U Chakravarthy

Summary

Affiliation: Queen's University Belfast
Country: UK

Publications

  1. doi request reprint Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial
    Usha Chakravarthy
    Institute of Clinical Science, The Queen s University of Belfast, Belfast, UK
    Lancet 382:1258-67. 2013
  2. doi request reprint ARMS2 increases the risk of early and late age-related macular degeneration in the European Eye Study
    Usha Chakravarthy
    Centre for Vision and Vascular Science, The Queen s University of Belfast, Belfast, United Kingdom
    Ophthalmology 120:342-8. 2013
  3. doi request reprint Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial
    Usha Chakravarthy
    Institute of Clinical Science, The Queen s University of Belfast, Belfast, Ireland
    Ophthalmology 119:1399-411. 2012
  4. ncbi request reprint Self-reported visual functioning and quality of life in age-related macular degeneration
    Usha Chakravarthy
    Centre for Ophthalmology and Vision Science, Queen s University, Institute for Clinical Science, Royal Group of Hospitals Trust, Belfast, UK
    Curr Opin Ophthalmol 16:179-83. 2005
  5. pmc Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis
    Usha Chakravarthy
    Centre for Vision Science, Queen s University Belfast, Northern Ireland, UK
    BMC Ophthalmol 10:31. 2010
  6. doi request reprint Factors associated with serum/plasma concentrations of vitamins A, C, E and carotenoids in older people throughout Europe: the EUREYE study
    J V Woodside
    Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Belfast, UK
    Eur J Nutr 52:1493-501. 2013
  7. doi request reprint Relationships between clinical measures of visual function, fluorescein angiographic and optical coherence tomography features in patients with subfoveal choroidal neovascularisation
    T Moutray
    Directorate of Ophthalmology, Head and Skeletal Division, Royal Victoria Hospital, Belfast, Northern Ireland
    Br J Ophthalmol 92:361-4. 2008
  8. pmc Identification of lesion components that influence visual function in age related macular degeneration
    R Hogg
    Queen s University Belfast, UK
    Br J Ophthalmol 87:609-14. 2003
  9. ncbi request reprint Cigarette smoking and age-related macular degeneration in the EUREYE Study
    U Chakravarthy
    Department of Ophthalmology, Queen s University of Belfast, Belfast, United Kingdom
    Ophthalmology 114:1157-63. 2007
  10. ncbi request reprint Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration
    U Chakravarthy
    Centre for Vision Sciences, The Queen s University of Belfast and The Royal Victoria Hospital, Belfast, United Kingdom
    Ophthalmology 113:1508.e1-25. 2006

Collaborators

Detail Information

Publications50

  1. doi request reprint Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial
    Usha Chakravarthy
    Institute of Clinical Science, The Queen s University of Belfast, Belfast, UK
    Lancet 382:1258-67. 2013
    ..The Inhibition of VEGF in Age-related choroidal Neovascularisation (IVAN) trial was designed to compare these drugs and different regimens. Here, we report the findings at the prespecified 2-year timepoint...
  2. doi request reprint ARMS2 increases the risk of early and late age-related macular degeneration in the European Eye Study
    Usha Chakravarthy
    Centre for Vision and Vascular Science, The Queen s University of Belfast, Belfast, United Kingdom
    Ophthalmology 120:342-8. 2013
    ....
  3. doi request reprint Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial
    Usha Chakravarthy
    Institute of Clinical Science, The Queen s University of Belfast, Belfast, Ireland
    Ophthalmology 119:1399-411. 2012
    ..To compare the efficacy and safety of ranibizumab and bevacizumab intravitreal injections to treat neovascular age-related macular degeneration (nAMD)...
  4. ncbi request reprint Self-reported visual functioning and quality of life in age-related macular degeneration
    Usha Chakravarthy
    Centre for Ophthalmology and Vision Science, Queen s University, Institute for Clinical Science, Royal Group of Hospitals Trust, Belfast, UK
    Curr Opin Ophthalmol 16:179-83. 2005
    ..To review the current literature on the impact of age-related macular degeneration on self-reported visual functioning, quality of life, and independent living...
  5. pmc Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis
    Usha Chakravarthy
    Centre for Vision Science, Queen s University Belfast, Northern Ireland, UK
    BMC Ophthalmol 10:31. 2010
    ..We aimed to identify those risk factors with strong levels of evidence which could be easily assessed by physicians or ophthalmologists to implement preventive interventions or address current behaviours...
  6. doi request reprint Factors associated with serum/plasma concentrations of vitamins A, C, E and carotenoids in older people throughout Europe: the EUREYE study
    J V Woodside
    Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Belfast, UK
    Eur J Nutr 52:1493-501. 2013
    ..To report on plasma/serum levels of antioxidant vitamin and carotenoids in older adults resident in multiple countries in Europe and examine relationships with potential modifiers...
  7. doi request reprint Relationships between clinical measures of visual function, fluorescein angiographic and optical coherence tomography features in patients with subfoveal choroidal neovascularisation
    T Moutray
    Directorate of Ophthalmology, Head and Skeletal Division, Royal Victoria Hospital, Belfast, Northern Ireland
    Br J Ophthalmol 92:361-4. 2008
    ..To examine the relationships between measures of vision, optical coherence tomography (OCT) and fundus fluorescein angiography (FFA) characteristics in patients with exudative age-related macular degeneration (AMD)...
  8. pmc Identification of lesion components that influence visual function in age related macular degeneration
    R Hogg
    Queen s University Belfast, UK
    Br J Ophthalmol 87:609-14. 2003
    ..To explore the relation between lesion composition as assessed by fundus photography and fluorescein angiography with clinical measures of vision in eyes of patients with age related macular degeneration (AMD)...
  9. ncbi request reprint Cigarette smoking and age-related macular degeneration in the EUREYE Study
    U Chakravarthy
    Department of Ophthalmology, Queen s University of Belfast, Belfast, United Kingdom
    Ophthalmology 114:1157-63. 2007
    ..To examine the association between cigarette smoking and age-related maculopathy (ARM) including age-related macular degeneration (AMD) in the European population...
  10. ncbi request reprint Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration
    U Chakravarthy
    Centre for Vision Sciences, The Queen s University of Belfast and The Royal Victoria Hospital, Belfast, United Kingdom
    Ophthalmology 113:1508.e1-25. 2006
    ..To evaluate the efficacy of a second year of pegaptanib sodium therapy in patients with neovascular age-related macular degeneration (AMD)...
  11. pmc Reduced vision in older adults with age related macular degeneration interferes with ability to care for self and impairs role as carer
    M R Stevenson
    Centre for Ophthalmology and Vision Science, The Queen s University of Belfast and Royal Group of Hospitals, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK
    Br J Ophthalmol 88:1125-30. 2004
    ..To study the relation between visual impairment and ability to care for oneself or a dependant in older people with age related macular degeneration (AMD)...
  12. pmc In vivo macular pigment measurements: a comparison of resonance Raman spectroscopy and heterochromatic flicker photometry
    R E Hogg
    Department of Ophthalmology, Queen s University Belfast BT12 6BA, UK
    Br J Ophthalmol 91:485-90. 2007
    ..To investigate whether two methods of measuring macular pigment-namely, heterochromatic flicker photometry (HFP) and resonance Raman spectroscopy (RRS)--yield comparable data...
  13. doi request reprint Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration
    Gareth J McKay
    Centre for Vision Sciences, Queen s University of Belfast, Belfast, Northern Ireland, United Kingdom
    Invest Ophthalmol Vis Sci 50:533-9. 2009
    ....
  14. ncbi request reprint A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration
    Anne E Hughes
    Department of Medical Genetics, Queen s University, Belfast, Belfast BT12 6BL, UK
    Nat Genet 38:1173-7. 2006
    ..The protective effect of the deletion haplotype cannot be attributed to linkage disequilibrium with Y402H and was replicated in an independent sample...
  15. pmc Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort
    Gareth J McKay
    Centre for Vision and Vascular Sciences, Queen s University of Belfast, Belfast, Northern Ireland BT12 6BA, UK
    Mol Vis 16:194-9. 2010
    ..We assess its effect on AMD risk in a Northern Irish sample, test for gene-gene and gene-environment interaction, and review a risk prediction model...
  16. pmc Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking
    Anne E Hughes
    Department of Medical Genetics, Queen s University Belfast, Belfast, United Kingdom
    PLoS Med 4:e355. 2007
    ..Polymorphisms in the complement factor H (CFH) gene, LOC387715, and the HTRA1 promoter are strongly associated with AMD. Smoking also contributes to the etiology. We aimed to provide a model of disease risk based on these factors...
  17. doi request reprint Exudative AMD subtypes and eligibility for treatment with ranibizumab
    S George
    Ophthalmology Department, Eye and Ear Clinic, Belfast Trust, Royal Group of Hospitals, Belfast, and Centre for Vision Science, Queen s University Belfast, Northern Ireland, UK
    Eye (Lond) 24:1247-51. 2010
    ....
  18. pmc CNV subtype in first eyes predicts severity of ARM in fellow eyes
    S Abugreen
    Royal Hospitals, Belfast, UK
    Br J Ophthalmol 87:307-11. 2003
    ..To examine the relation between the type of choroidal neovascularisation (CNV) in the first eye and age related maculopathy (ARM) severity in the fellow eye...
  19. pmc Evolving European guidance on the medical management of neovascular age related macular degeneration
    U Chakravarthy
    Queen s University and Royal Victoria Hospitals, Belfast, UK
    Br J Ophthalmol 90:1188-96. 2006
    ..In light of these new data, expert guidance is required to enable retina specialists with expertise in the management of AMD to select and use the most appropriate therapies for the treatment of neovascular AMD...
  20. ncbi request reprint Investigation of the effect of simulated lens yellowing, transparency loss and refractive error on in vivo resonance Raman spectroscopy
    R E Hogg
    Department of Ophthalmology and Vision Science, Queen s University, Belfast, UK
    Ophthalmic Physiol Opt 27:225-31. 2007
    ..To separately investigate the impact of simulated age-related lens yellowing, transparency loss and refractive error on measurements of macular pigment (MP) using resonance Raman spectroscopy...
  21. pmc Association study of detoxification genes in age related macular degeneration
    H Esfandiary
    Centre for Vision Sciences, Queen s University Belfast, Belfast BT12 6BA, UK
    Br J Ophthalmol 89:470-4. 2005
    ..The choice of genes was based on their function in the breakdown of industrial pollutants, cigarette smoke, defence against oxidative stress, or involvement in the general ageing process...
  22. doi request reprint Distortion maps from preferential hyperacuity perimetry are helpful in monitoring functional response to Lucentis therapy
    Radha Das
    Centre for Vision Sciences, Queen s University of Belfast, Institute of Clinical Science, Belfast, Northern Ireland
    Retina 29:1013-8. 2009
    ..To use preferential hyperacuity perimetry to obtain a quantitative measure of central visual field distortion that would aid in the monitoring of functional responsiveness to ranibizumab treatment...
  23. pmc Formal and informal care utilisation amongst elderly persons with visual impairment
    Kathleen M Ke
    School of Medicine and Dentistry, Queen s University, Belfast, UK
    Br J Ophthalmol 91:1279-81. 2007
    ..To examine the determinants of formal and informal care utilisation amongst persons with age-related macular degeneration (AMD)...
  24. ncbi request reprint Molecular genetics of microvascular disease in diabetic retinopathy
    K M Warpeha
    Ophthalmology and Vision Science, Queen s University and Royal Hospitals, Institute of Clinical Science, Grosvenor Road, Belfast BT12 6BA, N Ireland, UK
    Eye (Lond) 17:305-11. 2003
    ..This may reflect inaccurate case definition, small subject numbers and possibly inadequate markers for genetic studies...
  25. ncbi request reprint AMD and micronutrient antioxidants
    Ruth Hogg
    Ophthalmology and Vision Science, Institute of Clinical Science, The Royal Victoria Hospital, Belfast, Northern Ireland
    Curr Eye Res 29:387-401. 2004
    ..The positive outcomes in the Age-Related Eye Diseases Study, a major controlled clinical trial, have given hope that modulation of the antioxidant balance through supplementation can help prevent progression of ARM to AMD...
  26. doi request reprint How does the short-wavelength-sensitive contrast sensitivity function for detection and resolution change with age in the periphery?
    Raymond O Beirne
    Vision Science Research Group, School of Biomedical Sciences, University of Ulster at Coleraine, BT52 1SA, Northern Ireland, UK
    Vision Res 48:1894-901. 2008
    ..The age-related loss in the SWS resolution CSF at high spatial frequency probably reflects a loss occurring at the ganglion cells level...
  27. ncbi request reprint Morphometric analysis of angiograms of exudative lesions in age-related macular degeneration
    Farrukh Ali
    Eye and Ear Clinic, Royal Victoria Hospital, The Queen s University of Belfast, Belfast BT12 6BA, Northern Ireland, United Kingdom
    Arch Ophthalmol 122:710-5. 2004
    ..To analyze the morphometric composition of lesion components in exudative age-related macular degeneration and to study the relationships between individual lesion components and choroidal neovascularization (CNV) subtype, at 2 time points...
  28. ncbi request reprint Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration
    Cristina Augood
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Clin Nutr 88:398-406. 2008
    ..Fish intake, the major source of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), may reduce the risk of age-related macular degeneration (AMD)...
  29. ncbi request reprint Cardiovascular disease and hypertension are strong risk factors for choroidal neovascularization
    Ruth E Hogg
    Centre for Vision Sciences, Belfast, United Kingdom
    Ophthalmology 115:1046-1052.e2. 2008
    ..To investigate the association of cardiovascular risk factors and inflammatory markers with neovascular age-related macular degeneration (AMD)...
  30. ncbi request reprint The natural history and prognosis of neovascular age-related macular degeneration: a systematic review of the literature and meta-analysis
    Tien Y Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Ophthalmology 115:116-26. 2008
    ..To describe the natural history and progression of visual loss in eyes with untreated neovascular age-related macular degeneration (AMD)...
  31. doi request reprint Sunlight exposure, antioxidants, and age-related macular degeneration
    Astrid E Fletcher
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, England
    Arch Ophthalmol 126:1396-403. 2008
    ..To examine the association of sunlight exposure and antioxidant level with age-related macular degeneration (AMD)...
  32. ncbi request reprint Early features of AMD
    Ruth E Hogg
    Ophthalmology 114:1028. 2007
  33. ncbi request reprint Rasch analysis of the daily living tasks dependent on vision (DLTV)
    Frances Denny
    Centre for Vision Sciences, School of Mathematics and Physics, Queen s University of Belfast, Belfast Northern Ireland, United Kingdom
    Invest Ophthalmol Vis Sci 48:1976-82. 2007
    ..To examine internal consistency, refine the response scale, and obtain a linear scoring system for the visual function instrument, the Daily Living Tasks Dependent on Vision (DLTV)...
  34. ncbi request reprint A case-control study of drug risk factors for age-related macular degeneration
    Ian J Douglas
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Ophthalmology 114:1164-9. 2007
    ..To investigate the association between age-related macular degeneration (AMD) and exposure to antacids, antithyroids, thyroid hormones, and thiazide diuretics...
  35. ncbi request reprint Quantitative fluorescein angiographic analysis of choroidal neovascular membranes: validation and correlation with visual function
    Usha Chakravarthy
    Doheny Retina Institute Advanced Macular Diagnostics Lab, Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine, at the University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 48:349-54. 2007
    ....
  36. ncbi request reprint Prevalence of early and late age-related macular degeneration in a rural population in northern India: the INDEYE feasibility study
    Sanjeev K Gupta
    Department of Community Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    Invest Ophthalmol Vis Sci 48:1007-11. 2007
    ..To assess the prevalence of age-related macular degeneration (AMD) in a rural population in Northern India...
  37. pmc Trends in provision of photodynamic therapy and clinician attitudes: a tracker survey of a new health technology
    Robbie C Foy
    The Centre for Health Services Research, University of Newcastle upon Tyne, UK
    BMC Health Serv Res 5:34. 2005
    ..We assessed trends in PDT provision up to the point of release of the NICE guidance and identified likely sources of pressure on ophthalmologists to provide PDT...
  38. ncbi request reprint Methods for a population-based study of the prevalence of and risk factors for age-related maculopathy and macular degeneration in elderly European populations: the EUREYE study
    Cristina Augood
    Non communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Ophthalmic Epidemiol 11:117-29. 2004
    ....
  39. ncbi request reprint Increasing use of a new health technology during the wait for NICE guidance: findings from the third national tracker survey of photodynamic therapy
    Barny Foot
    The Royal College of Ophthalmologists, London
    J Public Health (Oxf) 26:52-5. 2004
    ..Over three annual tracker surveys, we describe trends in the provision of PDT in the NHS and potential difficulties in the implementation of NICE guidance...
  40. ncbi request reprint Grading of age-related maculopathy for epidemiological studies: is digital imaging as good as 35-mm film?
    Redmer van Leeuwen
    Department of Epidemiology and Biostatistics, and EUREYE Grading Center, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 110:1540-4. 2003
    ..To compare stereo digital images with stereo 35-mm color transparencies as to the quality and reliability of grading age-related maculopathy (ARM) in the context of a multicenter European epidemiologic study (the EUREYE Study)...
  41. pmc Age related macular degeneration
    Amresh Chopdar
    East Surrey Hospital, Redhill, Surrey RH1 5RH
    BMJ 326:485-8. 2003
  42. ncbi request reprint Retinal vein occlusion, homocysteine, and methylene tetrahydrofolate reductase genotype
    Stuart J McGimpsey
    Department of Ophthalmology, Royal Group of Hospitals, Belfast, Ireland, United Kingdom
    Invest Ophthalmol Vis Sci 46:4712-6. 2005
    ..The aim of this case-control study was to investigate the relationship between homocysteine (tHcy), 5,10 methylene tetrahydrofolate reductase (MTHFR) C677T genotype, folate and vitamin B12 status, and retinal vein occlusion (RVO)...
  43. ncbi request reprint Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE)
    Cristina A Augood
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, England
    Arch Ophthalmol 124:529-35. 2006
    ..To estimate the prevalence of age-related maculopathy in an older population from 7 European countries...
  44. ncbi request reprint Economic cost of age-related macular degeneration: a review of recent research
    Kathleen M Ke
    School of Economics and Politics, University of Ulster, Newtownabbey, UK
    Drugs Aging 23:217-25. 2006
    ..We further argue that significant gaps in our understanding of the costs of AMD (particularly in respect of indirect costs) also exist. Current research should be augmented by more comprehensive studies...
  45. ncbi request reprint Fundus autofluorescence in age-related macular degeneration: an epiphenomenon?
    Jill Hopkins
    Doheny Retina Institute, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 47:2269-71. 2006
  46. ncbi request reprint Severity staging by early features of age-related maculopathy exhibits weak relationships with functional deficits on SWS grating acuity
    Raymond O Beirne
    Vision Science Research Group, School of Biomedical Sciences, University of Ulster, Northern Ireland, United Kingdom
    Invest Ophthalmol Vis Sci 47:4624-31. 2006
    ..To examine the relationship between short-wavelength-sensitive (SWS) resolution acuity and epidemiologically defined stages of early age-related maculopathy (ARM)...
  47. pmc Age related macular degeneration
    Usha Chakravarthy
    BMJ 333:869-70. 2006
  48. doi request reprint Macular pigment and age-related macular degeneration: longitudinal data and better techniques of measurement are needed
    Stephen Beatty
    Macular Pigment Research Group, Waterford Institute of Technology, Waterford, Ireland
    Invest Ophthalmol Vis Sci 49:843-5. 2008
  49. pmc New treatments for neovascular acute macular degeneration
    Usha Chakravarthy
    BMJ 334:269-70. 2007
  50. doi request reprint Blood levels of vitamin C, carotenoids and retinol are inversely associated with cataract in a North Indian population
    Mukesh Dherani
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 49:3328-35. 2008
    ..To examine the association of blood antioxidants with cataract...