J A Wedzicha

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi request reprint Domiciliary oxygen therapy services: clinical guidelines and advice for prescribers. Summary of a report of the Royal College of Physicians
    J A Wedzicha
    St Bartholomew s Hospital, London
    J R Coll Physicians Lond 33:445-7. 1999
  2. ncbi request reprint Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels
    J A Wedzicha
    Department of Academic Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London, UK
    Thromb Haemost 84:210-5. 2000
  3. ncbi request reprint Inflammatory changes, recovery and recurrence at COPD exacerbation
    W R Perera
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Rowland Hill Street, Hampstead, London, NW3 2PF, UK
    Eur Respir J 29:527-34. 2007
  4. ncbi request reprint Effect of tiotropium on sputum and serum inflammatory markers and exacerbations in COPD
    D J Powrie
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Rowland Hill Street, London, UK
    Eur Respir J 30:472-8. 2007
  5. ncbi request reprint Effects of exacerbations and seasonality on exhaled nitric oxide in COPD
    A Bhowmik
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
    Eur Respir J 26:1009-15. 2005
  6. ncbi request reprint Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease
    T Seemungal
    Academic Department of Respiratory Medicine and Virology, St. Bartholomew's and Royal London School of Medicine and Dentistry, London, UK
    Am J Respir Crit Care Med 164:1618-23. 2001
  7. ncbi request reprint Randomised controlled trial of nasal ventilation in acute ventilatory failure due to chronic obstructive airways disease
    J Bott
    King s College School of Medicine and Dentistry, London, UK
    Lancet 341:1555-7. 1993
  8. ncbi request reprint Epidemiological relationships between the common cold and exacerbation frequency in COPD
    J R Hurst
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Hampstead, London, NW3 2QG, UK
    Eur Respir J 26:846-52. 2005
  9. doi request reprint Predictive accuracy of patient-reported exacerbation frequency in COPD
    J K Quint
    Academic Unit of Respiratory Medicine, University College London, Rowland Hill Street, London, NW3 2PF, UK
    Eur Respir J 37:501-7. 2011
  10. ncbi request reprint Airway epithelial inflammatory responses and clinical parameters in COPD
    I S Patel
    Academic Unit of Respiratory Medicine, St Bartholomew s and The Royal London Hospital School of Medicine and Dentistry, London, UK
    Eur Respir J 22:94-9. 2003

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Domiciliary oxygen therapy services: clinical guidelines and advice for prescribers. Summary of a report of the Royal College of Physicians
    J A Wedzicha
    St Bartholomew s Hospital, London
    J R Coll Physicians Lond 33:445-7. 1999
    ..New methods of prescribing are also recommended...
  2. ncbi request reprint Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels
    J A Wedzicha
    Department of Academic Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London, UK
    Thromb Haemost 84:210-5. 2000
    ....
  3. ncbi request reprint Inflammatory changes, recovery and recurrence at COPD exacerbation
    W R Perera
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Rowland Hill Street, Hampstead, London, NW3 2PF, UK
    Eur Respir J 29:527-34. 2007
    ..A high serum C-reactive protein concentration 14 days after an index exacerbation may be used as a predictor of recurrent exacerbations within 50 days...
  4. ncbi request reprint Effect of tiotropium on sputum and serum inflammatory markers and exacerbations in COPD
    D J Powrie
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Rowland Hill Street, London, UK
    Eur Respir J 30:472-8. 2007
    ..3 versus 34.5 days). Tiotropium reduces exacerbation frequency in chronic obstructive pulmonary disease, but this effect does not appear to be due to a reduction in airway or systemic inflammation...
  5. ncbi request reprint Effects of exacerbations and seasonality on exhaled nitric oxide in COPD
    A Bhowmik
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
    Eur Respir J 26:1009-15. 2005
    ..The levels were lower in more severe chronic obstructive pulmonary disease. Exhaled nitric oxide levels were raised at the onset of exacerbation, particularly in the presence of a cold...
  6. ncbi request reprint Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease
    T Seemungal
    Academic Department of Respiratory Medicine and Virology, St. Bartholomew's and Royal London School of Medicine and Dentistry, London, UK
    Am J Respir Crit Care Med 164:1618-23. 2001
    ..Prevention and early treatment of viral infections may lead to a decreased exacerbation frequency and morbidity associated with COPD...
  7. ncbi request reprint Randomised controlled trial of nasal ventilation in acute ventilatory failure due to chronic obstructive airways disease
    J Bott
    King s College School of Medicine and Dentistry, London, UK
    Lancet 341:1555-7. 1993
    ..33, CI = 0.10-1.11, p = 0.106). In patients with acute ventilatory failure due to COAD who received NIPPV there was a significant rise in pH, a reduction in PaCO2 and breathlessness, and reduced mortality...
  8. ncbi request reprint Epidemiological relationships between the common cold and exacerbation frequency in COPD
    J R Hurst
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Hampstead, London, NW3 2QG, UK
    Eur Respir J 26:846-52. 2005
    ..Exacerbation frequency in chronic obstructive pulmonary disease is associated with an increased frequency of acquiring the common cold, rather than an increased propensity to exacerbation once a cold has been acquired...
  9. doi request reprint Predictive accuracy of patient-reported exacerbation frequency in COPD
    J K Quint
    Academic Unit of Respiratory Medicine, University College London, Rowland Hill Street, London, NW3 2PF, UK
    Eur Respir J 37:501-7. 2011
    ..Accuracy is increased when comparing the same 1-yr period. Patient recall is sufficiently robust for stratification into frequent and infrequent exacerbator groups for subsequent years...
  10. ncbi request reprint Airway epithelial inflammatory responses and clinical parameters in COPD
    I S Patel
    Academic Unit of Respiratory Medicine, St Bartholomew s and The Royal London Hospital School of Medicine and Dentistry, London, UK
    Eur Respir J 22:94-9. 2003
    ....
  11. pmc Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
    G C Donaldson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
    Thorax 57:847-52. 2002
    ..The aim of this study was to investigate whether these are related...
  12. ncbi request reprint Longitudinal changes in the nature, severity and frequency of COPD exacerbations
    G C Donaldson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London, UK
    Eur Respir J 22:931-6. 2003
    ..1% x yr(-1) from an initial value of 17%. The results of this study suggest that over time, individual patients have more symptoms during exacerbations, with an increased chance of sputum purulence and longer recovery times...
  13. ncbi request reprint Patterns of home mechanical ventilation use in Europe: results from the Eurovent survey
    S J Lloyd-Owen
    Academic Unit of Respiratory Medicine, Dominion House, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Eur Respir J 25:1025-31. 2005
    ..In conclusion, wide variations exist in the patterns of home mechanical ventilation provision throughout Europe. Further work is needed to monitor its use and ensure equality of provision and access...
  14. ncbi request reprint Noninvasive ventilation in chronic obstructive pulmonary disease, bronchiectasis and cystic fibrosis
    J A Wedzicha
    St Bartholomew s Hospital, London, UK
    Eur Respir J 20:777-84. 2002
    ....
  15. ncbi request reprint Adverse effects of nasal continuous positive airway pressure therapy in sleep apnoea syndrome
    A Kalan
    Department of Otolaryngology, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
    J Laryngol Otol 113:888-92. 1999
    ..8 hours (SD 8.05) and with 83 per cent of the patients using the device every night. Although nCPAP treatment remains acceptable to most patients there exists a high incidence of adverse effects...
  16. pmc Chronic obstructive pulmonary disease: the clinical management of an acute exacerbation
    J R Hurst
    Academic Unit of Respiratory Medicine, Dominion House, St Bartholomew s Hospital, London EC1A 7BE, UK
    Postgrad Med J 80:497-505. 2004
    ..In this review we aim to bring the non-specialist reader up to date with current management principles and the evidence underlying such interventions...
  17. ncbi request reprint An evaluation of the reliability and sensitivity of the London Chest Activity of Daily Living Scale (LCADL)
    R Garrod
    School of Physiotherapy, St George s Hospital, London, UK
    Respir Med 96:725-30. 2002
    ..91 (from -9.23 to -2.60) after rehabilitation. These data support the use of the LCADL as an outcome measure in COPD which is valid, reliable and responsive to change...
  18. pmc Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations
    I S Patel
    Academic Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London EC1A 7BE, UK
    Thorax 57:759-64. 2002
    ..Stable COPD patients often have lower airway bacterial colonisation which may be an important stimulus to airway inflammation and thereby modulate exacerbation frequency...
  19. doi request reprint Defective macrophage phagocytosis of bacteria in COPD
    A E Taylor
    Airways Disease Section, National Heart and Lung Institute, Dovehouse Street, London, UK
    Eur Respir J 35:1039-47. 2010
    ..COPD macrophage innate responses are suppressed and may lead to bacterial colonisation and increased exacerbation frequency...
  20. ncbi request reprint Short burst oxygen therapy is helpful?
    J A Wedzicha
    Academic Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, St Bartholomew s Hospital, West Smithfield, London, UK
    Chron Respir Dis 1:101-3. 2004