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Genomes and Genes | D CraigSummaryAffiliation: Queen's University Belfast Country: UK Publications
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Publications
Analysis of the 5HT-2A T102C receptor polymorphism and psychotic symptoms in Alzheimer's diseaseDavid Craig
Department of Geriatric Medicine, Division of Psychiatry and Neuroscience, Queen s University, Belfast, Northern Ireland
Am J Med Genet B Neuropsychiatr Genet 144:126-8. 2007..The lack of influence of the T102C polymorphism of the 5HT-2A receptor on the emergence of psychotic symptoms in AD contrasts with previous reports in other cohorts involving smaller numbers of subjects...- Factors influencing prescription of CNS medications in different elderly populationsDavid Craig
Department of Geriatric Medicine, Queen s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
Pharmacoepidemiol Drug Saf 12:383-7. 2003..In this representative elderly cohort, patient characteristics: age, sex, cognitive score, functional score, place of residence and geographical location markedly influenced drug utilisation... - Genetically increased risk of sleep disruption in Alzheimer's diseaseDavid Craig
Department of Geriatric Medicine, Queen s University of Belfast, Northern Ireland, United Kingdom
Sleep 29:1003-7. 2006..To investigate the role of a monoamine A oxidase promoter polymorphism in sleep disruption in Alzheimer's disease (AD)... - Allelic variation at the A218C tryptophan hydroxylase polymorphism influences agitation and aggression in Alzheimer's diseaseDavid Craig
Department of Geriatric Medicine, Whitla Medical Building, The Queen s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
Neurosci Lett 363:199-202. 2004..044, OR = 1.65, CI = 0.98-2.76). We conclude that aggression in male subjects with Alzheimer's disease may be genetically linked to polymorphic variation at the tryptophan hydroxylase gene... - The interleukin 1beta gene promoter polymorphism (-511) acts as a risk factor for psychosis in Alzheimer's dementiaDavid Craig
Department of Geriatric Medicine, Queen s University of Belfast, Belfast BT9 7BL, United Kingdom
Ann Neurol 56:121-4. 2004..Significant associations between psychotic symptoms and the CC genotype (p = 0.001 - p = 0.043) and C allele (p = 0.014 vs p = 0.048) were found, thus confirming the previously noted increased risk in schizophrenia... - Apolipoprotein E e4 allele influences aggressive behaviour in Alzheimer's diseaseD Craig
Department of Geriatric Medicine, Queen s University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
J Neurol Neurosurg Psychiatry 75:1327-30. 2004..45, df = 1, p = 0.02, OR = 1.60, confidence interval (CI) 1.06 to 2.43). These results indicate that advanced Alzheimer's disease patients are at greater risk of aggressive symptoms because of a genetic weakness in apolipoprotein E... - Psychotic symptoms in Alzheimer's disease are not influenced by polymorphic variation at the dopamine receptor DRD3 geneDavid Craig
Department of Geriatric Medicine, Queen s University of Belfast, 97 Lisburn Road, Belfast BT97BL, Northern Ireland, UK
Neurosci Lett 368:33-6. 2004..In conclusion, we were unable to confirm previously reported associations between the DRD3 BalI polymorphism and psychotic symptoms in AD... - A cross-sectional study of neuropsychiatric symptoms in 435 patients with Alzheimer's diseaseDavid Craig
Dept of Geriatric Medicine, Queen s University of Belfast, 97 Lisburn Rd, Belfast, Ireland
Am J Geriatr Psychiatry 13:460-8. 2005..We attempted to characterize in detail these symptoms and the distress they cause to caregivers... - Association analysis of apolipoprotein E genotype and risk of depressive symptoms in Alzheimer's diseaseDavid Craig
Department of Geriatric Medicine, Queen s University of Belfast, Belfast, Northern Ireland
Dement Geriatr Cogn Disord 19:154-7. 2005..There is speculation these symptoms result from known genetic risk factors for AD, therefore we investigated the role of apolipoprotein E epsilon4 in the aetiology of depression in AD... - BACE1 polymorphisms do not influence platelet membrane beta-secretase activity or genetic susceptibility for Alzheimer's disease in the Northern Irish populationS Todd
Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK
Neuromolecular Med 10:368-76. 2008..Our results suggest that common BACE1 polymorphisms and putatively functional variants have no significant influence on genetic susceptibility to AD, or platelet beta-secretase activity, in this Caucasian Northern Irish population... - Elevated platelet beta-secretase activity in mild cognitive impairmentW W Liu
Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen s University Belfast, Belfast, UK
Dement Geriatr Cogn Disord 24:464-8. 2007..Mild cognitive impairment (MCI) exists prior to obvious dementia, and is associated with increased risk of conversion to overt disease... - Behavioural and psychological syndromes in Alzheimer's diseaseA Mirakhur
Department of Geriatric Medicine, Queen's University of Belfast, Belfast, Northern Ireland
Int J Geriatr Psychiatry 19:1035-9. 2004..CONCLUSIONS: We report novel observations that agitation/aggression/irritability cluster within a depressive symptom factor and apathy is found within a physical behaviour factor... - Executive functioning in Alzheimer's disease and vascular dementiaB McGuinness
Geriatric Medicine, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Whitla Medical Building, Queen s University Belfast, Belfast, UK
Int J Geriatr Psychiatry 25:562-8. 2010..To compare performance of patients with mild-moderate Alzheimer's disease (AD) and vascular dementia (VaD) on tests of executive functioning and working memory... - A retrospective study of the behavioural and psychological symptoms of mid and late phase Alzheimer's diseaseD J Hart
Department of Geriatric Medicine, Queen's University, Belfast, UK
Int J Geriatr Psychiatry 18:1037-42. 2003..CONCLUSION: The results show behavioural and psychological symptoms in AD are common and distressing for carers. They appear to require a consistent period of neurodegeneration in order to emerge... - Attention deficits in Alzheimer's disease and vascular dementiaBernadette McGuinness
Department of Geriatric Medicine, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
J Neurol Neurosurg Psychiatry 81:157-9. 2010..To compare the performance of patients with mild-moderate Alzheimer's disease (AD) and vascular dementia (VaD) on tests of information processing and attention... - Reduced estimated glomerular filtration rate in Alzheimer's diseaseEnda Kerr
Queen s University of Belfast, School of Medicine, Belfast BT9 7BL, UK
Int J Geriatr Psychiatry 24:927-32. 2009..We sought to examine estimates of glomerular filtration rate in AD and control groups... - Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's diseaseRobyn Carson
Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK
Neuromolecular Med 10:377-84. 2008..A significant association between delusions and the T allele of rs6494223 (P = 0.014, OR = 1.63, CI = 1.22-2.17) was found. This suggests that the alpha 7 receptor may be a suitable target for the treatment of AD with psychosis... - Apolipoprotein epsilon4 and neuropsychological performance in Alzheimer's disease and vascular dementiaBernadette McGuinness
Geriatric Medicine, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Whitla Medical Building, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom
Neurosci Lett 483:62-6. 2010..In AD and VaD groups epsilon4 present patients showed impairment in selective attention. These findings provide further support of the negative impact of the epsilon4 allele in cognition... - Neurobiology and genetics of behavioural syndromes of Alzheimer's diseaseStephen McIlroy
Department of Geriatric Medicine, Queen s University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
Curr Alzheimer Res 1:135-42. 2004.... - Platelet beta-secretase activity is increased in Alzheimer's diseaseJ A Johnston
Queen s University Belfast, School of Medicine and Dentistry, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, United Kingdom
Neurobiol Aging 29:661-8. 2008..7, range 1-23), indicating that the increase did not occur as a secondary result of the disease process, and may even have preceded symptom onset... - A novel reciprocal and biphasic relationship between membrane cholesterol and beta-secretase activity in SH-SY5Y cells and in human plateletsWei Wei Liu
School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, 97 Lisburn Road, Belfast, Northern Ireland, UK
J Neurochem 108:341-9. 2009.... - Variation in RTN3 and PPIL2 genes does not influence platelet membrane beta-secretase activity or susceptibility to alzheimer's disease in the northern Irish populationRobyn Carson
Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK
Neuromolecular Med 11:337-44. 2009..We conclude that common or potentially functional genetic variation in these BACE1 interacting proteins does not affect platelet membrane beta-secretase activity or contribute to risk of AD in this population... - The development of personalised cognitive prostheticsChris D Nugent
School of Computing and Mathematics and Computer Science Research Institute, University of Ulster, Belfast, Northern Ireland
Conf Proc IEEE Eng Med Biol Soc 2008:787-90. 2008..Within this paper we provide an overview of the first phase of our methodology and demonstrate how we have used the results from this to guide the second phase of our work, especially with regards to the notion of personalisation... - Development of a cell phone-based video streaming system for persons with early stage Alzheimer's diseaseMark P Donnelly
Computer Science Research Institute, University of Ulster, Belfast, Northern Ireland
Conf Proc IEEE Eng Med Biol Soc 2008:5330-3. 2008..Initially, only three patient carer dyads will be involved, however, the second field trial aims to involve 30 dyads in the study. Details of the first prototype and the methods of evaluation are presented herein... - Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's diseaseDenise Harold
Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK
Hum Genet 113:258-67. 2003..Levels of linkage disequilibrium were generally low across the CHAT locus but two of the coding variants, D7N and A120T, proved to be in complete linkage disequilibrium... - Healthy elderly individuals do not inevitably lose bone density and weight as they ageHugh Taggart
Department of Health Care for the Elderly, Belfast City Hospital, Lisburn Road, Belfast BT9 6BA, UK
Arch Gerontol Geriatr 39:283-90. 2004..In addition, there was good maintenance of BMD at most sites... - Multimarker analysis and imputation of multiple platform pooling-based genome-wide association studiesNils Homer
Translational Genomics Research Institute TGen, Phoenix, AZ 85004, USA
Bioinformatics 24:1896-902. 2008..This multimarker method can now be used to cost-effectively complete pooling-based GWA studies with multiple platforms across over one million SNPs and to impute neighboring SNPs weighted for the loss of information due to pooling...