Ryan F Donnelly

Summary

Affiliation: Queen's University Belfast
Country: UK

Publications

  1. ncbi request reprint Antifungal photodynamic therapy
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, Belfast, UK
    Microbiol Res 163:1-12. 2008
  2. pmc Microneedle mediated intradermal delivery of adjuvanted recombinant HIV-1 CN54gp140 effectively primes mucosal boost inoculations
    Aditya Pattani
    School of Pharmacy, Queen s University Belfast, Belfast BT9 7BL, UK
    J Control Release 162:529-37. 2012
  3. doi request reprint Hydrogel-forming microneedle arrays exhibit antimicrobial properties: potential for enhanced patient safety
    Ryan F Donnelly
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    Int J Pharm 451:76-91. 2013
  4. doi request reprint Microneedle-mediated vaccine delivery: harnessing cutaneous immunobiology to improve efficacy
    Sharifa Al-Zahrani
    School of Pharmacy, University Belfast, Belfast, UK
    Expert Opin Drug Deliv 9:541-50. 2012
  5. ncbi request reprint Influence of solution viscosity and injection protocol on distribution patterns of jet injectors: application to photodynamic tumour targeting
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Photochem Photobiol B 89:98-109. 2007
  6. ncbi request reprint Design and physicochemical characterisation of a bioadhesive patch for dose-controlled topical delivery of imiquimod
    Ryan F Donnelly
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, Belfast BT9 7BL, UK
    Int J Pharm 307:318-25. 2006
  7. ncbi request reprint Development and validation of procedures for assessment of competency of non-pharmacists in extemporaneous dispensing
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, Belfast, UK
    Int J Pharm Pract 17:67-71. 2009
  8. pmc Microneedle-based drug delivery systems: microfabrication, drug delivery, and safety
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Drug Deliv 17:187-207. 2010
  9. pmc Microneedle arrays allow lower microbial penetration than hypodermic needles in vitro
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, Belfast, BT9 7BL, UK
    Pharm Res 26:2513-22. 2009
  10. doi request reprint Microneedle-mediated intradermal delivery of 5-aminolevulinic acid: potential for enhanced topical photodynamic therapy
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Control Release 129:154-62. 2008

Collaborators

Detail Information

Publications77

  1. ncbi request reprint Antifungal photodynamic therapy
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, Belfast, UK
    Microbiol Res 163:1-12. 2008
    ....
  2. pmc Microneedle mediated intradermal delivery of adjuvanted recombinant HIV-1 CN54gp140 effectively primes mucosal boost inoculations
    Aditya Pattani
    School of Pharmacy, Queen s University Belfast, Belfast BT9 7BL, UK
    J Control Release 162:529-37. 2012
    ..This work opens up the possibility for microneedle-based HIV vaccination strategies that, once fully developed, will greatly reduce risk for vaccinators and patients, with those in the developing world set to benefit most...
  3. doi request reprint Hydrogel-forming microneedle arrays exhibit antimicrobial properties: potential for enhanced patient safety
    Ryan F Donnelly
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    Int J Pharm 451:76-91. 2013
    ..However, we are currently working towards a comprehensive specification set for this microneedle system that may inform future developments in this regard...
  4. doi request reprint Microneedle-mediated vaccine delivery: harnessing cutaneous immunobiology to improve efficacy
    Sharifa Al-Zahrani
    School of Pharmacy, University Belfast, Belfast, UK
    Expert Opin Drug Deliv 9:541-50. 2012
    ..Breaching the skin's stratum corneum barrier raises the possibility of the administration of vaccines, gene vectors, antibodies and even nanoparticles, all of which have at least their initial effect on populations of skin cells...
  5. ncbi request reprint Influence of solution viscosity and injection protocol on distribution patterns of jet injectors: application to photodynamic tumour targeting
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Photochem Photobiol B 89:98-109. 2007
    ..0mm and substantial reductions in drug concentration seen at depths below 3.0 mm. Consequently, jet injection may be suitable for selective targeting of ALA or preformed photosensitisers to skin tumours...
  6. ncbi request reprint Design and physicochemical characterisation of a bioadhesive patch for dose-controlled topical delivery of imiquimod
    Ryan F Donnelly
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, Belfast BT9 7BL, UK
    Int J Pharm 307:318-25. 2006
    ....
  7. ncbi request reprint Development and validation of procedures for assessment of competency of non-pharmacists in extemporaneous dispensing
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, Belfast, UK
    Int J Pharm Pract 17:67-71. 2009
    ..This is important given the prospect of remote supervision of community pharmacies in the UK...
  8. pmc Microneedle-based drug delivery systems: microfabrication, drug delivery, and safety
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Drug Deliv 17:187-207. 2010
    ..This review details various types of MNs, fabrication methods and, importantly, investigations of clinical safety of MN...
  9. pmc Microneedle arrays allow lower microbial penetration than hypodermic needles in vitro
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, Belfast, BT9 7BL, UK
    Pharm Res 26:2513-22. 2009
    ..In this study we determined, for the first time, the ability of microorganisms to traverse microneedle-induced holes using two different in vitro models...
  10. doi request reprint Microneedle-mediated intradermal delivery of 5-aminolevulinic acid: potential for enhanced topical photodynamic therapy
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Control Release 129:154-62. 2008
    ..As ALA is expensive and degrades rapidly via a second order reaction, reducing the required dose is also a notable advantage...
  11. doi request reprint Re: Microneedle-mediated intradermal delivery of 5-aminolevulinic acid
    Ryan F Donnelly
    School of Pharmacy, Queens University Belfast, Belfast, UK
    J Control Release 129:153. 2008
  12. ncbi request reprint Photosensitiser delivery for photodynamic therapy. Part 1: Topical carrier platforms
    Ryan F Donnelly
    School of Pharmacy, Medical Biology Centre, Queen s University Belfast, 97 Lisburn Road, Belfast, UK
    Expert Opin Drug Deliv 5:757-66. 2008
    ....
  13. doi request reprint Influence of formulation factors on PpIX production and photodynamic action of novel ALA-loaded microparticles
    Ryan F Donnelly
    Queen s University Belfast, Medical Biology Centre, UK
    Biopharm Drug Dispos 30:55-70. 2009
    ..Following the promising results obtained in this study, work is now going on to prepare particle-loaded gels under GMP conditions with the aim of initiating an exploratory clinical trial...
  14. doi request reprint Microneedle arrays permit enhanced intradermal delivery of a preformed photosensitizer
    Ryan F Donnelly
    School of Pharmacy, Medical Biology Centre, Queen s University Belfast, Belfast, UK
    Photochem Photobiol 85:195-204. 2009
    ..We believe that use of MN array technology in this way has the potential to significantly improve topical photodynamic therapy of skin tumors...
  15. ncbi request reprint Drug delivery systems for photodynamic therapy
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Recent Pat Drug Deliv Formul 3:1-7. 2009
    ..Accordingly, this article deals with the innovations pertaining to drug delivery systems for photodynamic therapy as disclosed in recent patent literature...
  16. pmc Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK
    Pharm Res 28:41-57. 2011
    ..The aim of this study was to optimise polymeric composition and assess the performance of microneedle devices that possess different geometries...
  17. ncbi request reprint Microstructured devices for transdermal drug delivery and minimally-invasive patient monitoring
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, Belfast, UK
    Recent Pat Drug Deliv Formul 1:195-200. 2007
    ..Accordingly, this article deals with the innovations pertaining to microprojection-based devices for transdermal drug delivery and minimally-invasive monitoring as disclosed in recent patent literature...
  18. doi request reprint Microneedle-mediated intradermal nanoparticle delivery: Potential for enhanced local administration of hydrophobic pre-formed photosensitisers
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Photodiagnosis Photodyn Ther 7:222-31. 2010
    ..This study aimed to deliver a model hydrophobic dye, Nile red, into the skin using novel microneedle (MN) technology...
  19. pmc Processing difficulties and instability of carbohydrate microneedle arrays
    Ryan F Donnelly
    Medical Biology Centre, School of Pharmacy, Queen s University Belfast, Belfast, UK
    Drug Dev Ind Pharm 35:1242-54. 2009
    ....
  20. ncbi request reprint Topical bioadhesive patch systems enhance selectivity of protoporphyrin IX accumulation
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, UK
    Photochem Photobiol 82:670-5. 2006
    ..The mechanisms of action of the patch, as compared with that of the cream, were studied by means of Cuprophan barriers that mimic compromised tumor stratum corneum and in a mouse model with transplanted tumors...
  21. ncbi request reprint Pharmaceutical analysis of 5-aminolevulinic acid in solution and in tissues
    Ryan F Donnelly
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Photochem Photobiol B 82:59-71. 2006
    ....
  22. doi request reprint Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution
    Ryan F Donnelly
    School of Pharmacy, Medical Biology Centre, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Control Release 147:333-41. 2010
    ..The successful use of OCT in this study could prove to be a key development for polymeric MN research, accelerating their commercial exploitation...
  23. ncbi request reprint Potential of photodynamic therapy in treatment of fungal infections of the mouth. Design and characterisation of a mucoadhesive patch containing toluidine blue O
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Photochem Photobiol B 86:59-69. 2007
    ..Longer patch application times may be required for persistent disease where biofilms are implicated...
  24. ncbi request reprint Bioadhesive patch-based delivery of 5-aminolevulinic acid to the nail for photodynamic therapy of onychomycosis
    Ryan F Donnelly
    School of Pharmacy, Queens University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    J Control Release 103:381-92. 2005
    ..Moreover, iron chelators can be used to increase PpIX production for a given ALA dose. Therefore, with suitable modifications, ALA-PDT may prove to be a viable alternative in the treatment of onychomycosis...
  25. ncbi request reprint Delivery of photosensitisers and light through mucus: investigations into the potential use of photodynamic therapy for treatment of Pseudomonas aeruginosa cystic fibrosis pulmonary infection
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, Belfast, UK
    J Control Release 117:217-26. 2007
    ..When photosensitisers were prepared in artificial mucus, higher concentrations were required to achieve reasonably high kill rates (>80%) of P. aeruginosa (PAO1) growing both planktonically and in biofilm...
  26. ncbi request reprint Autoradiographic and scintillation analysis of 5-aminolevulinic acid permeation through epithelialised tissue: implications for topical photodynamic therapy of superficial gynaecological neoplasias
    Paul A McCarron
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK
    Pharm Res 25:812-26. 2008
    ....
  27. doi request reprint Hexyl aminolaevulinate is a more effective topical photosensitiser precursor than methyl aminolaevulinate and 5-aminolaevulinic acids when applied in equimolar doses
    Desmond I J Morrow
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, Belfast, UK
    J Pharm Sci 99:3486-98. 2010
    ..2) and ALA (F(max) = 191.9). Importantly, this study indicates that when compared on an equimolar basis, h-ALA has improved skin penetration, leading to enhanced PpIX production compared to the parent drug and m-ALA...
  28. doi request reprint Novel patch-based systems for the localised delivery of ALA-esters
    Desmond I J Morrow
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Photochem Photobiol B 101:59-69. 2010
    ..In addition, owing to the relatively low loadings of h-ALA required in PSA patches, the costs of clinical PDT may potentially be reduced...
  29. doi request reprint Enhanced surface attachment of protein-type targeting ligands to poly(lactide-co-glycolide) nanoparticles using variable expression of polymeric acid functionality
    Paul A McCarron
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom
    J Biomed Mater Res A 87:873-84. 2008
    ..Also, high MW PLGA could be used to prolong drug release, but at the expense of conjugation efficiency on to the NP surface...
  30. doi request reprint Electrically enhanced solute permeation across poly(ethylene glycol)-crosslinked poly(methyl vinyl ether-co-maleic acid) hydrogels: effect of hydrogel crosslink density and ionic conductivity
    Martin J Garland
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    Int J Pharm 406:91-8. 2011
    ..The electro-responsive nature of these hydrogels suggests that have a potential application in electrically controlled drug delivery systems...
  31. doi request reprint Influence of penetration enhancers on topical delivery of 5-aminolevulinic acid from bioadhesive patches
    Desmond I J Morrow
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, UK
    J Pharm Pharmacol 62:685-95. 2010
    ..Poor penetration of ALA has been implicated as the primary factor for low response rates achieved with topical ALA-based photodynamic therapy of thicker neoplastic lesions, such as nodular basal cell carcinomas...
  32. doi request reprint Influence of skin model on in vitro performance of drug-loaded soluble microneedle arrays
    Martin J Garland
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Int J Pharm 434:80-9. 2012
    ..On the basis of these results, a wider discussion within the MN community will be necessary to standardise the experimental protocols used for the evaluation and comparison of MN devices...
  33. doi request reprint Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery
    Martin J Garland
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, UK
    J Control Release 159:52-9. 2012
    ..40%) for MN in combination with anodal ITP (p<0.001). As such, drug loaded soluble PMVE/MA MN arrays show promise for the electrically controlled transdermal delivery of biomacromolecules in a simple, one-step approach...
  34. doi request reprint Physical characterisation and component release of poly(vinyl alcohol)-tetrahydroxyborate hydrogels and their applicability as potential topical drug delivery systems
    Diarmaid J Murphy
    School of Pharmacy, Queen s University Belfast, Belfast, UK
    Int J Pharm 423:326-34. 2012
    ..The unique physical characteristics of these hydrogels make them an appealing delivery vehicle for chronic and acute wound management purposes...
  35. ncbi request reprint In vitro phototoxicity of 5-aminolevulinic acid and its methyl ester and the influence of barrier properties on their release from a bioadhesive patch
    Brendan F Gilmore
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, Belfast, UK
    Eur J Pharm Biopharm 63:295-309. 2006
    ..ALA/M-ALA will only be delivered in significant amounts to the abnormal tissue. PpIX will only then accumulate in the neoplastic cells and the normal surrounding tissue will be unharmed upon irradiation...
  36. doi request reprint Comparison of a novel spray congealing procedure with emulsion-based methods for the micro-encapsulation of water-soluble drugs in low melting point triglycerides
    Paul A McCarron
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, Belfast, UK
    J Microencapsul 25:365-78. 2008
    ..Therefore, such a system may find application in topical semi-solid formulations, where a temperature-induced burst release is preferred...
  37. doi request reprint Delivery of Methylene Blue and meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylate from cross-linked poly(vinyl alcohol) hydrogels: a potential means of photodynamic therapy of infected wounds
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Photochem Photobiol B 96:223-31. 2009
    ..Results support the contention that delivery of MB or TMP using gel-type vehicles as part of PACT could make a contribution to the photodynamic eradication of MRSA from infected wounds...
  38. ncbi request reprint Design and evaluation of a water-soluble bioadhesive patch formulation for cutaneous delivery of 5-aminolevulinic acid to superficial neoplastic lesions
    Paul A McCarron
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Eur J Pharm Sci 27:268-79. 2006
    ..Adhesion is sufficiently tenacious to allow photodynamic therapy (PDT), without the need to immobilise patients for up to 6 h, as was common with the cream-under-occlusion approach...
  39. ncbi request reprint Microporation techniques for enhanced delivery of therapeutic agents
    Thakur R R Singh
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Recent Pat Drug Deliv Formul 4:1-17. 2010
    ..This review deals with the innovations relating to microporation-based methods and devices for drug delivery and minimally invasive monitoring, as disclosed in recent patent literature...
  40. pmc Microneedle-mediated transdermal bacteriophage delivery
    Elizabeth Ryan
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Eur J Pharm Sci 47:297-304. 2012
    ..Accordingly, bacteriophage-based therapeutics may now have an alternative route for systemic delivery. Once fully-investigated, this could lead to more widespread investigation of these interesting therapeutic viruses...
  41. doi request reprint Aminolevulinic acid-loaded Witepsol microparticles manufactured using a spray congealing procedure: implications for topical photodynamic therapy
    Rasil Al-Kassas
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, Belfast, UK
    J Pharm Pharmacol 61:1125-35. 2009
    ....
  42. doi request reprint Laser-engineered dissolving microneedle arrays for transdermal macromolecular drug delivery
    Katarzyna Migalska
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Pharm Res 28:1919-30. 2011
    ..To assess the feasibility of transdermal macromolecule delivery using novel laser-engineered dissolving microneedles (MNs) prepared from aqueous blends of 20% w/w poly(methylvinylether maleic anhydride) (PMVE/MA) in vitro and in vivo...
  43. doi request reprint Aminolaevulinic acid diffusion characteristics in 'in vitro' normal human skin and actinic keratosis: implications for topical photodynamic therapy
    Nabla McLoone
    School of Pharmacy, Medical Biology Centre, Queen s University Belfast, Belfast, UK
    Photodermatol Photoimmunol Photomed 24:183-90. 2008
    ..A detailed and depth-related profile of spatial ALA permeation in AK following drug administration would lead to a greater understanding of concentrations achievable before protoporphyrin IX biosynthesis and subsequent PDT...
  44. doi request reprint Photodynamic Antimicrobial Chemotherapy (PACT) in combination with antibiotics for treatment of Burkholderia cepacia complex infection
    Corona M Cassidy
    CF and Airways Microbiology Research Group, Queen s University Belfast, Belfast, UK
    J Photochem Photobiol B 106:95-100. 2012
    ..PACT could be a viable treatment option, either alone or in combination with antibiotics for treatment of B. cepacia complex pulmonary infection...
  45. doi request reprint Development of novel oral formulations prepared via hot melt extrusion for targeted delivery of photosensitizer to the colon
    Corona M Cassidy
    School of Pharmacy, Queens University Belfast, Belfast, UK
    Photochem Photobiol 87:867-76. 2011
    ..TCDO could be used in vivo to generate oxygen, which could significantly impact on the success of PACT in the clinic...
  46. doi request reprint Drug and light delivery strategies for photodynamic antimicrobial chemotherapy (PACT) of pulmonary pathogens: a pilot study
    Corona M Cassidy
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, Belfast, UK
    Photodiagnosis Photodyn Ther 8:1-6. 2011
    ..The results of this study demonstrate the ability of light and methylene blue to be delivered to the site of infection in the CF lung. PACT remains a viable option for selective killing of CF lung pathogens...
  47. ncbi request reprint Celecoxib-loaded poly(D,L-lactide-co-glycolide) nanoparticles prepared using a novel and controllable combination of diffusion and emulsification steps as part of the salting-out procedure
    Paul A McCarron
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, Belfast, UK
    J Microencapsul 23:480-98. 2006
    ....
  48. doi request reprint Investigation of solute permeation across hydrogels composed of poly(methyl vinyl ether-co-maleic acid) and poly(ethylene glycol)
    Thakur Raghu Raj Singh
    School of Pharmacy, Queens University Belfast, Northern Ireland, UK
    J Pharm Pharmacol 62:829-37. 2010
    ..Swelling kinetics and solute permeation (theophylline, vitamin B(12) and fluorescein sodium) of hydrogels composed of poly(methyl vinyl ether-co-maleic acid) (PMVE/MA) and poly(ethylene glycol) (PEG) are presented...
  49. ncbi request reprint Stability of 5-aminolevulinic acid in novel non-aqueous gel and patch-type systems intended for topical application
    Paul A McCarron
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, Belfast BT9 7BL, N Ireland, UK
    J Pharm Sci 94:1756-71. 2005
    ..It is conceivable that skin esterases could duplicate this finding upon topical application of the gel and convert these derivatives back to ALA in situ, provided skin penetration is not affected adversely...
  50. doi request reprint Modulation of gel formation and drug-release characteristics of lidocaine-loaded poly(vinyl alcohol)-tetraborate hydrogel systems using scavenger polyol sugars
    Ryan G Loughlin
    School of Pharmacy, Queens University Belfast, Belfast, UK
    Eur J Pharm Biopharm 69:1135-46. 2008
    ..Furthermore, addition of a polyol, such as d-mannitol, allows incorporation of soluble salt forms of active therapeutic agents by modulation of cross-linking density...
  51. doi request reprint Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system
    Agnieszka A Zawislak
    Department of Gynaecology, Belfast City Hospital, Belfast, UK
    Photodermatol Photoimmunol Photomed 25:111-3. 2009
    ..It can be concluded that ALA-PDT patch-based formulation is pragmatic and primarily offers symptomatic management of vulval LS and SH...
  52. pmc Gentamicin-loaded nanoparticles show improved antimicrobial effects towards Pseudomonas aeruginosa infection
    Sharif M Abdelghany
    School of Pharmacy, Queen s University Belfast, UK
    Int J Nanomedicine 7:4053-63. 2012
    ..These data highlight that the controlled release of gentamicin may be applicable for treating Pseudomonas infections...
  53. doi request reprint Electrically-responsive anti-adherent hydrogels for photodynamic antimicrobial chemotherapy
    Steven J Fallows
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Photochem Photobiol B 114:61-72. 2012
    ....
  54. ncbi request reprint Formulation and characterization of poly(ethylene glycol)-based, 5-aminolevulinic acid-loaded solid-dosage forms intended for photodynamic and photodiagnostic methodologies in the colorectal region
    Paul A McCarron
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Rd, Belfast BT9 7BL, UK
    J Environ Pathol Toxicol Oncol 26:135-42. 2007
    ..Results suggest that this simple formulation containing ALA can be administered directly to the colorectal area and is a feasible alternative to peroral dosing of ALA...
  55. ncbi request reprint Innovative drug delivery strategies for topical photodynamic therapy using porphyrin precursors
    Desmond I J Morrow
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Environ Pathol Toxicol Oncol 26:105-16. 2007
    ..This paper briefly reviews traditional approaches to topical delivery of ALA and its esters, and highlights several innovative strategies recently employed to increase the efficacy of ALA-PDT...
  56. ncbi request reprint Evaluation of the penetration of 5-aminolevulinic acid through basal cell carcinoma: a pilot study
    Sharareh Ahmadi
    Department of Dermatology, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, Northern Ireland, UK
    Exp Dermatol 13:445-51. 2004
    ..Results from this work question the reasons given for poor outcomes of PDT in nodular BCC based solely on depth as a hindering factor...
  57. ncbi request reprint Anti-adherent and antifungal activities of surfactant-coated poly(ethylcyanoacrylate) nanoparticles
    Paul A McCarron
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Int J Pharm 340:182-90. 2007
    ..Results demonstrate that surfactant-coated NP, particularly the cationic types, form the possible basis of a prophylactic formulation that primes the candidal target (BEC) against fungal adhesion and infection...
  58. ncbi request reprint Evaluation of a water-soluble bioadhesive patch for photodynamic therapy of vulval lesions
    Paul A McCarron
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    Int J Pharm 293:11-23. 2005
    ..The patch achieves the extended application times obligatory in topical photodynamic therapy of vulval lesions, thereby contributing to potential methods for the eradication of neoplastic lesions in the lower female reproductive tract...
  59. ncbi request reprint Immunocolloidal targeting of the endocytotic siglec-7 receptor using peripheral attachment of siglec-7 antibodies to poly(lactide-co-glycolide) nanoparticles
    Christopher J Scott
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, Belfast, UK
    Pharm Res 25:135-46. 2008
    ..The aim is to exploit this receptor as a therapeutic target by constructing an internalising drug-loaded nanoparticle able to translocate into cytoplasm by siglec receptor-mediated internalisation...
  60. doi request reprint Designing photosensitizers for photodynamic therapy: strategies, challenges and promising developments
    Martin J Garland
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT97BL, UK
    Future Med Chem 1:667-91. 2009
    ....
  61. pmc Enhanced antitumor activity of the photosensitizer meso-Tetra(N-methyl-4-pyridyl) porphine tetra tosylate through encapsulation in antibody-targeted chitosan/alginate nanoparticles
    Sharif M Abdelghany
    School of Pharmacy, Centre for Cancer Research and Cell Biology, Queen s University Belfast, 97 Lisburn Road, Belfast, United Kingdom
    Biomacromolecules 14:302-10. 2013
    ..This novel approach provides a strategy for providing targeted site-specific delivery of TMP and other photosensitizer drugs to treat colorectal tumors using PDT...
  62. ncbi request reprint Phototoxicity of 5-aminolevulinic acid in the HeLa cell line as an indicative measure of photodynamic effect after topical administration to gynecological lesions of intraepithelial form
    Paul A McCarron
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, Belfast BT9 7BL, UK
    Pharm Res 21:1871-9. 2004
    ..From this data, the tissue concentration of ALA achievable at a specified depth from the surface could be related to the concentration needed to elicit a photodynamic effect in a model gynecological tumor cell line (HeLa)...
  63. ncbi request reprint Photosensitiser delivery for photodynamic therapy. Part 2: systemic carrier platforms
    St├ęphane A Sibani
    Queens University Belfast, Medical Biology Centre, School of Pharmacy, 97 Lisburn Road, Belfast BT9 7BL, UK
    Expert Opin Drug Deliv 5:1241-54. 2008
    ..There is currently great interest in the development of efficient and specific carrier delivery platforms for systemic PDT...
  64. doi request reprint Effect of sub-lethal challenge with Photodynamic Antimicrobial Chemotherapy (PACT) on the antibiotic susceptibility of clinical bacterial isolates
    Corona M Cassidy
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Photochem Photobiol B 99:62-6. 2010
    ..aureus isolate with TMP. However, for two of these three isolates, the log reduction for habituated cells was still greater than 4 log(10). PACT remains an attractive potential treatment for infection caused by these bacteria...
  65. ncbi request reprint Novel bioadhesive patch-type system for photodynamic vulvodynia therapy after delivery of 5-aminolevulinic acid: preliminary evaluation
    Agnieszka A Zawislak
    Department of Gynaecology, Belfast City Hospital School of Pharmacy, Queen s University Belfast, UK
    J Reprod Med 52:645-53. 2007
    ....
  66. doi request reprint Microneedle arrays as medical devices for enhanced transdermal drug delivery
    Martin J Garland
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, Northern Ireland, UK
    Expert Rev Med Devices 8:459-82. 2011
    ....
  67. ncbi request reprint Review of patents on microneedle applicators
    Thakur R R Singh
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, UK
    Recent Pat Drug Deliv Formul 5:11-23. 2011
    ....
  68. ncbi request reprint Drug delivery of aminolevulinic acid from topical formulations intended for photodynamic therapy
    Ryan F Donnelly
    School of Pharmacy, Queens University, Belfast, Northern Ireland, UK
    Photochem Photobiol 81:750-67. 2005
    ....
  69. doi request reprint Drug delivery strategies for photodynamic antimicrobial chemotherapy: from benchtop to clinical practice
    Corona M Cassidy
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT97BL, UK
    J Photochem Photobiol B 95:71-80. 2009
    ..It is hoped that, through a rational approach to formulation design and subsequent success in small-scale clinical trials, more widespread use will be made of PACT in the clinic, to the benefit of patients worldwide...
  70. ncbi request reprint Analysis of pyrazine 2,5-dipropionic acid in 5-aminolevulinic acid-loaded urological and topical delivery vehicles: methodology and assay validation
    Paul A McCarron
    School of Pharmacy, Queens University of Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, N Ireland BT9 7BL, UK
    J Pharm Biomed Anal 36:1099-105. 2005
    ..PY extraction from semi-solid devices approached 100% efficiency demonstrating that the reported assay is suitable for evaluating stability of novel dosage forms intended for ALA delivery...
  71. doi request reprint Recent advances in bacteriophage therapy: how delivery routes, formulation, concentration and timing influence the success of phage therapy
    Elizabeth M Ryan
    School of Pharmacy, Queens University Belfast, Belfast, UK
    J Pharm Pharmacol 63:1253-64. 2011
    ..This paper reviewed recent in-vivo phage therapy studies, with a distinct focus on the effect of delivery routes, phage concentration and timing of administration on the success of the therapy...
  72. doi request reprint The potential for human exposure, direct and indirect, to the suspected carcinogenic triphenylmethane dye Brilliant Green from green paper towels
    Michalina Oplatowska
    Institute of Agri food and Land Use, School of Biological Sciences, Queen s University Belfast, David Keir Building, Belfast BT9 5AG, Northern Ireland, UK
    Food Chem Toxicol 49:1870-6. 2011
    ....
  73. ncbi request reprint Bioadhesive, non-drug-loaded nanoparticles as modulators of candidal adherence to buccal epithelial cells: a potentially novel prophylaxis for candidosis
    Paul A McCarron
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, Belfast, Antrim BT9 7BL, UK
    Biomaterials 25:2399-407. 2004
    ..In light of their ability to reduce candidal adherence to BEC, it is suggested that polymeric nanoparticles may be useful in the prophylaxis of candidosis of the oral cavity...
  74. doi request reprint Dried blood spot assay for estimation of metronidazole concentrations in rats and its application in single animal drug pharmacokinetic study
    Prashant Laxman Kole
    PKPD Core Facility, School of Pharmacy, Medical Biology Centre, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom
    J Chromatogr B Analyt Technol Biomed Life Sci 879:1713-6. 2011
    ..Whole blood PK parameters observed in this study were in compliance with literature based PK parameters. The DBS sampling approach was found to be useful in a single animal pharmacokinetic study...
  75. pmc Derivatives of 5-aminolevulinic Acid for photodynamic therapy
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, U K
    Perspect Medicin Chem 1:49-63. 2008
    ..With respect to systemic ALA delivery, more study is required in the developing area of ALA-containing dendrons and dendrimers...
  76. pmc Mucoadhesive drug delivery systems
    Rahamatullah Shaikh
    Drug Delivery Group, School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK
    J Pharm Bioallied Sci 3:89-100. 2011
    ....