Genomes and Genes
G Brent Irvine
Affiliation: Queen's University Belfast
- Alpha-synuclein aggregationAngela M Bodles
University of Arkansas for Medical Sciences, Donald W Reynolds Center on Aging, Little Rock, AR 72205, USA
Protein Pept Lett 11:271-9. 2004..We have defined a sequence within the NAC region of alpha-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation...
- Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseasesG Brent Irvine
School of Medicine and Dentistry, The Queen s University of Belfast, Belfast, Northern Ireland
Mol Med 14:451-64. 2008..In this review, we discuss this theme as it relates to the two most common neurodegenerative conditions-Alzheimer's and Parkinson's diseases...
- Identification of valid reference genes for the normalization of RT qPCR gene expression data in human brain tissueDavid T R Coulson
Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen s University Belfast, Whitla Medical Building, Belfast, BT9 7BL, Northern Ireland, UK
BMC Mol Biol 9:46. 2008..Given that expression of some commonly used reference genes is altered in certain conditions, this study aimed to establish which reference genes were stably expressed in post mortem brain tissue from individuals with AD, PD or DLB...
- High-performance size-exclusion chromatography of peptidesG Brent Irvine
Centre for Peptide and Protein Engineering, School of Biology and Biochemistry, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
J Biochem Biophys Methods 56:233-42. 2003..In this report, HPSEC is described in relation to its application to peptides, especially regarding purification, estimation of molecular weight and study of molecular associations...
- α-Synuclein mRNA and soluble α-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's diseaseJoseph G Quinn
Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, N Ireland, UK
Brain Res 1459:71-80. 2012..This might result from altered translation, or removal of α-synuclein protein from a soluble detectable state, either by turnover or conversion to an insoluble form...
- Zinc transporter mRNA levels in Alzheimer's disease postmortem brainNancy Beyer
Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Belfast, N Ireland
J Alzheimers Dis 29:863-73. 2012..These expression changes could either reflect or cause the altered cortical Zn2+ distribution in AD, potentially increasing the likelihood of interactions between Zn2+ and Aβ or tau protein...
- Variation in RTN3 and PPIL2 genes does not influence platelet membrane beta-secretase activity or susceptibility to alzheimer's disease in the northern Irish populationRobyn Carson
Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK
Neuromolecular Med 11:337-44. 2009..We conclude that common or potentially functional genetic variation in these BACE1 interacting proteins does not affect platelet membrane beta-secretase activity or contribute to risk of AD in this population...
- BACE1 mRNA expression in Alzheimer's disease postmortem brain tissueDavid T R Coulson
Queen s University Belfast, School of Medicine, Dentistry and Biomedical Sciences, Northern Ireland
J Alzheimers Dis 22:1111-22. 2010..This analysis suggested that increased BACE1 mRNA expression in remaining neuronal cells may contribute to the increased BACE1 protein levels and activity found in brain regions affected by AD...
- ZnT3 mRNA levels are reduced in Alzheimer's disease post-mortem brainNancy Beyer
Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Northern Ireland
Mol Neurodegener 4:53. 2009....
- IQ motif selectivity in human IQGAP1: binding of myosin essential light chain and S100BSevvel Pathmanathan
Medical Biology Centre, School of Biological Sciences, Queen s University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK
Mol Cell Biochem 318:43-51. 2008..This clearly establishes that S100B can interact with its targets through IQ motifs in addition to interacting via previously reported sequences. These results are discussed in terms of the function of IQGAP1 and IQ motif recognition...
- A novel reciprocal and biphasic relationship between membrane cholesterol and beta-secretase activity in SH-SY5Y cells and in human plateletsWei Wei Liu
School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, 97 Lisburn Road, Belfast, Northern Ireland, UK
J Neurochem 108:341-9. 2009....
- Inhibition of fibril formation and toxicity of a fragment of alpha-synuclein by an N-methylated peptide analogueAngela M Bodles
Centre for Peptide and Protein Engineering, School of Biology and Biochemistry, The Queen s University of Belfast, Medical Biology Centre, Belfast BT9 7BL, UK
Neurosci Lett 359:89-93. 2004..Moreover, an equimolar mixture of the non-methylated and methylated peptides formed very few fibrils and toxicity was markedly reduced...
- Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's diseaseOwen A Ross
Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
Mech Ageing Dev 128:378-82. 2007..It is now crucial to identify the susceptibility allele and elucidate its functionality which may generate a therapeutic target for PD...
- Inhibitors of alpha-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disordersDena A M Amer
Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, United Arab Emirates
Exp Brain Res 173:223-33. 2006..These compounds could serve as lead compounds for the design of new drugs for the treatment of PD and related disorders in the future...
- Clinical traits of LRRK2-associated Parkinson's disease in Ireland: a link between familial and idiopathic PDDavid Gosal
Department of Neurology, Mater Misericordiae Hospital, Eccles St, Dublin 7, Ireland
Parkinsonism Relat Disord 11:349-52. 2005..The influence of the G2019S substitution on protein function and disease phenotype has yet to be fully resolved, but its elucidation will undoubtedly further our understanding of the mechanisms underlying Parkinson's disease...