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Genomes and Genes | T D WarnerSummaryAffiliation: Queen Mary Country: UK Publications
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Publications
Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysisT D Warner
The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, United Kingdom
Proc Natl Acad Sci U S A 96:7563-8. 1999..In conclusion, this full in vitro analysis of COX-1/2 selectivities in human tissues clearly supports the theory that inhibition of COX-1 underlies the gastrointestinal toxicity of NSAIDs in man...
Relationships between the endothelin and nitric oxide pathwaysT D Warner
William Harvey Research Institute, St Bartholomew s, London, UK
Clin Exp Pharmacol Physiol 26:247-52. 1999..5. Therefore, in pathological states, a new balance between NO and ET-1 production may be central to changes in blood vessel reactivity, smooth muscle proliferation and blood coagulability...- Use of the endothelin antagonists BQ-123 and PD 142893 to reveal three endothelin receptors mediating smooth muscle contraction and the release of EDRFT D Warner
William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
Br J Pharmacol 110:777-82. 1993..Thus, the receptor present on the endothelium responsible for the release of nitric oxide in response to the ET/SX peptides is most probably different from that present on smooth muscle that mediates BQ-123-insensitive contractions... - Contractile activity of endothelin precursors in the isolated gallbladder of the guinea-pig: presence of an endothelin-converting enzymeB Battistini
William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
Br J Pharmacol 114:1383-90. 1995..11) and not located on the epithelium, converts big ET-1 into ET-1 in the gallbladder of the guinea-pig. This ECE appears to act preferentially on big ET-1 or big ET-2 over bigET-3... - Characterization of ETB receptors mediating contractions induced by endothelin-1 or IRL 1620 in guinea-pig isolated airways: effects of BQ-123, FR139317 or PD 145065B Battistini
William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
Br J Pharmacol 111:1009-16. 1994..High concentrations(10-5 M) of ETA-selective antagonists also inhibit responses to IRL 1620, most probably by an effect at ETB receptors in both the trachea and the upper bronchus... - Induction by endotoxin of nitric oxide synthase in the rat mesentery: lack of effect on action of vasoconstrictorsJ A Mitchell
William Harvey Research Institute, Medical College of Saint Bartholomews Hospital, London
Br J Pharmacol 109:265-70. 1993..This may explain the poor perfusion and tissue damage in the splanchnic circulation associated with sepsis... - Characterization of endothelin receptors mediating the effects of the endothelin/sarafotoxin peptides on autonomic neurotransmission in the rat vas deferens and guinea-pig ileumT D Warner
William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
Br J Pharmacol 110:783-9. 1993..6. Thus, both ETA receptors and ETB receptors mediate the effects of the endothelin/sarafotoxinpeptides on neurotransmission... - Effects of nitric oxide-modulating amino acids on coronary vessels: relevance to sepsisJ A Mitchell
Unit of Critical Care Medicine, Imperial College School of Medicine, Royal Brompton Hospital, Sydney Street, London, UK
Eur J Pharmacol 389:209-15. 2000..Moreover, it suggests that vascular reactivity may be modulated positively or negatively by supplementation with the relevant amino acids... - Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donorsP A Gray
Department of Cardiac, Vascular and Inflammation Research, St Bartholomew's and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
Br J Pharmacol 137:1031-8. 2002..This suggests that NO-aspirin may be better tolerated than aspirin by aspirin-sensitive asthmatics... - Sodium salicylate inhibits prostaglandin formation without affecting the induction of cyclooxygenase-2 by bacterial lipopolysaccharide in vivoF Giuliano
Department of Cardiac, Vascular and Inflammation Research, The William Harvey Research Institute, St. Bartholomew's and the Royal London Queen Mary's School of Medicine and Dentistry, University of London, United Kingdom
J Pharmacol Exp Ther 299:894-900. 2001..In conclusion, our results exclude mechanisms other than direct enzyme inhibition as responsible for the anti-COX effects of salicylate... - Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065T D Warner
William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
Br J Pharmacol 112:207-13. 1994..This may be because PD 145065 also reduces vasodilatations induced by ET-1 in vivo, or could suggest that because of its peptide structure PD 145065 affects the elimination of ET-1... - Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoidsT A Swierkosz
William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
Br J Pharmacol 114:1335-42. 1995..In the absence of endogenous NO, lesser amounts of exogenous NO increase the activity of COX-2. In those situations in vivo when the level of NO induction is relatively low, NO does not regulate the increased activity of COX... - Rapid degradation of endothelin-1 by an enzyme released by the rat isolated perfused mesenteryF Perez-Vizcaino
William Harvey Research Institute, Medical College of Saint Bartholomews Hospital, London
Br J Pharmacol 114:867-71. 1995..It is tempting, therefore, to speculate that the endothelin degrading enzyme active at neutral pH that- we have found is important in the metabolism of ET-1 throughout the vasculature... - In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregationP C J Armstrong
The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
J Thromb Haemost 9:552-61. 2011..However, blockade of platelet P2Y(12) receptors can inhibit thromboxane A(2) (TXA(2))-dependent pathways of platelet activation independently of aspirin... - Characterization of endothelin (ET) receptors in the isolated gall bladder of the guinea-pig: evidence for an additional ET receptor subtypeB Battistini
William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
Br J Pharmacol 112:1244-50. 1994..Keywords: Endothelin; sarafotoxin; receptors; antagonists; gall bladder; guinea-pig.. - Aspirin has little additional anti-platelet effect in healthy volunteers receiving prasugrelP D M Leadbeater
Department of Cardiothoracic Pharmacology, Imperial College London, National Heart and Lung Institute, London, UK
J Thromb Haemost 9:2050-6. 2011.... - Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophagesL Moreno
Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London, UK
Br J Pharmacol 160:1997-2007. 2010..Lipopolysaccharide (LPS) activates TLR4, while peptidoglycan products activate NOD1. Activation of NOD1 by the specific agonist FK565 results in a profound vascular dysfunction and experimental shock in vivo... - Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluationF Giuliano
Department of Cardiac, Vascular and Inflammation Research, The William Harvey Research Institute, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Charterhouse Square, EC1M 6BQ, London, UK
Eur J Pharmacol 426:95-103. 2001.... - Endothelin-1 and U46619 potentiate selectively the venous responses to nerve stimulation within the perfused superior mesenteric vascular bed of the ratT D Warner
William Harvey Research Institute, Medical College of St Bartholomew s Hospital, London
Biochem Biophys Res Commun 172:745-50. 1990..In addition, endothelin-1 and U46619 potentiate selectively the effects of nerve stimulation on the veins... 
Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periodsN J Truss
Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK
J Thromb Haemost 7:1897-905. 2009..This constrains studies of platelet activity in clinical situations where samples need to be transported or there are unavoidable delays prior to assessment...- Evidence from receptor antagonists of an important role for ETB receptor-mediated vasoconstrictor effects of endothelin-1 in the rat kidneyR P Wellings
William Harvey Research Institute, Medical College, St Bartholomew s Hospital, London
Br J Pharmacol 111:515-20. 1994..This may be of therapeutic relevance for an ETA receptor-selective antagonist may offer only limited protection against the deleterious renal effects of endogenous ETs... - Comparison of effects of chronic and acute administration of NG-nitro-L-arginine methyl ester to the rat on inhibition of nitric oxide-mediated responsesC E Bryant
William Harvey Research Institute, Medical College of Saint Bartholomew s Hospital, London
Br J Pharmacol 114:1673-9. 1995..The resistance of peripheral neuronal NO responses to chronic treatment with L-NAME indicates that selective inhibition of different isoforms of NOS may be achieved in vivo... - Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cellsN Kvirkvelia
Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, London, UK
Clin Exp Immunol 127:263-9. 2002..Thus, addition of an EP4-selective antagonist, but not of EP1 or EP3 antagonists, abolished the immunosuppressive effect of PGE2 on CTLL-2 cells. This may have implications for attempts to selectively manipulate T-cell responses... - Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet production of thromboxane A2P C J Armstrong
William Harvey Research Institute, Barts and London School of Medicine and Dentistry, Charterhouse Square, London, UK
J Thromb Haemost 6:1933-43. 2008..This relationship, however, has never been rigorously tested. Objectives: To characterize, in vitro and ex vivo, the concentration-dependent relationships between TXA(2) generation and platelet activity... - Bisphenol A diglycidyl ether (BADGE) is a PPARgamma agonist in an ECV304 cell lineD Bishop-Bailey
Department of Cardiac, Vascular and Inflammation Research, William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK
Br J Pharmacol 131:651-4. 2000..Similar to 15-deoxy-Delta(12,14) PGJ(2), BADGE induces PPARgamma activation, nuclear localization of the receptor, and induces cell death... - Endothelin content, expression, and receptor type in normal and diseased human gallbladderS A McCartney
Digestive Diseases Research Centre, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
Dig Dis Sci 47:1786-92. 2002..ET-1/2 content is decreased with increasing degrees of histological inflammation. ET-2 is likely to be the physiologically significant endothelin isopeptide expressed and ETA receptors appear to predominate in the human gallbladder... - Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzymeM Woods
Vascular Inflammation, The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, United Kingdom
Mol Pharmacol 55:902-9. 1999....