Affiliation: Queen's University Belfast
- Molecular mechanism and physiological role of active-deactive transition of mitochondrial complex IMarion Babot
Queen s University Belfast, School of Biological Sciences, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, U K
Biochem Soc Trans 41:1325-30. 2013..The nature of thiol modification defines deactivation reversibility, the reactivation timescale, the status of mitochondrial bioenergetics and therefore the degree of recovery of the ischaemic tissues after reoxygenation...
- Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?Alexander Galkin
Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
J Biol Chem 284:36055-61. 2009..These observations provide a mechanism to account for the severe cell injury that follows hypoxia and reoxygenation when accompanied by NO generation...
- S-nitrosation of mitochondrial complex I depends on its structural conformationAlexander Galkin
Wolfson Institute for Biomedical Research, University College London, London, UK
J Biol Chem 282:37448-53. 2007..The implications of this finding for hypoxic or pathophysiological conditions in vivo are discussed...
- Nitric oxide and hypoxiaAlexander Galkin
The Wolfson Institute for Biomedical Research, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, U K
Essays Biochem 43:29-42. 2007..This chapter discusses the physiological and pathophysiological implications of the interactions of NO with the cytochrome c oxidase...