D Craig

Summary

Affiliation: Queen's University Belfast
Country: UK

Publications

  1. ncbi Analysis of the 5HT-2A T102C receptor polymorphism and psychotic symptoms in Alzheimer's disease
    David Craig
    Department of Geriatric Medicine, Division of Psychiatry and Neuroscience, Queen s University, Belfast, Northern Ireland
    Am J Med Genet B Neuropsychiatr Genet 144:126-8. 2007
  2. ncbi Factors influencing prescription of CNS medications in different elderly populations
    David Craig
    Department of Geriatric Medicine, Queen s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
    Pharmacoepidemiol Drug Saf 12:383-7. 2003
  3. ncbi Genetically increased risk of sleep disruption in Alzheimer's disease
    David Craig
    Department of Geriatric Medicine, Queen s University of Belfast, Northern Ireland, United Kingdom
    Sleep 29:1003-7. 2006
  4. ncbi Allelic variation at the A218C tryptophan hydroxylase polymorphism influences agitation and aggression in Alzheimer's disease
    David Craig
    Department of Geriatric Medicine, Whitla Medical Building, The Queen s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
    Neurosci Lett 363:199-202. 2004
  5. ncbi The interleukin 1beta gene promoter polymorphism (-511) acts as a risk factor for psychosis in Alzheimer's dementia
    David Craig
    Department of Geriatric Medicine, Queen s University of Belfast, Belfast BT9 7BL, United Kingdom
    Ann Neurol 56:121-4. 2004
  6. pmc Apolipoprotein E e4 allele influences aggressive behaviour in Alzheimer's disease
    D Craig
    Department of Geriatric Medicine, Queen s University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Neurol Neurosurg Psychiatry 75:1327-30. 2004
  7. ncbi Psychotic symptoms in Alzheimer's disease are not influenced by polymorphic variation at the dopamine receptor DRD3 gene
    David Craig
    Department of Geriatric Medicine, Queen s University of Belfast, 97 Lisburn Road, Belfast BT97BL, Northern Ireland, UK
    Neurosci Lett 368:33-6. 2004
  8. ncbi A cross-sectional study of neuropsychiatric symptoms in 435 patients with Alzheimer's disease
    David Craig
    Dept of Geriatric Medicine, Queen s University of Belfast, 97 Lisburn Rd, Belfast, Ireland
    Am J Geriatr Psychiatry 13:460-8. 2005
  9. ncbi Association analysis of apolipoprotein E genotype and risk of depressive symptoms in Alzheimer's disease
    David Craig
    Department of Geriatric Medicine, Queen s University of Belfast, Belfast, Northern Ireland
    Dement Geriatr Cogn Disord 19:154-7. 2005
  10. doi BACE1 polymorphisms do not influence platelet membrane beta-secretase activity or genetic susceptibility for Alzheimer's disease in the Northern Irish population
    S Todd
    Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK
    Neuromolecular Med 10:368-76. 2008

Collaborators

Detail Information

Publications27

  1. ncbi Analysis of the 5HT-2A T102C receptor polymorphism and psychotic symptoms in Alzheimer's disease
    David Craig
    Department of Geriatric Medicine, Division of Psychiatry and Neuroscience, Queen s University, Belfast, Northern Ireland
    Am J Med Genet B Neuropsychiatr Genet 144:126-8. 2007
    ..The lack of influence of the T102C polymorphism of the 5HT-2A receptor on the emergence of psychotic symptoms in AD contrasts with previous reports in other cohorts involving smaller numbers of subjects...
  2. ncbi Factors influencing prescription of CNS medications in different elderly populations
    David Craig
    Department of Geriatric Medicine, Queen s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
    Pharmacoepidemiol Drug Saf 12:383-7. 2003
    ..In this representative elderly cohort, patient characteristics: age, sex, cognitive score, functional score, place of residence and geographical location markedly influenced drug utilisation...
  3. ncbi Genetically increased risk of sleep disruption in Alzheimer's disease
    David Craig
    Department of Geriatric Medicine, Queen s University of Belfast, Northern Ireland, United Kingdom
    Sleep 29:1003-7. 2006
    ..To investigate the role of a monoamine A oxidase promoter polymorphism in sleep disruption in Alzheimer's disease (AD)...
  4. ncbi Allelic variation at the A218C tryptophan hydroxylase polymorphism influences agitation and aggression in Alzheimer's disease
    David Craig
    Department of Geriatric Medicine, Whitla Medical Building, The Queen s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
    Neurosci Lett 363:199-202. 2004
    ..044, OR = 1.65, CI = 0.98-2.76). We conclude that aggression in male subjects with Alzheimer's disease may be genetically linked to polymorphic variation at the tryptophan hydroxylase gene...
  5. ncbi The interleukin 1beta gene promoter polymorphism (-511) acts as a risk factor for psychosis in Alzheimer's dementia
    David Craig
    Department of Geriatric Medicine, Queen s University of Belfast, Belfast BT9 7BL, United Kingdom
    Ann Neurol 56:121-4. 2004
    ..Significant associations between psychotic symptoms and the CC genotype (p = 0.001 - p = 0.043) and C allele (p = 0.014 vs p = 0.048) were found, thus confirming the previously noted increased risk in schizophrenia...
  6. pmc Apolipoprotein E e4 allele influences aggressive behaviour in Alzheimer's disease
    D Craig
    Department of Geriatric Medicine, Queen s University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Neurol Neurosurg Psychiatry 75:1327-30. 2004
    ..45, df = 1, p = 0.02, OR = 1.60, confidence interval (CI) 1.06 to 2.43). These results indicate that advanced Alzheimer's disease patients are at greater risk of aggressive symptoms because of a genetic weakness in apolipoprotein E...
  7. ncbi Psychotic symptoms in Alzheimer's disease are not influenced by polymorphic variation at the dopamine receptor DRD3 gene
    David Craig
    Department of Geriatric Medicine, Queen s University of Belfast, 97 Lisburn Road, Belfast BT97BL, Northern Ireland, UK
    Neurosci Lett 368:33-6. 2004
    ..In conclusion, we were unable to confirm previously reported associations between the DRD3 BalI polymorphism and psychotic symptoms in AD...
  8. ncbi A cross-sectional study of neuropsychiatric symptoms in 435 patients with Alzheimer's disease
    David Craig
    Dept of Geriatric Medicine, Queen s University of Belfast, 97 Lisburn Rd, Belfast, Ireland
    Am J Geriatr Psychiatry 13:460-8. 2005
    ..We attempted to characterize in detail these symptoms and the distress they cause to caregivers...
  9. ncbi Association analysis of apolipoprotein E genotype and risk of depressive symptoms in Alzheimer's disease
    David Craig
    Department of Geriatric Medicine, Queen s University of Belfast, Belfast, Northern Ireland
    Dement Geriatr Cogn Disord 19:154-7. 2005
    ..There is speculation these symptoms result from known genetic risk factors for AD, therefore we investigated the role of apolipoprotein E epsilon4 in the aetiology of depression in AD...
  10. doi BACE1 polymorphisms do not influence platelet membrane beta-secretase activity or genetic susceptibility for Alzheimer's disease in the Northern Irish population
    S Todd
    Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK
    Neuromolecular Med 10:368-76. 2008
    ..Our results suggest that common BACE1 polymorphisms and putatively functional variants have no significant influence on genetic susceptibility to AD, or platelet beta-secretase activity, in this Caucasian Northern Irish population...
  11. ncbi Elevated platelet beta-secretase activity in mild cognitive impairment
    W W Liu
    Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen s University Belfast, Belfast, UK
    Dement Geriatr Cogn Disord 24:464-8. 2007
    ..Mild cognitive impairment (MCI) exists prior to obvious dementia, and is associated with increased risk of conversion to overt disease...
  12. ncbi Behavioural and psychological syndromes in Alzheimer's disease
    A Mirakhur
    Department of Geriatric Medicine, Queen s University of Belfast, Belfast, Northern Ireland
    Int J Geriatr Psychiatry 19:1035-9. 2004
    ..By focusing on piecemeal behaviours as opposed to more robust syndrome change valid biological correlates may be overlooked. Our understanding of BPSD via the identification of neuropsychiatric syndromes...
  13. doi Executive functioning in Alzheimer's disease and vascular dementia
    B McGuinness
    Geriatric Medicine, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Whitla Medical Building, Queen s University Belfast, Belfast, UK
    Int J Geriatr Psychiatry 25:562-8. 2010
    ..To compare performance of patients with mild-moderate Alzheimer's disease (AD) and vascular dementia (VaD) on tests of executive functioning and working memory...
  14. ncbi A retrospective study of the behavioural and psychological symptoms of mid and late phase Alzheimer's disease
    D J Hart
    Department of Geriatric Medicine, Queen s University, Belfast, UK
    Int J Geriatr Psychiatry 18:1037-42. 2003
    ..To document the behavioural and psychological symptoms in patients with a diagnosis of established Alzheimer's disease (AD) for at least 3 years...
  15. doi Attention deficits in Alzheimer's disease and vascular dementia
    Bernadette McGuinness
    Department of Geriatric Medicine, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Neurol Neurosurg Psychiatry 81:157-9. 2010
    ..To compare the performance of patients with mild-moderate Alzheimer's disease (AD) and vascular dementia (VaD) on tests of information processing and attention...
  16. doi Reduced estimated glomerular filtration rate in Alzheimer's disease
    Enda Kerr
    Queen s University of Belfast, School of Medicine, Belfast BT9 7BL, UK
    Int J Geriatr Psychiatry 24:927-32. 2009
    ..We sought to examine estimates of glomerular filtration rate in AD and control groups...
  17. doi Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease
    Robyn Carson
    Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK
    Neuromolecular Med 10:377-84. 2008
    ..A significant association between delusions and the T allele of rs6494223 (P = 0.014, OR = 1.63, CI = 1.22-2.17) was found. This suggests that the alpha 7 receptor may be a suitable target for the treatment of AD with psychosis...
  18. doi Apolipoprotein epsilon4 and neuropsychological performance in Alzheimer's disease and vascular dementia
    Bernadette McGuinness
    Geriatric Medicine, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Whitla Medical Building, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom
    Neurosci Lett 483:62-6. 2010
    ..In AD and VaD groups epsilon4 present patients showed impairment in selective attention. These findings provide further support of the negative impact of the epsilon4 allele in cognition...
  19. ncbi Neurobiology and genetics of behavioural syndromes of Alzheimer's disease
    Stephen McIlroy
    Department of Geriatric Medicine, Queen s University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Curr Alzheimer Res 1:135-42. 2004
    ....
  20. ncbi Platelet beta-secretase activity is increased in Alzheimer's disease
    J A Johnston
    Queen s University Belfast, School of Medicine and Dentistry, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, United Kingdom
    Neurobiol Aging 29:661-8. 2008
    ..7, range 1-23), indicating that the increase did not occur as a secondary result of the disease process, and may even have preceded symptom onset...
  21. doi A novel reciprocal and biphasic relationship between membrane cholesterol and beta-secretase activity in SH-SY5Y cells and in human platelets
    Wei Wei Liu
    School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, 97 Lisburn Road, Belfast, Northern Ireland, UK
    J Neurochem 108:341-9. 2009
    ....
  22. doi Variation in RTN3 and PPIL2 genes does not influence platelet membrane beta-secretase activity or susceptibility to alzheimer's disease in the northern Irish population
    Robyn Carson
    Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK
    Neuromolecular Med 11:337-44. 2009
    ..We conclude that common or potentially functional genetic variation in these BACE1 interacting proteins does not affect platelet membrane beta-secretase activity or contribute to risk of AD in this population...
  23. doi The development of personalised cognitive prosthetics
    Chris D Nugent
    School of Computing and Mathematics and Computer Science Research Institute, University of Ulster, Belfast, Northern Ireland
    Conf Proc IEEE Eng Med Biol Soc 2008:787-90. 2008
    ..Within this paper we provide an overview of the first phase of our methodology and demonstrate how we have used the results from this to guide the second phase of our work, especially with regards to the notion of personalisation...
  24. doi Development of a cell phone-based video streaming system for persons with early stage Alzheimer's disease
    Mark P Donnelly
    Computer Science Research Institute, University of Ulster, Belfast, Northern Ireland
    Conf Proc IEEE Eng Med Biol Soc 2008:5330-3. 2008
    ..Initially, only three patient carer dyads will be involved, however, the second field trial aims to involve 30 dyads in the study. Details of the first prototype and the methods of evaluation are presented herein...
  25. ncbi Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease
    Denise Harold
    Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK
    Hum Genet 113:258-67. 2003
    ..Levels of linkage disequilibrium were generally low across the CHAT locus but two of the coding variants, D7N and A120T, proved to be in complete linkage disequilibrium...
  26. ncbi Healthy elderly individuals do not inevitably lose bone density and weight as they age
    Hugh Taggart
    Department of Health Care for the Elderly, Belfast City Hospital, Lisburn Road, Belfast BT9 6BA, UK
    Arch Gerontol Geriatr 39:283-90. 2004
    ..In addition, there was good maintenance of BMD at most sites...
  27. pmc Multimarker analysis and imputation of multiple platform pooling-based genome-wide association studies
    Nils Homer
    Translational Genomics Research Institute TGen, Phoenix, AZ 85004, USA
    Bioinformatics 24:1896-902. 2008
    ..This multimarker method can now be used to cost-effectively complete pooling-based GWA studies with multiple platforms across over one million SNPs and to impute neighboring SNPs weighted for the loss of information due to pooling...