Affiliation: Queen's University Belfast
- Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM ProjectMarie Lise Grisoni
INSERM, UMR_S 937, Paris, France
BMC Med Genet 10:44. 2009....
- Critical thinking and critical appraisal: the chicken and the egg?F Kee
Department of Epidemiology and Public Health, Queen s University Belfast, UK
QJM 97:609-14. 2004
- Decision making in a multidisciplinary cancer team: does team discussion result in better quality decisions?Frank Kee
Department of Epidemiology and Public Health, Queen s University Belfast, Belfast Northern Ireland
Med Decis Making 24:602-13. 2004..This study does not support the theory that team discussion improves decision making by closing a knowledge gap...
- Late referral for assessment of renal failureFrank Kee
Department of Epidemiology and Public Health, The Queens University of Belfast, Mulhouse Building, Grosvenor Road, Belfast BT12 6BJ, UK
J Epidemiol Community Health 59:386-8. 2005..There was no difference in referral rates between male and female patients. However, only 6.5% of all non-diabetic subjects and 19% of diabetic patients were referred within 12 months after a first increased serum creatinine test...
- Judgment analysis of prioritization decisions within a dialysis program in one United Kingdom regionFrank Kee
Department of Epidemiology and Public Health, Queen s University of Belfast
Med Decis Making 22:140-51. 2002..Our objective was to study the basis and extent of variation among nephrologists in one NHS region in their views concerning prioritization for dialysis...
- Polymorphisms of the P-selectin gene and risk of myocardial infarction in men and women in the ECTIM extension study. Etude cas-temoin de l'infarctus myocardeF Kee
Department of Epidemiology and Public Health, The Queen s University of Belfast, Mulhouse Building, Royal Victoria Hospital, Grosvenor Rd, Belfast BT12 6BJ, Northern Ireland, UK
Heart 84:548-52. 2000..PATIENTS AND STUDY SETTING: 696 cases with a recent myocardial infarction and 561 age matched controls (both male and female) were recruited into a case-control study in MONICA project areas of Belfast and Glasgow...
- Fast and frugal models of clinical judgment in novice and expert physiciansFrank Kee
Department of Epidemiology and Public Health, Queens University, Mulhouse Building, Grosvenor Road, Belfast BT 12 6 BJ, United Kingdom
Med Decis Making 23:293-300. 2003..In this vignette study, neither model provided any better description of judgments made by consultants or by pediatricians compared to other grades and specialties...
- Offering a prognosis in lung cancer: when is a team of experts an expert team?F Kee
Epidemiology and Public Health, Queens University of Belfast, Mulhouse Building, Grosvenor Road, Belfast BT12 6BJ, UK
J Epidemiol Community Health 61:308-13. 2007..As such predictions are integral to decision making, further research on decision-making processes of clinical teams is required...
- Clinical decision making in nephrology...renal function might not be the most important thing to measureF Kee
Department of Epidemiology and Public Health, The Queen s University of Belfast, Royal Victoria Hospital, UK
J Nephrol 13:415-8. 2000..There is a pressing need to understand and diagnose the decision making problem and the choice of intervention to improve clinical decision making must ultimately depend on clinical context...
- Angiotensin II type-I receptor and ACE polymorphisms and risk of myocardial infarction in men and womenF Kee
Queen s University of Belfast, Belfast, Northern Ireland, UK
Eur J Clin Invest 30:1076-82. 2000..We aimed to study whether the findings in respect of ACE and AT1R in UK men were borne out in women...
- Do polymorphisms of apoB, LPL or apoE affect the hypocholesterolemic response to weight loss?F Kee
Department of Epidemiology and Public Health, The Queen s University of Belfast QUB, Mulhouse Building, Grosvenor Rd, Northern Ireland BT12 6BJ, Belfast, UK
Atherosclerosis 153:119-28. 2000..Although, this study is one of the largest of its kind, it has not replicated the findings of other smaller studies. These findings do not provide support for the use of genotype-targeted dietary advice in routine practice...
- Persistently raised C-reactive protein levels are associated with advanced periodontal diseaseGerard J Linden
Oral Science Research Centre, Queen s University, Belfast, UK
J Clin Periodontol 35:741-7. 2008..The aim was to investigate whether there was an association between periodontitis or tooth loss in a homogeneous group of 60-70-year-old Western European men and either a sustained high or low level of C-reactive protein (CRP)...
- Antioxidants and periodontitis in 60-70-year-old menGerard J Linden
Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, Belfast, Northern Ireland, UK
J Clin Periodontol 36:843-9. 2009..The aim was to investigate the association between periodontal health and the serum levels of various antioxidants including carotenoids, retinol and vitamin E in a homogenous group of Western European men...
- Patterns of hospitalisation before and following initiation of haemodialysis: a 5 year single centre studyMichael P Quinn
Regional Nephrology Unit, Belfast City Hospital, Belfast, UK
Postgrad Med J 87:389-93. 2011..Such patients require admission more frequently than the general hospital population, particularly within 100 days before and after initiation of their first dialysis treatment...
- Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish populationWeihua Meng
Centre for Clinical and Population Sciences, Queen s University Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, Northern Ireland, UK
Dis Markers 25:81-5. 2008..9 x 10(-7)). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD...
- Decision making in asthma exacerbation: a clinical judgement analysisJohn Jenkins
Queen s University Belfast, Paediatric Department, Antrim Hospital, Antrim, Belfast, UK
Arch Dis Child 92:672-7. 2007..Clinical judgement analysis provides a methodology for comparing decisions between practitioners with different training and experience, and improving decision making...
- All-cause mortality and periodontitis in 60-70-year-old men: a prospective cohort studyGerard J Linden
Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Belfast, Northern Ireland, UK
J Clin Periodontol 39:940-6. 2012..To investigate the association between periodontitis and mortality from all causes in a prospective study in a homogenous group of 60- to 70-year-old West European men...
- Genetic markers enhance coronary risk prediction in men: the MORGAM prospective cohortsMaria F Hughes
UKCRC Centre of Excellence for Public Health, Queens University of Belfast, Belfast, Northern Ireland, United Kingdom
PLoS ONE 7:e40922. 2012..We hypothesised that a multilocus genetic risk score could refine CHD prediction beyond classic risk scores and obtain more precise risk estimates using a prospective cohort design...
- Modelling coronary heart disease mortality in Northern Ireland between 1987 and 2007: broader lessons for preventionJohn Hughes
Queen s University, Belfast, UK
Eur J Prev Cardiol 20:310-21. 2013..To quantify how much of the coronary heart disease (CHD) mortality decline in Northern Ireland between 1987 and 2007 could be attributed to medical and surgical treatments and how much to changes in population cardiovascular risk factors...
- Prescribing for weight loss in primary care: evidence from a population based studyLynsey Patterson
UKCRC Centre of Excellence for Public Health, Queen s University Belfast, Institute of Clinical Sciences B, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland, UK
J Epidemiol Community Health 67:530-2. 2013..Uptake is determined in part by a General Practitioner's decision to prescribe weight loss medication and, in part, by patient preference. It is probable that the latter may indicate a patient's readiness to lose weight...
- A multiple biomarker risk score for guiding clinical decisions using a decision curve approachMaria F Hughes
UKCRC Centre of Excellence for Public Health, School of Medicine Dentistry and Biomedical Sciences, Institute of Clinical Sciences B, Queens University Belfast, Grosvenor Road, Belfast, BT12 6BJ, UK
Eur J Prev Cardiol 19:874-84. 2012....
- The impact of admissions for the management of end-stage renal disease on hospital bed occupancyMichael P Quinn
Regional Nephrology Unit, Belfast City Hospital, Belfast, UK
Nephron Clin Pract 113:c315-20. 2009..The impact of admissions primarily for the management of ESRD on hospital bed utilisation was assessed over a 5-year period in a large teaching hospital...
- Are gatekeepers to renal services referring patients equitably?Frank Kee
Department of Epidemiology and Public Health, Queen s University of Belfast, Belfast, UK
J Health Serv Res Policy 12:36-41. 2007..This study used a population-based laboratory database to investigate access to and timeliness of referral to renal specialists relatively early in the course of the disease...
- The finding of reduced estimated glomerular filtration rate is associated with increased mortality in a large UK populationMichael P Quinn
Nephrology Research Group, Centre for Public Health, Queen s University and Regional Nephrology Unit, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, UK
Nephrol Dial Transplant 26:875-80. 2011..This retrospective cohort study investigates the association between reduced kidney function and mortality in a large UK population...
- Genetic variants of complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish populationWeihua Meng
Centre for Clinical and Population Sciences, Queen s University Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland, UK
BMC Med Genet 8:62. 2007..This study was designed to investigate if, using a family-based approach, there was an association between genetic variants of the CFH gene and risk of early-onset coronary heart disease...
- The epidemiology of motor neuron disease in Northern Ireland using capture-recapture methodologyColette Donaghy
Department of Neurology, Royal Victoria Hospital, Belfast, Northern Ireland
Amyotroph Lateral Scler 11:374-8. 2010..The authors feel that future investigators should consider employing capture-recapture methods, where possible, to validate their estimations of disease frequency in MND...
- The practical implications of using standardized estimation equations in calculating the prevalence of chronic kidney diseaseMichael P Quinn
Department of Public Health and Epidemiology, The Queen s University of Belfast, Mulhouse Building, The Royal Victoria Hospital, Grosvenor Road, BT126BJ, United Kingdom
Nephrol Dial Transplant 23:542-8. 2008..study assesses the practical implications of eGFR correction equations on the range of creatinine assays currently used in the UK and further investigates the effect of these equations on the calculated prevalence of CKD in one UK region..
- The value of positron emission tomography in patients with non-small cell lung cancerFrank Kee
Centre for Public Health, Queen s University Belfast, Mulhouse Building, Royal Victoria Hospital Site, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, UK
Eur J Radiol 73:50-8. 2010..Despite substantial evidence of diagnostic accuracy, relatively little attention has been paid to its effects on patient outcomes. This paper addresses this by extending an existing decision model to include patient-elicited utilities...
- Obesity and periodontitis in 60-70-year-old menGerry Linden
Oral Science Research Centre, School of Dentistry, Queen s University, Belfast, UK
J Clin Periodontol 34:461-6. 2007..The study also explored whether a high body mass index (BMI) in early life predicted poor periodontal status in later life...
- Bilirubin and coronary heart disease risk in the Prospective Epidemiological Study of Myocardial Infarction (PRIME)Judith A Troughton
Faculty of Medicine, Queen s University Belfast, Northern Ireland, UK
Eur J Cardiovasc Prev Rehabil 14:79-84. 2007..We tested the hypothesis that higher bilirubin, a bile pigment possessing antioxidant properties, is associated with decreased coronary heart disease risk...
- Physical activity loyalty cards for behavior change: a quasi-experimental studyRuth F Hunter
Centre for Public Health, Queen s University Belfast, Institute of Clinical Sciences B, Royal Victoria Hospital, Belfast, Northern Ireland, United Kingdom
Am J Prev Med 45:56-63. 2013..Financial incentives have been advocated by the UK and U.S. governments to encourage adoption of healthy lifestyles. However, evidence to support the use of incentives for changing physical activity (PA) behavior is sparse...
- The effectiveness of physical activity interventions in socio-economically disadvantaged communities: a systematic reviewClaire L Cleland
Centre for Public Health, Queen s University Belfast, Clinical Sciences Block B, Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland, BT12 6BJ, UK
Prev Med 54:371-80. 2012..This review examines the effectiveness of interventions designed to increase PA in these communities and the theoretical frameworks and components used...
- High expressor paraoxonase PON1 gene promoter polymorphisms are associated with reduced risk of vascular disease in younger coronary patientsIlia Leviev
Clinical Diabetes Unit, Division of Endocrinology and Diabetes, University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
Atherosclerosis 161:463-7. 2002..The data are consistent with the high expressor promoter genotype being linked to reduced risk of myocardial infarction. The influence of the genotype may be compromised in older patients...
- Polymorphisms of the beta2 -adrenoceptor (ADRB2) gene and essential hypertension: the ECTIM and PEGASE studiesStefan Martin Herrmann
Institut National de la Santé et de la Recherche Médicale Inserm SC7 U525, Paris, France
J Hypertens 20:229-35. 2002..We investigated whether genetic variation of the ADRB2 gene might be related to essential hypertension or myocardial infarction (MI)...
- Serotonin transporter gene polymorphism and myocardial infarction: Etude Cas-Témoins de l'Infarctus du Myocarde (ECTIM)Frederic Fumeron
EA 3516, Faculte de Medecine Xavier Bichat, Paris, France
Circulation 105:2943-5. 2002..A functional polymorphism in the promoter region of the SLC6A4 gene has been described. This polymorphism may be associated with the risk of MI...
- Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter studyRolando Herrero
International Agency for Research on Cancer, Lyon, France rherrero amnet co cr
J Natl Cancer Inst 95:1772-83. 2003..To investigate these associations, we conducted a multicenter case-control study of cancer of the oral cavity and oropharynx in nine countries...
- Neutrophil elastase gene variation and coronary heart diseaseJacqueline Schönfelder
Department of Molecular Genetics of Cardiovascular Disease, Leibniz Institute for Arteriosclerosis Research, University of Muenster, Muenster, Germany
Pharmacogenet Genomics 17:629-37. 2007..Identification and functional characterization of variants in the neutrophil elastase (ELA2) gene in cardiovascular disease...
- Polymorphisms in 33 inflammatory genes and risk of myocardial infarction--a system genetics approachSandrine Barbaux
INSERM, UMR S 525, Paris 75634, France
J Mol Med (Berl) 85:1271-80. 2007..Overall, there was weak evidence for an implication of inflammatory polymorphisms on susceptibility to MI...
- Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular riskStefan Blankenberg
Department of Medicine II, Johannes Gutenberg University Mainz, Mainz, Germany
Circ Res 99:102-8. 2006..The role of CASP1 genetic variations in the susceptibility to myocardial infarction requires further investigation...
- Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery diseaseHeribert Schunkert
Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
Circulation 117:1675-84. 2008..3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a meta-analysis...
- In-depth haplotype analysis of ABCA1 gene polymorphisms in relation to plasma ApoA1 levels and myocardial infarctionDavid Alexandre Tregouet
INSERM U525, Faculté de Médecine de la Pitié Salpétrière, Paris, France
Arterioscler Thromb Vasc Biol 24:775-81. 2004..Twenty-six polymorphisms of the ABCA1 gene were genotyped and tested for association with plasma levels of ApoA1 and myocardial infarction (MI) in the ECTIM study...
- Lack of association between complement factor H polymorphisms and coronary artery disease or myocardial infarctionViviane Nicaud
INSERM UMR S525, Faculté de Médecine Pitié Salpêtrière, 91 Boulevard de l Hopital, Paris, 75013, France
J Mol Med (Berl) 85:771-5. 2007..Genotype and allele frequencies were similar in cases and controls. These results do not support an involvement of common nonsynonymous polymorphisms of the CFH gene in predisposition to CAD and its complications...
- Prevalence of obstructive lung disease in a general population sample: the NICECOPD studyEoin Murtagh
Regional Respiratory Centre, Belfast City Hospital, N Ireland
Eur J Epidemiol 20:443-53. 2005..The Northern Ireland Cost and Epidemiology of Chronic Obstructive Pulmonary Disease (NICECOPD) study is a two-stage survey to examine the prevalence of obstructive lung disease in a general population sample in the Greater Belfast area...
- Colorectal cancer mortality in first-degree relatives of early-onset colorectal cancer casesLouise E Johns
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom
Dis Colon Rectum 45:681-6. 2002..There is a paucity of data about the familial colorectal cancer risk associated with early-onset disease outside the recognized cancer predisposition syndromes...
- A novel cholesteryl ester transfer protein promoter polymorphism (-971G/A) associated with plasma high-density lipoprotein cholesterol levels. Interaction with the TaqIB and -629C/A polymorphismsWilfried Le Goff
Institut National de la Sante et de la Recherche Medicale, Hopital de la Pitie, Unité 321 Lipoprotéines et Athérogénèse, Pavillon Benjamin Delessert, 83 Boulevard de l Hôpital 75651 Paris 13, France
Atherosclerosis 161:269-79. 2002....