Alexander Galkin

Summary

Affiliation: Queen's University Belfast
Country: UK

Publications

  1. pmc Characterisation of the active/de-active transition of mitochondrial complex I
    Marion Babot
    Queen s University Belfast, School of Biological Sciences, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Biochim Biophys Acta 1837:1083-92. 2014
  2. pmc ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I
    Marion Babot
    Queen s University Belfast, School of Biological Sciences, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Biochim Biophys Acta 1837:929-39. 2014
  3. pmc Molecular mechanism and physiological role of active-deactive transition of mitochondrial complex I
    Marion Babot
    Queen s University Belfast, School of Biological Sciences, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, U K
    Biochem Soc Trans 41:1325-30. 2013
  4. pmc Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?
    Alexander Galkin
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
    J Biol Chem 284:36055-61. 2009
  5. ncbi request reprint S-nitrosation of mitochondrial complex I depends on its structural conformation
    Alexander Galkin
    Wolfson Institute for Biomedical Research, University College London, London, UK
    J Biol Chem 282:37448-53. 2007
  6. ncbi request reprint Nitric oxide and hypoxia
    Alexander Galkin
    The Wolfson Institute for Biomedical Research, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, U K
    Essays Biochem 43:29-42. 2007

Collaborators

Detail Information

Publications7

  1. pmc Characterisation of the active/de-active transition of mitochondrial complex I
    Marion Babot
    Queen s University Belfast, School of Biological Sciences, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Biochim Biophys Acta 1837:1083-92. 2014
    ..This article is part of a Special Issue entitled: 18th European Bioenergetic Conference. Guest Editors: Manuela Pereira and Miguel Teixeira. ..
  2. pmc ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I
    Marion Babot
    Queen s University Belfast, School of Biological Sciences, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Biochim Biophys Acta 1837:929-39. 2014
    ..De-activation of mitochondrial complex I results in concerted structural rearrangement of membrane subunits which leads to the disruption of the sealed quinone chamber required for catalytic turnover. ..
  3. pmc Molecular mechanism and physiological role of active-deactive transition of mitochondrial complex I
    Marion Babot
    Queen s University Belfast, School of Biological Sciences, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, U K
    Biochem Soc Trans 41:1325-30. 2013
    ..The nature of thiol modification defines deactivation reversibility, the reactivation timescale, the status of mitochondrial bioenergetics and therefore the degree of recovery of the ischaemic tissues after reoxygenation...
  4. pmc Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?
    Alexander Galkin
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
    J Biol Chem 284:36055-61. 2009
    ..These observations provide a mechanism to account for the severe cell injury that follows hypoxia and reoxygenation when accompanied by NO generation...
  5. ncbi request reprint S-nitrosation of mitochondrial complex I depends on its structural conformation
    Alexander Galkin
    Wolfson Institute for Biomedical Research, University College London, London, UK
    J Biol Chem 282:37448-53. 2007
    ..The implications of this finding for hypoxic or pathophysiological conditions in vivo are discussed...
  6. ncbi request reprint Nitric oxide and hypoxia
    Alexander Galkin
    The Wolfson Institute for Biomedical Research, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, U K
    Essays Biochem 43:29-42. 2007
    ..This chapter discusses the physiological and pathophysiological implications of the interactions of NO with the cytochrome c oxidase...