Research Topics
Genomes and GenesSpecies | Lesley A AndersonSummaryAffiliation: Queen's University Belfast Country: UK Publications
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Publications
Inverse association between gastroesophageal reflux and blood pressure: results of a large community based studyLiam J Murray
Bolton Hospitals NHS Trust, Bolton, UK
BMC Gastroenterol 8:10. 2008..In a cross-sectional community based study, as part of a randomised controlled trial of eradication of Helicobacter pylori infection, the association between blood pressure and symptoms of gastro-oesophageal reflux was examined...
Survival patterns among lymphoma patients with a family history of lymphomaLesley A Anderson
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
J Clin Oncol 26:4958-65. 2008..Only a few small studies have assessed clinical characteristics and prognosis for familial patients, with inconsistent findings...
Relationship between Helicobacter pylori infection and gastric atrophy and the stages of the oesophageal inflammation, metaplasia, adenocarcinoma sequence: results from the FINBAR case-control studyL A Anderson
Centre for Clinical and Population Sciences, Queen s University Belfast, Mulhouse Building, Grosvenor Road, Belfast BT12 6BJ, UK
Gut 57:734-9. 2008..The relationship between all stages of the oesophageal inflammation, metaplasia, adenocarcinoma sequence and H pylori infection and gastric atrophy was explored...
Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR studyLesley A Anderson
Centre for Clinical and Population Sciences, Queen s University, Mulhouse Building, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland
World J Gastroenterol 13:1585-94. 2007..To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma...
Risks of myeloid malignancies in patients with autoimmune conditionsL A Anderson
Centre for Public Health, Queen s University Belfast, Northern Ireland, UK
Br J Cancer 100:822-8. 2009..15). Medications used to treat autoimmune conditions, shared genetic predisposition and/or direct infiltration of bone marrow by autoimmune conditions, could explain these excess risks of myeloid malignancies...
Malignancy and mortality in a population-based cohort of patients with coeliac disease or "gluten sensitivity"L A Anderson
Centre for Clinical and Population Sciences, Mulhouse Building, Grosvenor Road, Belfast, BT12 6BJ, United Kingdom
World J Gastroenterol 13:146-51. 2007..To determine the risk of malignancy and mortality in patients with a positive endomysial or anti-gliadin antibody test in Northern Ireland...
Nonsteroidal anti-inflammatory drugs and the esophageal inflammation-metaplasia-adenocarcinoma sequenceLesley A Anderson
Centre for Clinical and Population Sciences, Queen s University, Belfast, Northern Ireland
Cancer Res 66:4975-82. 2006..If NSAIDs have a true protective effect on the esophageal inflammation-metaplasia-adenocarcinoma sequence, they may act early in the sequence...
Common community acquired infections and subsequent risk of chronic lymphocytic leukaemiaLesley A Anderson
Centre for Public Health, Queen s University Belfast, Belfast, Northern Ireland, UK
Br J Haematol 147:444-9. 2009..001). Our findings suggest that common infections may play a role in CLL aetiology. Alternatively, the associations might reflect an underlying immune disturbance present several years prior to CLL diagnosis...
Autoimmune conditions and hairy cell leukemia: an exploratory case-control studyLesley A Anderson
Cancer Epidemiology and Health Services Research Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, Northern Ireland, UK
J Hematol Oncol 3:35. 2010..Case reports suggest that hairy cell leukemia (HCL) may be associated with autoimmune conditions, however no systematic investigations in this area have been undertaken...
Mortality in Barrett's oesophagus: results from a population based studyL A Anderson
Northern Ireland Cancer Registry, Department of Epidemiology and Public Health, The Queen s University Belfast, UK
Gut 52:1081-4. 2003..Other causes of death are reportedly raised in this group. We examined cause specific mortality among individuals in a population based Barrett's oesophagus register...
The association between alcohol and reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinomaLesley A Anderson
Centre for Public Health, Queen s University, Belfast, Northern Ireland
Gastroenterology 136:799-805. 2009..However, reports about the association between alcohol and reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma are conflicting...
Glycemic index, carbohydrate and fiber intakes and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinomaHelen G Mulholland
Cancer Epidemiology and Prevention Research Group, Centre for Clinical and Population Sciences, Queens University Belfast, Grosvenor Road, Belfast, Northern Ireland, UK
Cancer Causes Control 20:279-88. 2009..To examine the association between dietary glycemic index (GI), glycemic load (GL), total carbohydrate, sugars, starch, and fiber intakes and the risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma...
Dietary antioxidant and mineral intake in humans is associated with reduced risk of esophageal adenocarcinoma but not reflux esophagitis or Barrett's esophagusSeamus J Murphy
Centre for Public Health, Queen s University Belfast, Belfast BT12 6BJ, Northern Ireland
J Nutr 140:1757-63. 2010..These results suggest that antioxidants may play a role in the pathogenesis of RE and EAC and may be more important in terms of progression rather than initiation of the disease process...
Cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphisms and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinomaHeather R Ferguson
Division of Gastroenterology, Belfast City Hospital, Belfast, United Kingdom
Cancer Epidemiol Biomarkers Prev 17:727-31. 2008..Our study suggests that the COX-2 8473 C allele is a potential genetic marker for susceptibility to esophageal adenocarcinoma...
A population-based association study of SNPs of GSTP1, MnSOD, GPX2 and Barrett's esophagus and esophageal adenocarcinomaSeamus J Murphy
Department of Medical Genetics, Queen s University Belfast, Royal Group of Hospitals, Grosvenor Road, Belfast, Ireland
Carcinogenesis 28:1323-8. 2007..SNPs involving the GSTP1, MnSOD and GPX2 genes were not associated with BE or EAC. Further studies aimed at identifying susceptibility genes should focus on different antioxidant genes or different pathways...
Risk of Barrett's oesophagus, oesophageal adenocarcinoma and reflux oesophagitis and the use of nitrates and asthma medicationsTodd C Ladanchuk
Centre for Public Health, Queen s University, and Royal Group of Hospitals, Belfast, Northern Ireland, UK
Scand J Gastroenterol 45:1397-403. 2010..To investigate the relationship between use of asthma medication and nitrates and risk of reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma...
Vitamin D, calcium and dairy intake, and risk of oesophageal adenocarcinoma and its precursor conditionsHelen G Mulholland
Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queens University Belfast, Mulhouse Building, RVH Site, Grosvenor Road, Belfast BT12 6BJ, UK
Br J Nutr 106:732-41. 2011..Limited work has been conducted in this area, and further research is required...
Hematopoietic malignancies associated with viral and alcoholic hepatitisLesley A Anderson
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7076 Rockville, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 17:3069-75. 2008..In summary, HCV, but not other causes of hepatitis, was associated with the elevated risk of non-Hodgkin lymphoma and acute myeloid leukemia. HCV may induce lymphoproliferative malignancies through chronic immune stimulation...
Cigarette smoking increases risk of Barrett's esophagus: an analysis of the Barrett's and Esophageal Adenocarcinoma ConsortiumMichael B Cook
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852 7234, USA
Gastroenterology 142:744-53. 2012..We investigated whether tobacco smoking and other factors increase risk for Barrett's esophagus...
Incidence of colorectal cancer in a population-based cohort of patients with Barrett's oesophagusSeamus J Murphy
Northern Ireland Cancer Registry, Belfast, Northern Ireland
Scand J Gastroenterol 40:1449-53. 2005..No population-based studies have examined the incidence of this cancer in patients with Barrett's oesophagus...
Increased risk for lymphoid and myeloid neoplasms in elderly solid-organ transplant recipientsScott C Quinlan
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7076, Rockville, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 19:1229-37. 2010....
Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based studySeamus J Murphy
Department of Epidemiology and Public Health, Mulhouse Building, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland
World J Gastroenterol 11:7290-5. 2005..To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma...
Increased risk of stomach and esophageal malignancies in people with AIDSE Christina Persson
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852 7234, USA
Gastroenterology 143:943-950.e2. 2012..We evaluated the risks of different histologic and anatomic subtypes of carcinomas and non-Hodgkin lymphomas (NHLs) of the stomach and esophagus in people with acquired immunodeficiency syndrome (AIDS)...
Socio-economic and other correlates of Kaposi sarcoma-associated herpesvirus seroprevalence among older adults in SicilyColleen Pelser
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA
J Med Virol 81:1938-44. 2009..3, CI 0.1-0.9). Other demographic and household variables were unrelated to seroprevalence. From these data, KSHV in Sicily appears to be related to low socio-economic status, but micro-endemicity in small communities cannot be excluded...
Dietary fat and meat intakes and risk of reflux esophagitis, Barrett's esophagus and esophageal adenocarcinomaMark G O'Doherty
Cancer Epidemiology Health Services Research Group, Centre for Public Health, Queens University Belfast, Belfast, Northern Ireland, United Kingdom
Int J Cancer 129:1493-502. 2011..67; 95% CI = 1.71-12.74). No consistent associations were seen for BE with either fat or meat intakes. Further studies investigating the association between dietary fat and food sources of fat are needed to confirm these results...
Concomitant and antecedent deep venous thrombosis and cancer survival in male US veteransLesley A Anderson
Centre for Public Health, Queen s University Belfast, Northern Ireland, United Kingdom
Leuk Lymphoma 52:764-70. 2011..Advanced stage at diagnosis, treatment effects, lifestyle factors, and comorbidity could explain differences by cancer site and time frame between a prior deep venous thrombosis diagnosis and cancer outcome...
Iron intake and markers of iron status and risk of Barrett's esophagus and esophageal adenocarcinomaMark G O'Doherty
Cancer Epidemiology Health Services Research Group, Centre for Public Health, Queens University Belfast, Mulhouse Building, Grosvenor Road, Belfast BT12 6BJ, UK
Cancer Causes Control 21:2269-79. 2010..To investigate the association between iron intake and iron status with Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC)...
Population-based study of autoimmune conditions and the risk of specific lymphoid malignanciesLesley A Anderson
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Int J Cancer 125:398-405. 2009..These results support a mechanism whereby chronic antigenic stimulation leads to lymphoid malignancy...
Withdrawal of corticosteroids in inflammatory bowel disease patients after dependency periods ranging from 2 to 45 years: a proposed methodS J Murphy
Centre for Colorectal Disease, St Vincent s University Hospital, Dublin, Ireland
Aliment Pharmacol Ther 30:1078-86. 2009..Even in the biologic era, corticosteroid dependency in IBD patients is common and causes a lot of morbidity, but methods of withdrawal are not well described...
Oesophageal cancer: caregiver mental health and strainM Donnelly
Centre for Clinical and Population Sciences, Queen s University, Belfast, Northern Ireland
Psychooncology 17:1196-201. 2008..To investigate strain and mental health among family caregivers of oesophageal cancer patients and possible factors associated with caregiver mental health and strain...
Risk of classic Kaposi sarcoma with exposures to plants and soils in SicilyJames J Goedert
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
Infect Agent Cancer 5:23. 2010..Ecologic and in vitro studies suggest that exposures to plants or soil may influence risk of Kaposi sarcoma (KS)...
Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer: a systematic reviewJessica C Wilson
Centre for Public Health, School of Medicine Dentistry and Biomedical Sciences, Queen s University Belfast, Belfast, UK
Cancer Causes Control 22:803-10. 2011..Evidence for NSAIDs preventing head and neck cancer (HNC) is conflicting. We conducted a systematic literature review to investigate the association between NSAID/aspirin use and risk of head and neck cancer (HNC)...
Environmental, lifestyle, and familial/ethnic factors associated with myeloproliferative neoplasmsLesley A Anderson
Centre for Public Health, Queen s University Belfast, Northern Ireland
Am J Hematol 87:175-82. 2012..The vast heterogeneity in studies identified as part of this review suggests that large scale systematic assessment of etiological factors associated with MPNs is warranted. © 2011 Wiley-Liss, Inc...
Psychosocial factors and their association with reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinomaPaul Denver
Paul Denver, Michael Donnelly, Liam J Murray, Lesley A Anderson, Centre for Public Health, Queen s University Belfast, Belfast BT12 6BJ, Northern Ireland, United Kingdom
World J Gastroenterol 19:1770-7. 2013..To investigate the role of psychological characteristics as risk factors for oesophageal adenocarcinoma (OAC), as well as the reflux-mediated precursor pathway...
Human herpesvirus 8 seroprevalence among children and adolescents in the United StatesLesley A Anderson
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Pediatr Infect Dis J 27:661-4. 2008..4%). K8.1 seropositivity was associated with asthma (odds ratio: 6.3; 95% confidence interval: 2.4-16.9) and hay fever (3.5; 1.1-11.0), and there were borderline associations with measures of crowding and low socioeconomic status...
Antibiotic use and risk of non-Hodgkin's lymphoma: a population-based case-control studyL A Anderson
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Br J Cancer 98:161-4. 2008..7, 95% confidence interval=0.5-1.2), nor antibiotic use by site, was associated with total NHL, or NHL subtypes. There were no trends with frequency or age at first use (P trend=0.23 and 0.26, respectively)...
Patients with Barrett esophagus have poor understanding of the diagnosis and its implicationsSeamus J Murphy
J Clin Gastroenterol 42:431-2. 2008
No association between hOGG1, XRCC1, and XPD polymorphisms and risk of reflux esophagitis, Barrett's esophagus, or esophageal adenocarcinoma: results from the factors influencing the Barrett's adenocarcinoma relationship case-control studyHeather R Ferguson
Division of Gastroenterology, Belfast City Hospital, Belfast BT9 7AB, Northern Ireland
Cancer Epidemiol Biomarkers Prev 17:736-9. 2008..There were no statistically significant associations between these polymorphisms and risk of esophageal adenocarcinoma, Barrett's esophagus, or reflux esophagitis...
Hepatitis C virus infection and non-Hodgkin lymphoma: interesting association or causal relationship?Lesley A Anderson
Int J Cancer 122:x-xii. 2008
