Research Topics
Genomes and Genes | Martin J WarrenSummaryAffiliation: Queen Mary Country: UK Publications
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Publications
The biosynthesis of adenosylcobalamin (vitamin B12)Martin J Warren
School of Biological Sciences, Queen Mary, University of London, Mile End Road, London, UK E1 4NS
Nat Prod Rep 19:390-412. 2002..This review covers some of the most important findings that have been made and provides the reader with a complete description of the transformation of uroporphyrinogen III into adenosylcobalamin (AdoCbl). 183 references are cited...- Identification and characterization of the terminal enzyme of siroheme biosynthesis from Arabidopsis thaliana: a plastid-located sirohydrochlorin ferrochelatase containing a 2FE-2S centerEvelyne Raux-Deery
School of Biological Sciences, Queen Mary, University of London, Mile End Rd, London E1 4NS, United Kingdom
J Biol Chem 280:4713-21. 2005..This is the first Fe-S center to be reported in a higher plant ferrochelatase. The implications of the Fe-S center in an enzyme that is so closely associated with the metabolism of sulfur and iron are discussed... - Identification and characterization of a novel vitamin B12 (cobalamin) biosynthetic enzyme (CobZ) from Rhodobacter capsulatus, containing flavin, heme, and Fe-S cofactorsHelen M McGoldrick
School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom
J Biol Chem 280:1086-94. 2005..A mechanism for Orf663 (CobZ) in cobalamin biosynthesis is proposed... 
Characterization of retinaldehyde dehydrogenase 3Caroline E Graham
School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
Biochem J 394:67-75. 2006..The macroscopic pKa of the minor ionization (5.0) is considered to approximate to that of the carboxy group of Glu488...- Characterization of the cobaltochelatase CbiXL: evidence for a 4Fe-4S center housed within an MXCXXC motifHelen K Leech
School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
J Biol Chem 278:41900-7. 2003..The potential physiological role of the iron-sulfur center is discussed... - A story of chelatase evolution: identification and characterization of a small 13-15-kDa "ancestral" cobaltochelatase (CbiXS) in the archaeaAmanda A Brindley
School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom
J Biol Chem 278:22388-95. 2003..A classification scheme for chelatases is proposed... - Identification and functional analysis of enzymes required for precorrin-2 dehydrogenation and metal ion insertion in the biosynthesis of sirohaem and cobalamin in Bacillus megateriumEvelyne Raux
School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
Biochem J 370:505-16. 2003..Sequence alignments suggest that SirB and CbiX share a similar active site to the cobaltochelatase, CbiK, from Salmonella enterica... - Purification, characterisation and intracellular localisation of aryl hydrocarbon interacting protein-like 1 (AIPL1) and effects of mutations associated with inherited retinal dystrophiesVictoria A Gallon
School of Biological Sciences, Queen Mary, University of London, Mile End Road, E1 4NS, UK
Biochim Biophys Acta 1690:141-9. 2004..Other mutations appear to have a more localised effect on secondary structure, which does not result in insolubility or affect protein targeting, but reduces the stability of the protein at human body temperature... - Elucidation of substrate specificity in the cobalamin (vitamin B12) biosynthetic methyltransferases. Structure and function of the C20 methyltransferase (CbiL) from Methanothermobacter thermautotrophicusStefanie Frank
Protein Science Group, Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, United Kingdom
J Biol Chem 282:23957-69. 2007..The chemical logic underpinning the methylation is discussed... - Isolation and characterization of 14 additional genes specifying the anaerobic biosynthesis of cobalamin (vitamin B12) in Propionibacterium freudenreichii (P. shermanii)Charles A Roessner
Center for Biological NMR, Department of Chemistry, Texas A and M University, College Station, TX 77843 3255, USA
Microbiology 148:1845-53. 2002..The functions of the P. freudenreichii B12 pathway genes are discussed, and a mechanism for the regulation of cobalamin and propionic acid production by oxygen in this organism is proposed... - Structure/function studies on a S-adenosyl-L-methionine-dependent uroporphyrinogen III C methyltransferase (SUMT), a key regulatory enzyme of tetrapyrrole biosynthesisJitka Vévodová
Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW, UK
J Mol Biol 344:419-33. 2004..The activity of these variants is interpreted with respect to the structure of the enzyme... 
Identification, characterization, and structure/function analysis of a corrin reductase involved in adenosylcobalamin biosynthesisAndrew D Lawrence
Protein Science Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
J Biol Chem 283:10813-21. 2008..Kinetic and EPR analysis reveals that the enzyme proceeds via a semiquinone form. It is proposed that CobR may interact with the adenosyltransferase to overcome the large thermodynamic barrier required for co(II)rrin reduction...- Iron-sulfur proteins as initiators of radical chemistryAndree Marquet
Universite Pierre et Marie Curie Paris 6, CNRS UMR 7613, Synthèse, Structure et Fonction de Molécules Bioactives, Paris, France
Nat Prod Rep 24:1027-40. 2007..This set of enzymes, which represent a means to perform oxidation under reductive conditions, are often present in anaerobic organisms. Some other, non-SAM-dependent, radical reactions obeying the same chemical logic are also covered... - Metal and cofactor insertionRalf R Mendel
Department of Plant Biology, Technical University of Braunschweig, 38106, Braunschweig, Germany
Nat Prod Rep 24:963-71. 2007.... - Roles of vitamins B5, B8, B9, B12 and molybdenum cofactor at cellular and organismal levelsFabrice Rebeille
Laboratoire de Physiologie Cellulaire Végétale, UMR5168, Université Joseph Fourier CNRS CEA INRA, Institut de Recherche en Technologies et Sciences du Vivant, CEA Grenoble, Grenoble, Cedex 9, France
Nat Prod Rep 24:949-62. 2007..In the second part we will present some nutritional aspects and potential strategies to enhance the cofactor contents in organisms of interest... - Two distinct roles for two functional cobaltochelatases (CbiK) in Desulfovibrio vulgaris hildenboroughSusana A L Lobo
Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Avenida da Republica EAN, 2780 157 Oeiras, Portugal
Biochemistry 47:5851-7. 2008..Finally, the ability of D. vulgaris to produce vitamin B 12 was also demonstrated in this work... - Algae need their vitaminsMartin T Croft
Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom
Eukaryot Cell 5:1175-83. 2006 - Crystal structure of the vitamin B12 biosynthetic cobaltochelatase, CbiXS, from Archaeoglobus fulgidusJiang Yin
Group in Protein Structure and Function, Department of Biochemistry, University of Alberta, Edmonton, AB, Canada, T6G 2H7
J Struct Funct Genomics 7:37-50. 2006.... - Finding the final pieces of the vitamin B12 biosynthetic jigsawMartin J Warren
Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
Proc Natl Acad Sci U S A 103:4799-800. 2006 - Interactions of RadB, a DNA repair protein in archaea, with DNA and ATPColin P Guy
Institute of Genetics School of Biology, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK
J Mol Biol 358:46-56. 2006..ATP-induced conformational change in RadB may explain previous reports that RadB controls Holliday junction resolution by Hjc, depending on the presence or the absence of ATP... - Crystallization and preliminary structure analysis of CobE, an essential protein of cobalamin (vitamin B12) biosynthesisJitka Vévodová
Department of Chemistry, University of York, Heslington, York YO10 5YW, England
Acta Crystallogr Sect F Struct Biol Cryst Commun 61:442-4. 2005..SeMet-labelled CobE has been prepared and crystallizes under the same conditions as the native protein with diffraction to 1.7 A. The anomalous measurements will be used for phasing... - Algae acquire vitamin B12 through a symbiotic relationship with bacteriaMartin T Croft
Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK
Nature 438:90-3. 2005..The source of cobalamin seems to be bacteria, indicating an important and unsuspected symbiosis... - The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylaseRajasekhar Neeli
Manchester Interdisciplinary Biocentre, School of Chemical Engineering and Analytical Science, The University of Manchester, Jackson's Mill, UK
FEBS Lett 579:5582-8. 2005..Fatty acid oxidation is reconstituted by mixing inactive oxygenase (A264H) and FMN-depleted (G570D) mutants, demonstrating that inter-monomer (FMN(1)-to-heme(2)) electron transfer supports oxygenase activity in the BM3 dimer... - CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesisM Elizabeth Stroupe
Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Nat Struct Biol 10:1064-73. 2003..From mutational analysis of the post-translationally modified serine, we suggest a conserved role for phosphorylation in inhibiting dehydrogenase activity and modulating metabolic flux between siroheme and cobalamin pathways... - Cobalamin synthesis in Yersinia enterocolitica 8081. Functional aspects of a putative metabolic islandMichael B Prentice
Bart's and the London Medical School, London EC1A 7BE, UK
Adv Exp Med Biol 529:43-6. 2003 - Lactobacillus reuteri DSM 20016 produces cobalamin-dependent diol dehydratase in metabolosomes and metabolizes 1,2-propanediol by disproportionationDinesh Diraviam Sriramulu
Department of Microbiology, University College Cork, Cork, Ireland
J Bacteriol 190:4559-67. 2008..reuteri. The metabolosome-associated diol dehydratase we describe is the only candidate glycerol dehydratase present on inspection of the L. reuteri F275 genome sequence...