together, these features make mRFP1 an attractive marker for broad applications in transgenic research...
  68. ncbi request reprint Aberrant expression of collagen triple helix repeat containing 1 in human solid cancers
    Liren Tang
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada
    Clin Cancer Res 12:3716-22. 2006
    ..However, the full significance of CTHRC1 to human carcinogenesis remains unclear. This study is to further characterize the clinical and functional relevance of CTHRC1 in melanoma and other human solid cancers...
  69. ncbi request reprint RalA-exocyst interaction mediates GTP-dependent exocytosis
    Li Wang
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, University Health Network, Department of Physiology, University of Toronto, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    J Biol Chem 279:19875-81. 2004
    ..Furthermore, GTP- and Ca2+-dependent exocytosis use different sensors and effectors for triggering exocytosis whereas their final fusion steps are both SNARE-dependent...
  70. ncbi request reprint Rapid demonstration of diversity of sulfatide molecular species from biological materials by MALDI-TOF MS
    Mamoru Kyogashima
    Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1, Asahi, Matsumoto, Nagano, 390 8621, Japan
    Glycobiology 16:719-28. 2006
    ....
  71. ncbi request reprint Suppression of Epstein-Barr virus-encoded latent membrane protein-1 by RNA interference inhibits the metastatic potential of nasopharyngeal carcinoma cells
    Xiang Ping Li
    Department of Otolaryngology Head and Neck Surgery, Nanfang Hospital, The First Military Medical University, Guangzhou, China
    Biochem Biophys Res Commun 315:212-8. 2004
    ..These results demonstrated the effectiveness of RNAi in suppressing LMP-1, supporting an important role of LMP-1 in NPC metastasis, and suggested a potential application of RNAi-mediated therapeutic strategy for EBV-related NPC...
  72. ncbi request reprint PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin
    Gang Li
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095 1735, USA
    J Biol Chem 281:10663-8. 2006
    ..Our results suggest that PTN participates in tumorigenesis caused by PTEN loss and PTN may be a potential target for anticancer therapy, especially for those tumors with PTEN deficiencies...
  73. ncbi request reprint Osteopontin expression correlates with melanoma invasion
    Youwen Zhou
    Division of Dermatology, Department of Medicine, University British Columbia, Vancouver, Canada
    J Invest Dermatol 124:1044-52. 2005
    ..Our observations suggest that OPN may be acquired early in melanoma development and progression, and may enhance tumor cell growth in invasive melanoma...