Affiliation: Queen's University Belfast
- Thiol and cardiovascular risk factor status in a male northern Irish populationKevin S Edgar
Centre for Clinical and Population Science, School of Medicine and Dentistry, Queen s University Belfast, Belfast, Nothern Ireland
Int J Vitam Nutr Res 78:208-16. 2008..Cysteine has also been associated with CVD risk. In this study, we investigated the association between known CVD risk factors, dietary factors, and total plasma cysteine, cysteinyl-glycine, and homocysteine...
- Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM ProjectMarie Lise Grisoni
INSERM, UMR_S 937, Paris, France
BMC Med Genet 10:44. 2009....
- Richard and Emma Stevens and the new photographyA Evans
Department of Epidemiology adn Public Health, The Queen s University of Belfast, UK
J Ir Coll Physicians Surg 29:229-32. 2000..The couple subsequently returned to India where Captain Stevens died in 1900. Emma, possibly the first woman to take X-rays, survived into old age and enjoyed a varied and interesting life...
- Commentary: The six biological inventions in Haldane's DaedalusAlun Evans
Department of Epidemiology and Public Health, The Queen s University of Belfast, Belfast, UK
Int J Epidemiol 37:454-69. 2008
- ET Craig: proto-socialist, phrenologist and public health engineerAlun Evans
Department of Epidemiology and Public Health, The Queen s University of Belfast, UK
Int J Epidemiol 37:490-505. 2008
- MORGAM (an international pooling of cardiovascular cohorts)Alun Evans
Department of Epidemiology and Public Health, Mulhouse Building, Queen s University Belfast, Belfast BT12 6BJ, N Ireland, UK
Int J Epidemiol 34:21-7. 2005
- Practical directions to the preservation of healthAlun Evans
Department of Epidemiology and Public Health, Queen s University Belfast, Mulhouse Building, RVH, Belfast BT12 6BJ, Northern Ireland, UK
Int J Epidemiol 33:640-9. 2004
- Trends in coronary risk factors in the WHO MONICA projectA Evans
Department of Epidemiology and Public Health, The Queen s University of Belfast, Mulhouse Building, Belfast BT12 6BJ, UK
Int J Epidemiol 30:S35-40. 2001..Risk factors were therefore monitored over ten years across 38 populations from 21 countries in four continents (overall period covered: 1979-1996)...
- The genetics of coronary heart disease: the contribution of twin studiesAlun Evans
Department of Epidemiology and Public Health, Queen s University Belfast, Belfast, Northern Ireland, UK
Twin Res 6:432-41. 2003..Twin studies have also contributed to our understanding of the life course hypothesis, and GenomEUtwin has the potential to add to this...
- Commentary: Sibling trials in Banbridge, County DownAlun Evans
Department of Epidemiology and Public Health, The Queen s University of Belfast, UK
Int J Epidemiol 37:42-5. 2008
- Persistently raised C-reactive protein levels are associated with advanced periodontal diseaseGerard J Linden
Oral Science Research Centre, Queen s University, Belfast, UK
J Clin Periodontol 35:741-7. 2008..The aim was to investigate whether there was an association between periodontitis or tooth loss in a homogeneous group of 60-70-year-old Western European men and either a sustained high or low level of C-reactive protein (CRP)...
- Antioxidants and periodontitis in 60-70-year-old menGerard J Linden
Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, Belfast, Northern Ireland, UK
J Clin Periodontol 36:843-9. 2009..The aim was to investigate the association between periodontal health and the serum levels of various antioxidants including carotenoids, retinol and vitamin E in a homogenous group of Western European men...
- Dietary patterns and smoking in Northern Irish men: a population at high risk of coronary heart diseaseMark G O'Doherty
Centre for Public Health, Queens University Belfast, Institute of Clinical Science B, Belfast, UK
Int J Vitam Nutr Res 81:21-33. 2011....
- Effect of supplementation with B vitamins and antioxidants on levels of asymmetric dimethylarginine (ADMA) and C-reactive protein (CRP): a double-blind, randomised, factorial design, placebo-controlled trialMark G O'Doherty
School of Medicine, Dentistry and Biomedical Sciences, Queen s University, Belfast, UK
Eur J Nutr 49:483-92. 2010....
- Bilirubin and coronary heart disease risk in the Prospective Epidemiological Study of Myocardial Infarction (PRIME)Judith A Troughton
Faculty of Medicine, Queen s University Belfast, Northern Ireland, UK
Eur J Cardiovasc Prev Rehabil 14:79-84. 2007..We tested the hypothesis that higher bilirubin, a bile pigment possessing antioxidant properties, is associated with decreased coronary heart disease risk...
- Obesity and periodontitis in 60-70-year-old menGerry Linden
Oral Science Research Centre, School of Dentistry, Queen s University, Belfast, UK
J Clin Periodontol 34:461-6. 2007..The study also explored whether a high body mass index (BMI) in early life predicted poor periodontal status in later life...
- A multiple biomarker risk score for guiding clinical decisions using a decision curve approachMaria F Hughes
UKCRC Centre of Excellence for Public Health, School of Medicine Dentistry and Biomedical Sciences, Institute of Clinical Sciences B, Queens University Belfast, Grosvenor Road, Belfast, BT12 6BJ, UK
Eur J Prev Cardiol 19:874-84. 2012....
- All-cause mortality and periodontitis in 60-70-year-old men: a prospective cohort studyGerard J Linden
Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Belfast, Northern Ireland, UK
J Clin Periodontol 39:940-6. 2012..To investigate the association between periodontitis and mortality from all causes in a prospective study in a homogenous group of 60- to 70-year-old West European men...
- Genetic markers enhance coronary risk prediction in men: the MORGAM prospective cohortsMaria F Hughes
UKCRC Centre of Excellence for Public Health, Queens University of Belfast, Belfast, Northern Ireland, United Kingdom
PLoS ONE 7:e40922. 2012..We hypothesised that a multilocus genetic risk score could refine CHD prediction beyond classic risk scores and obtain more precise risk estimates using a prospective cohort design...
- Education, socioeconomic and lifestyle factors, and risk of coronary heart disease: the PRIME StudyJ Yarnell
Belfast MONICA, Department of Epidemiology and Public Health, Queen s University Belfast, Belfast, UK
Int J Epidemiol 34:268-75. 2005..We have examined the contribution of socio-economic factors to risk of CHD in a large cohort study in France and Northern Ireland...
- Homocysteine and coronary heart disease risk in the PRIME studyJ A Troughton
Faculty of Medicine, Queen s University Belfast, Belfast, Northern Ireland, UK
Atherosclerosis 191:90-7. 2007..We investigated: (1) whether higher homocysteine is associated with increased CHD risk in the PRIME case-control cohort; (2) whether homocysteine interacts synergistically with pre-existing CHD risk factors...
- Family-based association studies of lipid gene polymorphisms in coronary artery diseaseAdrian Allen
Department of Medicine, Queen s University Belfast, Belfast, Northern Ireland, UK
Am J Cardiol 96:52-5. 2005..0083) to affected patients of the hepatic lipase -514 T allele, which suggests that this may constitute a novel disease-susceptibility locus...
- Association of European population levels of thrombotic and inflammatory factors with risk of coronary heart disease: the MONICA Optional Haemostasis StudyJohn Yarnell
Department of Epidemiology and Public Health, Queen s University of Belfast, UK
Eur Heart J 26:332-42; discussion 317-8. 2005..We therefore measured thrombotic and inflammatory markers in a substudy of the WHO MONICA project and correlated these with CHD event rates...
- Angiographically confirmed coronary heart disease and periodontal disease in middle-aged malesJames E Briggs
Oral Science Research Centre, School of Dentistry, Queen s University, Belfast, Northern Ireland, UK
J Periodontol 77:95-102. 2006..The aim of this study was to investigate whether an association could be demonstrated between coronary heart disease (CHD) and chronic periodontitis in a population of middle-aged males in Northern Ireland...
- The matrix metalloproteinase-3 (MMP-3) 5A/6A promoter polymorphism is not associated with ischaemic heart disease: analysis employing a family based approachPaul G McGlinchey
Regional Medical Cardiology Centre, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, UK
Dis Markers 20:289-94. 2004..Our data demonstrate that, in an Irish population, the MMP-3 -1612 5A/6A polymorphism is not associated with IHD...
- Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: a double-blind, randomized, factorial-design, controlled trialJ V Woodside
School of Clinical Medicine, The Queen s University of Belfast, United Kingdom
Am J Clin Nutr 67:858-66. 1998..Supplementation with the B-group vitamins with or without antioxidants reduced homocysteine in the men with mildly elevated concentrations, and hence may be effective in reducing cardiovascular risk...
- Apolipoprotein E alleles in nonagenarian subjects in the Belfast Elderly Longitudinal Free-living Ageing Study (BELFAST)I M Rea
Department of Geriatric Medicine, The Queen s University, Belfast BT7 1NN, UK
Mech Ageing Dev 122:1367-72. 2001..1; P=0.0006), the E3 unchanged and E2 frequency was increased (X(2)=4.0; P=0.047). These results suggest that longevity is negatively associated with the E4 allele and may be associated with carriage of E2...
- Infection with virulent strains of Helicobacter pylori is not associated with ischaemic heart disease: evidence from a population-based case-control study of myocardial infarctionL J Murray
Department of Epidemiology and Public Health, The Queen s University of Belfast, Mulhouse Building, Grosvenor Road, Belfast, UK
Atherosclerosis 149:379-85. 2000..Although the majority of evidence does not support association between Helicobacter pylori infection and ischaemic heart disease, the nature of this relationship may differ when virulence of the infecting strains are examined...
- Depressed mood and dietary fish intake: direct relationship or indirect relationship as a result of diet and lifestyle?K M Appleton
School of Psychology, Queen s University Belfast, 18 30 Malone Road, Belfast, BT9 5BP, United Kingdom
J Affect Disord 104:217-23. 2007..However, while diet is not measured and until lifestyle can be adequately measured, the potential roles of diet and lifestyle in the association between depressed mood and dietary fish intake should not be ignored...
- Type A behaviour and consumption of an atherogenic diet: no association in the PRIME studyK M Appleton
School of Psychology, Queen s University of Belfast, 18 30 Malone Road, Belfast BT9 5BP, UK
Appetite 49:554-60. 2007..These findings suggest that any association between Type A behaviour and CHD is unlikely to be mediated through diet...
- Cytokine phenotype, genotype, and renal outcomes at cardiac surgeryWilliam T McBride
Department of Cardiac Anaesthesia, Belfast Health and Social Care Trust, Belfast BT12 6BA, Northern Ireland, UK
Cytokine 61:275-84. 2013..Since angiotensin-2 (AG2), modulates TGFβ1 production, we determined whether angiotensin converting enzyme insertion/deletion (ACE I/D) genotype affects urinary TGFβ1 phenotype as well as renal outcome...
- The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern IrelandChristopher B Kelly
Department of Mental Health, Queen s University Belfast, Belfast BT9 7BL, UK
J Psychopharmacol 18:567-71. 2004..03). Serum levels of folate, homocysteine and vitamin B(12) did not differ significantly between groups. A MTHFR C677T genotype is associated with increased risk of depressive episodes in this homogenous patient population...
- Alcohol increases homocysteine and reduces B vitamin concentration in healthy male volunteers--a randomized, crossover intervention studyA Gibson
Centre for Clinical and Population Science, Queen s University Belfast, Belfast, UK
QJM 101:881-7. 2008..Few studies have examined the effect of alcohol consumption on total homocysteine (tHcy) concentrations...
- Family history, longevity, and risk of coronary heart disease: the PRIME StudyJohn Yarnell
Belfast MONICA, Department of Epidemiology and Public Health, Queen s University Belfast, Belfast, UK
Int J Epidemiol 32:71-7. 2003..To assess the contribution of family history of coronary heart disease (CHD) and longevity in parents to 5-year incidence of coronary events in middle-aged men...
- Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular riskStefan Blankenberg
Department of Medicine II, Johannes Gutenberg University Mainz, Mainz, Germany
Circ Res 99:102-8. 2006..The role of CASP1 genetic variations in the susceptibility to myocardial infarction requires further investigation...
- Polymorphisms of the beta2 -adrenoceptor (ADRB2) gene and essential hypertension: the ECTIM and PEGASE studiesStefan Martin Herrmann
Institut National de la Santé et de la Recherche Médicale Inserm SC7 U525, Paris, France
J Hypertens 20:229-35. 2002..We investigated whether genetic variation of the ADRB2 gene might be related to essential hypertension or myocardial infarction (MI)...
- Lipoprotein (a) as a predictor of coronary heart disease: the PRIME StudyGerald Luc
Department of Atherosclerosis, INSERM UR545, Pasteur Institute of Lille, 1, rue du Professeur Calmette, France and University Lille II, France
Atherosclerosis 163:377-84. 2002..This study which analyzed Lp(a) level using a measurement independent of apolipoprotein (a) size on fresh plasma, has confirmed utility of Lp(a) as a predictor of CHD...
- Plasma cystatin-C and development of coronary heart disease: The PRIME StudyGerald Luc
Department of Atherosclerosis, SERLIA INSERM UR545, Institut Pasteur de Lille, 1, rue du Professeur Calmette, 59019 Lille Cedex, France and University Lille II, France
Atherosclerosis 185:375-80. 2006..Cystatin-C is not a more predictive risk marker of CHD than CRP or interleukin-6, but could be useful in detecting moderate chronic renal disease...
- The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo EuropeNadia Haddy
INSERM U 525 Equipe 4, 30 rue Lionnois, 54000 Nancy, France
Eur J Hum Genet 10:841-50. 2002..Total cholesterol and TG concentrations were significantly dependent on apoE genotype in both sexes. These differences in lipids between genotypes were more pronounced when plasma apoE concentrations were taken into account...
- Sex hormone-binding globulin is a major determinant of the lipid profile: the PRIME studyVincent Bataille
INSERM U 558, Faculte de Medecine, Département d Epidémiologie, 37 Allees Jules Guesde, 31073 Toulouse Cedex, France
Atherosclerosis 179:369-73. 2005..0001). The association between SHBG and TG was weakened but remained also significant. Our results suggest that SHBG might to be a central protein in the hormonal regulation of the lipid profile...
- Body mass index, hypertension and 5-year coronary heart disease incidence in middle aged men: the PRIME studyAba Mahamat
Monica Lille, INSERM U 508, Institut Pasteur de Lille, 1 rue du Prof Calmette, 59019 Lille Cedex, France
J Hypertens 21:519-24. 2003..DESIGN Prospective study on men aged 50-59 years free of coronary heart disease at entry recruited in three regions of France (n = 7359) and in Northern Ireland (n = 2399)...
- Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and incident coronary heart disease: the PRIME StudyGerald Luc
Department of Atherosclerosis, SERLIA INSERM UR325, Institut Pasteur de Lille, 1, rue du Professeur Calmette, 59019 Lille, France
Atherosclerosis 170:169-76. 2003....
- Alcohol consumption and cardiovascular disease: differential effects in France and Northern Ireland. The PRIME studyPedro Marques-Vidal
INSERM U558, Faculte de Medecine Purpan, Toulouse, France
Eur J Cardiovasc Prev Rehabil 11:336-43. 2004..The effects of wine and other alcoholic beverages on coronary heart disease (CHD) have seldom been studied in several countries using a common methodology...
- C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: the PRIME StudyGerald Luc
Department of Atherosclerosis, SERLIA INSERM UR545, Institut Pasteur de Lille and University Lille II, 1 rue du Professeur Calmette, 59019 Lille Cedex, France
Arterioscler Thromb Vasc Biol 23:1255-61. 2003....
- Interleukin-18 and the risk of coronary heart disease in European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME)Stefan Blankenberg
INSERM U525, Faculté de Médecine Pitié Salpêtrière, Paris, France
Circulation 108:2453-9. 2003..Interleukin (IL)-18 promotes atherosclerotic plaque growth and vulnerability. It is unknown, however, whether elevations of circulating IL-18 precede the onset of coronary events in apparently healthy individuals...
- Lycopene status is not associated with insulin-like growth factor-1 concentration in a healthy male populationRyan Graydon
Nutrition and Metabolism Group, Centre for Clinical and Population Science, Queen s University Belfast, BT12 6BJ Northern Ireland
Int J Vitam Nutr Res 77:75-8. 2007..The aim of this study was to assess the relationship between lycopene and insulin-like growth factor-1 levels in a healthy male population...
- Awareness, treatment and control of hyperlipidaemia in middle-aged men in France and northern ireland in 1991-1993: the PRIME study. Prospective epidemiological study of myocardial infarctionPedro Marques-Vidal
INSERM U558, Faculte de Medecine Purpan, Toulouse, France
Acta Cardiol 57:117-23. 2002..To assess how well screening and preventive measures are implemented in the general population...
- Neutrophil elastase gene variation and coronary heart diseaseJacqueline Schönfelder
Department of Molecular Genetics of Cardiovascular Disease, Leibniz Institute for Arteriosclerosis Research, University of Muenster, Muenster, Germany
Pharmacogenet Genomics 17:629-37. 2007..Identification and functional characterization of variants in the neutrophil elastase (ELA2) gene in cardiovascular disease...
- Lack of association between complement factor H polymorphisms and coronary artery disease or myocardial infarctionViviane Nicaud
INSERM UMR S525, Faculté de Médecine Pitié Salpêtrière, 91 Boulevard de l Hopital, Paris, 75013, France
J Mol Med (Berl) 85:771-5. 2007..Genotype and allele frequencies were similar in cases and controls. These results do not support an involvement of common nonsynonymous polymorphisms of the CFH gene in predisposition to CAD and its complications...
- High expressor paraoxonase PON1 gene promoter polymorphisms are associated with reduced risk of vascular disease in younger coronary patientsIlia Leviev
Clinical Diabetes Unit, Division of Endocrinology and Diabetes, University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
Atherosclerosis 161:463-7. 2002..The data are consistent with the high expressor promoter genotype being linked to reduced risk of myocardial infarction. The influence of the genotype may be compromised in older patients...
- Physical activity and coronary event incidence in Northern Ireland and France: the Prospective Epidemiological Study of Myocardial Infarction (PRIME)Aline Wagner
Laboratoire d épidémiologie et de santé publique, Strasbourg, France
Circulation 105:2247-52. 2002....
- Serotonin transporter gene polymorphism and myocardial infarction: Etude Cas-Témoins de l'Infarctus du Myocarde (ECTIM)Frederic Fumeron
EA 3516, Faculte de Medecine Xavier Bichat, Paris, France
Circulation 105:2943-5. 2002..A functional polymorphism in the promoter region of the SLC6A4 gene has been described. This polymorphism may be associated with the risk of MI...
- Value of HDL cholesterol, apolipoprotein A-I, lipoprotein A-I, and lipoprotein A-I/A-II in prediction of coronary heart disease: the PRIME Study. Prospective Epidemiological Study of Myocardial InfarctionGerald Luc
Department of Atherosclerosis, INSERM UR545, Institut Pasteur de Lille, and University Lille II, Lille, France
Arterioscler Thromb Vasc Biol 22:1155-61. 2002..We have examined the association between the incidence of coronary heart disease (CHD) and plasma high density lipoprotein (HDL) cholesterol, apolipoprotein A-I (apoA-I), and 2 HDL fractions, lipoprotein A-I and lipoprotein A-I:A-II...
- Plasma fibrinogen explains much of the difference in risk of coronary heart disease between France and Northern Ireland. The PRIME studyPierre Yves Scarabin
Cardiovascular Epidemiology Unit U258, INSERM, 16, avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
Atherosclerosis 166:103-9. 2003..These findings add to the epidemiological evidence that elevated fibrinogen is a major risk factor for coronary heart disease...
- Association between TAFI antigen and Ala147Thr polymorphism of the TAFI gene and the angina pectoris incidence. The PRIME Study (Prospective Epidemiological Study of MI)Pierre E Morange
Department of Hematology, Hospital de la Timone, INSERM 99 36 Marseilles, France
Thromb Haemost 89:554-60. 2003..7 (95%CI 1.2-5.8). Increase in plasma TAFI antigen levels is a risk factor for angina pectoris in France. Genotyping for the Ala147Thr polymorphism seems to be a reliable tool to assess the risk mediated by TAFI...
- Ethical issues and GenomEUtwinJennifer R Harris
Division of Epidemiology, Department of Genes and Environment, The Norwegian Institute of Public Health, Oslo, Norway
Twin Res 6:455-63. 2003..Finally, the role of empirically based ethics research is discussed for understanding the ethical, legal, social and economic implications of human genetics and genomics research...
- Polymorphism R92Q of the tumour necrosis factor receptor 1 gene is associated with myocardial infarction and carotid intima-media thickness--the ECTIM, AXA, EVA and GENIC StudiesOdette Poirier
INSERM U525, Epidemiologic and Molecular Genetics of Cardiovascular Diseases, Paris, France
Eur J Hum Genet 12:213-9. 2004..70 (0.09) vs 0.67 (0.13), P=0.02). No significant association of the 92Q allele was found with BI in the GENIC Study. Overall, these results may suggest that carriers of the 92Q allele may be at increased risk of atherosclerosis...
- Residual coronary risk in men aged 50-59 years treated for hypertension and hyperlipidaemia in the population: the PRIME studyJacques Blacher
INSERM U 258, Hopital Paul Brousse, Villejuif, France
J Hypertens 22:415-23. 2004..e. their 'residual coronary risk')...
- Frequency of fruit and vegetable consumption and coronary heart disease in France and Northern Ireland: the PRIME studyLuc Dauchet
Monica Lille, INSERM U 508, Institut Pasteur de Lille, 1 rue du Prof Calmette, 59019 Lille, France
Br J Nutr 92:963-72. 2004....
- Genetic stratification of pathogen-response-related and other variants within a homogeneous Caucasian Irish populationCiara Dolan
Institute for Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
Eur J Hum Genet 13:798-806. 2005..This suggests that the specific population structure of particular genes may not typically be a cause of strong confounding in genetic studies where population structure is controlled...
- In-depth haplotype analysis of ABCA1 gene polymorphisms in relation to plasma ApoA1 levels and myocardial infarctionDavid Alexandre Tregouet
INSERM U525, Faculté de Médecine de la Pitié Salpétrière, Paris, France
Arterioscler Thromb Vasc Biol 24:775-81. 2004..Twenty-six polymorphisms of the ABCA1 gene were genotyped and tested for association with plasma levels of ApoA1 and myocardial infarction (MI) in the ECTIM study...
- Further evidence that the UGT1A1*28 allele is not associated with coronary heart disease: The ECTIM StudyVincent Gajdos
Clin Chem 52:2313-4. 2006
- A novel cholesteryl ester transfer protein promoter polymorphism (-971G/A) associated with plasma high-density lipoprotein cholesterol levels. Interaction with the TaqIB and -629C/A polymorphismsWilfried Le Goff
Institut National de la Sante et de la Recherche Medicale, Hopital de la Pitie, Unité 321 Lipoprotéines et Athérogénèse, Pavillon Benjamin Delessert, 83 Boulevard de l Hôpital 75651 Paris 13, France
Atherosclerosis 161:269-79. 2002....