Brian D Green

Summary

Affiliation: Queen's University Belfast
Country: UK

Publications

  1. pmc In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1)
    Eamon P Rafferty
    School of Biological Sciences, Queen s University Belfast, BT9 5AG, Northern Ireland, United Kingdom
    Sci Pharm 79:615-21. 2011
  2. doi request reprint Examining acute and chronic effects of short- and long-chain fatty acids on peptide YY (PYY) gene expression, cellular storage and secretion in STC-1 cells
    Katharine V Hand
    Institute of Agri food and Land Use, School of Biological Sciences, Queen s University Belfast, Stranmillis Road, Belfast, UK
    Eur J Nutr 52:1303-13. 2013
  3. ncbi request reprint Incretin hormone mimetics and analogues in diabetes therapeutics
    Brian D Green
    School of Biological Sciences, Queens University Belfast, David Keir Building, Stranmillis Road, Belfast BT6 0NJ, Northern Ireland, UK
    Best Pract Res Clin Endocrinol Metab 21:497-516. 2007
  4. ncbi request reprint Long-term administration of PACAP receptor antagonist, PACAP(6-27), impairs glucose tolerance and insulin sensitivity in obese diabetic ob/ob mice
    Brian D Green
    School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, Northern Ireland, United Kingdom
    Peptides 27:2343-9. 2006
  5. ncbi request reprint GLP-1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving KATP and cAMP
    Brian D Green
    Human Nutrition and Health Group, School of Biological Sciences, Queens University Belfast, David Keir Building, Stranmillis Road, Belfast BT9 5AG, UK
    Arch Biochem Biophys 478:136-42. 2008
  6. ncbi request reprint Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1
    Brian D Green
    School of Biological Sciences, Queens University Belfast, David Keir Building, Stranmillis Road, Belfast BT9 5AG, Northern Ireland
    Eur J Pharmacol 547:192-9. 2006
  7. ncbi request reprint Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice
    B D Green
    School of Biological Sciences, Queens University Belfast, Northern Ireland, UK
    Peptides 28:981-7. 2007
  8. ncbi request reprint Dipeptidyl peptidase IV (DPP IV) inhibitors: A newly emerging drug class for the treatment of type 2 diabetes
    Brian D Green
    School of Biological Sciences, Queens University Belfast, Belfast, BT9 5AG, UK
    Diab Vasc Dis Res 3:159-65. 2006
  9. ncbi request reprint Antagonistic effects of two novel GIP analogs, (Hyp3)GIP and (Hyp3)GIPLys16PAL, on the biological actions of GIP and longer-term effects in diabetic ob/ob mice
    Finbarr P M O'Harte
    School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, Northern Ireland
    Am J Physiol Endocrinol Metab 292:E1674-82. 2007
  10. ncbi request reprint Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu9-substituted analogues of glucagon-like peptide-1
    Brian D Green
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Biol Chem 384:1543-51. 2003

Collaborators

Detail Information

Publications56

  1. pmc In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1)
    Eamon P Rafferty
    School of Biological Sciences, Queen s University Belfast, BT9 5AG, Northern Ireland, United Kingdom
    Sci Pharm 79:615-21. 2011
    ..OLE and GLN are potent stimulators of GLP-1 secretion both in vitro and in vivo and chronic studies should assess their suitability as nutritional therapies for type 2 diabetes...
  2. doi request reprint Examining acute and chronic effects of short- and long-chain fatty acids on peptide YY (PYY) gene expression, cellular storage and secretion in STC-1 cells
    Katharine V Hand
    Institute of Agri food and Land Use, School of Biological Sciences, Queen s University Belfast, Stranmillis Road, Belfast, UK
    Eur J Nutr 52:1303-13. 2013
    ..The cellular mechanisms by which nutrients stimulate PYY secretion from intestinal enteroendocrine cells are still being elucidated...
  3. ncbi request reprint Incretin hormone mimetics and analogues in diabetes therapeutics
    Brian D Green
    School of Biological Sciences, Queens University Belfast, David Keir Building, Stranmillis Road, Belfast BT6 0NJ, Northern Ireland, UK
    Best Pract Res Clin Endocrinol Metab 21:497-516. 2007
    ..Additionally, it explores the therapeutic possibilities offered by preclinical agents, such as non-peptide GLP-1 mimetics, GLP-1/glucagon hybrid peptides, and specific GIP receptor antagonists...
  4. ncbi request reprint Long-term administration of PACAP receptor antagonist, PACAP(6-27), impairs glucose tolerance and insulin sensitivity in obese diabetic ob/ob mice
    Brian D Green
    School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, Northern Ireland, United Kingdom
    Peptides 27:2343-9. 2006
    ..Plasma glucagon and lipids were unchanged. These observations indicate a role of endogenous PACAP for normal glucose homeostasis, but indicate a minor involvement in the regulation of insulin secretion in ob/ob mice...
  5. ncbi request reprint GLP-1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving KATP and cAMP
    Brian D Green
    Human Nutrition and Health Group, School of Biological Sciences, Queens University Belfast, David Keir Building, Stranmillis Road, Belfast BT9 5AG, UK
    Arch Biochem Biophys 478:136-42. 2008
    ..However, further studies are required in order to establish whether GLP-1 related agents may confer additional cardiovascular benefits to diabetic patients...
  6. ncbi request reprint Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1
    Brian D Green
    School of Biological Sciences, Queens University Belfast, David Keir Building, Stranmillis Road, Belfast BT9 5AG, Northern Ireland
    Eur J Pharmacol 547:192-9. 2006
    ..These findings indicate that metformin decreases the plasma DPP IV activity, limiting the inactivation of exogenously administered GLP-1 and improving glycaemic control...
  7. ncbi request reprint Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice
    B D Green
    School of Biological Sciences, Queens University Belfast, Northern Ireland, UK
    Peptides 28:981-7. 2007
    ..Our observations support a role for obestatin in regulating metabolism through changes of appetite, but indicate no direct actions on glucose homeostasis or insulin secretion...
  8. ncbi request reprint Dipeptidyl peptidase IV (DPP IV) inhibitors: A newly emerging drug class for the treatment of type 2 diabetes
    Brian D Green
    School of Biological Sciences, Queens University Belfast, Belfast, BT9 5AG, UK
    Diab Vasc Dis Res 3:159-65. 2006
    ..In clinical trials DPP IV inhibitors (or 'gliptins') have shown efficacy and tolerability in the management of hyperglycaemia in type 2 diabetes, without causing weight gain or hypoglycaemia...
  9. ncbi request reprint Antagonistic effects of two novel GIP analogs, (Hyp3)GIP and (Hyp3)GIPLys16PAL, on the biological actions of GIP and longer-term effects in diabetic ob/ob mice
    Finbarr P M O'Harte
    School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, Northern Ireland
    Am J Physiol Endocrinol Metab 292:E1674-82. 2007
    ..Acylation of (Hyp(3))GIP to extend bioactivity does not appear to be of any additional benefit...
  10. ncbi request reprint Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu9-substituted analogues of glucagon-like peptide-1
    Brian D Green
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Biol Chem 384:1543-51. 2003
    ..These observations indicate the importance of Glu9 for the biological activity of GLP-1 and susceptibility to DPP IV-mediated degradation...
  11. ncbi request reprint Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes
    Victor A Gault
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK
    Diabetes 54:2436-46. 2005
    ..These studies highlight a role for GIP in obesity-related glucose intolerance and emphasize the potential of specific GIP-R antagonists as a new class of drugs for the alleviation of insulin resistance and treatment of type 2 diabetes...
  12. ncbi request reprint Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala8-substituted GLP-1 analogues
    Brian D Green
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Biol Chem 385:169-77. 2004
    ..These studies support the potential usefulness of fatty acid linked analogues of GLP-1 but indicate the importance of chain length for peptide kinetics and bioavailability...
  13. ncbi request reprint Degradation, insulin secretion, and antihyperglycemic actions of two palmitate-derivitized N-terminal pyroglutamyl analogues of glucose-dependent insulinotropic polypeptide
    Nigel Irwin
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    J Med Chem 48:1244-50. 2005
    ..These data indicate that palmitate-derivitized analogues of N-terminal pyroglutamyl GIP represent a novel class of stable, long-acting, and effective GIP analogues for potential type 2 diabetes therapy...
  14. ncbi request reprint GIP(Lys16PAL) and GIP(Lys37PAL): novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide with improved antidiabetic potential
    Nigel Irwin
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, U K
    J Med Chem 49:1047-54. 2006
    ..These data demonstrate that fatty acid derivatized GIP peptides represent a novel class of long-acting stable GIP analogues for therapy of type 2 diabetes...
  15. ncbi request reprint Metabolic effects of sub-chronic ablation of the incretin receptors by daily administration of (Pro3)GIP and exendin(9-39)amide in obese diabetic (ob/ob) mice
    Jeremy C Parker
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Biol Chem 388:221-6. 2007
    ..These studies highlight an important role for GIP in obesity-related forms of diabetes, suggesting the possible involvement of GLP-1 in the beneficial actions of GIP receptor antagonism...
  16. ncbi request reprint Novel glucagon-like peptide-1 (GLP-1) analog (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic (ob/ob) mice
    Brian D Green
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    J Pharmacol Exp Ther 318:914-21. 2006
    ..2-fold without changing the number of islets, resulting in an increased number of larger islets. These data demonstrate that (Val8)GLP-1 is more effective and longer acting than native GLP-1 in obese-diabetic ob/ob mice...
  17. ncbi request reprint A novel, long-acting agonist of glucose-dependent insulinotropic polypeptide suitable for once-daily administration in type 2 diabetes
    Nigel Irwin
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, UK
    J Pharmacol Exp Ther 314:1187-94. 2005
    ....
  18. ncbi request reprint Characterisation and glucoregulatory actions of a novel acylated form of the (Pro3)GIP receptor antagonist in type 2 diabetes
    Victor A Gault
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Biol Chem 388:173-9. 2007
    ..05) in the (Pro3)GIPLys16PAL-treated mice. These data demonstrate that acylation of Lys16 with palmitic acid in (Pro3)GIP does not improve its biological effectiveness as a GIP receptor antagonist...
  19. ncbi request reprint Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide
    Nigel Irwin
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, UK
    Biochem Pharmacol 72:719-28. 2006
    ..These data demonstrate the therapeutic potential of once daily injection of enzyme resistant GIP analogues and indicate that N-AcGIP is equally as effective as related palmitate derivatised analogues of GIP...
  20. ncbi request reprint Biological activity and antidiabetic potential of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide, GIP(1-16) and (Pro3)GIP(1-16)
    Nigel Irwin
    Diabetes Research Group, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Regul Pept 135:45-53. 2006
    ..These data demonstrate that C-terminal truncation of GIP or (Pro3)GIP yields small molecular weight GIP molecules with significantly reduced biological activity that precludes therapeutic utility...
  21. ncbi request reprint Characterisation and biological activity of Glu3 amino acid substituted GIP receptor antagonists
    Victor A Gault
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK
    Arch Biochem Biophys 461:263-74. 2007
    ..These data demonstrate that position 3 amino acid substitution of GIP with (Ala(3)), (Phe(3)), (Tyr(3)) or (Pro(3)) provides a new class of functional GIP receptor antagonists...
  22. ncbi request reprint Comparison of the anti-diabetic effects of GIP- and GLP-1-receptor activation in obese diabetic (ob/ob) mice: studies with DPP IV resistant N-AcGIP and exendin(1-39)amide
    Nigel Irwin
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, UK
    Diabetes Metab Res Rev 23:572-9. 2007
    ....
  23. ncbi request reprint Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice
    Nigel Irwin
    Diabetes Research Group, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Biol Chem 385:845-52. 2004
    ..These data indicate that ablation of GIP signaling causes a readily reversible glucose intolerance without appreciable change of insulin secretion...
  24. ncbi request reprint Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1
    Nicola A Duffy
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, UK
    Eur J Pharmacol 568:278-86. 2007
    ..These data indicate that the use of nateglinide as a prandial insulin-releasing agent may partly rely on inhibition of GLP-1 degradation as well as beta-cell K(ATP) channel inhibition...
  25. ncbi request reprint Effects on glucose homeostasis and insulin secretion of long term activation of the glucose-dependent insulinotropic polypeptide (GIP) receptor by N-AcGIP(LysPAL37) in normal mice
    Nigel Irwin
    Diabetes Research Group, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Peptides 27:893-900. 2006
    ..These data indicate that long term activation of the GIP receptor by daily treatment with N-AcGIP(LysPAL37) improved glucose tolerance due to enhancement of pancreatic beta cell glucose responsiveness and insulin secretion...
  26. ncbi request reprint Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation
    Aine M McKillop
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Eur J Endocrinol 161:877-85. 2009
    ..36+/-1.2 mmol/l) following administration of oral nateglinide (120 mg) 10 min prior to a 75 g oral glucose load in a randomised crossover design...
  27. ncbi request reprint Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes
    Peter R Flatt
    School of Biomedical Sciences, University of Ulster, Coleraine, UK
    Front Biosci 13:3648-60. 2008
    ..Here we examine the information available on DPP IV and related enzymes, review recent preclinical and clinical data for DPP IV inhibitors, and assess their clinical significance...
  28. ncbi request reprint Stable agonist of glucose-dependent insulinotropic polypeptide (GIP) restores pancreatic beta cell glucose responsiveness but not glucose intolerance in aging mice
    Nigel Irwin
    Diabetes Research Group, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Exp Gerontol 41:151-6. 2006
    ..Native GIP had a similar overall effect in younger and older mice. These data indicate that N-AcGIP(LysPAL37) is able to counter the age-related deterioration of pancreatic beta cell glucose sensitivity and insulin secretion...
  29. ncbi request reprint Acute and chronic effects of dietary fatty acids on cholecystokinin expression, storage and secretion in enteroendocrine STC-1 cells
    Katharine V Hand
    Institute of Agri food and Land Use, School of Biological Sciences, Queen s University Belfast, Belfast, UK
    Mol Nutr Food Res 54:S93-S103. 2010
    ..These actions of conjugated linoleic acid may explain satiating actions observed in dietary intervention studies...
  30. ncbi request reprint Antidiabetic potential of two novel fatty acid derivatised, N-terminally modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-AcGIP(LysPAL16) and N-AcGIP(LysPAL37)
    Nigel Irwin
    School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, N Ireland, UK
    Biol Chem 386:679-87. 2005
    ..These data demonstrate that novel fatty acid-derivatised analogues of N-terminally modified AcGIP function as long-acting GIP-receptor agonists, with significant antidiabetic potential...
  31. ncbi request reprint Long-term beneficial effects of vanadate, tungstate, and molybdate on insulin secretion and function of cultured beta cells
    Hui Kang Liu
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, UK
    Pancreas 28:364-8. 2004
    ..These observations suggest significant effects of ultratrace elements on pancreatic beta cells that may contribute to their antihyperglycemic action...
  32. ncbi request reprint Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) as future antidiabetic agents
    Brian D Green
    School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, Northern Ireland, UK
    Curr Pharm Des 10:3651-62. 2004
    ..This approach is currently being pursued actively by the pharmaceutical industry...
  33. ncbi request reprint Insulin-releasing and metabolic effects of small molecule GLP-1 receptor agonist 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline
    Nigel Irwin
    SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences Research Institute, University of Ulster, Coleraine, United Kingdom
    Eur J Pharmacol 628:268-73. 2010
    ..These results provide evidence to support the development and potential use of low molecular weight GLP-1 receptor agonists for the treatment of type 2 diabetes...
  34. ncbi request reprint N-acetyl-GLP-1: a DPP IV-resistant analogue of glucagon-like peptide-1 (GLP-1) with improved effects on pancreatic beta-cell-associated gene expression
    Hui Kang Liu
    School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, Northern Ireland, UK
    Cell Biol Int 28:69-73. 2004
    ..Further investigation of the effects of stable GLP-1 analogues on beta-cell differentiation is required to assess their potential in diabetic therapy...
  35. ncbi request reprint Effects of long-term exposure to nicotinamide and sodium butyrate on growth, viability, and the function of clonal insulin secreting cells
    Hui Kang Liu
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, UK
    Endocr Res 30:61-8. 2004
    ..These data illustrate that long term exposure to NIC and BUT has both positive and negative effects on the function of insulin-secreting cells...
  36. pmc Emerging cardiovascular actions of the incretin hormone glucagon-like peptide-1: potential therapeutic benefits beyond glycaemic control?
    David J Grieve
    Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, UK
    Br J Pharmacol 157:1340-51. 2009
    ..This review will discuss the current understanding of GLP-1 biology, examine its emerging cardiovascular actions in both health and disease and explore the potential use of GLP-1 as a novel treatment for CVD...
  37. doi request reprint Investigating the effects of physiological bile acids on GLP-1 secretion and glucose tolerance in normal and GLP-1R(-/-) mice
    Eamon P Rafferty
    School of Biological Sciences, Queen s University Belfast, BT9 5AG, UK
    Biol Chem 392:539-46. 2011
    ..However, GLP-1 secretion appears to be only part of the glucose-lowering mechanism and our studies indicate that the other major incretin GIP is not involved...
  38. ncbi request reprint Inhibition of dipeptidylpeptidase IV activity as a therapy of type 2 diabetes
    Brian D Green
    Queens University Belfast, School of Biological Sciences, David Keir Building, Stranmillis Road, Belfast BT9 5AG, Northern Ireland
    Expert Opin Emerg Drugs 11:525-39. 2006
    ..If long-term clinical trials confirm sustained and safe control of blood glucose, DPP IV inhibitors (known as 'gliptins') may be expected to provide a new treatment modality for Type 2 diabetes...
  39. ncbi request reprint Deleterious effects of supplementation with dehydroepiandrosterone sulphate or dexamethasone on rat insulin-secreting cells under in vitro culture condition
    Hui Kang Liu
    School of Biomedical Sciences, University of Ulster, BT52 1SA, Coleraine, N Ireland, UK
    Biosci Rep 26:31-8. 2006
    ..Therefore, we conclude that this steroid hormone and synthetic glucocorticoid are not beneficial to pancreatic beta-cells in vitro...
  40. doi request reprint Hormone profiling in a novel enteroendocrine cell line pGIP/neo: STC-1
    Katharine V Hand
    Institute of Agri food and Land Use, School of Biological Sciences, Queen s University Belfast, David Keir Building, Stranmillis Road, Belfast BT9 5AG, UK
    Metabolism 61:1683-6. 2012
    ..GIP is a peptide hormone of therapeutic interest in type 2 diabetes and obesity. This study evaluated pGIP/neo STC-1 as a potential K-cell model for studying GIP secretion...
  41. ncbi request reprint Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity
    João C Miguel
    School of Biomedical Sciences, University of Ulster, Coleraine, Co Londonderry, Northern Ireland, BT52 1SA, UK
    Biochem Pharmacol 65:283-92. 2003
    ..An imbalance between these pathways may contribute to dysfunctional insulin secretion...
  42. ncbi request reprint Metabolic profile changes in the testes of mice with streptozotocin-induced type 1 diabetes mellitus
    C Mallidis
    Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Queen s University, Belfast, UK
    Int J Androl 32:156-65. 2009
    ....
  43. pmc The gastrointestinal peptide obestatin induces vascular relaxation via specific activation of endothelium-dependent NO signalling
    Andrew J Agnew
    School of Biological Sciences, Queen s University Belfast, Belfast, UK
    Br J Pharmacol 166:327-38. 2012
    ..Here we aimed to investigate the specific effects of obestatin on vascular relaxation...
  44. ncbi request reprint Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1(9-36)amide, on insulin secretion and glucose homeosta
    J C Parker
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK
    J Endocrinol 191:93-100. 2006
    ..GIP(3-42) might exert an overall beneficial effect by improving insulin sensitivity through extrapancreatic action...
  45. ncbi request reprint Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid
    B D Green
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Arch Biochem Biophys 428:136-43. 2004
    ....
  46. doi request reprint Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer's disease
    Stewart F Graham
    ASSET Technology Centre, Institute for Global Food Security, Queen s University Belfast, Stranmillis Road, Belfast, BT9 5AG, United Kingdom
    Anal Chem 85:1803-11. 2013
    ....
  47. doi request reprint Inward rectifier potassium channels in the HL-1 cardiomyocyte-derived cell line
    Dana Goldoni
    Cardiovascular Remodelling Group, Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, Belfast, UK
    J Cell Physiol 225:751-6. 2010
    ..1 mRNA. This cell line may have use as a system for studying inward rectifier gene regulation in a cardiomyocyte phenotype...
  48. ncbi request reprint Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin
    V A Gault
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA Northern Ireland, United Kingdom
    Diabetologia 46:222-30. 2003
    ..This study examined the biological effects of the GIP receptor antagonist, (Pro3)GIP and the GLP-1 receptor antagonist, exendin(9-39)amide...
  49. ncbi request reprint Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo
    B D Green
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    J Mol Endocrinol 31:529-40. 2003
    ..These data indicate that substitution of Ala(8) in GLP-1 with Abu or Val confers resistance to DPP IV inactivation and that (Val(8))GLP-1 is a particularly potent N-terminally modified GLP-1 analogue of possible use in type 2 diabetes...
  50. ncbi request reprint Lys9 for Glu9 substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39)
    B D Green
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern, Ireland
    Metabolism 53:252-9. 2004
    ..We investigated the in vivo antagonistic actions of (Lys(9))GLP-1 in comparison with GLP-1(9-36)amide and exendin (9-39) and revealed that this novel analogue may serve as a functional antagonist of the GLP-1 receptor...
  51. ncbi request reprint N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity
    B D Green
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, N Ireland, UK
    J Endocrinol 180:379-88. 2004
    ..The particularly powerful antihyperglycaemic action of N-pyroglutamyl-GLP-1 shows potential for the treatment of type 2 diabetes...
  52. ncbi request reprint Chronic treatment with exendin(9-39)amide indicates a minor role for endogenous glucagon-like peptide-1 in metabolic abnormalities of obesity-related diabetes in ob/ob mice
    B D Green
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, United Kingdom
    J Endocrinol 185:307-17. 2005
    ....
  53. ncbi request reprint A comparison of the cellular and biological properties of DPP-IV-resistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide
    B D Green
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, UK
    Diabetes Obes Metab 7:595-604. 2005
    ..This study directly compares the cellular and biological properties of GLP-1, GIP and their N-terminally modified counterparts, with glucitol extension at positions His7 and Tyr1 respectively, to confer DPP-IV resistance...
  54. ncbi request reprint Pituitary adenylate cyclase-activating peptide (PACAP): assessment of dipeptidyl peptidase IV degradation, insulin-releasing activity and antidiabetic potential
    B D Green
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, United Kingdom
    Peptides 27:1349-58. 2006
    ..In conclusion, PACAP is inactivated by DPP IV and despite insulin-releasing effects, its actions on glucagon secretion and glucose homeostasis do not make it a good therapeutic tool for the treatment of type 2 diabetes...
  55. ncbi request reprint Function of a long-term, GLP-1-treated, insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of GLP-1
    B D Green
    School of Biomedical Sciences, University of Ulster, Coleraine, N Ireland, UK
    Diabetes Obes Metab 7:563-9. 2005
    ..These observations also support the ongoing development of DPP-IV-resistant forms of GLP-1, such as N-acetyl-GLP-1...
  56. ncbi request reprint Capturing the uncultivated majority
    Brian D Green
    Diversa Corporation, San Diego, CA 92121, USA
    Curr Opin Biotechnol 17:236-40. 2006
    ..Finally, new cultivation methods continue to be developed to improve our ability to capture a greater diversity of microorganisms within the environment...