T D Warner

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. pmc Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis
    T D Warner
    The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, United Kingdom
    Proc Natl Acad Sci U S A 96:7563-8. 1999
  2. ncbi request reprint Relationships between the endothelin and nitric oxide pathways
    T D Warner
    William Harvey Research Institute, St Bartholomew s, London, UK
    Clin Exp Pharmacol Physiol 26:247-52. 1999
  3. pmc Use of the endothelin antagonists BQ-123 and PD 142893 to reveal three endothelin receptors mediating smooth muscle contraction and the release of EDRF
    T D Warner
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 110:777-82. 1993
  4. pmc Contractile activity of endothelin precursors in the isolated gallbladder of the guinea-pig: presence of an endothelin-converting enzyme
    B Battistini
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 114:1383-90. 1995
  5. pmc Characterization of ETB receptors mediating contractions induced by endothelin-1 or IRL 1620 in guinea-pig isolated airways: effects of BQ-123, FR139317 or PD 145065
    B Battistini
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 111:1009-16. 1994
  6. pmc Induction by endotoxin of nitric oxide synthase in the rat mesentery: lack of effect on action of vasoconstrictors
    J A Mitchell
    William Harvey Research Institute, Medical College of Saint Bartholomews Hospital, London
    Br J Pharmacol 109:265-70. 1993
  7. pmc Characterization of endothelin receptors mediating the effects of the endothelin/sarafotoxin peptides on autonomic neurotransmission in the rat vas deferens and guinea-pig ileum
    T D Warner
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 110:783-9. 1993
  8. ncbi request reprint Effects of nitric oxide-modulating amino acids on coronary vessels: relevance to sepsis
    J A Mitchell
    Unit of Critical Care Medicine, Imperial College School of Medicine, Royal Brompton Hospital, Sydney Street, London, UK
    Eur J Pharmacol 389:209-15. 2000
  9. pmc Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors
    P A Gray
    Department of Cardiac, Vascular and Inflammation Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Br J Pharmacol 137:1031-8. 2002
  10. ncbi request reprint Sodium salicylate inhibits prostaglandin formation without affecting the induction of cyclooxygenase-2 by bacterial lipopolysaccharide in vivo
    F Giuliano
    Department of Cardiac, Vascular and Inflammation Research, The William Harvey Research Institute, St. Bartholomew's and the Royal London Queen Mary's School of Medicine and Dentistry, University of London, United Kingdom
    J Pharmacol Exp Ther 299:894-900. 2001

Collaborators

Detail Information

Publications27

  1. pmc Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis
    T D Warner
    The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, United Kingdom
    Proc Natl Acad Sci U S A 96:7563-8. 1999
    ..In conclusion, this full in vitro analysis of COX-1/2 selectivities in human tissues clearly supports the theory that inhibition of COX-1 underlies the gastrointestinal toxicity of NSAIDs in man...
  2. ncbi request reprint Relationships between the endothelin and nitric oxide pathways
    T D Warner
    William Harvey Research Institute, St Bartholomew s, London, UK
    Clin Exp Pharmacol Physiol 26:247-52. 1999
    ..5. Therefore, in pathological states, a new balance between NO and ET-1 production may be central to changes in blood vessel reactivity, smooth muscle proliferation and blood coagulability...
  3. pmc Use of the endothelin antagonists BQ-123 and PD 142893 to reveal three endothelin receptors mediating smooth muscle contraction and the release of EDRF
    T D Warner
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 110:777-82. 1993
    ..Thus, the receptor present on the endothelium responsible for the release of nitric oxide in response to the ET/SX peptides is most probably different from that present on smooth muscle that mediates BQ-123-insensitive contractions...
  4. pmc Contractile activity of endothelin precursors in the isolated gallbladder of the guinea-pig: presence of an endothelin-converting enzyme
    B Battistini
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 114:1383-90. 1995
    ..11) and not located on the epithelium, converts big ET-1 into ET-1 in the gallbladder of the guinea-pig. This ECE appears to act preferentially on big ET-1 or big ET-2 over bigET-3...
  5. pmc Characterization of ETB receptors mediating contractions induced by endothelin-1 or IRL 1620 in guinea-pig isolated airways: effects of BQ-123, FR139317 or PD 145065
    B Battistini
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 111:1009-16. 1994
    ..High concentrations(10-5 M) of ETA-selective antagonists also inhibit responses to IRL 1620, most probably by an effect at ETB receptors in both the trachea and the upper bronchus...
  6. pmc Induction by endotoxin of nitric oxide synthase in the rat mesentery: lack of effect on action of vasoconstrictors
    J A Mitchell
    William Harvey Research Institute, Medical College of Saint Bartholomews Hospital, London
    Br J Pharmacol 109:265-70. 1993
    ..This may explain the poor perfusion and tissue damage in the splanchnic circulation associated with sepsis...
  7. pmc Characterization of endothelin receptors mediating the effects of the endothelin/sarafotoxin peptides on autonomic neurotransmission in the rat vas deferens and guinea-pig ileum
    T D Warner
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 110:783-9. 1993
    ..6. Thus, both ETA receptors and ETB receptors mediate the effects of the endothelin/sarafotoxinpeptides on neurotransmission...
  8. ncbi request reprint Effects of nitric oxide-modulating amino acids on coronary vessels: relevance to sepsis
    J A Mitchell
    Unit of Critical Care Medicine, Imperial College School of Medicine, Royal Brompton Hospital, Sydney Street, London, UK
    Eur J Pharmacol 389:209-15. 2000
    ..Moreover, it suggests that vascular reactivity may be modulated positively or negatively by supplementation with the relevant amino acids...
  9. pmc Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors
    P A Gray
    Department of Cardiac, Vascular and Inflammation Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Br J Pharmacol 137:1031-8. 2002
    ..This suggests that NO-aspirin may be better tolerated than aspirin by aspirin-sensitive asthmatics...
  10. ncbi request reprint Sodium salicylate inhibits prostaglandin formation without affecting the induction of cyclooxygenase-2 by bacterial lipopolysaccharide in vivo
    F Giuliano
    Department of Cardiac, Vascular and Inflammation Research, The William Harvey Research Institute, St. Bartholomew's and the Royal London Queen Mary's School of Medicine and Dentistry, University of London, United Kingdom
    J Pharmacol Exp Ther 299:894-900. 2001
    ..In conclusion, our results exclude mechanisms other than direct enzyme inhibition as responsible for the anti-COX effects of salicylate...
  11. pmc Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065
    T D Warner
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 112:207-13. 1994
    ..This may be because PD 145065 also reduces vasodilatations induced by ET-1 in vivo, or could suggest that because of its peptide structure PD 145065 affects the elimination of ET-1...
  12. pmc Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids
    T A Swierkosz
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 114:1335-42. 1995
    ..In the absence of endogenous NO, lesser amounts of exogenous NO increase the activity of COX-2. In those situations in vivo when the level of NO induction is relatively low, NO does not regulate the increased activity of COX...
  13. pmc Rapid degradation of endothelin-1 by an enzyme released by the rat isolated perfused mesentery
    F Perez-Vizcaino
    William Harvey Research Institute, Medical College of Saint Bartholomews Hospital, London
    Br J Pharmacol 114:867-71. 1995
    ..It is tempting, therefore, to speculate that the endothelin degrading enzyme active at neutral pH that- we have found is important in the metabolism of ET-1 throughout the vasculature...
  14. pmc In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation
    P C J Armstrong
    The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    J Thromb Haemost 9:552-61. 2011
    ..However, blockade of platelet P2Y(12) receptors can inhibit thromboxane A(2) (TXA(2))-dependent pathways of platelet activation independently of aspirin...
  15. pmc Characterization of endothelin (ET) receptors in the isolated gall bladder of the guinea-pig: evidence for an additional ET receptor subtype
    B Battistini
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 112:1244-50. 1994
    ..Keywords: Endothelin; sarafotoxin; receptors; antagonists; gall bladder; guinea-pig..
  16. pmc Aspirin has little additional anti-platelet effect in healthy volunteers receiving prasugrel
    P D M Leadbeater
    Department of Cardiothoracic Pharmacology, Imperial College London, National Heart and Lung Institute, London, UK
    J Thromb Haemost 9:2050-6. 2011
    ....
  17. pmc Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages
    L Moreno
    Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London, UK
    Br J Pharmacol 160:1997-2007. 2010
    ..Lipopolysaccharide (LPS) activates TLR4, while peptidoglycan products activate NOD1. Activation of NOD1 by the specific agonist FK565 results in a profound vascular dysfunction and experimental shock in vivo...
  18. ncbi request reprint Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluation
    F Giuliano
    Department of Cardiac, Vascular and Inflammation Research, The William Harvey Research Institute, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Charterhouse Square, EC1M 6BQ, London, UK
    Eur J Pharmacol 426:95-103. 2001
    ....
  19. ncbi request reprint Endothelin-1 and U46619 potentiate selectively the venous responses to nerve stimulation within the perfused superior mesenteric vascular bed of the rat
    T D Warner
    William Harvey Research Institute, Medical College of St Bartholomew s Hospital, London
    Biochem Biophys Res Commun 172:745-50. 1990
    ..In addition, endothelin-1 and U46619 potentiate selectively the effects of nerve stimulation on the veins...
  20. doi request reprint Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periods
    N J Truss
    Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK
    J Thromb Haemost 7:1897-905. 2009
    ..This constrains studies of platelet activity in clinical situations where samples need to be transported or there are unavoidable delays prior to assessment...
  21. pmc Evidence from receptor antagonists of an important role for ETB receptor-mediated vasoconstrictor effects of endothelin-1 in the rat kidney
    R P Wellings
    William Harvey Research Institute, Medical College, St Bartholomew s Hospital, London
    Br J Pharmacol 111:515-20. 1994
    ..This may be of therapeutic relevance for an ETA receptor-selective antagonist may offer only limited protection against the deleterious renal effects of endogenous ETs...
  22. pmc Comparison of effects of chronic and acute administration of NG-nitro-L-arginine methyl ester to the rat on inhibition of nitric oxide-mediated responses
    C E Bryant
    William Harvey Research Institute, Medical College of Saint Bartholomew s Hospital, London
    Br J Pharmacol 114:1673-9. 1995
    ..The resistance of peripheral neuronal NO responses to chronic treatment with L-NAME indicates that selective inhibition of different isoforms of NOS may be achieved in vivo...
  23. pmc Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells
    N Kvirkvelia
    Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, London, UK
    Clin Exp Immunol 127:263-9. 2002
    ..Thus, addition of an EP4-selective antagonist, but not of EP1 or EP3 antagonists, abolished the immunosuppressive effect of PGE2 on CTLL-2 cells. This may have implications for attempts to selectively manipulate T-cell responses...
  24. doi request reprint Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet production of thromboxane A2
    P C J Armstrong
    William Harvey Research Institute, Barts and London School of Medicine and Dentistry, Charterhouse Square, London, UK
    J Thromb Haemost 6:1933-43. 2008
    ..This relationship, however, has never been rigorously tested. Objectives: To characterize, in vitro and ex vivo, the concentration-dependent relationships between TXA(2) generation and platelet activity...
  25. pmc Bisphenol A diglycidyl ether (BADGE) is a PPARgamma agonist in an ECV304 cell line
    D Bishop-Bailey
    Department of Cardiac, Vascular and Inflammation Research, William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK
    Br J Pharmacol 131:651-4. 2000
    ..Similar to 15-deoxy-Delta(12,14) PGJ(2), BADGE induces PPARgamma activation, nuclear localization of the receptor, and induces cell death...
  26. ncbi request reprint Endothelin content, expression, and receptor type in normal and diseased human gallbladder
    S A McCartney
    Digestive Diseases Research Centre, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    Dig Dis Sci 47:1786-92. 2002
    ..ET-1/2 content is decreased with increasing degrees of histological inflammation. ET-2 is likely to be the physiologically significant endothelin isopeptide expressed and ETA receptors appear to predominate in the human gallbladder...
  27. ncbi request reprint Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzyme
    M Woods
    Vascular Inflammation, The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, United Kingdom
    Mol Pharmacol 55:902-9. 1999
    ....