Madeleine Ennis

Summary

Affiliation: Queen's University Belfast
Country: UK

Publications

  1. ncbi request reprint Neutrophils in asthma pathophysiology
    Madeleine Ennis
    Department of Clinical Biochemistry, Institute of Clinical Science, The Queen s University of Belfast, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, UK
    Curr Allergy Asthma Rep 3:159-65. 2003
  2. doi request reprint Basophil models of homeopathy: a sceptical view
    Madeleine Ennis
    Respiratory Medicine Research Group, Centre for Infection and Immunity, Microbiology Building, The Queen s University of Belfast, Grosvenor Road, Belfast BT12 6BN, Northern Ireland, UK
    Homeopathy 99:51-6. 2010
  3. doi request reprint Inflammatory and cytotoxic effects of acrolein, nicotine, acetylaldehyde and cigarette smoke extract on human nasal epithelial cells
    David M Comer
    Centre for Infection and Immunity, Health Sciences Building, School of Medicine, Dentistry and Biomedical Sciences, Queen s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
    BMC Pulm Med 14:32. 2014
  4. doi request reprint Development of primary human nasal epithelial cell cultures for the study of cystic fibrosis pathophysiology
    F de Courcey
    Centre for Infection and Immunity, Queen s University Belfast, Health Sciences Building, Belfast, UK
    Am J Physiol Cell Physiol 303:C1173-9. 2012
  5. ncbi request reprint Adverse reactions to drugs: in vitro studies with isolated cells
    M Ennis
    Respiratory Research Group, Department of Clinical Biochemistry and Metabolic Medicine, Institute of Clinical Science, The Queen s University of Belfast, Grosvenor Road, BT12 6BJ, Belfast, Northern Ireland, UK
    Inflamm Res 53:S105-8. 2004
  6. ncbi request reprint New targets for modifying mast cell activation in asthma
    Madeleine Ennis
    Respiratory Research Group, School of Medicine and Dentistry, The Queen s University of Belfast, Institute of Clinical Science, Grosvenor Road, Belfast BT12 6BJ, UK
    Curr Allergy Asthma Rep 6:247-51. 2006
  7. doi request reprint Expression of the inflammatory regulator A20 correlates with lung function in patients with cystic fibrosis
    Catriona Kelly
    Centre for Infection and Immunity, Queen s University of Belfast, Belfast BT97AE, UK
    J Cyst Fibros 12:411-5. 2013
  8. doi request reprint Toll-like receptor 4 is not targeted to the lysosome in cystic fibrosis airway epithelial cells
    Catriona Kelly
    Centre for Infection and Immunity, Queen s University of Belfast, Belfast, UK
    Am J Physiol Lung Cell Mol Physiol 304:L371-82. 2013
  9. doi request reprint Expression of the nuclear factor-κB inhibitor A20 is altered in the cystic fibrosis epithelium
    Catriona Kelly
    Centre for Infection and Immunity, Queen s University of Belfast, Belfast, UK
    Eur Respir J 41:1315-23. 2013
  10. pmc Comparison of nasal and bronchial epithelial cells obtained from patients with COPD
    David M Comer
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, The Queen s University of Belfast, Belfast, United Kingdom
    PLoS ONE 7:e32924. 2012

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Neutrophils in asthma pathophysiology
    Madeleine Ennis
    Department of Clinical Biochemistry, Institute of Clinical Science, The Queen s University of Belfast, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, UK
    Curr Allergy Asthma Rep 3:159-65. 2003
    ..Measurements of inflammatory mediators in the airways of asthmatic subjects suggest that neutrophils are activated...
  2. doi request reprint Basophil models of homeopathy: a sceptical view
    Madeleine Ennis
    Respiratory Medicine Research Group, Centre for Infection and Immunity, Microbiology Building, The Queen s University of Belfast, Grosvenor Road, Belfast BT12 6BN, Northern Ireland, UK
    Homeopathy 99:51-6. 2010
    ..After standardization of a number of parameters, it is recommended that a multi-centre trial be performed to hopefully put an end to this "never-ending story"...
  3. doi request reprint Inflammatory and cytotoxic effects of acrolein, nicotine, acetylaldehyde and cigarette smoke extract on human nasal epithelial cells
    David M Comer
    Centre for Infection and Immunity, Health Sciences Building, School of Medicine, Dentistry and Biomedical Sciences, Queen s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
    BMC Pulm Med 14:32. 2014
    ....
  4. doi request reprint Development of primary human nasal epithelial cell cultures for the study of cystic fibrosis pathophysiology
    F de Courcey
    Centre for Infection and Immunity, Queen s University Belfast, Health Sciences Building, Belfast, UK
    Am J Physiol Cell Physiol 303:C1173-9. 2012
    ..Thus nasal epithelial cells from patients with CF can be grown from nasal brushings and used in electrophysiological and mediator release studies in CF research...
  5. ncbi request reprint Adverse reactions to drugs: in vitro studies with isolated cells
    M Ennis
    Respiratory Research Group, Department of Clinical Biochemistry and Metabolic Medicine, Institute of Clinical Science, The Queen s University of Belfast, Grosvenor Road, BT12 6BJ, Belfast, Northern Ireland, UK
    Inflamm Res 53:S105-8. 2004
    ....
  6. ncbi request reprint New targets for modifying mast cell activation in asthma
    Madeleine Ennis
    Respiratory Research Group, School of Medicine and Dentistry, The Queen s University of Belfast, Institute of Clinical Science, Grosvenor Road, Belfast BT12 6BJ, UK
    Curr Allergy Asthma Rep 6:247-51. 2006
    ..In each case, where data are available, the action of the agents on human lung mast cells is described...
  7. doi request reprint Expression of the inflammatory regulator A20 correlates with lung function in patients with cystic fibrosis
    Catriona Kelly
    Centre for Infection and Immunity, Queen s University of Belfast, Belfast BT97AE, UK
    J Cyst Fibros 12:411-5. 2013
    ..A20 expression is altered in F508del/F508del patients. Here we explore the effect of CFTR and CFTR genotype on A20 and TAX1BP1 expression. The relationship with lung function is also assessed...
  8. doi request reprint Toll-like receptor 4 is not targeted to the lysosome in cystic fibrosis airway epithelial cells
    Catriona Kelly
    Centre for Infection and Immunity, Queen s University of Belfast, Belfast, UK
    Am J Physiol Lung Cell Mol Physiol 304:L371-82. 2013
    ..This defect may account for the prolonged cycle of chronic inflammation associated with CF...
  9. doi request reprint Expression of the nuclear factor-κB inhibitor A20 is altered in the cystic fibrosis epithelium
    Catriona Kelly
    Centre for Infection and Immunity, Queen s University of Belfast, Belfast, UK
    Eur Respir J 41:1315-23. 2013
    ..The expression of A20 is significantly altered in CF, and important interactions with complex members and target proteins are lost, which may contribute to the state of chronic NF-κB-driven inflammation...
  10. pmc Comparison of nasal and bronchial epithelial cells obtained from patients with COPD
    David M Comer
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, The Queen s University of Belfast, Belfast, United Kingdom
    PLoS ONE 7:e32924. 2012
    ..In subjects with COPD, nasal epithelial cells cannot substitute for in vitro bronchial epithelial cells in airway inflammation studies...
  11. doi request reprint Airway epithelial cell apoptosis and inflammation in COPD, smokers and nonsmokers
    David M Comer
    Belfast City Hospital, Belfast, UK
    Eur Respir J 41:1058-67. 2013
    ..CSE attenuates inflammatory responses to LPS in cells from people with COPD but not those from nonsmoking individuals and those who smoke without airflow obstruction...
  12. ncbi request reprint The effect of treatment of cystic fibrosis pulmonary exacerbations on airways and systemic inflammation
    Damian G Downey
    Respiratory Research Group, Queens University of Belfast, Belfast, Northern Ireland, UK
    Pediatr Pulmonol 42:729-35. 2007
    ..The aims of this study were to investigate the change of inflammatory biomarkers and cells within sputum and blood before and after intravenous antibiotics for a pulmonary exacerbation of CF...
  13. ncbi request reprint Exhaled nitric oxide in relation to the clinical features of childhood asthma
    Timothy J Warke
    Department of Child Health, The Queen s University of Belfast, Northern Ireland, UK
    J Asthma 41:751-7. 2004
    ..The aim of this study was to examine children attending a routine asthma clinic and evaluate the relationship between ENO levels and clinical parameters including decision making...
  14. doi request reprint Anti-inflammatory effects of DX-890, a human neutrophil elastase inhibitor
    Fiona K Dunlevy
    Centre for Infection and Immunity, Queens University Belfast, Belfast BT9 7BL, UK
    J Cyst Fibros 11:300-4. 2012
    ..We investigated if DX-890, a small-protein NE inhibitor, could reduce neutrophil trans-epithelial migration and reduce activity released from neutrophils and NE-induced cytokine expression in airway epithelial cells...
  15. doi request reprint Effect of fruit and vegetable intake on oxidative stress and inflammation in COPD: a randomised controlled trial
    Francina R Baldrick
    Centre for Public Health, School of Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Belfast, UK
    Eur Respir J 39:1377-84. 2012
    ....
  16. pmc Dysregulated apoptosis and NFkappaB expression in COPD subjects
    Vanessa Brown
    Respiratory Research Group, Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Belfast, UK
    Respir Res 10:24. 2009
    ....
  17. ncbi request reprint Bronchial epithelial cell growth regulation in fibroblast cocultures: the role of hepatocyte growth factor
    Grzegorz Skibinski
    Respiratory Medicine Research Cluster, School of Medicine and Dentistry, Queen s University Belfast, Belfast, Northern Ireland, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 293:L69-76. 2007
    ....
  18. ncbi request reprint Mast cell mediator release in nonasthmatic subjects after endobronchial adenosine challenge
    Fionnuala Crummy
    Respiratory Research Group, Inflammation Research Centre, Department of Medicine, Queen s University of Belfast, Ireland
    J Allergy Clin Immunol 114:34-9. 2004
    ....
  19. ncbi request reprint Endobronchial adenosine monophosphate challenge causes tachykinin release in the human airway
    Fionnuala Crummy
    Respiratory Research Group, School of Medicine, Queen s University of Belfast, Belfast
    J Allergy Clin Immunol 116:312-7. 2005
    ..This response is attenuated after repeated inhalation of bradykinin, suggesting that AMP may act in part by the release of neuropeptides...
  20. doi request reprint Effect of Aspergillus fumigatus and Candida albicans on pro-inflammatory response in cystic fibrosis epithelium
    James A Reihill
    Respiratory Medicine Research Group, Centre for Infection and Immunity, Queens University Belfast, Health Sciences Building, 97 Lisburn Road, Belfast, Northern Ireland, BT9 7BL, UK
    J Cyst Fibros 10:401-6. 2011
    ....
  21. ncbi request reprint Comparison of sputum induction using high-output and low-output ultrasonic nebulizers in normal subjects and patients with COPD
    Martin G Kelly
    Department of Respiratory Medicine, Belfast City Hospital, Northern Ireland
    Chest 122:955-9. 2002
    ..We hypothesized that a low-output nebulizer would give comparable results to a high-output nebulizer, with an acceptable safety profile...
  22. doi request reprint Does airway allergic inflammation pre-exist before late onset wheeze in children?
    Surendran Thavagnanam
    Centre for Infection and Immunity, Queen s University of Belfast, Hospital for Sick Children, Belfast, Northern Ireland, UK
    Pediatr Allergy Immunol 21:1002-7. 2010
    ..Before late onset childhood wheezing developed, we found evidence of elevated eosinophils in the airways. These data suggest pre-existent airways inflammation in childhood asthma some years before clinical presentation...
  23. doi request reprint Lung clearance index is a repeatable and sensitive indicator of radiological changes in bronchiectasis
    Stephen A Rowan
    1 Centre for Infection and Immunity, Queen s University of Belfast, Belfast, United Kingdom
    Am J Respir Crit Care Med 189:586-92. 2014
    ..The lung clearance index has the potential to be a useful clinical and research tool in patients with bronchiectasis. ..
  24. pmc Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation
    Michael M Tunney
    Cystic Fibrosis and Airways Microbiology Research Group, School of Medicine, Dentistry, and Biomedical Sciences, Queen s University Belfast, Belfast, United Kingdom
    Am J Respir Crit Care Med 187:1118-26. 2013
    ..Characterization of bacterial populations in infectious respiratory diseases will provide improved understanding of the relationship between the lung microbiota, disease pathogenesis, and treatment outcomes...
  25. ncbi request reprint Frequency of cytokine gene promoter polymorphisms in the Northern Ireland cystic fibrosis population
    Alison P Watt
    Respiratory Research Group, The Queen s University of Belfast, United Kingdom
    J Cyst Fibros 6:363-5. 2007
    ..This study observed no differences in the frequency of cytokine promoter polymorphisms associated with variant levels of expression in patients with CF and a non-CF population of Northern Ireland...
  26. ncbi request reprint Association of improved pulmonary phenotype in Irish cystic fibrosis patients with a 3' enhancer polymorphism in alpha-1-antitrypsin
    Julia M Courtney
    Respiratory Research Group, Department of Medicine, Queen s University of Belfast, Belfast, UK
    Pediatr Pulmonol 41:584-91. 2006
    ..This lack of a demonstrable functional effect in vivo suggests that the polymorphism is a marker for a modifying effect on pulmonary phenotype in the Irish CF population by a mechanism that is yet to be explained...
  27. pmc Staphylococcus aureus enterotoxins induce IL-8 secretion by human nasal epithelial cells
    Garrett J O'Brien
    Respiratory Research Group, School of Medicine and Dentistry, Queen s University Belfast, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, UK
    Respir Res 7:115. 2006
    ..Staphylococcus aureus produces a set of proteins which act both as superantigens and toxins. Although their mode of action as superantigens is well understood, little is known about their effects on airway epithelial cells...
  28. doi request reprint Raman microscopy in the diagnosis and prognosis of surgically resected nonsmall cell lung cancer
    Nicholas David Magee
    The Queen s University of Belfast, Centre for Infection and Immunity, Respiratory Medicine Research Group, Microbiology Building, Grosvenor Road, Belfast, BT12 6BN United Kingdom
    J Biomed Opt 15:026015. 2010
    ..Raman microscopy can be a useful technique for the diagnosis and prognosis of lung cancer patients receiving surgery, and for elucidating the biochemical properties of lung tumors...
  29. doi request reprint Population structure and characterization of viridans group streptococci (VGS) including Streptococcus pneumoniae isolated from adult patients with cystic fibrosis (CF)
    Yasunori Maeda
    Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital, Lisburn Road, Belfast, Northern Ireland, BT9 7AD, UK
    J Cyst Fibros 10:133-9. 2011
    ..None of the non-CF VGS organisms were resistant to ciprofloxacin, but 42% showed intermediate resistance...
  30. doi request reprint Ex vivo diagnosis of lung cancer using a Raman miniprobe
    Nicholas D Magee
    Respiratory Medicine Research Group, Centre for Infection and Immunity, Microbiology Building, Queens University Belfast, Grosvenor Road, Belfast, BT12 6BN, United Kingdom
    J Phys Chem B 113:8137-41. 2009
    ..Using principal component analysis with a leave-one-out analysis, the tissues were classified accurately. This novel technique has the potential to obtain Raman spectra from tumors from patients with lung cancer in vivo...
  31. ncbi request reprint Effect of cystic fibrosis exacerbations on neutrophil function
    Simon Brockbank
    Respiratory Research Group, Inflammation Research Centre, The Queen s University of Belfast, Northern Ireland, UK
    Int Immunopharmacol 5:601-8. 2005
    ..Neutrophils from CF patients displayed a different pattern of response than those from control subjects; however, CF exacerbations did not appear to modulate neutrophil function...
  32. ncbi request reprint Possible association between passive smoking and lower exhaled nitric oxide in asthmatic children
    Timothy J Warke
    Department of Child Health, The Queen s University of Belfast Belfast, Northern Ireland, UK
    Arch Environ Health 58:613-6. 2003
    ..Consequently, ETS exposure may need to be considered when physicians interpret eNO levels in asthmatic children. Further study of the effects of ETS on eNO levels is recommended...
  33. ncbi request reprint Interleukin-4 and interleukin-4 soluble receptor alpha levels in bronchoalveolar lavage from children with asthma
    Patrick S Fitch
    Department of Clinical Biochemistry, The Queen s University of Belfast, The Institute of Clinical Science, Belfast, Northern Ireland, United Kingdom
    Ann Allergy Asthma Immunol 90:429-33. 2003
    ..In asthma there is increased expression of the Th2-type cytokine interleukin-4 (IL-4). IL-4 is important in immunoglobulin isotype switching to immunoglobulin E and adhesion of eosinophils to endothelium...
  34. ncbi request reprint Antioxidants and oxidative stress in BAL fluid of atopic asthmatic children
    Bettina C Schock
    Department of Clinical Biochemistry, The Queen s University of Belfast, Belfast BT12 6BJ, Northern Ireland, UK
    Pediatr Res 53:375-81. 2003
    ..Overall, increased bronchoalveolar lavage eosinophils indicate ongoing airway inflammation, which may increase oxidatively modified proteins as reflected by increased protein carbonyl concentrations...
  35. ncbi request reprint The use of Raman microscopy to determine and localize vitamin E in biological samples
    J Renwick Beattie
    Queen s University Belfast, School of Chemistry and Chemical Engineering, UK
    FASEB J 21:766-76. 2007
    ....