Martin J Warren

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi request reprint The biosynthesis of adenosylcobalamin (vitamin B12)
    Martin J Warren
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London, UK E1 4NS
    Nat Prod Rep 19:390-412. 2002
  2. ncbi request reprint Identification and characterization of the terminal enzyme of siroheme biosynthesis from Arabidopsis thaliana: a plastid-located sirohydrochlorin ferrochelatase containing a 2FE-2S center
    Evelyne Raux-Deery
    School of Biological Sciences, Queen Mary, University of London, Mile End Rd, London E1 4NS, United Kingdom
    J Biol Chem 280:4713-21. 2005
  3. ncbi request reprint Identification and characterization of a novel vitamin B12 (cobalamin) biosynthetic enzyme (CobZ) from Rhodobacter capsulatus, containing flavin, heme, and Fe-S cofactors
    Helen M McGoldrick
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom
    J Biol Chem 280:1086-94. 2005
  4. pmc Characterization of retinaldehyde dehydrogenase 3
    Caroline E Graham
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Biochem J 394:67-75. 2006
  5. ncbi request reprint Characterization of the cobaltochelatase CbiXL: evidence for a 4Fe-4S center housed within an MXCXXC motif
    Helen K Leech
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    J Biol Chem 278:41900-7. 2003
  6. ncbi request reprint A story of chelatase evolution: identification and characterization of a small 13-15-kDa "ancestral" cobaltochelatase (CbiXS) in the archaea
    Amanda A Brindley
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom
    J Biol Chem 278:22388-95. 2003
  7. pmc Identification and functional analysis of enzymes required for precorrin-2 dehydrogenation and metal ion insertion in the biosynthesis of sirohaem and cobalamin in Bacillus megaterium
    Evelyne Raux
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Biochem J 370:505-16. 2003
  8. ncbi request reprint Purification, characterisation and intracellular localisation of aryl hydrocarbon interacting protein-like 1 (AIPL1) and effects of mutations associated with inherited retinal dystrophies
    Victoria A Gallon
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, E1 4NS, UK
    Biochim Biophys Acta 1690:141-9. 2004
  9. ncbi request reprint Elucidation of substrate specificity in the cobalamin (vitamin B12) biosynthetic methyltransferases. Structure and function of the C20 methyltransferase (CbiL) from Methanothermobacter thermautotrophicus
    Stefanie Frank
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, United Kingdom
    J Biol Chem 282:23957-69. 2007
  10. ncbi request reprint Isolation and characterization of 14 additional genes specifying the anaerobic biosynthesis of cobalamin (vitamin B12) in Propionibacterium freudenreichii (P. shermanii)
    Charles A Roessner
    Center for Biological NMR, Department of Chemistry, Texas A and M University, College Station, TX 77843 3255, USA
    Microbiology 148:1845-53. 2002

Collaborators

  • Heidi L Schubert
  • Andrew W Munro
  • Kirsty J McLean
  • Peter Heathcote
  • A Ian Scott
  • Charles A Roessner
  • Stefano Santabarbara
  • Jorge C Escalante-Semerena
  • David M Hunt
  • Andrew W Foster
  • Michael N G James
  • Fabrice Rebeille
  • Amanda A Brindley
  • ELIZABETH GETZOFF
  • David Leys
  • Helen K Leech
  • Evelyne Raux
  • Alison G Smith
  • Evelyne Raux-Deery
  • Andrew D Lawrence
  • Martin T Croft
  • Stephen E J Rigby
  • Jitka Vévodová
  • Richard W Pickersgill
  • Andree Marquet
  • Michael B Prentice
  • M Elizabeth Stroupe
  • Susana A L Lobo
  • Dinesh Diraviam Sriramulu
  • Evelyne Deery
  • Stefanie Frank
  • Ralf R Mendel
  • Keith Brocklehurst
  • Caroline E Graham
  • Andrew Lawrence
  • Jiang Yin
  • Colin P Guy
  • Rajasekhar Neeli
  • Helen M McGoldrick
  • Keith S Wilson
  • Ross M Graham
  • Victoria A Gallon
  • Dieter Jahn
  • Célia V Romão
  • Mingzhi Liang
  • Lígia M Saraiva
  • Joshua B Parsons
  • Heinrich Lünsdorf
  • Diana Hernandez-Romero
  • Steve E J Rigby
  • Bernadette Tse Sum Bui
  • Amanda A Bindley
  • Maia M Cherney
  • John R Walker
  • David A Walsh
  • Edward L Bolt
  • Thorsten Allers
  • Linda X Xu
  • Sam Haldenby
  • Marianne E Cuff
  • Alexei Savchenko
  • Geoffrey S Briggs
  • Nigel S Scrutton
  • Kerry Ann Nakrieko
  • Hazel M Girvan
  • Melanie M Sohocki
  • Richard J Newbold
  • Evelyne C Deery
  • A Ian Scott
  • N Patrick J Stamford
  • David I Roper
  • Susan E Wilkie
  • Shomi S Bhattacharya
  • Evelyn Deery
  • Nigel J Robinson
  • Claude Thermes
  • Nick Thomson
  • Marco Malten
  • Patricio J Santander
  • Douglas S Daniels
  • Richard Beck
  • Jon Cuccui
  • Alain Rambach
  • Julian Parkhill
  • Gilles P M Borrelly
  • Jan H Martens

Detail Information

Publications26

  1. ncbi request reprint The biosynthesis of adenosylcobalamin (vitamin B12)
    Martin J Warren
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London, UK E1 4NS
    Nat Prod Rep 19:390-412. 2002
    ..This review covers some of the most important findings that have been made and provides the reader with a complete description of the transformation of uroporphyrinogen III into adenosylcobalamin (AdoCbl). 183 references are cited...
  2. ncbi request reprint Identification and characterization of the terminal enzyme of siroheme biosynthesis from Arabidopsis thaliana: a plastid-located sirohydrochlorin ferrochelatase containing a 2FE-2S center
    Evelyne Raux-Deery
    School of Biological Sciences, Queen Mary, University of London, Mile End Rd, London E1 4NS, United Kingdom
    J Biol Chem 280:4713-21. 2005
    ..This is the first Fe-S center to be reported in a higher plant ferrochelatase. The implications of the Fe-S center in an enzyme that is so closely associated with the metabolism of sulfur and iron are discussed...
  3. ncbi request reprint Identification and characterization of a novel vitamin B12 (cobalamin) biosynthetic enzyme (CobZ) from Rhodobacter capsulatus, containing flavin, heme, and Fe-S cofactors
    Helen M McGoldrick
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom
    J Biol Chem 280:1086-94. 2005
    ..A mechanism for Orf663 (CobZ) in cobalamin biosynthesis is proposed...
  4. pmc Characterization of retinaldehyde dehydrogenase 3
    Caroline E Graham
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Biochem J 394:67-75. 2006
    ..The macroscopic pKa of the minor ionization (5.0) is considered to approximate to that of the carboxy group of Glu488...
  5. ncbi request reprint Characterization of the cobaltochelatase CbiXL: evidence for a 4Fe-4S center housed within an MXCXXC motif
    Helen K Leech
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    J Biol Chem 278:41900-7. 2003
    ..The potential physiological role of the iron-sulfur center is discussed...
  6. ncbi request reprint A story of chelatase evolution: identification and characterization of a small 13-15-kDa "ancestral" cobaltochelatase (CbiXS) in the archaea
    Amanda A Brindley
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom
    J Biol Chem 278:22388-95. 2003
    ..A classification scheme for chelatases is proposed...
  7. pmc Identification and functional analysis of enzymes required for precorrin-2 dehydrogenation and metal ion insertion in the biosynthesis of sirohaem and cobalamin in Bacillus megaterium
    Evelyne Raux
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Biochem J 370:505-16. 2003
    ..Sequence alignments suggest that SirB and CbiX share a similar active site to the cobaltochelatase, CbiK, from Salmonella enterica...
  8. ncbi request reprint Purification, characterisation and intracellular localisation of aryl hydrocarbon interacting protein-like 1 (AIPL1) and effects of mutations associated with inherited retinal dystrophies
    Victoria A Gallon
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, E1 4NS, UK
    Biochim Biophys Acta 1690:141-9. 2004
    ..Other mutations appear to have a more localised effect on secondary structure, which does not result in insolubility or affect protein targeting, but reduces the stability of the protein at human body temperature...
  9. ncbi request reprint Elucidation of substrate specificity in the cobalamin (vitamin B12) biosynthetic methyltransferases. Structure and function of the C20 methyltransferase (CbiL) from Methanothermobacter thermautotrophicus
    Stefanie Frank
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, United Kingdom
    J Biol Chem 282:23957-69. 2007
    ..The chemical logic underpinning the methylation is discussed...
  10. ncbi request reprint Isolation and characterization of 14 additional genes specifying the anaerobic biosynthesis of cobalamin (vitamin B12) in Propionibacterium freudenreichii (P. shermanii)
    Charles A Roessner
    Center for Biological NMR, Department of Chemistry, Texas A and M University, College Station, TX 77843 3255, USA
    Microbiology 148:1845-53. 2002
    ..The functions of the P. freudenreichii B12 pathway genes are discussed, and a mechanism for the regulation of cobalamin and propionic acid production by oxygen in this organism is proposed...
  11. ncbi request reprint Structure/function studies on a S-adenosyl-L-methionine-dependent uroporphyrinogen III C methyltransferase (SUMT), a key regulatory enzyme of tetrapyrrole biosynthesis
    Jitka Vévodová
    Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW, UK
    J Mol Biol 344:419-33. 2004
    ..The activity of these variants is interpreted with respect to the structure of the enzyme...
  12. doi request reprint Identification, characterization, and structure/function analysis of a corrin reductase involved in adenosylcobalamin biosynthesis
    Andrew D Lawrence
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    J Biol Chem 283:10813-21. 2008
    ..Kinetic and EPR analysis reveals that the enzyme proceeds via a semiquinone form. It is proposed that CobR may interact with the adenosyltransferase to overcome the large thermodynamic barrier required for co(II)rrin reduction...
  13. ncbi request reprint Iron-sulfur proteins as initiators of radical chemistry
    Andree Marquet
    Universite Pierre et Marie Curie Paris 6, CNRS UMR 7613, Synthèse, Structure et Fonction de Molécules Bioactives, Paris, France
    Nat Prod Rep 24:1027-40. 2007
    ..This set of enzymes, which represent a means to perform oxidation under reductive conditions, are often present in anaerobic organisms. Some other, non-SAM-dependent, radical reactions obeying the same chemical logic are also covered...
  14. ncbi request reprint Metal and cofactor insertion
    Ralf R Mendel
    Department of Plant Biology, Technical University of Braunschweig, 38106, Braunschweig, Germany
    Nat Prod Rep 24:963-71. 2007
    ....
  15. ncbi request reprint Roles of vitamins B5, B8, B9, B12 and molybdenum cofactor at cellular and organismal levels
    Fabrice Rebeille
    Laboratoire de Physiologie Cellulaire Végétale, UMR5168, Université Joseph Fourier CNRS CEA INRA, Institut de Recherche en Technologies et Sciences du Vivant, CEA Grenoble, Grenoble, Cedex 9, France
    Nat Prod Rep 24:949-62. 2007
    ..In the second part we will present some nutritional aspects and potential strategies to enhance the cofactor contents in organisms of interest...
  16. doi request reprint Two distinct roles for two functional cobaltochelatases (CbiK) in Desulfovibrio vulgaris hildenborough
    Susana A L Lobo
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Avenida da Republica EAN, 2780 157 Oeiras, Portugal
    Biochemistry 47:5851-7. 2008
    ..Finally, the ability of D. vulgaris to produce vitamin B 12 was also demonstrated in this work...
  17. pmc Algae need their vitamins
    Martin T Croft
    Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom
    Eukaryot Cell 5:1175-83. 2006
  18. ncbi request reprint Crystal structure of the vitamin B12 biosynthetic cobaltochelatase, CbiXS, from Archaeoglobus fulgidus
    Jiang Yin
    Group in Protein Structure and Function, Department of Biochemistry, University of Alberta, Edmonton, AB, Canada, T6G 2H7
    J Struct Funct Genomics 7:37-50. 2006
    ....
  19. pmc Finding the final pieces of the vitamin B12 biosynthetic jigsaw
    Martin J Warren
    Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Proc Natl Acad Sci U S A 103:4799-800. 2006
  20. ncbi request reprint Interactions of RadB, a DNA repair protein in archaea, with DNA and ATP
    Colin P Guy
    Institute of Genetics School of Biology, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    J Mol Biol 358:46-56. 2006
    ..ATP-induced conformational change in RadB may explain previous reports that RadB controls Holliday junction resolution by Hjc, depending on the presence or the absence of ATP...
  21. pmc Crystallization and preliminary structure analysis of CobE, an essential protein of cobalamin (vitamin B12) biosynthesis
    Jitka Vévodová
    Department of Chemistry, University of York, Heslington, York YO10 5YW, England
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:442-4. 2005
    ..SeMet-labelled CobE has been prepared and crystallizes under the same conditions as the native protein with diffraction to 1.7 A. The anomalous measurements will be used for phasing...
  22. ncbi request reprint Algae acquire vitamin B12 through a symbiotic relationship with bacteria
    Martin T Croft
    Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK
    Nature 438:90-3. 2005
    ..The source of cobalamin seems to be bacteria, indicating an important and unsuspected symbiosis...
  23. ncbi request reprint The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase
    Rajasekhar Neeli
    Manchester Interdisciplinary Biocentre, School of Chemical Engineering and Analytical Science, The University of Manchester, Jackson s Mill, UK
    FEBS Lett 579:5582-8. 2005
    ..Fatty acid oxidation is reconstituted by mixing inactive oxygenase (A264H) and FMN-depleted (G570D) mutants, demonstrating that inter-monomer (FMN(1)-to-heme(2)) electron transfer supports oxygenase activity in the BM3 dimer...
  24. ncbi request reprint CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis
    M Elizabeth Stroupe
    Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Struct Biol 10:1064-73. 2003
    ..From mutational analysis of the post-translationally modified serine, we suggest a conserved role for phosphorylation in inhibiting dehydrogenase activity and modulating metabolic flux between siroheme and cobalamin pathways...
  25. ncbi request reprint Cobalamin synthesis in Yersinia enterocolitica 8081. Functional aspects of a putative metabolic island
    Michael B Prentice
    Bart s and The London Medical School, London EC1A 7BE, UK
    Adv Exp Med Biol 529:43-6. 2003
  26. pmc Lactobacillus reuteri DSM 20016 produces cobalamin-dependent diol dehydratase in metabolosomes and metabolizes 1,2-propanediol by disproportionation
    Dinesh Diraviam Sriramulu
    Department of Microbiology, University College Cork, Cork, Ireland
    J Bacteriol 190:4559-67. 2008
    ..reuteri. The metabolosome-associated diol dehydratase we describe is the only candidate glycerol dehydratase present on inspection of the L. reuteri F275 genome sequence...